{"id":"https://openalex.org/W1590937185","doi":"https://doi.org/10.4049/jimmunol.170.2.703","title":"Impaired Lymphopoiesis and Altered B Cell Subpopulations in Mice Overexpressing Lnk Adaptor Protein","display_name":"Impaired Lymphopoiesis and Altered B Cell Subpopulations in Mice Overexpressing Lnk Adaptor Protein","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1590937185","doi":"https://doi.org/10.4049/jimmunol.170.2.703","mag":"1590937185","pmid":"https://pubmed.ncbi.nlm.nih.gov/12517931"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.170.2.703","doi":"https://doi.org/10.4049/jimmunol.170.2.703","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.2.703","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102879598","display_name":"Satoshi \u03a4\u03b1\u03ba\u03b1\u03ba\u03b9","orcid":"https://orcid.org/0000-0003-3490-0886","observed_orcids":["https://orcid.org/0000-0003-3490-0886"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Takaki","raw_affiliation_strings":["Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004942140","display_name":"Yoshinari Tezuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinari Tezuka","raw_affiliation_strings":["Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082196069","display_name":"Karsten Sauer","orcid":"https://orcid.org/0000-0002-8355-9429","observed_orcids":["https://orcid.org/0000-0002-8355-9429"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsten Sauer","raw_affiliation_strings":["Department of Immunology and Rheumatology, Merck Research Laboratories , Rahway, NJ 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Merck Research Laboratories , Rahway, NJ 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080334112","display_name":"Chiyomi Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiyomi Kubo","raw_affiliation_strings":["Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006471447","display_name":"Sang\u2010Mo Kwon","orcid":"https://orcid.org/0000-0001-9925-8682","observed_orcids":["https://orcid.org/0000-0001-9925-8682","https://orcid.org/0000-0001-5951-2877"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sang-Mo Kwon","raw_affiliation_strings":["Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077868223","display_name":"Erin Armstead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Armstead","raw_affiliation_strings":["Department of Immunology and Rheumatology, Merck Research Laboratories , Rahway, NJ 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Merck Research Laboratories , Rahway, NJ 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627059","display_name":"Kazuki Nakao","orcid":"https://orcid.org/0009-0001-5407-0819","observed_orcids":["https://orcid.org/0009-0001-5407-0819"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Nakao","raw_affiliation_strings":["Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology , Kobe ,","\u2021Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology , Kobe ,","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"\u2021Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan;","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040582134","display_name":"Motoya Katsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138804964","display_name":"National Institute for Basic Biology","ror":"https://ror.org/05q8wtt20","country_code":"JP","type":"education","lineage":["https://openalex.org/I1319490839","https://openalex.org/I138804964","https://openalex.org/I199525922"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoya Katsuki","raw_affiliation_strings":["National Institute for Basic Biology , Aichi ,","\u00a7National Institute for Basic Biology, Aichi, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Basic Biology , Aichi ,","institution_ids":["https://openalex.org/I138804964"]},{"raw_affiliation_string":"\u00a7National Institute for Basic Biology, Aichi, Japan; and","institution_ids":["https://openalex.org/I138804964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108193594","display_name":"Roger M. Perlmutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger M Perlmutter","raw_affiliation_strings":["AMGEN, Thousand Oaks, CA 91320"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMGEN, Thousand Oaks, CA 91320","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061109700","display_name":"Kiyoshi Takatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Takatsu","raw_affiliation_strings":["Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"*Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.1905,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.76698294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"170","issue":"2","first_page":"703","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.9279999732971191},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.890999972820282},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/b-1-cells","display_name":"B-1 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5649999976158142},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.8605791926383972},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7044211030006409},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.6927727460861206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6500968337059021},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6368567943572998},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6054580807685852},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.41897547245025635},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4111787676811218},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3462124764919281},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28937095403671265},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27178874611854553},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18873891234397888},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.16905620694160461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11715465784072876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11543172597885132}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038041","descriptor_name":"Lymphopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D038041","descriptor_name":"Lymphopoiesis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.170.2.703","doi":"https://doi.org/10.4049/jimmunol.170.2.703","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.170.2.703","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12517931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12517931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W208730735","https://openalex.org/W1545234501","https://openalex.org/W1965031549","https://openalex.org/W1968759697","https://openalex.org/W1971833736","https://openalex.org/W1972172786","https://openalex.org/W1983255429","https://openalex.org/W1988976227","https://openalex.org/W1995205975","https://openalex.org/W1996162251","https://openalex.org/W1996418577","https://openalex.org/W2005285519","https://openalex.org/W2009783794","https://openalex.org/W2025146835","https://openalex.org/W2028415754","https://openalex.org/W2028862728","https://openalex.org/W2031026925","https://openalex.org/W2036107389","https://openalex.org/W2041572974","https://openalex.org/W2045594979","https://openalex.org/W2047240921","https://openalex.org/W2060341688","https://openalex.org/W2067222394","https://openalex.org/W2069501059","https://openalex.org/W2069556423","https://openalex.org/W2076211600","https://openalex.org/W2083289299","https://openalex.org/W2095222091","https://openalex.org/W2098471323","https://openalex.org/W2104467009","https://openalex.org/W2113674401","https://openalex.org/W2127173897","https://openalex.org/W2132012375","https://openalex.org/W2140619590","https://openalex.org/W2140646145","https://openalex.org/W2146513661","https://openalex.org/W2149690803","https://openalex.org/W2151042873","https://openalex.org/W2151871635","https://openalex.org/W2154546525","https://openalex.org/W2163127671","https://openalex.org/W2164964449","https://openalex.org/W2171483790","https://openalex.org/W2316182158","https://openalex.org/W2326925476","https://openalex.org/W2335669842","https://openalex.org/W2345420683","https://openalex.org/W4211075026"],"related_works":["https://openalex.org/W2083289299","https://openalex.org/W4241888952","https://openalex.org/W2030480985","https://openalex.org/W1971493646","https://openalex.org/W2414285627","https://openalex.org/W2132012375","https://openalex.org/W2140619590","https://openalex.org/W1977794420","https://openalex.org/W2103663842","https://openalex.org/W2090538162"],"abstract_inverted_index":{"Lnk":[0,25,59,91,112,133,141,153,168],"is":[1],"an":[2,42],"adaptor":[3,143,169],"protein":[4,113,170],"expressed":[5],"primarily":[6],"in":[7,20,44,62,87,120,125,154,171],"lymphocytes":[8],"and":[9,69,81,106,122,175],"hemopoietic":[10,39,47],"precursor":[11,67],"cells.":[12],"Marked":[13],"expansion":[14,64],"of":[15,49,65,77,95,104,152],"B":[16,27,72,79,105,118],"lineage":[17,80,83],"cells":[18,68,84,108,119,124],"occurs":[19],"lnk(-/-)":[21,38],"mice,":[22],"indicating":[23],"that":[24,58],"regulates":[26],"cell":[28,34,73],"production":[29,174],"by":[30,166],"negatively":[31],"controlling":[32,172],"pro-B":[33],"expansion.":[35],"In":[36,53],"addition,":[37],"precursors":[40],"have":[41],"advantage":[43],"repopulating":[45],"the":[46,93,101,126,148,160,167],"system":[48],"irradiated":[50],"host":[51],"animals.":[52],"this":[54],"study,":[55],"we":[56],"show":[57],"overexpression":[60],"results":[61,158],"impaired":[63],"lymphoid":[66],"altered":[70],"mature":[71],"subpopulations.":[74],"The":[75,135],"representation":[76],"both":[78],"T":[82,107],"was":[85,109,145],"reduced":[86],"transgenic":[88],"mice":[89],"overexpressing":[90],"under":[92],"control":[94],"a":[96],"lymphocyte-specific":[97],"expression":[98,114],"vector.":[99],"Whereas":[100],"overall":[102],"number":[103],"correlated":[110],"with":[111],"levels,":[115],"marginal":[116],"zone":[117],"spleen":[121],"B1":[123],"peritoneal":[127],"cavity":[128],"were":[129],"relatively":[130],"resistant":[131],"to":[132],"overexpression.":[134],"C-terminal":[136],"tyrosine":[137],"residue,":[138],"conserved":[139],"among":[140],"family":[142],"proteins,":[144],"dispensable":[146],"for":[147],"negative":[149,162],"regulatory":[150,163],"roles":[151],"lymphocyte":[155,173],"development.":[156],"Our":[157],"illuminate":[159],"novel":[161],"mechanism":[164],"mediated":[165],"function.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
