{"id":"https://openalex.org/W1590212924","doi":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","title":"ORIGINAL ARTICLE: An Interleukin\u201023 Binding Protein in Mid\u2010Trimester Amniotic Fluid","display_name":"ORIGINAL ARTICLE: An Interleukin\u201023 Binding Protein in Mid\u2010Trimester Amniotic Fluid","publication_year":2009,"publication_date":"2009-10-07","ids":{"openalex":"https://openalex.org/W1590212924","doi":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","mag":"1590212924","pmid":"https://pubmed.ncbi.nlm.nih.gov/19811465"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0897.2009.00740.x","doi":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044701049","display_name":"Catherine Herway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801107848","display_name":"New York Hospital Queens","ror":"https://ror.org/01j17xg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801107848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Herway","raw_affiliation_strings":["Department of Obstetrics and Gynecology, New York Hospital Queens Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, New York Hospital Queens Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2801107848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029797196","display_name":"Ann Marie Bongiovanni","orcid":"https://orcid.org/0000-0001-9801-570X","observed_orcids":["https://orcid.org/0000-0001-9801-570X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Marie Bongiovanni","raw_affiliation_strings":["Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075942862","display_name":"Daniel W. Skupski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801107848","display_name":"New York Hospital Queens","ror":"https://ror.org/01j17xg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801107848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Skupski","raw_affiliation_strings":["Department of Obstetrics and Gynecology, New York Hospital Queens Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, New York Hospital Queens Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2801107848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055608441","display_name":"Steven Sol Witkin","orcid":"https://orcid.org/0000-0002-3502-3929","observed_orcids":["https://orcid.org/0000-0002-3502-3929"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven S. Witkin","raw_affiliation_strings":["Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055608441"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":null,"fwci":0.5922,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.71742809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"62","issue":"5","first_page":"308","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.5116999745368958,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.5116999745368958,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.1800999939441681,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amniotic-fluid","display_name":"amniotic fluid","score":0.9169999957084656},{"id":"https://openalex.org/keywords/second-trimester","display_name":"second trimester","score":0.828000009059906},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9340000152587891},{"id":"https://openalex.org/keywords/intra-amniotic-inflammation","display_name":"intra-amniotic inflammation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8809999823570251},{"id":"https://openalex.org/keywords/amniocentesis","display_name":"amniocentesis","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.9436368942260742},{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.6639858484268188},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6371814012527466},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.480601042509079},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4216739237308502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4087664484977722},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.39135870337486267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3820820152759552},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3790164887905121},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3605477809906006},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.35139477252960205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24452629685401917},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.07488507032394409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000653","descriptor_name":"Amniotic Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000653","descriptor_name":"Amniotic Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011262","descriptor_name":"Pregnancy Trimester, Second","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0897.2009.00740.x","doi":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0897.2009.00740.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},{"id":"pmid:19811465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19811465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of reproductive immunology (New York, N.Y. : 1989)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1981680925","https://openalex.org/W1986986277","https://openalex.org/W2006050183","https://openalex.org/W2022104546","https://openalex.org/W2022871764","https://openalex.org/W2025568822","https://openalex.org/W2027442935","https://openalex.org/W2031253528","https://openalex.org/W2038626236","https://openalex.org/W2038851450","https://openalex.org/W2039467806","https://openalex.org/W2060267424","https://openalex.org/W2069968649","https://openalex.org/W2070211700","https://openalex.org/W2078231673","https://openalex.org/W2087905758","https://openalex.org/W2137759512","https://openalex.org/W2154237405"],"related_works":["https://openalex.org/W2038851450","https://openalex.org/W1997401821","https://openalex.org/W2068869473","https://openalex.org/W2399751976","https://openalex.org/W1966399531","https://openalex.org/W1509393062","https://openalex.org/W2034523293","https://openalex.org/W2027442935","https://openalex.org/W2142463917","https://openalex.org/W2095336200"],"abstract_inverted_index":{"PROBLEM:":[0],"The":[1,72,116],"binding":[2,45],"of":[3,54,74,118,167,176],"mid-trimester":[4,34,177],"amniotic":[5,27,55,75,85,102,125,178,190],"fluid":[6,28,56,76,103,126,179,191],"to":[7,46,59,111,123,187,199],"cytokines":[8],"was":[9,49,81,120,129,169],"evaluated.":[10,82],"METHOD":[11],"OF":[12],"STUDY:":[13],"Purified":[14],"tumor":[15],"necrosis":[16],"factor-alpha":[17],"(TNF-alpha),":[18],"interleukin":[19],"(IL)-10,":[20],"IL-12,":[21],"and":[22,43,66,94,128,149,157,164],"IL-23":[23,70,79,113,194],"were":[24,57,152],"incubated":[25],"with":[26,37,101,182,193],"from":[29,104,143],"25":[30],"women":[31,151],"undergoing":[32],"a":[33,88,160,174,197],"amniocentesis,":[35],"or":[36,41],"bovine":[38],"serum":[39],"albumin":[40],"saline,":[42],"cytokine":[44],"monoclonal":[47],"antibodies":[48],"quantitated":[50],"by":[51,114],"ELISA.":[52],"Aliquots":[53],"heated":[58],"95":[60,135],"degrees":[61,136],"C":[62,137],"for":[63,69,138],"15":[64,139],"min":[65],"then":[67],"retested":[68],"binding.":[71],"effect":[73,90],"dilution":[77,127],"on":[78,91],"quantitation":[80],"RESULTS:":[83],"All":[84],"fluids":[86,142],"had":[87],"negligible":[89],"TNF-alpha,":[92],"IL-10,":[93],"IL-12":[95,158,168],"detection.":[96],"In":[97],"marked":[98],"contrast,":[99],"pre-incubation":[100],"each":[105],"subject":[106],"reduced":[107,131],"the":[108,124,183],"subsequent":[109],"ability":[110],"detect":[112],">50%.":[115],"extent":[117],"inhibition":[119,166],"directly":[121],"proportional":[122],"markedly":[130],"following":[132],"heating":[133],"at":[134],"min.":[140],"Amniotic":[141],"White,":[144],"Black,":[145],"Asian,":[146],"East":[147],"Indian,":[148],"Hispanic":[150],"equally":[153],"effective.":[154],"CONCLUSION:":[155],"Interleukin-23":[156],"share":[159],"common":[161],"p40":[162],"subunit":[163,185],"no":[165],"apparent.":[170],"It":[171],"appeared":[172],"that":[173],"component":[175],"specifically":[180],"interacts":[181],"p19":[184],"unique":[186],"IL-23.":[188],"Mid-trimester":[189],"reactivity":[192],"may":[195],"be":[196],"mechanism":[198],"limit":[200],"intra-amniotic":[201],"neutrophil-derived":[202],"inflammation.":[203]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}