{"id":"https://openalex.org/W1590214320","doi":null,"title":"CYP2C19 and CYP2C9 : New aspects of pharmacogenetics and transcriptional regulation","display_name":"CYP2C19 and CYP2C9 : New aspects of pharmacogenetics and transcriptional regulation","publication_year":2010,"publication_date":"2010-09-24","ids":{"openalex":"https://openalex.org/W1590214320","mag":"1590214320"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26896504","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/CYP2C19_and_CYP2C9_new_aspects_of_pharmacogenetics_and_transcriptional_regulation/26896504","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38476","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083095311","display_name":"Jessica Mwinyi","orcid":"https://orcid.org/0000-0001-9976-5342","observed_orcids":["https://orcid.org/0000-0001-9976-5342"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica Mwinyi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9976-5342","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083095311"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-p450-polymorphisms","display_name":"cytochrome P450 polymorphisms","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cyp2c19-17","display_name":"CYP2C19*17","score":0.972000002861023},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gata-factors","display_name":"GATA transcription factors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9100000262260437},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.48399999737739563},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.38999998569488525},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.9419882893562317},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6147778034210205},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5897583365440369},{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.5013248920440674},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.478482186794281},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.47727006673812866},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.4730716645717621},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4725337326526642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4634648859500885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3482164740562439},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2965523898601532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23330745100975037},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.23060473799705505}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:figshare.com:article/26896504","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/CYP2C19_and_CYP2C9_new_aspects_of_pharmacogenetics_and_transcriptional_regulation/26896504","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/26906386","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/CYP2C19_and_CYP2C9_new_aspects_of_pharmacogenetics_and_transcriptional_regulation/26906386","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:openarchive.ki.se:10616/43586","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10616/43586","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1590214320","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/38476/thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W66128193","https://openalex.org/W122783581","https://openalex.org/W1481426711","https://openalex.org/W1510331108","https://openalex.org/W1550666015","https://openalex.org/W1568913878","https://openalex.org/W1666830708","https://openalex.org/W1679888853","https://openalex.org/W1875488666","https://openalex.org/W1890021536","https://openalex.org/W1964126006","https://openalex.org/W1964149730","https://openalex.org/W1966617583","https://openalex.org/W1975522565","https://openalex.org/W1977244553","https://openalex.org/W1977370347","https://openalex.org/W1977524804","https://openalex.org/W1978234864","https://openalex.org/W1980754065","https://openalex.org/W1982581314","https://openalex.org/W1985059672","https://openalex.org/W1990904235","https://openalex.org/W1992621257","https://openalex.org/W1995644530","https://openalex.org/W1999449749","https://openalex.org/W2001286676","https://openalex.org/W2001657113","https://openalex.org/W2002779112","https://openalex.org/W2002842589","https://openalex.org/W2006537112","https://openalex.org/W2007816633","https://openalex.org/W2008731908","https://openalex.org/W2009386434","https://openalex.org/W2009817985","https://openalex.org/W2012407966","https://openalex.org/W2013216633","https://openalex.org/W2014533692","https://openalex.org/W2015062968","https://openalex.org/W2017294431","https://openalex.org/W2022083108","https://openalex.org/W2023160406","https://openalex.org/W2024875479","https://openalex.org/W2025120110","https://openalex.org/W2025585440","https://openalex.org/W2025982106","https://openalex.org/W2029567501","https://openalex.org/W2030422162","https://openalex.org/W2030566485","https://openalex.org/W2031994833","https://openalex.org/W2034451783","https://openalex.org/W2037911192","https://openalex.org/W2045530950","https://openalex.org/W2048646391","https://openalex.org/W2049377642","https://openalex.org/W2050102690","https://openalex.org/W2054338068","https://openalex.org/W2056770708","https://openalex.org/W2058510946","https://openalex.org/W2061647374","https://openalex.org/W2063345843","https://openalex.org/W2063905878","https://openalex.org/W2067980525","https://openalex.org/W2070536631","https://openalex.org/W2070653557","https://openalex.org/W2071728786","https://openalex.org/W2073234102","https://openalex.org/W2073642973","https://openalex.org/W2073889366","https://openalex.org/W2077522929","https://openalex.org/W2077762861","https://openalex.org/W2079574569","https://openalex.org/W2081558811","https://openalex.org/W2083347345","https://openalex.org/W2086439537","https://openalex.org/W2092521092","https://openalex.org/W2093443634","https://openalex.org/W2094651478","https://openalex.org/W2094722170","https://openalex.org/W2096121276","https://openalex.org/W2097102749","https://openalex.org/W2098025302","https://openalex.org/W2098126121","https://openalex.org/W2098371153","https://openalex.org/W2098720060","https://openalex.org/W2098807072","https://openalex.org/W2102464054","https://openalex.org/W2106123100","https://openalex.org/W2106443841","https://openalex.org/W2108260564","https://openalex.org/W2109471213","https://openalex.org/W2111073764","https://openalex.org/W2116570511","https://openalex.org/W2119290374","https://openalex.org/W2121074897","https://openalex.org/W2127187069","https://openalex.org/W2128265565","https://openalex.org/W2131833120","https://openalex.org/W2132163703","https://openalex.org/W2132171434","https://openalex.org/W2132479491","https://openalex.org/W2135575592","https://openalex.org/W2136924569","https://openalex.org/W2143241514","https://openalex.org/W2144199131","https://openalex.org/W2146727351","https://openalex.org/W2147505468","https://openalex.org/W2148232829","https://openalex.org/W2149167705","https://openalex.org/W2149319043","https://openalex.org/W2151968503","https://openalex.org/W2153047555","https://openalex.org/W2153252164","https://openalex.org/W2154940301","https://openalex.org/W2159670968","https://openalex.org/W2160716066","https://openalex.org/W2162787841","https://openalex.org/W2163470415","https://openalex.org/W2167361504","https://openalex.org/W2168349092","https://openalex.org/W2170276453","https://openalex.org/W2171302228","https://openalex.org/W2187452737","https://openalex.org/W2313921179","https://openalex.org/W2403174808"],"related_works":["https://openalex.org/W2158824094","https://openalex.org/W1550821665","https://openalex.org/W7043822907","https://openalex.org/W2058024738","https://openalex.org/W2012407966","https://openalex.org/W2000789841","https://openalex.org/W2073344843","https://openalex.org/W1481455433","https://openalex.org/W2580961670","https://openalex.org/W2081558811"],"abstract_inverted_index":{"Cytochrome":[0],"P450s":[1],"(CYPs)":[2],"are":[3,20,32,39],"responsible":[4,40],"for":[5,41,125,139,168,256,629],"approximately":[6],"75%":[7],"of":[8,44,67,75,96,108,114,148,180,205,295,304,313,320,332,364,395,413,442,451,475,514,586,592,621,633,660],"the":[9,25,42,65,76,94,105,111,121,134,201,207,210,257,288,293,296,333,370,378,388,393,424,437,476,521,584,590,593,658],"phase":[10],"I-dependent":[11],"drug":[12,27,634],"metabolism.":[13],"Several":[14],"important":[15,48],"polymorphisms":[16],"in":[17,93,99,116,133,198,222,227,280,348,387,473,482,518,524],"these":[18],"enzymes":[19],"known":[21],"to":[22,64,151,369,377,520],"significantly":[23,144,340],"affect":[24],"individual":[26],"response.":[28],"CYP2C9":[29,68,181,208,245,271,323,343,401,414,448,587],"and":[30,53,69,110,182,190,209,229,238,278,322,344,367,376,398,402,415,427,447,516,616,649],"CYP2C19":[31,70,84,89,126,152,183,211,247,269,321,345,403,416,446,622],"polymorphically":[33],"expressed":[34],"CYP":[35],"family":[36,426],"members":[37],"which":[38],"metabolism":[43,472],"many":[45],"different":[46],"clinically":[47,438],"drugs,":[49],"e.g.":[50],"anticoagulants,":[51],"antidepressants":[52],"antiulcer":[54],"drugs.":[55],"This":[56,156],"thesis":[57],"focuses":[58],"on":[59,83,445],"novel":[60,411],"aspects":[61],"with":[62,120,173,218,244,253,310,400],"regard":[63],"regulation":[66,179,418,434,585,656],"gene":[71,184,234,404,557,588],"expression.":[72],"The":[73,102,177,431],"influence":[74],"recently":[77],"found":[78],"common":[79],"allele":[80,523],"variant":[81],"CYP2C19*17":[82,477,522],"enzyme":[85],"activity":[86,325],"towards":[87],"two":[88,97,213,371],"substrates":[90],"was":[91,196,327],"investigated":[92,197],"frame":[95],"pharmacokinetic":[98,122,480],"vivo":[100],"studies.":[101],"studies":[103],"compared":[104,150],"single-dose":[106],"pharmacokinetics":[107],"omeprazole":[109,149,471,515],"steady-state":[112],"kinetics":[113],"escitalopram":[115,517],"healthy":[117,483,525],"CYP2C19*17/*17":[118,141,160],"carriers":[119,161,474],"outcome":[123],"obtained":[124],"wild-type":[127,268],"subjects.":[128],"While":[129],"no":[130],"significant":[131,302,318],"differences":[132],"metabolic":[135],"efficacy":[136],"were":[137,225,242,273],"observed":[138,439],"escitalopram,":[140],"subjects":[142],"showed":[143],"lower":[145],"plasma":[146],"levels":[147],"wild":[153],"type":[154],"carriers.":[155],"observation":[157],"suggests":[158],"that":[159,326,419],"might":[162],"be":[163],"at":[164],"a":[165,301,317,479],"higher":[166],"risk":[167],"therapy":[169],"failure":[170],"during":[171],"treatment":[172,309],"proton":[174],"pump":[175],"inhibitors.":[176],"transcriptional":[178,417],"expression":[185,254,347,623],"by":[186,191,232,267,276,329,353,624,657],"GATA":[187,289,373,425],"transcription":[188,258,421,551,594],"factors":[189,259,422],"estrogen":[192,428,432,625,630,661],"receptor":[193,429,626,662],"\u03b1":[194],"(ER\u03b1)":[195],"vitro.":[199],"In":[200,307,406],"proximal":[202],"promoter":[203,248,272,324],"regions":[204],"both":[206,281,342,396],"gene,":[212],"adjacent":[214,372],"putative":[215,334],"GATA-binding":[216],"sites":[217,291,375],"an":[219],"ER-binding":[220],"half-site":[221],"their":[223],"vicinity":[224],"predicted":[226,379],"silico":[228],"initially":[230],"studied":[231],"luciferase":[233,305],"reporter":[235],"assay.":[236],"HepG2":[237],"Huh-7":[239],"hepatoma":[240],"cells":[241,315,390],"transfected":[243],"or":[246,262,270,292],"fragment":[249],"carrying":[250],"pGL3basic-constructs":[251],"along":[252],"vectors":[255],"GATA-2,":[260],"GATA-4,":[261,365],"ER\u03b1.":[263],"Luciferase":[264],"activities":[265],"driven":[266],"highly":[274],"increased":[275],"GATA-4":[277,297,397,553],"GATA-2":[279],"cell":[282],"lines,":[283],"whereas":[284],"mutations":[285],"introduced":[286],"into":[287,583],"binding":[290,363,374,381],"co-transfection":[294],"antagonist":[298],"FOG-2":[299],"caused":[300,316],"loss":[303],"activity.":[306,449],"contrast,":[308],"estradiol":[311,338],"derivatives":[312,339],"ER\u03b1-transfected":[314],"inhibition":[319,632],"antagonized":[328],"site-directed":[330],"mutagenesis":[331],"ER\u03b1-binding":[335],"half-sites.":[336],"Additionally,":[337],"suppressed":[341],"mRNA":[346],"human":[349],"hepatocytes,":[350],"as":[351],"measured":[352],"real":[354],"time":[355],"PCR.":[356],"Electrophoretic":[357],"mobility":[358],"shift":[359],"assays":[360],"revealed":[361],"sequence-specific":[362],"GATA-6,":[366],"ER\u03b1":[368,399],"ER":[380],"half":[382],"sites,":[383],"respectively.":[384],"ChIP":[385],"assay":[386],"cultured":[389],"furthermore":[391],"confirmed":[392],"association":[394],"promoter.":[405],"conclusion,":[407],"we":[408],"have":[409],"established":[410],"mechanisms":[412],"involve":[420],"from":[423],"\udbc0\udc00.":[430],"mediated":[433],"may":[435],"explain":[436],"inhibitory":[440],"effects":[441],"oral":[443],"contraceptives":[444],"List":[450],"scientific":[452],"papers":[453],"I.":[454],"Baldwin":[455,500],"RM,":[456,501],"Ohlsson":[457,493],"S,":[458,495,546,578,613],"Pedersen":[459,502,539,573,608],"RS,":[460,503,540,574,609],"Mwinyi":[461,496,535,565,604,641],"J,":[462,497,536,542,566,568,605,642],"Ingelman-Sundberg":[463,508,547,579,617,650],"M,":[464,499,509],"Eliasson":[465,510],"E,":[466,576],"Bertilsson":[467,506],"L.":[468],"(2008).":[469,512],"\"Increased":[470],"allele;":[478],"study":[481],"volunteers.\"":[484],"Br":[485],"J":[486,528],"Clin":[487,529],"Pharmacol":[488,530],"65:":[489],"767-774.":[490],"https://pubmed.ncbi.nlm.nih.gov/18294333":[491],"II.":[492],"Rosenborg":[494],"Andersson":[498],"Sim":[504],"SC,":[505],"L,":[507],"E.":[511],"\"Kinetics":[513],"relation":[519],"subjects.\"":[526],"Eur":[527],"64:":[531],"1175-1179.":[532],"https://pubmed.ncbi.nlm.nih.gov/18654768":[533],"III.":[534],"Hofmann":[537,571],"Y,":[538,572],"Nekvindov\u00e1":[541,567],"Cavaco":[543,569,606,643],"I,":[544,570,607,644],"Mkrtchian":[545,577,614,647],"M":[548,618,651],"(2009).":[549],"\"The":[550],"factor":[552,595],"regulates":[554],"cytochrome":[555],"P4502C19":[556],"expression\"":[558],"Life":[559],"Sci":[560],"86:":[561],"699-706.":[562],"https://pubmed.ncbi.nlm.nih.gov/20206639":[563],"IV.":[564],"Landman":[575],"M.":[580],"\"New":[581],"insights":[582],"expression:":[589],"role":[591],"GATA-4.\"":[596],"Drug":[597],"Metab":[598],"Dispos":[599],"38:":[600],"415-421.":[601],"https://pubmed.ncbi.nlm.nih.gov/19995889":[602],"V.":[603],"Persson":[610],"A,":[611],"Burkhardt":[612],"S":[615,648],"(2010).":[619,652],"\"Regulation":[620],"alpha.":[627],"Implications":[628],"dependent":[631],"metabolism.\"":[635],"Mol":[636],"Pharmacy.":[637],"[Accepted]":[638],"https://pubmed.ncbi.nlm.nih.gov/20675569":[639],"VI.":[640],"Yurdakok":[645],"B,":[646],"\"Cytochrome":[653],"P4502C9":[654],"(CYP2C9)":[655],"ligands":[659],"\u03b1\".":[663],"[Manuscript]":[664]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
