{"id":"https://openalex.org/W1590680932","doi":"https://doi.org/10.1002/gepi.1370170740","title":"Incorporating larger families in identity\u2010by\u2010descent based linkage analysis","display_name":"Incorporating larger families in identity\u2010by\u2010descent based linkage analysis","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1590680932","doi":"https://doi.org/10.1002/gepi.1370170740","mag":"1590680932","pmid":"https://pubmed.ncbi.nlm.nih.gov/10597442"},"language":"en","primary_location":{"id":"doi:10.1002/gepi.1370170740","doi":"https://doi.org/10.1002/gepi.1370170740","is_oa":true,"landing_page_url":"https://doi.org/10.1002/gepi.1370170740","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gepi.1370170740","source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gepi.1370170740","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014571943","display_name":"Sabine Loesgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Loesgen","raw_affiliation_strings":["Institute for Medical Statistics and Epidemiology, Technische Universit\u00e4t M\u00fcnchen, Germany","Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany","Institute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Statistics and Epidemiology, Technische Universit\u00e4t M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Scholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Scholz","raw_affiliation_strings":["Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017596515","display_name":"Silke Schmidt","orcid":"https://orcid.org/0000-0002-4194-1937","observed_orcids":["https://orcid.org/0000-0002-4194-1937","https://orcid.org/0000-0001-7924-2763"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silke Schmidt","raw_affiliation_strings":["Division of Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071248262","display_name":"Heike Bickeb\u00f6ller","orcid":"https://orcid.org/0000-0002-3361-5488","observed_orcids":["https://orcid.org/0000-0002-3361-5488"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Heike Bickeb\u00f6ller","raw_affiliation_strings":["Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Statistics and Epidemiology, Technische Universita\u0308t Mu\u0308nchen, Heidelberg, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071248262"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09529021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"S1","first_page":"S235","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.7789999842643738},{"id":"https://openalex.org/keywords/identity-by-descent","display_name":"identity by descent","score":0.796999990940094},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/large-pedigrees","display_name":"large pedigrees","score":0.7070000171661377},{"id":"https://openalex.org/keywords/genome-scan","display_name":"genome scan","score":0.6079999804496765},{"id":"https://openalex.org/keywords/qualitative-traits","display_name":"qualitative traits","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.9513434767723083},{"id":"https://openalex.org/C178221405","wikidata":"https://www.wikidata.org/wiki/Q5988338","display_name":"Identity by descent","level":5,"score":0.8912618160247803},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.7423542141914368},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.6503943800926208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5802415013313293},{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.5146163702011108},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.4871613681316376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4632391333580017},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4488056004047394},{"id":"https://openalex.org/C2993098900","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Lod score","level":5,"score":0.4478675425052643},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42412757873535156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3806152939796448},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.36685463786125183},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.17147281765937805},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.1379401683807373},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13779139518737793},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.08938318490982056},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.08821719884872437},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gepi.1370170740","doi":"https://doi.org/10.1002/gepi.1370170740","is_oa":true,"landing_page_url":"https://doi.org/10.1002/gepi.1370170740","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gepi.1370170740","source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:10597442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10597442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/gepi.1370170740","doi":"https://doi.org/10.1002/gepi.1370170740","is_oa":true,"landing_page_url":"https://doi.org/10.1002/gepi.1370170740","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gepi.1370170740","source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1590680932.pdf","grobid_xml":"https://content.openalex.org/works/W1590680932.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1519466388","https://openalex.org/W2017428806","https://openalex.org/W2073271176","https://openalex.org/W2107871825","https://openalex.org/W2115335486","https://openalex.org/W2160729986","https://openalex.org/W4300942465"],"related_works":["https://openalex.org/W7095724468","https://openalex.org/W1575832933","https://openalex.org/W7095725113","https://openalex.org/W2088151669","https://openalex.org/W1525257197","https://openalex.org/W1991495308","https://openalex.org/W2070289997","https://openalex.org/W2222870386","https://openalex.org/W7096422846","https://openalex.org/W1550371590"],"abstract_inverted_index":{"Genome":[0],"scans":[1],"for":[2,12,25,40,59,78],"alcoholism":[3],"susceptibility":[4,77],"genes":[5],"were":[6,47,66],"carried":[7],"out":[8],"using":[9],"identity-by-descent-based":[10],"statistics":[11],"qualitative":[13],"traits.":[14],"We":[15],"compared":[16],"the":[17,64,76],"results":[18],"when":[19],"1)":[20],"multipoint":[21,35],"information":[22,36],"was":[23,37,57],"used":[24,38,58],"all":[26,60],"families,":[27],"where":[28],"some":[29],"had":[30],"to":[31,75],"be":[32],"truncated,":[33],"2)":[34],"only":[39],"small":[41],"families":[42],"while":[43],"large":[44],"(untruncated)":[45],"pedigrees":[46],"analyzed":[48],"with":[49],"a":[50],"single-point":[51,55],"approach,":[52],"and":[53],"3)":[54],"analysis":[56],"pedigrees.":[61],"Differences":[62],"between":[63],"methods":[65],"observed,":[67],"but":[68],"neither":[69],"method":[70],"could":[71],"identify":[72],"regions":[73],"related":[74],"alcoholism.":[79]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}