{"id":"https://openalex.org/W1587953652","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","title":"Harnessing sulfinic acid reactivity to report protein S\u2010nitrosylation (968.2)","display_name":"Harnessing sulfinic acid reactivity to report protein S\u2010nitrosylation (968.2)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1587953652","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","mag":"1587953652"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.968.2","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014739166","display_name":"Brent R. Martin","orcid":"https://orcid.org/0000-0002-7136-2397","observed_orcids":["https://orcid.org/0000-0002-7136-2397"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brent Martin","raw_affiliation_strings":["Chemistry University of Michigan Ann Arbor MI United States","1Chemistry University of Michigan Ann Arbor MI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry University of Michigan Ann Arbor MI United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"1Chemistry University of Michigan Ann Arbor MI United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014739166"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05127529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sulfinic-acids","display_name":"sulfinic acids","score":0.75},{"id":"https://openalex.org/keywords/s-nitrosothiols","display_name":"S-nitrosothiols","score":0.871999979019165},{"id":"https://openalex.org/keywords/dj-1","display_name":"DJ-1","score":0.7200000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/peroxiredoxin","display_name":"peroxiredoxin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.703000009059906},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2780731314","wikidata":"https://www.wikidata.org/wiki/Q420304","display_name":"Sulfinic acid","level":2,"score":0.846546471118927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7581108808517456},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.6758015751838684},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.642485499382019},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6420538425445557},{"id":"https://openalex.org/C2777553025","wikidata":"https://www.wikidata.org/wiki/Q25323683","display_name":"S-Nitrosylation","level":4,"score":0.5934572219848633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5876198410987854},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5756171345710754},{"id":"https://openalex.org/C45068187","wikidata":"https://www.wikidata.org/wiki/Q9050270","display_name":"Nitrosylation","level":3,"score":0.5027215480804443},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49967527389526367},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.46220752596855164},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45146867632865906},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06147608160972595},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.968.2","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.968.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2289786785","https://openalex.org/W2889365936","https://openalex.org/W2411125134","https://openalex.org/W2895863927","https://openalex.org/W1983016535","https://openalex.org/W2897098347","https://openalex.org/W4313336063","https://openalex.org/W2043168997","https://openalex.org/W1576616161","https://openalex.org/W2226570272"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"describes":[2],"the":[3,103,190],"accumulation":[4],"of":[5,18,66,90,99,116,143,183,192],"reactive":[6,10,159],"oxygen":[7],"(ROS)":[8],"and":[9,14,20,62,113,130,153],"nitrogen":[11],"species":[12],"(RNS),":[13],"is":[15,187],"a":[16,37,51,96,122,180],"hallmark":[17],"neurodegeneration":[19],"cancer.":[21],"Cysteine":[22],"residues":[23],"can":[24],"be":[25],"oxidized":[26,139],"by":[27,34],"nitric":[28,144],"oxide":[29],"to":[30,36,49,121,151,175],"nitrosocysteine":[31],"(RSNO)":[32],"or":[33],"peroxide":[35],"sulfinic":[38,44,55,123,168],"acid":[39],"(RSO2H).":[40],"We":[41],"find":[42],"that":[43,135,167],"acids":[45],"react":[46],"with":[47,138],"nitrosothiols":[48],"form":[50],"thiosulfonate":[52],"linkage.":[53],"Using":[54],"acid\u2010linked":[56],"probes,":[57],"we":[58,147,165],"demonstrate":[59],"selective":[60],"enrichment":[61],"mass":[63,127],"spectrometry":[64,128],"annotation":[65],"more":[67],"than":[68],"1500":[69],"endogenous":[70],"S\u2010nitrosylated":[71,80],"proteins.":[72,101],"This":[73],"list":[74],"includes":[75],"nearly":[76],"all":[77],"previously":[78],"annotated":[79],"proteins,":[81],"including":[82],"ion":[83],"channels,":[84],"chaperones,":[85],"peroxiredoxins,":[86],"p53,":[87],"HDACs,":[88],"hundreds":[89],"metabolic":[91],"enzymes,":[92],"as":[93,95,171],"well":[94],"rich":[97],"set":[98],"novel":[100,149,181],"Interestingly,":[102],"familial":[104],"PD":[105],"gene":[106],"DJ\u20101":[107],"protects":[108],"cells":[109],"from":[110,189],"oxidative":[111],"stress,":[112,178],"requires":[114],"oxidation":[115],"an":[117],"evolutionarily":[118],"conserved":[119],"cysteine":[120],"acid.":[124],"Furthermore,":[125,146],"high\u2010resolution":[126],"analysis":[129],"chemiluminescence":[131],"NO":[132],"detection":[133],"confirms":[134],"S\u2010nitroso\u2010cysteine":[136],"reacts":[137],"DJ\u20101,":[140,173],"causing":[141],"elimination":[142],"oxide.":[145],"discuss":[148],"strategies":[150],"annotate":[152],"profile":[154],"protein":[155],"sulfinylation":[156],"using":[157],"orthogonal":[158],"probes.":[160],"Based":[161],"on":[162],"these":[163],"findings,":[164],"propose":[166],"acids,":[169],"such":[170],"in":[172],"function":[174],"reduce":[176],"nitrosative":[177],"establishing":[179],"mechanism":[182],"redox":[184],"regulation.":[185],"Support":[186],"provided":[188],"University":[191],"Michigan.":[193]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
