{"id":"https://openalex.org/W1589549031","doi":null,"title":"Bronchial Hyperresponsiveness and its Risk Factors in Finnish Adult Population","display_name":"Bronchial Hyperresponsiveness and its Risk Factors in Finnish Adult Population","publication_year":2012,"publication_date":"2012-09-21","ids":{"openalex":"https://openalex.org/W1589549031","mag":"1589549031"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/36426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/36426","pdf_url":"http://hdl.handle.net/10138/36426","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/36426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003637566","display_name":"Maria Juusela","orcid":"https://orcid.org/0000-0003-0395-5673","observed_orcids":["https://orcid.org/0000-0003-0395-5673"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Juusela","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0395-5673","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003637566"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.777999997138977},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.8629999756813049},{"id":"https://openalex.org/keywords/histamine-challenge","display_name":"histamine challenge","score":0.9980000257492065},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6240000128746033},{"id":"https://openalex.org/keywords/passive-smoking","display_name":"passive smoking","score":0.8650000095367432},{"id":"https://openalex.org/keywords/environmental-tobacco-smoke","display_name":"environmental tobacco smoke","score":0.9309999942779541},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/childhood-wheezing","display_name":"childhood wheezing","score":0.7149999737739563},{"id":"https://openalex.org/keywords/asthma-incidence","display_name":"asthma incidence","score":0.4959999918937683},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.5889999866485596},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5640000104904175},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8230000138282776},{"id":"https://openalex.org/keywords/finnish-adults","display_name":"Finnish adults","score":0.6060000061988831},{"id":"https://openalex.org/keywords/helsinki","display_name":"Helsinki","score":0.503000020980835},{"id":"https://openalex.org/keywords/kemi","display_name":"Kemi","score":0.9290000200271606},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2776238763","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Bronchial hyperresponsiveness","level":4,"score":0.5021951198577881},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47169092297554016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4527589678764343},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.44009560346603394},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.32139137387275696},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.18604913353919983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17943182587623596},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.09742182493209839}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/36426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/36426","pdf_url":"http://hdl.handle.net/10138/36426","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1589549031","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/36426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/36426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/36426","pdf_url":"http://hdl.handle.net/10138/36426","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1589549031.pdf","grobid_xml":"https://content.openalex.org/works/W1589549031.grobid-xml"},"referenced_works_count":176,"referenced_works":["https://openalex.org/W467154","https://openalex.org/W622763911","https://openalex.org/W646393751","https://openalex.org/W1161365658","https://openalex.org/W1512439286","https://openalex.org/W1535051419","https://openalex.org/W1562644666","https://openalex.org/W1563969119","https://openalex.org/W1657740120","https://openalex.org/W1751621284","https://openalex.org/W1782758271","https://openalex.org/W1862829273","https://openalex.org/W1899229346","https://openalex.org/W1907389751","https://openalex.org/W1930044933","https://openalex.org/W1956940855","https://openalex.org/W1964793578","https://openalex.org/W1966436914","https://openalex.org/W1966901640","https://openalex.org/W1970879128","https://openalex.org/W1971566616","https://openalex.org/W1973948212","https://openalex.org/W1975696541","https://openalex.org/W1978455270","https://openalex.org/W1980205834","https://openalex.org/W1982298873","https://openalex.org/W1984819212","https://openalex.org/W1989206146","https://openalex.org/W1989697230","https://openalex.org/W1992771780","https://openalex.org/W1994403072","https://openalex.org/W1995553664","https://openalex.org/W1995727724","https://openalex.org/W1996172332","https://openalex.org/W1996176170","https://openalex.org/W1998900186","https://openalex.org/W2001643672","https://openalex.org/W2002818848","https://openalex.org/W2003921119","https://openalex.org/W2005005699","https://openalex.org/W2006924064","https://openalex.org/W2009079383","https://openalex.org/W2009996739","https://openalex.org/W2014218956","https://openalex.org/W2015795623","https://openalex.org/W2016835468","https://openalex.org/W2017876346","https://openalex.org/W2019454503","https://openalex.org/W2019496644","https://openalex.org/W2024517895","https://openalex.org/W2025315052","https://openalex.org/W2028091927","https://openalex.org/W2031465811","https://openalex.org/W2032064406","https://openalex.org/W2035527861","https://openalex.org/W2035831689","https://openalex.org/W2037527883","https://openalex.org/W2037540059","https://openalex.org/W2046951514","https://openalex.org/W2050237494","https://openalex.org/W2050903584","https://openalex.org/W2053724325","https://openalex.org/W2059241546","https://openalex.org/W2063014521","https://openalex.org/W2066371072","https://openalex.org/W2068899452","https://openalex.org/W2069583167","https://openalex.org/W2069762077","https://openalex.org/W2071121426","https://openalex.org/W2071754888","https://openalex.org/W2072687024","https://openalex.org/W2073093526","https://openalex.org/W2073133162","https://openalex.org/W2074926332","https://openalex.org/W2078513373","https://openalex.org/W2078889932","https://openalex.org/W2078900153","https://openalex.org/W2079718411","https://openalex.org/W2080387649","https://openalex.org/W2082119261","https://openalex.org/W2082242655","https://openalex.org/W2083061399","https://openalex.org/W2086566909","https://openalex.org/W2086958200","https://openalex.org/W2087017010","https://openalex.org/W2087914649","https://openalex.org/W2088423784","https://openalex.org/W2092288491","https://openalex.org/W2092608164","https://openalex.org/W2095414619","https://openalex.org/W2095430348","https://openalex.org/W2096892209","https://openalex.org/W2097209223","https://openalex.org/W2099123547","https://openalex.org/W2099169955","https://openalex.org/W2100637477","https://openalex.org/W2101102426","https://openalex.org/W2101117478","https://openalex.org/W2101535048","https://openalex.org/W2102652101","https://openalex.org/W2103216743","https://openalex.org/W2105883431","https://openalex.org/W2106245415","https://openalex.org/W2106416057","https://openalex.org/W2106657345","https://openalex.org/W2110269800","https://openalex.org/W2112146063","https://openalex.org/W2113475741","https://openalex.org/W2113623880","https://openalex.org/W2114188018","https://openalex.org/W2116120311","https://openalex.org/W2116866283","https://openalex.org/W2116926077","https://openalex.org/W2117484254","https://openalex.org/W2118304778","https://openalex.org/W2118646506","https://openalex.org/W2119511930","https://openalex.org/W2120270144","https://openalex.org/W2122743397","https://openalex.org/W2123247260","https://openalex.org/W2123847800","https://openalex.org/W2124879124","https://openalex.org/W2128955138","https://openalex.org/W2130923098","https://openalex.org/W2132110968","https://openalex.org/W2133750711","https://openalex.org/W2134540475","https://openalex.org/W2135151455","https://openalex.org/W2137401824","https://openalex.org/W2139961805","https://openalex.org/W2143095512","https://openalex.org/W2144906393","https://openalex.org/W2145783587","https://openalex.org/W2147517442","https://openalex.org/W2148396162","https://openalex.org/W2149855943","https://openalex.org/W2150478055","https://openalex.org/W2152276343","https://openalex.org/W2153421219","https://openalex.org/W2155021615","https://openalex.org/W2155687796","https://openalex.org/W2155979288","https://openalex.org/W2156296808","https://openalex.org/W2156822702","https://openalex.org/W2157864045","https://openalex.org/W2157930595","https://openalex.org/W2159262373","https://openalex.org/W2160941421","https://openalex.org/W2161528133","https://openalex.org/W2161768389","https://openalex.org/W2162109259","https://openalex.org/W2163290380","https://openalex.org/W2163753078","https://openalex.org/W2164964161","https://openalex.org/W2165098074","https://openalex.org/W2165981929","https://openalex.org/W2167229428","https://openalex.org/W2169949930","https://openalex.org/W2170182979","https://openalex.org/W2170321108","https://openalex.org/W2171838005","https://openalex.org/W2177761601","https://openalex.org/W2187647517","https://openalex.org/W2230717736","https://openalex.org/W2239430705","https://openalex.org/W2270897439","https://openalex.org/W2319329477","https://openalex.org/W2406284862","https://openalex.org/W2409983824","https://openalex.org/W2410837732","https://openalex.org/W2414327053","https://openalex.org/W2485219807","https://openalex.org/W2485705032","https://openalex.org/W2581684202","https://openalex.org/W2993300170","https://openalex.org/W4313065599"],"related_works":["https://openalex.org/W1907389751","https://openalex.org/W2157864045","https://openalex.org/W7100289798","https://openalex.org/W2004404162","https://openalex.org/W2133469236","https://openalex.org/W1562644666","https://openalex.org/W2035610409","https://openalex.org/W2105883431","https://openalex.org/W2347880730","https://openalex.org/W2043813744"],"abstract_inverted_index":{"The":[0,35,87,167,256,331],"aim":[1],"of":[2,10,37,91,101,218,227,247,285,363,381,414,421,433,435],"the":[3,8,15,55,63,84,110,136,149,177,200,239,245,282,305,343,348,377,384,391],"study":[4,66,90],"was":[5,45,60,154,173,183,249,337,352,356,367],"to":[6,31,120,126,287,291],"assess":[7,32],"prevalence":[9],"bronchial":[11,118],"hyperresponsiveness":[12],"(BHR)":[13,194],"in":[14,47,52,71,97,109,114,129,199,215,220,243,304,373,406,438],"Finnish":[16],"adult":[17,50,241],"general":[18,240],"population,":[19],"its":[20],"determinants":[21,258],"and":[22,26,39,94,122,142,159,163,176,191,208,251,265,276,281,289,309,335],"risk":[23,272,385,392],"factors.":[24],"Histamine":[25,186],"methacholine":[27,121,164,172],"challenges":[28,119],"were":[29,69,81,124,165,261,278,312],"compared":[30],"their":[33],"agreement.":[34],"association":[36,332],"active":[38],"passive":[40],"smoking":[41,340],"with":[42,152,206,223,314,329],"BHR":[43,64,150,204,219,248,260,277,336,422],"severity":[44,217],"studied":[46],"detail.":[48],"Incident":[49],"asthma":[51,93,228,301,349,404],"Helsinki":[53,85],"over":[54,270],"11":[56,344],"years":[57,345,380],"follow":[58,88,346],"up":[59,89],"investigated.":[61],"For":[62],"comparison":[65],"79":[67],"subjects":[68,78],"included":[70,82,99],"Kemi,":[72,117],"Finland,":[73],"whereas":[74],"292":[75],"randomly":[76],"selected":[77],"(26-66":[79],"years)":[80],"for":[83,161,171,181,252,259,273,386,393,431],"BHR-study.":[86],"incident":[92,387,394],"respiratory":[95],"symptoms":[96],"2007":[98],"4302":[100],"those,":[102],"who":[103],"had":[104],"originally":[105],"(n=6062)":[106],"taken":[107],"part":[108],"FinEsS-Helsinki":[111],"postal":[112],"survey":[113],"1996.":[115],"In":[116,133,238,342,396],"histamine":[123,153,162,182,209],"performed":[125],"each":[127],"subject":[128],"a":[130,196,212,221,262,374,397,411,429],"randomized":[131],"order.":[132],"Helsinki,":[134,244],"following":[135],"interview,":[137],"skin":[138],"prick":[139],"tests,":[140],"spirometry,":[141],"fractional":[143],"exhaled":[144],"nitric":[145],"oxide":[146],"(FENO)":[147],"measurement,":[148],"test":[151],"assessed.":[155,166],"Provocative":[156],"doses":[157],"(PD15FEV1":[158],"PD20FEV1)":[160],"highest":[168,178],"cumulative":[169],"dose":[170,180],"2.6":[174],"mg,":[175],"non-cumulative":[179],"1.6":[184],"mg.":[185],"PD15FEV1":[187],"\u22640.4":[188],"mg":[189,193],"(BHRms)":[190],"\u22641.6":[192],"served":[195],"cut-off":[197],"points":[198],"logistic":[201],"regression":[202],"analysis.":[203],"tests":[205,210],"metacholine":[207],"showed":[211],"good":[213],"agreement":[214],"classifying":[216],"population":[222,242],"no":[224],"previous":[225],"diagnosis":[226],"or":[229,302,372],"chronic":[230],"bronchitis":[231],"(weighted":[232],"kappa":[233],"0.64;":[234],"CI":[235],"95%":[236],"0.46-0.82).":[237],"prevalance":[246],"21%,":[250],"BHRms":[253],"6%":[254],".":[255],"main":[257],"decreased":[263,383],"FEV1":[264],"airway":[266,436],"obstruction,":[267],"which":[268],"yielded":[269],"four-fold":[271],"BHR.":[274,298,330],"Smoking":[275],"dose-dependently":[279],"associated,":[280],"young":[283],"age":[284],"starting":[286],"smoke":[288,294],"exposure":[290],"environmental":[292],"tobacco":[293],"(ETS),":[295],"constituted":[296],"on":[297,339,370,410],"Respiratory":[299],"symptoms,":[300],"wheezing":[303],"early":[306],"childhood":[307],"(<5)":[308],"female":[310],"gender":[311],"associated":[313],"BHR,":[315],"as":[316],"did":[317,326],"MEF50":[318],"<":[319],"63%":[320],"predicted.":[321],"Body":[322],"mass":[323],"index":[324],"(BMI)":[325],"not":[327],"associate":[328],"between":[333],"FENO":[334],"dependent":[338],"habits.":[341],"up,":[347],"incidence":[350,405],"rate":[351,362],"3.7/1000/":[353],"year.":[354],"Remission":[355],"17%":[357],"during":[358,376],"that":[359,403,418],"period.":[360],"Incidence":[361],"allergic":[364],"rhinoconjunctivitis":[365],"(ARC)":[366],"16.8/1000/year.":[368],"Living":[369],"countryside":[371],"farm":[375],"first":[378],"5":[379],"life":[382],"ARC.":[388],"ARC":[389],"doubled":[390],"asthma.":[395],"longitudinal":[398],"setting,":[399],"our":[400],"results":[401],"suggested":[402],"Finland":[407],"has":[408],"leveled":[409],"plateau.":[412],"Findings":[413],"this":[415],"thesis":[416],"suggest":[417],"quantitative":[419],"assessment":[420],"by":[423],"different":[424],"cut":[425],"off":[426],"levels":[427],"provides":[428],"tool":[430],"characterization":[432],"phenotypes":[434],"disorders":[437],"epidemiological":[439],"studies.":[440]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}