{"id":"https://openalex.org/W1590144202","doi":null,"title":"Pediatric phase I trial and pharmacokinetic study of tiazofurin (NSC 286193).","display_name":"Pediatric phase I trial and pharmacokinetic study of tiazofurin (NSC 286193).","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W1590144202","mag":"1590144202","pmid":"https://pubmed.ncbi.nlm.nih.gov/4027992"},"language":"en","primary_location":{"id":"pmid:4027992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4027992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Balis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112245077","display_name":"Beverly J. Lange","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Lange","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025567999","display_name":"Roger J. Packer","orcid":"https://orcid.org/0000-0001-9413-7531","observed_orcids":["https://orcid.org/0000-0001-9413-7531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Packer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109892235","display_name":"John S. Holcenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Holcenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030658031","display_name":"Lawrence J. Ettinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Ettinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082614208","display_name":"Stephen E. Sallan","orcid":"https://orcid.org/0000-0002-1064-8981","observed_orcids":["https://orcid.org/0000-0002-1064-8981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Sallan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020203091","display_name":"Richard L. Heideman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Heideman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042376097","display_name":"Solomon Zimm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Zimm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704012","display_name":"William A. Smithson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W A Smithson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076396591","display_name":"Nancy A. Cogliano-Shutta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Cogliano-Shutta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4538,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.56770275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"10","first_page":"5169","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiazofurin","display_name":"tiazofurin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/refractory-cancer","display_name":"refractory cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.5400000214576721},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8235229253768921},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7395745515823364},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.6390121579170227},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6164804697036743},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5651805996894836},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5296342968940735},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5083817839622498},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.49028280377388},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.43880704045295715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39450138807296753},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32157212495803833},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:4027992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4027992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1590144202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4027992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131821327","https://openalex.org/W2440054521","https://openalex.org/W1963954109","https://openalex.org/W1763432695","https://openalex.org/W2052191720","https://openalex.org/W1994586295","https://openalex.org/W2323360204","https://openalex.org/W1978473334","https://openalex.org/W1999757494","https://openalex.org/W1978122521"],"abstract_inverted_index":{"Tiazofurin":[0],"(2-beta-D-ribofuranosylthiazole-4-carboxamide),":[1],"a":[2,9,24],"new":[3],"nucleoside":[4],"antimetabolite,":[5],"was":[6,20,59,75,78,122,129,136,149,174],"evaluated":[7],"in":[8,93,103,131,182,189],"phase":[10],"I":[11],"trial":[12],"involving":[13],"children":[14],"with":[15,138,176],"refractory":[16],"cancers.":[17],"The":[18,36,55,63,125,169],"drug":[19,180],"administered":[21],"i.v.":[22],"as":[23,185],"10-min":[25],"infusion":[26],"daily":[27],"for":[28,53],"5":[29],"consecutive":[30],"days":[31],"repeated":[32],"at":[33,83,157,165],"3-week":[34],"intervals.":[35],"dose":[37,58,91,150],"ranged":[38],"from":[39,153],"550":[40,158],"to":[41,161],"3300":[42,166],"mg/sq":[43,61,159,167],"m/day.":[44,62,168],"Seventeen":[45],"patients":[46],"received":[47],"23":[48],"courses":[49],"and":[50,73,77,108,113,119,145],"were":[51,67,89,99],"evaluable":[52],"toxicity.":[54],"maximally":[56],"tolerated":[57],"2200":[60],"major":[64],"dose-limiting":[65,81],"toxicities":[66],"nonhematological.":[68],"Neurotoxicity,":[69],"including":[70],"headache,":[71],"drowsiness,":[72],"irritability,":[74],"common":[76],"the":[79,84,117,179,183,186,190],"principal":[80],"toxicity":[82],"higher":[85],"doses.":[86],"Severe":[87],"myalgias":[88],"also":[90],"limiting":[92],"one":[94],"patient.":[95],"Other":[96],"side":[97],"effects":[98],"mild,":[100],"reversible":[101],"elevations":[102],"serum":[104],"transaminases;":[105],"nausea,":[106],"vomiting,":[107],"diarrhea;":[109],"mild":[110],"hypertension;":[111],"dysphagia;":[112],"exfoliative":[114],"dermatitis":[115],"of":[116,127,140,172,178],"hands":[118],"feet.":[120],"Myelotoxicity":[121],"not":[123],"significant.":[124],"pharmacokinetics":[126],"tiazofurin":[128],"studied":[130],"16":[132],"patients.":[133],"Plasma":[134],"disappearance":[135],"triphasic":[137],"half-lives":[139],"9.7":[141],"min,":[142],"1.6":[143],"h,":[144],"5.5":[146],"h.":[147],"Clearance":[148],"related,":[151],"ranging":[152],"120":[154],"ml/min/sq":[155,163],"m":[156,164],"m/day":[160],"70":[162],"primary":[170],"route":[171],"elimination":[173],"renal":[175],"85%":[177],"recoverable":[181],"urine":[184],"parent":[187],"compound":[188],"24":[191],"h":[192],"following":[193],"administration.":[194]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
