{"id":"https://openalex.org/W1590537482","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","title":"Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia.","display_name":"Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia.","publication_year":2013,"publication_date":"2013-03-15","ids":{"openalex":"https://openalex.org/W1590537482","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","mag":"1590537482","pmid":"https://pubmed.ncbi.nlm.nih.gov/25206715","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146079"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4146079","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062667128","display_name":"Kwang Taek Kim","orcid":"https://orcid.org/0000-0002-3495-369X","observed_orcids":["https://orcid.org/0000-0002-3495-369X"]},"institutions":[{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Taek Kim","raw_affiliation_strings":["Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011682572","display_name":"Kyung Jin Chung","orcid":"https://orcid.org/0000-0003-0153-7814","observed_orcids":["https://orcid.org/0000-0003-0153-7814"]},"institutions":[{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Jin Chung","raw_affiliation_strings":["Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062031548","display_name":"Han Sae Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Sae Lee","raw_affiliation_strings":["Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109189019","display_name":"Il Gyu Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Il Gyu Ko","raw_affiliation_strings":["Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087513369","display_name":"Chang\u2010Ju Kim","orcid":"https://orcid.org/0000-0003-4749-5795","observed_orcids":["https://orcid.org/0000-0003-4749-5795"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Ju Kim","raw_affiliation_strings":["Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027384108","display_name":"Yong Gil Na","orcid":"https://orcid.org/0000-0002-0794-5459","observed_orcids":["https://orcid.org/0000-0002-0794-5459"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]},{"id":"https://openalex.org/I4210143602","display_name":"Chungnam National University Hospital","ror":"https://ror.org/04353mq94","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I196345858","https://openalex.org/I4210143602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Gil Na","raw_affiliation_strings":["Department of Urology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 301-721, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 301-721, Republic of Korea","institution_ids":["https://openalex.org/I196345858","https://openalex.org/I4210143602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069907838","display_name":"Khae Hawn Kim","orcid":"https://orcid.org/0000-0002-7045-8004","observed_orcids":["https://orcid.org/0000-0002-7045-8004"]},"institutions":[{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Khae Hawn Kim","raw_affiliation_strings":["Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gachon University Gil Medical Center, Gachon University, Incheon 405-760, Republic of Korea","institution_ids":["https://openalex.org/I4210088426"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4878,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.64764331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"8","first_page":"693","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tadalafil","display_name":"tadalafil","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9909999966621399},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8199999928474426},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dopaminergic-function","display_name":"dopaminergic activity","score":0.4790000021457672},{"id":"https://openalex.org/keywords/mongolian-gerbil","display_name":"Mongolian gerbil","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2780816001","wikidata":"https://www.wikidata.org/wiki/Q424156","display_name":"Tadalafil","level":3,"score":0.817291259765625},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.6943821907043457},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6855614185333252},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6422094106674194},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.6089006662368774},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6068333983421326},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5674617290496826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5451218485832214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5296187996864319},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4796505272388458},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44212692975997925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43958547711372375},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.42788153886795044},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3873363435268402},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18741226196289062},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.0},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4146079","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},{"id":"pmid:25206715","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25206715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural regeneration research","raw_type":"Journal Article"},{"id":"mag:1590537482","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25206715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2254516495","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/88507X/201308/45245911.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542097","display_name":"\u4e2d\u56fd\u795e\u7ecf\u518d\u751f\u7814\u7a76\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u795e\u7ecf\u518d\u751f\u7814\u7a76\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4146079","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.08.003","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4146079/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321366","display_name":"Gachon University","ror":"https://ror.org/03ryywt80"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1590537482.pdf","grobid_xml":"https://content.openalex.org/works/W1590537482.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W10058053","https://openalex.org/W1528717512","https://openalex.org/W1597878594","https://openalex.org/W1966303286","https://openalex.org/W1967596491","https://openalex.org/W1969350622","https://openalex.org/W1970252918","https://openalex.org/W1973363781","https://openalex.org/W1973449790","https://openalex.org/W1974010122","https://openalex.org/W1976749972","https://openalex.org/W1977154945","https://openalex.org/W1987906873","https://openalex.org/W1991954443","https://openalex.org/W1993336124","https://openalex.org/W1994682771","https://openalex.org/W1997064745","https://openalex.org/W1998549874","https://openalex.org/W2000631088","https://openalex.org/W2003415154","https://openalex.org/W2004923981","https://openalex.org/W2005415607","https://openalex.org/W2008156619","https://openalex.org/W2009024366","https://openalex.org/W2022459496","https://openalex.org/W2024885339","https://openalex.org/W2032489041","https://openalex.org/W2041816586","https://openalex.org/W2052964454","https://openalex.org/W2062225147","https://openalex.org/W2066704515","https://openalex.org/W2071584366","https://openalex.org/W2076009972","https://openalex.org/W2090383885","https://openalex.org/W2109558379","https://openalex.org/W2113220524","https://openalex.org/W2114647023","https://openalex.org/W2120752600","https://openalex.org/W2124604818","https://openalex.org/W2132390812","https://openalex.org/W2140389564","https://openalex.org/W2146896966","https://openalex.org/W2158104996","https://openalex.org/W2167709577","https://openalex.org/W2169079203","https://openalex.org/W2329338552","https://openalex.org/W2472296685","https://openalex.org/W2477154527"],"related_works":["https://openalex.org/W2005415607","https://openalex.org/W1508894676","https://openalex.org/W2332690329","https://openalex.org/W2119415434","https://openalex.org/W1973363781","https://openalex.org/W284073984","https://openalex.org/W2029347992","https://openalex.org/W2898840374","https://openalex.org/W1759262195","https://openalex.org/W1992844146"],"abstract_inverted_index":{"Impairment":[0],"of":[1,17,51],"dopamine":[2,61,132,159,185],"function,":[3],"which":[4],"is":[5,15,31],"known":[6,32],"to":[7,33],"have":[8],"major":[9],"effects":[10,50],"on":[11,55],"behaviors":[12],"and":[13,60,72,88,92,119,127,155,166,183,192],"cognition,":[14],"one":[16],"the":[18,48,164,190,211],"main":[19],"problems":[20],"associated":[21],"with":[22,53,148,172],"cerebral":[23,64,86,144,203,220],"ischemia.":[24,65],"Tadalafil,":[25],"a":[26,156,197,214],"long-acting":[27],"phosphodiesterase":[28],"type-5":[29],"inhibitor,":[30],"ameliorate":[34,202],"neurologic":[35],"impairment":[36],"induced":[37],"by":[38],"brain":[39],"injury,":[40],"but":[41],"not":[42],"in":[43,81,100,138,151,158,163,189,196],"dopaminergic":[44,205],"regions.":[45],"We":[46],"investigated":[47],"neuroprotective":[49,216],"treatment":[52,171,217],"tadalafil":[54,173,209],"cyclic":[56,139,175],"guanosine":[57,116,140,176],"monophosphate":[58,117,141,177],"level":[59,142],"function":[62],"following":[63,143],"Forty":[66],"adult":[67],"Mongolian":[68],"gerbils":[69],"were":[70,121],"randomly":[71],"evenly":[73],"divided":[74],"into":[75],"five":[76],"groups":[77],"(n":[78],"=":[79],"8":[80],"each":[82],"group):":[83],"Sham-operation":[84],"group,":[85],"ischemia-induced":[87,204],"0,":[89],"0.1,":[90],"1,":[91],"10":[93],"mg/kg":[94],"tadalafil-treated":[95],"groups,":[96],"respectively.":[97],"Tadalafil":[98,200],"dissolved":[99],"distilled":[101],"water":[102],"was":[103,146],"administered":[104],"orally":[105],"for":[106,123,131,219],"7":[107],"consecutive":[108],"days,":[109],"starting":[110],"1":[111],"day":[112],"after":[113],"surgery.":[114],"Cyclic":[115],"assay":[118],"immunohistochemistry":[120],"performed":[122],"thyrosine":[124,152,180],"hydroxylase":[125,153,181],"expression":[126,162,182,188],"western":[128],"blot":[129],"analysis":[130],"D2":[133,160,186],"receptor":[134,161,187],"expression.":[135],"A":[136],"decrease":[137,157],"ischemia":[145],"found":[147],"an":[149],"increase":[150],"activity":[154],"striatum":[165,191],"substantia":[167,193],"nigra":[168,194],"region.":[169],"However,":[170],"increased":[174,184],"expression,":[178],"suppressed":[179],"region":[195],"dose-dependent":[198],"manner.":[199],"might":[201],"neuron":[206],"injury.":[207,222],"Therefore,":[208],"has":[210],"potential":[212],"as":[213],"new":[215],"strategy":[218],"ischemic":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}