{"id":"https://openalex.org/W1590888301","doi":null,"title":"Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion.","display_name":"Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion.","publication_year":1983,"publication_date":"1983-03-01","ids":{"openalex":"https://openalex.org/W1590888301","mag":"1590888301","pmid":"https://pubmed.ncbi.nlm.nih.gov/6825118"},"language":"en","primary_location":{"id":"pmid:6825118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6825118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104110040","display_name":"James B. Mitchell","orcid":"https://orcid.org/0000-0003-1396-6499","observed_orcids":["https://orcid.org/0000-0003-1396-6499","https://orcid.org/0000-0002-2343-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Mitchell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000621452","display_name":"Angelo Russo","orcid":"https://orcid.org/0000-0002-0322-2640","observed_orcids":["https://orcid.org/0000-0002-0322-2640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Russo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080497","display_name":"Timothy James Kinsella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Kinsella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038738545","display_name":"ELI J. GLATSTEIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Glatstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.14,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.9562493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"3","first_page":"987","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.21690000593662262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.14149999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9279999732971191},{"id":"https://openalex.org/keywords/thermal-tolerance","display_name":"heat tolerance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/thermosensitization","display_name":"thermosensitization","score":0.9359999895095825},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.625},{"id":"https://openalex.org/keywords/v79-cells","display_name":"V79 cells","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.40799999237060547},{"id":"https://openalex.org/keywords/diethyl-maleate","display_name":"diethyl maleate","score":0.9419999718666077},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.996999979019165},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.6380000114440918},{"id":"https://openalex.org/keywords/thermal-stress-response","display_name":"thermal stress response","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.9742482304573059},{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.89918053150177},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.5674254298210144},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.5372457504272461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5129560828208923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4558190405368805},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4103530943393707},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4103468656539917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3827119767665863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32988613843917847},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27769941091537476},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17997980117797852},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13661745190620422}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6825118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6825118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1590888301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6825118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W320634106","https://openalex.org/W1188871022","https://openalex.org/W1481477668","https://openalex.org/W1509068857","https://openalex.org/W1522354384","https://openalex.org/W1530814774","https://openalex.org/W1535828429","https://openalex.org/W1543860669","https://openalex.org/W1581953349","https://openalex.org/W1584766147","https://openalex.org/W1850776626","https://openalex.org/W1966907932","https://openalex.org/W1968209090","https://openalex.org/W1990806892","https://openalex.org/W1991344098","https://openalex.org/W2007064404","https://openalex.org/W2011607607","https://openalex.org/W2012333825","https://openalex.org/W2017334338","https://openalex.org/W2023178182","https://openalex.org/W2023345140","https://openalex.org/W2048048020","https://openalex.org/W2061668125","https://openalex.org/W2069030183","https://openalex.org/W2076936056","https://openalex.org/W2107817773","https://openalex.org/W2148047579","https://openalex.org/W2220702704","https://openalex.org/W2323864228","https://openalex.org/W4323254786"],"related_works":["https://openalex.org/W1536082938","https://openalex.org/W2013677839","https://openalex.org/W1547462934","https://openalex.org/W1760309955","https://openalex.org/W2050112629","https://openalex.org/W1589511293","https://openalex.org/W2166922971","https://openalex.org/W2314182550","https://openalex.org/W2085694879","https://openalex.org/W2218028034"],"abstract_inverted_index":{"Chinese":[0],"hamster":[1],"V79":[2],"cells":[3],"were":[4,37,92],"made":[5],"thermotolerant":[6],"by":[7,15,94],"either":[8,95],"continuous":[9],"heating":[10,83,107],"at":[11,23,84],"42.5":[12,85],"degrees":[13,18,86],"or":[14,81,104],"fractionated":[16],"43":[17],"exposures":[19],"with":[20,97,108],"interfraction":[21],"incubation":[22],"37":[24],"degrees.":[25],"For":[26],"both":[27],"methods":[28],"of":[29],"thermotolerance":[30,64],"induction,":[31],"elevations":[32,59],"in":[33,60,66,76,121,131],"cellular":[34,61,77,134],"glutathione":[35],"(GSH)":[36],"observed.":[38],"Additionally,":[39],"GSH":[40,62,78,90,115,127],"was":[41],"also":[42,55],"shown":[43],"to":[44,51,68,80,136],"be":[45,129],"elevated":[46],"following":[47],"a":[48,74],"1-hr":[49],"exposure":[50],"6%":[52],"ethanol,":[53],"which":[54],"induces":[56],"thermotolerance.":[57],"These":[58,123],"preceded":[63],"induction":[65],"regard":[67],"cell":[69],"survival.":[70],"To":[71],"determine":[72],"if":[73],"reduction":[75],"prior":[79],"during":[82,106],"would":[87],"influence":[88],"thermotolerance,":[89],"levels":[91],"reduced":[93],"pretreatment":[96],"diethylmaleate,":[98],"an":[99,111],"agent":[100,112],"that":[101,113,126],"binds":[102],"GSH,":[103],"treatment":[105],"buthionine":[109],"sulfoximine,":[110],"inhibits":[114],"synthesis.":[116],"Both":[117],"depleting":[118],"protocols":[119],"resulted":[120],"thermosensitization.":[122],"data":[124],"suggest":[125],"may":[128],"important":[130],"the":[132],"early":[133],"response":[135],"thermal":[137],"stress.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}