{"id":"https://openalex.org/W159098617","doi":null,"title":"Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference","display_name":"Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W159098617","mag":"159098617"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-180920","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180920","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065796691","display_name":"Carl Nettelblad","orcid":"https://orcid.org/0000-0003-0458-6902","observed_orcids":["https://orcid.org/0000-0003-0458-6902"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carl Nettelblad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0458-6902","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065796691"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2605000138282776,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.13220000267028809,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.949999988079071},{"id":"https://openalex.org/keywords/haplotype-inference","display_name":"haplotype inference","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hidden-markov-models","display_name":"hidden Markov models","score":0.8560000061988831},{"id":"https://openalex.org/keywords/allele-inheritance","display_name":"allele inheritance","score":0.46299999952316284},{"id":"https://openalex.org/keywords/experimental-crosses","display_name":"experimental crosses","score":0.6150000095367432},{"id":"https://openalex.org/keywords/genotype-imputation","display_name":"genotype imputation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7829999923706055},{"id":"https://openalex.org/keywords/model-selection","display_name":"model selection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/orthogonal-models","display_name":"orthogonal models","score":0.6790000200271606},{"id":"https://openalex.org/keywords/permutation-tests","display_name":"permutation tests","score":0.4860000014305115},{"id":"https://openalex.org/keywords/grid-computing","display_name":"grid computing","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.7825757265090942},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6649451851844788},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6242490410804749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5845111608505249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45764416456222534},{"id":"https://openalex.org/C44432683","wikidata":"https://www.wikidata.org/wiki/Q17145705","display_name":"Haplotype estimation","level":5,"score":0.4206335246562958},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38115254044532776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3794756233692169},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3350663185119629},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27341580390930176},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.24711468815803528},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16741624474525452}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-180920","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180920","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:159098617","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:552121/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-180920","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180920","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W230060033","https://openalex.org/W1542772707","https://openalex.org/W1556029148","https://openalex.org/W1577941315","https://openalex.org/W1820420379","https://openalex.org/W1910684458","https://openalex.org/W1943221061","https://openalex.org/W1945581881","https://openalex.org/W1963666037","https://openalex.org/W1978837378","https://openalex.org/W1980991473","https://openalex.org/W1992436001","https://openalex.org/W1998158007","https://openalex.org/W2003333103","https://openalex.org/W2022072257","https://openalex.org/W2025871123","https://openalex.org/W2026299065","https://openalex.org/W2032367243","https://openalex.org/W2034608799","https://openalex.org/W2034979835","https://openalex.org/W2036233001","https://openalex.org/W2043882061","https://openalex.org/W2044758663","https://openalex.org/W2049633694","https://openalex.org/W2060964883","https://openalex.org/W2061744749","https://openalex.org/W2068403353","https://openalex.org/W2072956915","https://openalex.org/W2073126845","https://openalex.org/W2074709231","https://openalex.org/W2077683863","https://openalex.org/W2086699924","https://openalex.org/W2086764330","https://openalex.org/W2088510619","https://openalex.org/W2096140674","https://openalex.org/W2097758663","https://openalex.org/W2100604298","https://openalex.org/W2101470512","https://openalex.org/W2105052737","https://openalex.org/W2105306382","https://openalex.org/W2105419086","https://openalex.org/W2105594594","https://openalex.org/W2106121393","https://openalex.org/W2107916366","https://openalex.org/W2107966280","https://openalex.org/W2108076619","https://openalex.org/W2109085886","https://openalex.org/W2113741278","https://openalex.org/W2114611642","https://openalex.org/W2115038037","https://openalex.org/W2116053845","https://openalex.org/W2125838338","https://openalex.org/W2125860227","https://openalex.org/W2126466006","https://openalex.org/W2129250732","https://openalex.org/W2132055897","https://openalex.org/W2132356956","https://openalex.org/W2135843243","https://openalex.org/W2142635246","https://openalex.org/W2146855196","https://openalex.org/W2149943693","https://openalex.org/W2149945426","https://openalex.org/W2151464048","https://openalex.org/W2151831732","https://openalex.org/W2152992515","https://openalex.org/W2154954280","https://openalex.org/W2157106797","https://openalex.org/W2162683818","https://openalex.org/W2163285329","https://openalex.org/W2166501262","https://openalex.org/W2168792943","https://openalex.org/W2169580220","https://openalex.org/W2303043072","https://openalex.org/W2528234406","https://openalex.org/W4292239814"],"related_works":["https://openalex.org/W1608317046","https://openalex.org/W7099524947","https://openalex.org/W311494643","https://openalex.org/W2551553892","https://openalex.org/W7096050200","https://openalex.org/W7095278227","https://openalex.org/W7099398140","https://openalex.org/W2412215757","https://openalex.org/W2019663952","https://openalex.org/W52893749"],"abstract_inverted_index":{"The":[0,58,73,133,153,196,223,269],"existence":[1],"of":[2,19,38,44,49,60,76,205,326],"new":[3,142,158,247],"technologies,":[4],"implemented":[5,181],"in":[6,32,87,182,199,214,237,257,284,311],"efficient":[7,53],"platforms":[8],"and":[9,21,68,138,163,167,219,232,254,260,282,287],"workflows":[10],"has":[11,179],"made":[12],"massive":[13],"genotyping":[14],"available":[15],"to":[16,99,106,115,123,131,251,298],"all":[17],"fields":[18],"biology":[20],"medicine.":[22],"Genetic":[23],"analyses":[24],"are":[25,51,56,249,295,303],"no":[26],"longer":[27],"dominated":[28],"by":[29],"experimental":[30,88,238],"work":[31],"laboratories,":[33],"but":[34],"rather":[35],"the":[36,39,77,108,169,190,200,203,227,246,292,309],"interpretation":[37],"resulting":[40],"data.":[41],"When":[42],"billions":[43],"data":[45,101,171],"points":[46],"representing":[47],"thousands":[48],"individuals":[50,92,259],"available,":[52],"computational":[54],"tools":[55,248,270],"required.":[57],"focus":[59],"this":[61,319],"thesis":[62,78,134,154,201],"is":[63,79,97,121,202,307],"on":[64,192,264],"developing":[65],"models,":[66],"methods":[67,293],"implementations":[69],"for":[70,82,161,174,209,229,318,324],"such":[71],"tools.":[72],"first":[74],"theme":[75,198],"multi-dimensional":[80],"scans":[81],"quantitative":[83],"trait":[84,130],"loci":[85],"(QTL)":[86],"crosses.":[89],"By":[90],"mating":[91],"from":[93],"different":[94],"lines,":[95],"it":[96,120],"possible":[98],"gather":[100],"that":[102,111,186,245],"can":[103,150,187,271],"be":[104,151,321],"used":[105],"pinpoint":[107],"genetic":[109],"variation":[110],"influences":[112],"specific":[113,116],"traits":[114],"genome":[117],"loci.":[118],"However,":[119],"natural":[122],"expect":[124],"multiple":[125],"genes":[126],"influencing":[127],"a":[128,157,183],"single":[129],"interact.":[132],"discusses":[135],"model":[136,139],"structure":[137],"selection,":[140],"giving":[141],"insight":[143],"regarding":[144],"under":[145],"what":[146],"conditions":[147],"orthogonal":[148],"models":[149,213],"devised.":[152],"also":[155,272,296],"presents":[156],"optimization":[159,207],"method":[160,178],"efficiently":[162],"accurately":[164],"locating":[165],"QTL,":[166],"performing":[168],"permuted":[170],"searches":[172,191],"needed":[173],"significance":[175],"testing.":[176],"This":[177],"been":[180],"software":[184],"package":[185],"seamlessly":[188],"perform":[189],"grid":[193],"computing":[194],"infrastructures.":[195],"other":[197],"development":[204],"adapted":[206],"schemes":[208],"using":[210],"hidden":[211],"Markov":[212],"tracing":[215],"allele":[216],"inheritance":[217,280],"pathways,":[218],"specifically":[220],"inferring":[221],"haplotypes.":[222],"advances":[224],"presented":[225,294],"form":[226],"basis":[228],"more":[230,288],"accurate":[231],"non-biased":[233],"line":[234],"origin":[235],"probabilities":[236],"crosses,":[239],"especially":[240],"multi-generational":[241],"ones.":[242],"We":[243],"show":[244],"able":[250],"reconstruct":[252],"haplotypes":[253],"even":[255],"genotypes":[256],"founder":[258],"offspring":[261,267],"alike,":[262],"based":[263],"only":[265],"unordered":[266],"genotypes.":[268],"handle":[273],"larger":[274,286],"populations":[275],"than":[276],"competing":[277],"methods,":[278],"resolving":[279],"pathways":[281],"phase":[283],"much":[285],"complex":[289],"populations.":[290],"Finally,":[291],"applicable":[297],"datasets":[299],"where":[300],"individual":[301],"relationships":[302],"not":[304],"known,":[305],"which":[306],"frequently":[308],"case":[310],"human":[312],"genetics":[313],"studies.":[314],"One":[315],"immediate":[316],"application":[317],"would":[320],"improved":[322],"accuracy":[323],"imputation":[325],"SNP":[327],"markers":[328],"within":[329],"genome-wide":[330],"association":[331],"studies":[332],"(GWAS).":[333]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-06-24T00:00:00"}