{"id":"https://openalex.org/W1587797128","doi":null,"title":"Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta.","display_name":"Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta.","publication_year":1987,"publication_date":"1987-12-15","ids":{"openalex":"https://openalex.org/W1587797128","mag":"1587797128","pmid":"https://pubmed.ncbi.nlm.nih.gov/3499977"},"language":"en","primary_location":{"id":"pmid:3499977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039055430","display_name":"Gordon K. Wollenberg","orcid":"https://orcid.org/0000-0003-2264-1493","observed_orcids":["https://orcid.org/0000-0003-2264-1493"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G K Wollenberg","raw_affiliation_strings":["Department of Pathology, University of Guelph, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Guelph, Ontario, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069153174","display_name":"E. Semple","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Semple","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666950","display_name":"Bette Anne Quinn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Quinn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"M A Hayes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Hayes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8587,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.85594736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"47","issue":"24 Pt 1","first_page":"6595","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.44290000200271606,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.6800000071525574},{"id":"https://openalex.org/keywords/preneoplastic-nodules","display_name":"preneoplastic nodules","score":0.9430000185966492},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.902999997138977},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.7749999761581421},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.453000009059906},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7688481211662292},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5654308795928955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5372393727302551},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.528153657913208},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5247167348861694},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5080599784851074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47584864497184753},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.46862274408340454},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.45293760299682617},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4255390167236328},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.4171416163444519},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.41434726119041443},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3549082279205322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32771623134613037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21435251832008362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1653432846069336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14657315611839294},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13540402054786682},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3499977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1587797128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1918161163","https://openalex.org/W1976794059","https://openalex.org/W2066538325","https://openalex.org/W2093313960","https://openalex.org/W2140586060","https://openalex.org/W1966727181","https://openalex.org/W2090962290","https://openalex.org/W1982940199","https://openalex.org/W2069375283","https://openalex.org/W1969393024"],"abstract_inverted_index":{"The":[0,76,149],"influences":[1],"of":[2,11,78,199,212,237,258,260,272],"purified":[3],"transforming":[4],"growth":[5,31],"factor":[6,32],"beta":[7],"(TGF-beta)":[8],"on":[9],"proliferation":[10,259,271],"normal,":[12,261],"preneoplastic,":[13,263],"and":[14,54,91,120,169,203,216,239,264],"neoplastic":[15,265,273],"rat":[16],"hepatocytes":[17,80,200,241,274],"were":[18,52,123,144,182,243],"examined":[19],"in":[20,45,56,83,275,283],"primary":[21],"monolayer":[22],"culture":[23],"with":[24,29,114],"or":[25,38,42],"without":[26],"prior":[27],"stimulation":[28],"epidermal":[30],"(EGF).":[33],"Hepatocytes":[34,116,134],"from":[35,117,136,201],"normal":[36,79,137,202,238],"livers":[37,138,205],"discrete":[39],"preneoplastic":[40],"nodules":[41],"carcinomas":[43],"generated":[44],"F344":[46],"rats":[47],"by":[48,70,73,126,132,147,280],"the":[49,176,188,192,209,221,235],"Solt-Farber":[50],"model":[51],"isolated":[53,135],"cultured":[55],"serum-free":[57],"modified":[58],"Williams'":[59],"E.":[60],"medium":[61],"for":[62,154],"up":[63],"to":[64,85,156,179,208,246,285],"72":[65,92,217],"h.":[66,93,161],"Proliferation":[67],"was":[68,101,159,195],"quantified":[69],"labeling":[71,177,189,236],"index":[72,178,190],"[3H]thymidine":[74],"autoradiography.":[75],"majority":[77],"became":[81,206],"labeled":[82],"response":[84,284],"EGF":[86,127,173],"(20":[87],"ng/ml)":[88],"between":[89,167,214],"24":[90,139],"TGF-beta":[94,155,162,194,213,226,252],"had":[95],"a":[96,254,281],"dose-dependent":[97],"inhibitory":[98,210,222],"effect":[99,223],"which":[100],"virtually":[102,232],"complete":[103],"at":[104,110,164,191,228],"concentrations":[105],"above":[106],"0.5":[107],"ng/ml":[108],"added":[109,163,227],"0":[111,229],"h":[112,140,171,230],"together":[113],"EGF.":[115,247],"all":[118],"nodule":[119],"carcinoma":[121],"populations":[122],"less":[124],"stimulated":[125],"but":[128,184],"also":[129,231],"strongly":[130],"inhibited":[131,146,175,234],"TGF-beta.":[133,148,286],"after":[141,172],"partial":[142],"hepatectomy":[143],"similarly":[145],"minimal":[150],"initial":[151],"exposure":[152],"period":[153],"maximally":[157],"inhibit":[158],"2":[160],"various":[165],"times":[166],"8":[168],"48":[170,215],"partially":[174],"levels":[180],"that":[181,220,242,251,269],"constant":[183],"substantially":[185],"greater":[186],"than":[187],"time":[193],"added.":[196],"A":[197],"proportion":[198],"nodular":[204,240],"resistant":[207],"effects":[211],"h,":[218],"suggesting":[219],"is":[224,253],"transient.":[225],"completely":[233],"not":[244],"exposed":[245],"These":[248],"studies":[249],"demonstrate":[250],"potent":[255],"negative":[256],"regulator":[257],"regenerating,":[262],"hepatocytes.":[266],"This":[267],"suggests":[268],"persistent":[270],"vivo":[276],"cannot":[277],"be":[278],"explained":[279],"difference":[282]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}