{"id":"https://openalex.org/W1587979699","doi":"https://doi.org/10.1182/blood.v96.5.1879","title":"Heparin and heparan sulfate bind interleukin-10 and modulate its activity","display_name":"Heparin and heparan sulfate bind interleukin-10 and modulate its activity","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W1587979699","doi":"https://doi.org/10.1182/blood.v96.5.1879","mag":"1587979699","pmid":"https://pubmed.ncbi.nlm.nih.gov/10961890"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v96.5.1879","doi":"https://doi.org/10.1182/blood.v96.5.1879","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.5.1879","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013760474","display_name":"Shahram Salek\u2010Ardakani","orcid":"https://orcid.org/0000-0002-2336-8452","observed_orcids":["https://orcid.org/0000-0002-2336-8452"]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shahram Salek-Ardakani","raw_affiliation_strings":["From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108464622","display_name":"John R. Arrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John R. Arrand","raw_affiliation_strings":["From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044053285","display_name":"David M Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Shaw","raw_affiliation_strings":["From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110885337","display_name":"Mike Mackett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mike Mackett","raw_affiliation_strings":["From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.5563,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.79060219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"96","issue":"5","first_page":"1879","last_page":"1888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9629999995231628},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":1.0},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cytokine-binding","display_name":"cytokine binding","score":0.7910000085830688},{"id":"https://openalex.org/keywords/n-sulfation","display_name":"N-sulfation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sulfated-proteoglycans","display_name":"sulfated proteoglycans","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cd64","display_name":"CD64","score":0.9959999918937683},{"id":"https://openalex.org/keywords/monocytes-macrophages","display_name":"monocytes/macrophages","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.847000002861023},{"id":"https://openalex.org/keywords/dermatan-sulfate","display_name":"dermatan sulfate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokine-antagonism","display_name":"cytokine antagonism","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2778066728","wikidata":"https://www.wikidata.org/wiki/Q2335618","display_name":"Dermatan sulfate","level":4,"score":0.7532162666320801},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7322483062744141},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.7126504778862},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7040673494338989},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.6733452081680298},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.6698586940765381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5364243388175964},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.5213105082511902},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5060135722160339},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4444884657859802},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33303511142730713},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2050122320652008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17100399732589722},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002704","descriptor_name":"Chlorates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012685","descriptor_name":"Sepharose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v96.5.1879","doi":"https://doi.org/10.1182/blood.v96.5.1879","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.5.1879","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v96.5.1879.h8001879_1879_1888","doi":"https://doi.org/10.1182/blood.v96.5.1879.h8001879_1879_1888","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.5.1879.h8001879_1879_1888","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10961890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10961890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W58613392","https://openalex.org/W87082738","https://openalex.org/W145969329","https://openalex.org/W342411828","https://openalex.org/W1494048992","https://openalex.org/W1536980415","https://openalex.org/W1554690897","https://openalex.org/W1559464451","https://openalex.org/W1587500817","https://openalex.org/W1608390571","https://openalex.org/W1657567895","https://openalex.org/W1965144118","https://openalex.org/W1965540093","https://openalex.org/W1968419122","https://openalex.org/W1970639095","https://openalex.org/W1971540677","https://openalex.org/W1971767029","https://openalex.org/W1972855766","https://openalex.org/W1974873948","https://openalex.org/W1976740882","https://openalex.org/W1977163915","https://openalex.org/W1980146497","https://openalex.org/W1980982223","https://openalex.org/W1986151431","https://openalex.org/W1988051431","https://openalex.org/W1990586383","https://openalex.org/W1991261634","https://openalex.org/W1996207927","https://openalex.org/W2000724318","https://openalex.org/W2003275504","https://openalex.org/W2006641366","https://openalex.org/W2009096028","https://openalex.org/W2009342621","https://openalex.org/W2009745676","https://openalex.org/W2009933667","https://openalex.org/W2011455879","https://openalex.org/W2011610089","https://openalex.org/W2012180376","https://openalex.org/W2013840551","https://openalex.org/W2015228929","https://openalex.org/W2024787221","https://openalex.org/W2027601570","https://openalex.org/W2033818437","https://openalex.org/W2035034977","https://openalex.org/W2036072927","https://openalex.org/W2038029503","https://openalex.org/W2040854254","https://openalex.org/W2040967556","https://openalex.org/W2044245263","https://openalex.org/W2047107802","https://openalex.org/W2049482600","https://openalex.org/W2054816398","https://openalex.org/W2055114143","https://openalex.org/W2055336483","https://openalex.org/W2060546545","https://openalex.org/W2064936643","https://openalex.org/W2071347224","https://openalex.org/W2073956665","https://openalex.org/W2074431231","https://openalex.org/W2079058719","https://openalex.org/W2084390990","https://openalex.org/W2084990572","https://openalex.org/W2086368414","https://openalex.org/W2092751827","https://openalex.org/W2094210266","https://openalex.org/W2094393536","https://openalex.org/W2100554044","https://openalex.org/W2100837269","https://openalex.org/W2101561346","https://openalex.org/W2107675979","https://openalex.org/W2113266466","https://openalex.org/W2132415356","https://openalex.org/W2136530946","https://openalex.org/W2138975417","https://openalex.org/W2139887220","https://openalex.org/W2151630675","https://openalex.org/W2157021835","https://openalex.org/W2163170931","https://openalex.org/W2170282770","https://openalex.org/W2180209555","https://openalex.org/W2265877479","https://openalex.org/W2337221123","https://openalex.org/W2395248221","https://openalex.org/W2399232796","https://openalex.org/W2400121121","https://openalex.org/W2406861563","https://openalex.org/W2409219342","https://openalex.org/W2410390538","https://openalex.org/W2414365588","https://openalex.org/W2416820743","https://openalex.org/W2582398023","https://openalex.org/W4231581694","https://openalex.org/W4248044859","https://openalex.org/W6712199988"],"related_works":["https://openalex.org/W2730458643","https://openalex.org/W3032455108","https://openalex.org/W2920802345","https://openalex.org/W2124151860","https://openalex.org/W3175501917","https://openalex.org/W2911584197","https://openalex.org/W1834182183","https://openalex.org/W2091048213","https://openalex.org/W4392810524","https://openalex.org/W1554690897"],"abstract_inverted_index":{"Glycosaminoglycans":[0],"(GAG)":[1],"are":[2,257],"a":[3,135],"group":[4],"of":[5,20,39,50,84,130,148,156,167,181,208,213,220,226,234,263],"negatively":[6],"charged":[7],"molecules":[8,236],"that":[9,65,219,246],"have":[10],"been":[11],"shown":[12,124,187],"to":[13,41,69,125,150,169,188,218],"bind":[14],"and":[15,23,35,47,94,111,120,132,139,159,248,261],"directly":[16],"regulate":[17],"the":[18,48,98,127,204,211,224,231,244],"bioactivity":[19],"growth":[21,29,32],"factors":[22],"cytokines":[24],"such":[25],"as":[26,194],"basic":[27],"fibroblast":[28],"factor,":[30],"transforming":[31],"factor-beta,":[33],"IL-7,":[34],"interferon-gamma.":[36],"The":[37,178],"ability":[38],"GAG":[40,250],"interact":[42],"with":[43,106,145,164],"human":[44],"IL-10":[45,91],"(hIL-10)":[46],"effect":[49,180,202,212],"these":[51,241],"interactions":[52],"on":[53,97,183,191,203,237],"its":[54],"biologic":[55],"activity":[56,185],"were":[57,123,142,162],"analyzed.":[58],"It":[59],"was":[60,175,186,216],"demonstrated":[61],"by":[62],"affinity":[63],"chromatography":[64],"hIL-10":[66,184,264],"binds":[67],"strongly":[68],"heparin-agarose":[70],"at":[71],"physiological":[72],"pH.":[73],"Biosensor-based":[74],"binding":[75,260],"kinetic":[76],"analysis":[77],"indicated":[78],"an":[79,165],"equilibrium":[80],"dissociation":[81],"constant,":[82],"K(d),":[83],"54":[85],"nmol/L":[86],"for":[87],"this":[88],"interaction.":[89],"Human":[90],"stimulated":[92],"CD16":[93,131,235],"CD64":[95,133],"expression":[96,129,207,233],"monocyte/macrophage":[99],"population":[100],"within":[101],"peripheral":[102],"blood":[103],"mononuclear":[104],"cells,":[105],"optimal":[107],"concentrations":[108,155],"between":[109],"1":[110],"10":[112],"ng/mL.":[113],"Soluble":[114],"heparin,":[115],"heparan":[116,140],"sulfate,":[117,119],"chondroitin":[118,160,173],"dermatan":[121,157],"sulfate":[122,141,158,255],"inhibit":[126],"hIL-10-induced":[128],"in":[134,252,259],"concentration-dependent":[136],"manner.":[137],"Heparin":[138],"most":[143],"effective":[144],"IC(50)":[146,166],"values":[147],"100":[149],"500":[151],"microg/mL.":[152],"Considerably":[153],"higher":[154],"4-sulfate":[161],"required":[163],"2,000":[168],"5,000":[170],"microg/mL,":[171],"whereas":[172,210],"6-sulfate":[174],"essentially":[176],"inactive.":[177],"antagonistic":[179],"heparin":[182,196,215],"be":[189],"dependent":[190],"N-sulfation,":[192],"inasmuch":[193],"de-N-sulfated":[195],"had":[197],"little":[198],"or":[199],"no":[200],"inhibitory":[201],"IL-10-":[205],"induced":[206],"CD16,":[209],"de-O-sulfated":[214],"comparable":[217],"unmodified":[221],"heparin.":[222],"Furthermore,":[223],"inhibition":[225],"cell-bound":[227],"proteoglycan":[228],"sulfation":[229],"reduced":[230],"hIL-10-mediated":[232],"monocytes/macrophages.":[238],"Taken":[239],"together,":[240],"findings":[242],"support":[243],"hypothesis":[245],"soluble":[247],"cell-surface":[249],"and,":[251],"particular,":[253],"their":[254],"groups":[256],"important":[258],"modulation":[262],"activity.":[265],"(Blood.":[266],"2000;96:1879-1888)":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}