{"id":"https://openalex.org/W159086264","doi":null,"title":"Regulation of calcium stores in normal and diabetic endothelial cells","display_name":"Regulation of calcium stores in normal and diabetic endothelial cells","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W159086264","mag":"159086264"},"language":"en","primary_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/20360","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/20360","pdf_url":"https://ttu-ir.tdl.org/bitstreams/737b19ea-b404-4614-a837-972ed200e3b8/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ttu-ir.tdl.org/bitstreams/737b19ea-b404-4614-a837-972ed200e3b8/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063890930","display_name":"Shankar C. Sanka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shankar C. Sanka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063890930"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.8009999990463257},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium-atpase","display_name":"endoplasmic reticulum calcium ATPase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.4740000069141388},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.7329999804496765},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.656000018119812},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6084261536598206},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48795264959335327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45460787415504456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36526209115982056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35880404710769653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3558328151702881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32508915662765503}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ttu-ir.tdl.org:2346/20360","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/20360","pdf_url":"https://ttu-ir.tdl.org/bitstreams/737b19ea-b404-4614-a837-972ed200e3b8/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:159086264","doi":null,"is_oa":false,"landing_page_url":"https://ttu-ir.tdl.org/ttu-ir/bitstream/2346/20360/1/31295016587288.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/20360","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/20360","pdf_url":"https://ttu-ir.tdl.org/bitstreams/737b19ea-b404-4614-a837-972ed200e3b8/download","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W159086264.pdf","grobid_xml":"https://content.openalex.org/works/W159086264.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W40168305","https://openalex.org/W59236889","https://openalex.org/W173670965","https://openalex.org/W958091135","https://openalex.org/W1965223001","https://openalex.org/W1980060407","https://openalex.org/W1985114018","https://openalex.org/W1986706568","https://openalex.org/W1989755903","https://openalex.org/W1990606304","https://openalex.org/W1994232119","https://openalex.org/W1996567124","https://openalex.org/W1996744375","https://openalex.org/W1997843453","https://openalex.org/W2001308564","https://openalex.org/W2007459574","https://openalex.org/W2009754583","https://openalex.org/W2015121184","https://openalex.org/W2018419028","https://openalex.org/W2025316493","https://openalex.org/W2028238005","https://openalex.org/W2032781637","https://openalex.org/W2034040262","https://openalex.org/W2035553954","https://openalex.org/W2036509457","https://openalex.org/W2038734992","https://openalex.org/W2042236177","https://openalex.org/W2045785885","https://openalex.org/W2051442396","https://openalex.org/W2053669087","https://openalex.org/W2055271340","https://openalex.org/W2059127706","https://openalex.org/W2059414246","https://openalex.org/W2091300304","https://openalex.org/W2102834464","https://openalex.org/W2106142505","https://openalex.org/W2109654007","https://openalex.org/W2111698016","https://openalex.org/W2114277918","https://openalex.org/W2133810122","https://openalex.org/W2135224653","https://openalex.org/W2154540873","https://openalex.org/W2157730619","https://openalex.org/W2163678769","https://openalex.org/W2176061808","https://openalex.org/W2178853808","https://openalex.org/W2223849105","https://openalex.org/W2267823124","https://openalex.org/W2288277503","https://openalex.org/W2324247336","https://openalex.org/W2406573011","https://openalex.org/W2415916913","https://openalex.org/W2418835489","https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W2042236177","https://openalex.org/W2019698966","https://openalex.org/W4280619381","https://openalex.org/W2070852505","https://openalex.org/W2157172533","https://openalex.org/W1492787704","https://openalex.org/W2021933665","https://openalex.org/W7095072011","https://openalex.org/W6940087745","https://openalex.org/W2997332089"],"abstract_inverted_index":{"Cytosolic":[0],"Ca^^":[1,51,65,133,146,168,213,226],"([Ca^^]*'^^)":[2],"mediates":[3],"many":[4,14],"cellular":[5],"ftinctions,":[6],"e.g..":[7],"cell":[8,15,33],"growth,":[9],"motility,":[10],"secretion,":[11],"etc.":[12],"In":[13,31,56],"types,":[16,34],"ion":[17],"transport":[18],"processes":[19],"appear":[20],"to":[21,77],"be":[22],"dependent":[23],"on":[24],"metabolism":[25],"of":[26,43,80,85,113,130,151,181,198],"glucose":[27,58],"for":[28,212],"maximal":[29],"activity.":[30],"certain":[32],"a":[35,78,236],"strict":[36],"coupling":[37,82],"between":[38],"glycolysis":[39,81],"and":[40,132,176,190,222],"the":[41,83,152,182,240],"acfivity":[42],"Endoplasmic":[44],"Reticulum":[45],"Ca^\"-ATPases":[46],"(SERCA).":[47],"involved":[48,97,242],"in":[49,67,98,119,134,158,173,215,228,233,243,247],"regulating":[50],"homeostasis,":[52],"has":[53],"been":[54],"suggested.":[55],"diabetes,":[57],"homeostasis":[59,66,214,246],"is":[60,74,231,249],"altered.":[61],"We":[62,87],"hypothesize":[63,89],"that":[64,90,104,116,142,196,206],"microvascular":[68,159,216],"endothelial":[69,120,160,217],"cells":[70,121,161,218,234],"from":[71,122,125,162,170,219,235],"diabetic":[72,123,163,177,191,223],"animals":[73],"altered":[75,244],"due":[76],"dysfunction":[79],"activity":[84],"SERCA.":[86,202],"further":[88],"endosomal/lysosomal":[91],"(E/L)":[92],"compartments":[93,136,144,172,200,209,230],"exhibiting":[94],"SERCA":[95,165],"are":[96,210],"this":[99],"dysfunction.":[100],"Our":[101],"data":[102,204],"indicated":[103,141],"agonist":[105],"stimulation":[106],"(ATP,":[107],"vasopressin,":[108],"angiotensin-II)elicited":[109],"[Ca^\"]^^*":[110],"increases":[111],"(independent":[112],"extracellular":[114],"Ca^^)":[115],"were":[117],"larger":[118,157],"than":[124],"normal":[126,175,189,221],"animals.":[127],"Simultaneous":[128],"measurements":[129],"[Ca^^]'^^'":[131],"E/L":[135,143,171,199,208,229],"([Ca^^]^)":[137],"using":[138],"fluorescence":[139],"spectroscopy,":[140],"released":[145],"following":[147],"agonist-stimulation.":[148],"The":[149,179],"magnitude":[150,180],"Ca'*":[153,245],"release":[154,184],"was":[155,185],"significantly":[156],"rats.":[164],"inhibitors":[166],"elicited":[167],"releases":[169],"both":[174,220],"models.":[178],"[Ca^^]^":[183],"however":[186],"similar":[187],"among":[188],"cells.":[192],"Immunocytochemical":[193],"experiments":[194],"demonstrated":[195],"60%":[197],"exhibited":[201],"These":[203],"indicate":[205],"(a)":[207],"important":[211],"models;":[224],"(b)":[225],"regulation":[227],"different":[232],"diabefic":[237],"model,":[238],"(c)":[239],"compartment":[241],"diabetes":[248],"unknown.":[250]},"counts_by_year":[],"updated_date":"2026-09-16T18:09:00.828671","created_date":"2016-06-24T00:00:00"}