{"id":"https://openalex.org/W1587963927","doi":null,"title":"HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis.","display_name":"HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis.","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1587963927","mag":"1587963927","pmid":"https://pubmed.ncbi.nlm.nih.gov/11479208"},"language":"en","primary_location":{"id":"pmid:11479208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11479208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033471083","display_name":"Jianmin Fang","orcid":"https://orcid.org/0000-0002-4332-4967","observed_orcids":["https://orcid.org/0000-0002-4332-4967"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Fang","raw_affiliation_strings":["Laboratory for Surgical Research, Department of Surgery, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Surgical Research, Department of Surgery, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100708580","display_name":"Yan Li","orcid":"https://orcid.org/0000-0003-1146-5578","observed_orcids":["https://orcid.org/0000-0003-1146-5578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110086789","display_name":"Yuen Shing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028523107","display_name":"Marsha A. Moses","orcid":"https://orcid.org/0000-0003-3108-0704","observed_orcids":["https://orcid.org/0000-0003-3108-0704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Moses","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8852,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.91482726,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"61","issue":"15","first_page":"5731","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.871999979019165},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiogenic-switch","display_name":"angiogenic switch","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-vascularization","display_name":"tumor vascularization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/early-tumorigenesis","display_name":"early tumorigenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hif-1alpha-nuclear-translocation","display_name":"HIF-1\u03b1 nuclear translocation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7059903144836426},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.695065438747406},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5486494302749634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5429186820983887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5421924591064453},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.5287073850631714},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46840450167655945},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44833096861839294},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4409847557544708},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4389420747756958},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.4305749535560608},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.41656947135925293},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31111058592796326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2076314389705658},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19001242518424988},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.16682592034339905},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12201640009880066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04835253953933716},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.047885388135910034}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11479208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11479208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1587963927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11479208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1543662618","https://openalex.org/W1574172480","https://openalex.org/W1578283200","https://openalex.org/W1589090830","https://openalex.org/W1937401270","https://openalex.org/W1953884850","https://openalex.org/W1956944003","https://openalex.org/W1978139448","https://openalex.org/W1980241898","https://openalex.org/W1985804036","https://openalex.org/W2000000541","https://openalex.org/W2008786326","https://openalex.org/W2015344488","https://openalex.org/W2030504206","https://openalex.org/W2056574134","https://openalex.org/W2061230824","https://openalex.org/W2064739543","https://openalex.org/W2083535354","https://openalex.org/W2085609942","https://openalex.org/W2111487800","https://openalex.org/W2114098415","https://openalex.org/W2125257427","https://openalex.org/W2130219349","https://openalex.org/W2138798328","https://openalex.org/W2163069245"],"related_works":["https://openalex.org/W2007519158","https://openalex.org/W2024131284","https://openalex.org/W14551237","https://openalex.org/W2017709634","https://openalex.org/W2483743002","https://openalex.org/W93997529","https://openalex.org/W1992576088","https://openalex.org/W7010177673","https://openalex.org/W2019482977","https://openalex.org/W127294888"],"abstract_inverted_index":{"The":[0,13],"switch":[1,205],"to":[2,39,206],"the":[3,37,49,71,105,159,181,204,207],"angiogenic":[4,72,208],"phenotype":[5,209],"represents":[6],"a":[7,25],"critical":[8],"checkpoint":[9],"during":[10,210],"tumor":[11,22,66,118,161,191],"progression.":[12],"acquisition":[14],"of":[15,104,111,173,184,198],"new":[16],"capillary":[17],"vessels":[18],"provides":[19],"newly":[20],"vascularized":[21],"nodules":[23,119,143,156,175],"with":[24,121,158],"distinct":[26],"biological":[27],"advantage":[28],"over":[29],"their":[30],"avascular":[31,99,117,125,142,160,190],"counterparts":[32],"by":[33,169],"conferring":[34],"upon":[35],"them":[36],"ability":[38],"expand":[40],"and":[41,45,51,90,95,100,178],"develop":[42],"both":[43,98],"locally":[44],"metastatically.":[46],"To":[47],"identify":[48],"molecules":[50],"mechanisms":[52],"underlying":[53],"this":[54,75],"rate-limiting":[55],"step":[56],"in":[57,64,97,116,141,154,189,203],"successful":[58],"tumorigenesis,":[59],"we":[60,77],"have":[61,78],"developed":[62],"an":[63],"vivo":[65],"model":[67],"that":[68,164,180],"reproducibly":[69],"recapitulates":[70],"switch.":[73],"Using":[74],"model,":[76],"analyzed":[79],"vascular":[80,101,122,155],"endothelial":[81],"growth":[82,87,102],"factor":[83,88],"(VEGF),":[84],"basic":[85],"fibroblast":[86],"(bFGF),":[89],"hypoxia-inducible":[91],"factor-1alpha":[92],"(HIF-1alpha)":[93],"expression":[94],"activity":[96],"phases":[103],"tumor.":[106],"A":[107],"significantly":[108],"higher":[109,153],"level":[110],"VEGF":[112,129,165,199],"protein":[113],"was":[114,186],"detected":[115,147,187],"compared":[120,157],"nodules.":[123,162,192],"As":[124],"tumors":[126],"became":[127],"vascularized,":[128],"levels":[130,137,149],"decreased":[131],"approximately":[132,150],"10-fold.":[133],"In":[134],"contrast,":[135],"bFGF":[136,202],"were":[138,146,176],"not":[139,201],"elevated":[140],"but":[144,200],"rather":[145],"at":[148],"2":[151],"times":[152],"Given":[163],"is":[166],"transcriptionally":[167],"regulated":[168],"HIF-1alpha,":[170],"immunohistochemical":[171],"studies":[172],"chondrosarcoma":[174],"conducted":[177],"revealed":[179],"nuclear":[182],"translocation":[183],"HIF-1alpha":[185],"exclusively":[188],"This":[193],"study":[194],"implicates":[195],"HIF-1alpha-mediated":[196],"up-regulation":[197],"tumorigenesis.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
