{"id":"https://openalex.org/W1587905882","doi":null,"title":"Microrheology of mechanosensitive bone cells","display_name":"Microrheology of mechanosensitive bone cells","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1587905882","mag":"1587905882"},"language":"en","primary_location":{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/e3baf553-756d-4634-b9a0-2e1ef6c5bd59","doi":null,"is_oa":false,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/microrheology-of-mechanosensitive-bone-cells(e3baf553-756d-4634-b9a0-2e1ef6c5bd59).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bacabac, R G, Mizuno, D, Schmidt, C F, MacKintosh, F C, Smit, T H, van Loon, J J W A & Klein Nulend, J 2006, 'Microrheology of mechanosensitive bone cells', Journal of gravitational physiology, vol. 13, pp. 135-136.","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031734259","display_name":"Rommel G. Bacabac","orcid":"https://orcid.org/0000-0001-6148-6268","observed_orcids":["https://orcid.org/0000-0001-6148-6268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rommel G. Bacabac","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6148-6268","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012197403","display_name":"Daisuke Mizuno","orcid":"https://orcid.org/0000-0001-7749-3681","observed_orcids":["https://orcid.org/0000-0001-7749-3681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Mizuno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7749-3681","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054599909","display_name":"Christoph F. Schmidt","orcid":"https://orcid.org/0000-0003-2864-6973","observed_orcids":["https://orcid.org/0000-0003-2864-6973","https://orcid.org/0000-0002-0240-4864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph F. Schmidt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2864-6973","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067373320","display_name":"F. C. MacKintosh","orcid":"https://orcid.org/0000-0002-2607-9541","observed_orcids":["https://orcid.org/0000-0002-2607-9541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. C. MacKintosh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2607-9541","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009598025","display_name":"Theo H. Smit","orcid":"https://orcid.org/0000-0002-8906-7433","observed_orcids":["https://orcid.org/0000-0002-8906-7433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theo H. Smit","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8906-7433","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063868518","display_name":"Jack J. W. A. van Loon","orcid":"https://orcid.org/0000-0001-9051-6016","observed_orcids":["https://orcid.org/0000-0001-9051-6016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack J. W. A. van Loon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9051-6016","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081816088","display_name":"Jenneke Klein\u2010Nulend","orcid":"https://orcid.org/0000-0001-7661-199X","observed_orcids":["https://orcid.org/0000-0001-7661-199X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Klein Nulend","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0961,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43985526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"135","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11379","display_name":"Rheology and Fluid Dynamics Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.7160000205039978},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.796999990940094},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-viscoelasticity","display_name":"cell viscoelasticity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.765999972820282},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cell-morphology-changes","display_name":"cell shape changes","score":0.5580000281333923},{"id":"https://openalex.org/keywords/force-fluctuations","display_name":"force fluctuations","score":0.777999997138977},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.6079999804496765},{"id":"https://openalex.org/keywords/osteogenic-response","display_name":"osteogenic response","score":0.656000018119812},{"id":"https://openalex.org/keywords/mlo-y4-cells","display_name":"MLO-Y4 cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2779463800","wikidata":"https://www.wikidata.org/wiki/Q5062222","display_name":"Center (category theory)","level":2,"score":0.507028341293335},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4862002730369568},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.46231609582901},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21997258067131042},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1338598132133484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09284040331840515},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/e3baf553-756d-4634-b9a0-2e1ef6c5bd59","doi":null,"is_oa":false,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/microrheology-of-mechanosensitive-bone-cells(e3baf553-756d-4634-b9a0-2e1ef6c5bd59).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bacabac, R G, Mizuno, D, Schmidt, C F, MacKintosh, F C, Smit, T H, van Loon, J J W A & Klein Nulend, J 2006, 'Microrheology of mechanosensitive bone cells', Journal of gravitational physiology, vol. 13, pp. 135-136.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/3193","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/3193","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/7e1aa0c4-9abd-4eb1-b7d8-49c1756e7e86","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/7e1aa0c4-9abd-4eb1-b7d8-49c1756e7e86","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bacabac, R G, Mizuno, D, Schmidt, C F, MacKintosh, F C, Smit, T H, van Loon, J J W A & Klein Nulend, J 2006, 'Microrheology of mechanosensitive bone cells', Journal of Gravitational Physiology, vol. 13, pp. 135-136.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/e3baf553-756d-4634-b9a0-2e1ef6c5bd59","doi":null,"is_oa":false,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/microrheology-of-mechanosensitive-bone-cells(e3baf553-756d-4634-b9a0-2e1ef6c5bd59).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of gravitational physiology, 13, 135 - 136. Galileo Foundation","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/7e1aa0c4-9abd-4eb1-b7d8-49c1756e7e86","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/7e1aa0c4-9abd-4eb1-b7d8-49c1756e7e86","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Gravitational Physiology, 13, 135 - 136. Galileo Foundation","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1587905882","doi":null,"is_oa":false,"landing_page_url":"http://www.descsite.nl/Publications/Thesis/Bacabac/CHAPTER7prn.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2756273966","display_name":"Journal of gravitational physiology","issn_l":"1077-9248","issn":["1077-9248"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of gravitational physiology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1784155883","https://openalex.org/W1875886495","https://openalex.org/W1947096230","https://openalex.org/W1973089587","https://openalex.org/W1978173156","https://openalex.org/W1980039414","https://openalex.org/W1992899755","https://openalex.org/W1996016298","https://openalex.org/W2002208582","https://openalex.org/W2005115078","https://openalex.org/W2013872595","https://openalex.org/W2030335451","https://openalex.org/W2037127091","https://openalex.org/W2043098612","https://openalex.org/W2052766715","https://openalex.org/W2059193195","https://openalex.org/W2079873850","https://openalex.org/W2084058002","https://openalex.org/W2085989796","https://openalex.org/W2091799660","https://openalex.org/W2095524315","https://openalex.org/W2097818208","https://openalex.org/W2100041293","https://openalex.org/W2101712645","https://openalex.org/W2115522515","https://openalex.org/W2120000044","https://openalex.org/W2121343308","https://openalex.org/W2125692365","https://openalex.org/W2150212358","https://openalex.org/W2164319357","https://openalex.org/W2169237541","https://openalex.org/W2170683123"],"related_works":["https://openalex.org/W2119482041","https://openalex.org/W1968805816","https://openalex.org/W1971894055","https://openalex.org/W2597441551","https://openalex.org/W2056996452","https://openalex.org/W2768968545","https://openalex.org/W2522485232","https://openalex.org/W2399106294","https://openalex.org/W6906452552","https://openalex.org/W2081839513"],"abstract_inverted_index":{"To":[0,155],"understand":[1],"how":[2],"the":[3,39,45,54,76,115,130,157,164,172,175,200,225,229,254,286,300],"mechanosensing":[4,292],"by":[5,80,118,138,171,181,293],"bone":[6,98,160,294,304],"cells":[7,82,99,112,173,183,295],"might":[8,250],"relate":[9],"to":[10,37,101,124,186,205,232,236,305],"cellular":[11,233],"metabolism":[12],"and":[13,43,70,73,296],"mechanical":[14,86,230,306],"properties,":[15],"a":[16,27,85,104,149,219,242,268,281],"physical":[17],"portrait":[18],"of":[19,30,47,57,159,166,228,256,262,289,303],"cell":[20,49,153],"viscoelasticity":[21],"is":[22,267,280],"needed.":[23],"Thus,":[24,214],"we":[25,162],"developed":[26],"novel":[28],"application":[29],"two-particle":[31],"microrheology":[32,279],"using":[33],"fibronectin-coated":[34],"spherical":[35,123],"probes":[36,117],"characterize":[38],"viscoelasticity,":[40],"mechanically":[41],"stimulate,":[42],"probe":[44,156],"mechano-activity":[46,158],"various":[48],"types.":[50],"We":[51],"found":[52],"that":[53,97,146],"elastic":[55],"modulus":[56],"MLO-Y4":[58,81,111,182,237],"osteocytes":[59,72],"was":[60,136,203],"below":[61],"500":[62],"Pa,":[63],"as":[64,66,107,249],"well":[65],"for":[67,108,207,271,284],"MC3T3-E1":[68],"osteoblasts,":[69],"primary":[71],"osteoblasts.":[74],"Interestingly,":[75],"nitric":[77],"oxide":[78],"released":[79],"increased":[83],"after":[84],"stimulation":[87,139],"at":[88,103,127,134,192,197,212,247],"5":[89],"pN,":[90],"with":[91,114,140,265,273],"cell-attached":[92],"integrin-bound":[93,116,176],"probes.":[94,177],"This":[95,144],"suggests":[96,145],"respond":[100],"forces":[102],"similar":[105],"range":[106],"deforming":[109],"integrins.":[110],"interacted":[113],"changing":[119],"their":[120],"shape":[121,132],"from":[122],"being":[125],"polar":[126],"37oC.":[128,213],"However,":[129,199],"same":[131],"change":[133,216],"22oC":[135],"acquired":[137],"5-20":[141],"pN":[142],"forces.":[143],"temperature":[147,215],"has":[148],"significant":[150,226],"effect":[151,227],"on":[152,174,291,299],"morphology.":[154],"cells,":[161,238],"measured":[163],"fluctuation":[165,202],"force":[167,201],"<ff":[168,178,244,263],">":[169,179,245,264],"induced":[170,180],"were":[184],"proportional":[185,204],"\u03c9-2":[187,206,266],"(where":[188],"frequency":[189],"=":[190],"\u03c9/(2\u03c0))":[191],"frequencies":[193,208],"<":[194,209],"3":[195],"Hz":[196,211],"22oC.":[198],"10":[210],"possibly":[217],"induces":[218],"sharp":[220],"non-linear":[221],"metabolic":[222],"increase":[223],"underlining":[224],"environment":[231],"metabolism.":[234],"Compared":[235],"CCL-224":[239],"fibroblasts":[240],"had":[241],"higher":[243],"magnitude":[246],"37oC,":[248],"be":[251],"expected":[252,270],"considering":[253],"motility":[255],"fibroblastic":[257],"cells.":[258],"The":[259],"linear":[260],"relation":[261],"signature":[269],"continuums":[272],"slowly":[274],"evolving":[275],"internal":[276],"processes.":[277],"Hence,":[278],"useful":[282],"tool":[283],"understanding":[285],"varied":[287],"set":[288],"observations":[290],"its":[297],"implicatioimplications":[298],"osteogenic":[301],"response":[302],"loading.":[307]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}