{"id":"https://openalex.org/W1590002145","doi":"https://doi.org/10.3760/cma.j.issn.1009-9921.2014.04.003","title":"Effect of histone deacetylase inhibitor LBH589 on proliferation, apoptosis and drug resistance of acute myeloid leukemia cell line HL60/ADM","display_name":"Effect of histone deacetylase inhibitor LBH589 on proliferation, apoptosis and drug resistance of acute myeloid leukemia cell line HL60/ADM","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1590002145","doi":"https://doi.org/10.3760/cma.j.issn.1009-9921.2014.04.003","mag":"1590002145"},"language":"en","primary_location":{"id":"mag:1590002145","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/97751B/201404/49576597.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555461","display_name":"\u767d\u8840\u75c5\u00b7\u6dcb\u5df4\u7624","issn_l":"1009-9921","issn":["1009-9921"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u767d\u8840\u75c5\uff0e\u6dcb\u5df4\u7624","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004056248","display_name":"\u6c5f\u96ea\u6770","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c5f\u96ea\u6770","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004934598","display_name":"\u8d75\u9752\u971e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8d75\u9752\u971e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074697518","display_name":"\u738b\u6cbb\u9999","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u738b\u6cbb\u9999","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072799662","display_name":"\u4e01\u51b0\u6d01","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4e01\u51b0\u6d01","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031733548","display_name":"\u9ec4\u51ef\u51ef","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9ec4\u51ef\u51ef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057987362","display_name":"\u53f6\u6d01\u745c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u53f6\u6d01\u745c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008572773","display_name":"\u5b5f\u51e1\u4e49","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5b5f\u51e1\u4e49","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05294596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"04","first_page":"199","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9490000009536743},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9829999804496765},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.6600000262260437},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.4659999907016754},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3974246680736542}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:1590002145","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/97751B/201404/49576597.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555461","display_name":"\u767d\u8840\u75c5\u00b7\u6dcb\u5df4\u7624","issn_l":"1009-9921","issn":["1009-9921"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u767d\u8840\u75c5\uff0e\u6dcb\u5df4\u7624","raw_type":null},{"id":"mag:3028714981","doi":"https://doi.org/10.3760/cma.j.issn.1009-9921.2014.04.003","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN11535620142304/375004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306555461","display_name":"\u767d\u8840\u75c5\u00b7\u6dcb\u5df4\u7624","issn_l":"1009-9921","issn":["1009-9921"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u767d\u8840\u75c5\u00b7\u6dcb\u5df4\u7624","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3028714981","https://openalex.org/W2238681626","https://openalex.org/W4250705761","https://openalex.org/W2550109795","https://openalex.org/W2413043545","https://openalex.org/W2104337841","https://openalex.org/W3173891460","https://openalex.org/W2412955604","https://openalex.org/W3029675130","https://openalex.org/W2233315780"],"abstract_inverted_index":{"\u76ee\u7684":[0],"\u63a2\u8ba8\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\u6291\u5236\u5242LBH589\u5bf9\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7ec6\u80de\u682aHL660/ADM\u7684\u589e\u6b96\u3001\u51cb\u4ea1\u548c\u8010\u836f\u7684\u5f71\u54cd.\u65b9\u6cd5":[1],"\u91c7\u7528\u4e0d\u540c\u6d53\u5ea6LBH589\u5904\u7406\u8010\u836f\u7684HL60/ADM\u7ec6\u80de,\u56db\u7532\u57fa\u5076\u6c2e\u5511\u84dd\uff08MTT\uff09\u6cd5\u68c0\u6d4b\u7ec6\u80de\u589e\u6b96\u548c\u591a\u67d4\u6bd4\u661f\u4f5c\u752824h":[2],"IC50\u503c,AnnexinV-FITC/PI\u8367\u5149\u67d3\u8272\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1\u3001\u591a\u67d4\u6bd4\u661f\u6444\u53d6\u7387\u548c\u591a\u836f\u8010\u836f\u86cb\u767d1\uff08MRP1\uff09\u8868\u8fbe,\u8bc4\u4f30LBH589\u9006\u8f6c\u8010\u836f\u6548\u5e94.Westemblot\u68c0\u6d4bp53\u3001Akt\u3001p-Akt\u3001\u7ec4\u86cb\u767d-3\u3001\u4e59\u9170\u5316\u7ec4\u86cb\u767d-3\u3001\u03b2-actin\u86cb\u767d\u8868\u8fbe.\u7ed3\u679c":[3],"10\uff5e80":[4],"nmol/L":[5],"LBH589\u80fd\u591f\u6291\u5236HL60/ADM\u7ec6\u80de\u589e\u6b96\u548c\u8bf1\u5bfc\u51cb\u4ea1,70":[6],"nmol/LLBH589\u4f5c\u752860":[7],"h\u6291\u5236\u6548\u679c\u6700\u4f73.20":[8],"nmol/LLBH589\u663e\u8457\u4e0b\u8c03HL60/ADM\u7ec6\u80de\u8868\u9762MRP1\u7684\u8868\u8fbe[\uff0893.90\u00b14.20\uff09\uff05\u6bd4\uff0876.19\u00b16.53\uff09\uff05,P\uff1c0.05]\u3001\u63d0\u9ad8HL60/ADM\u7ec6\u80de\u591a\u67d4\u6bd4\u661f\u6444\u53d6\u7387[\uff088.53\u00b10.68\uff09\uff05\u6bd4\uff0825.67\u00b11.34\uff09\uff05,P\uff1c":[9],"0.01]\u3001\u964d\u4f4e\u591a\u67d4\u6bd4\u661f24":[10],"hIG0\u503c[\uff086.833\u00b10.319\uff09":[11],"\u03bcg/ml\u6bd4\uff081.382\u00b10.104\uff09\u03bcg/ml,P\uff1c":[12],"0.01],\u5176\u9006\u8f6c\u8010\u836f\u500d\u6570\u4e3a4.9\u500d.LBH589\u5904\u7406HL60/ADM\u7ec6\u80de24\u300148":[13],"h,\u4e59\u9170\u5316\u7ec4\u86cb\u767d-3\u76f8\u5bf9\u8868\u8fbe\u6c34\u5e73\u5747\u9ad8\u4e8eLBH589\u5904\u7406\u524d\uff08P\uff1c0.01\uff09,\u5904\u7406\u540e24h\u548c48":[14],"h":[15],"p-Akt\u76f8\u5bf9\u8868\u8fbe\u6c34\u5e73\u5206\u522b\u4e3a1.07\u00b10.09\u548c0.59\u00b10.01,\u4f4e\u4e8e\u5904\u7406\u524d\u8868\u8fbe\u6c34\u5e73\uff082.03\u00b10.12\uff09\uff08P\uff1c0.01\uff09,p53\u86cb\u767d\u76f8\u5bf9\u8868\u8fbe\u6c34\u5e73\u5206\u522b\u4e3a0.57\u00b10.04\u548c1.31\u00b10.09,\u660e\u663e\u9ad8\u4e8e\u5904\u7406\u524d\u7684\u8868\u8fbe\uff080.21\u00b10.02\uff09\uff08P\uff1c":[16],"0.01\uff09.\u7ed3\u8bba":[17],"LBH589\u901a\u8fc7\u963b\u65adPI3K-Akt\u901a\u8def\u3001\u4e0b\u8c03\u5176MRP1\u7684\u8868\u8fbe\u53ca\u63d0\u9ad8\u591a\u67d4\u6bd4\u661f\u6444\u53d6\u7387\u6709\u6548\u5730\u6291\u5236HL60/ADM\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8bf1\u5bfc\u5176\u51cb\u4ea1,\u5e76\u9006\u8f6c\u5176\u8010\u836f.":[18]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}