{"id":"https://openalex.org/W1587400519","doi":null,"title":"Next generation genomic sequencing and bioinformatics approaches for the study of the human gut microbiome in selected diseases of the human gut","display_name":"Next generation genomic sequencing and bioinformatics approaches for the study of the human gut microbiome in selected diseases of the human gut","publication_year":2014,"publication_date":"2014-03-24","ids":{"openalex":"https://openalex.org/W1587400519","mag":"1587400519"},"language":"en","primary_location":{"id":"mag:1587400519","doi":null,"is_oa":false,"landing_page_url":"http://www.fedoa.unina.it/9660/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069682862","display_name":"Giorgio Casaburi","orcid":"https://orcid.org/0000-0002-5980-8704","observed_orcids":["https://orcid.org/0000-0002-5980-8704"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giorgio Casaburi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5980-8704","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069682862"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9150000214576721},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.9160000085830688},{"id":"https://openalex.org/keywords/duodenal-biopsy","display_name":"duodenal biopsy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nutritional-therapy","display_name":"nutritional therapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gluten-free-diet","display_name":"gluten-free diet","score":0.953000009059906},{"id":"https://openalex.org/keywords/microbial-signatures","display_name":"microbial signatures","score":0.7080000042915344},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.5839999914169312},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7300000190734863},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.8468644618988037},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7786450386047363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6741254925727844},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5759073495864868},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.5531387329101562},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5121986269950867},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5029222369194031},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4963570237159729},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48443320393562317},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.47922617197036743},{"id":"https://openalex.org/C2993206177","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon sequencing","level":4,"score":0.470562219619751},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4607035219669342},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.45212864875793457},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.41105571389198303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35027575492858887},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3231539726257324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22964131832122803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1990799903869629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14240917563438416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1587400519","doi":null,"is_oa":false,"landing_page_url":"http://www.fedoa.unina.it/9660/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W110920306","https://openalex.org/W1497287772","https://openalex.org/W1519781644","https://openalex.org/W1534340623","https://openalex.org/W1546962148","https://openalex.org/W1552685796","https://openalex.org/W1556097148","https://openalex.org/W1558982506","https://openalex.org/W1588428936","https://openalex.org/W1670573097","https://openalex.org/W1820461377","https://openalex.org/W1830760524","https://openalex.org/W1963710004","https://openalex.org/W1966641706","https://openalex.org/W1967997195","https://openalex.org/W1968288149","https://openalex.org/W1972505691","https://openalex.org/W1976381426","https://openalex.org/W1979948289","https://openalex.org/W1987306123","https://openalex.org/W1988654243","https://openalex.org/W1988925586","https://openalex.org/W1989348205","https://openalex.org/W1992153121","https://openalex.org/W1993399595","https://openalex.org/W1995875735","https://openalex.org/W1996106963","https://openalex.org/W2000259070","https://openalex.org/W2002477604","https://openalex.org/W2003732927","https://openalex.org/W2004548026","https://openalex.org/W2005129098","https://openalex.org/W2006465310","https://openalex.org/W2006690660","https://openalex.org/W2007159007","https://openalex.org/W2009170813","https://openalex.org/W2009460670","https://openalex.org/W2010532879","https://openalex.org/W2011365171","https://openalex.org/W2016271868","https://openalex.org/W2020762219","https://openalex.org/W2022825068","https://openalex.org/W2023574331","https://openalex.org/W2024372253","https://openalex.org/W2030154486","https://openalex.org/W2036509718","https://openalex.org/W2036647435","https://openalex.org/W2038343076","https://openalex.org/W2046434400","https://openalex.org/W2047208232","https://openalex.org/W2048710178","https://openalex.org/W2051256815","https://openalex.org/W2053395478","https://openalex.org/W2053871041","https://openalex.org/W2055043387","https://openalex.org/W2057447694","https://openalex.org/W2058686993","https://openalex.org/W2061132897","https://openalex.org/W2061680337","https://openalex.org/W2062192957","https://openalex.org/W2064318892","https://openalex.org/W2067104364","https://openalex.org/W2068046737","https://openalex.org/W2070063001","https://openalex.org/W2070376189","https://openalex.org/W2071985027","https://openalex.org/W2072970694","https://openalex.org/W2076151007","https://openalex.org/W2076966647","https://openalex.org/W2077378171","https://openalex.org/W2077972576","https://openalex.org/W2078621117","https://openalex.org/W2080170237","https://openalex.org/W2080499435","https://openalex.org/W2080525752","https://openalex.org/W2083759302","https://openalex.org/W2084251919","https://openalex.org/W2084793748","https://openalex.org/W2085429049","https://openalex.org/W2087484128","https://openalex.org/W2091214043","https://openalex.org/W2092347839","https://openalex.org/W2094250612","https://openalex.org/W2094547695","https://openalex.org/W2095158284","https://openalex.org/W2095824228","https://openalex.org/W2096525273","https://openalex.org/W2097557545","https://openalex.org/W2097734528","https://openalex.org/W2097875133","https://openalex.org/W2098290178","https://openalex.org/W2101092920","https://openalex.org/W2101120467","https://openalex.org/W2103015797","https://openalex.org/W2104318549","https://openalex.org/W2107414352","https://openalex.org/W2107805776","https://openalex.org/W2108718991","https://openalex.org/W2110696566","https://openalex.org/W2112182790","https://openalex.org/W2112635226","https://openalex.org/W2116753165","https://openalex.org/W2117727476","https://openalex.org/W2118480671","https://openalex.org/W2118526609","https://openalex.org/W2119679108","https://openalex.org/W2120048439","https://openalex.org/W2120243636","https://openalex.org/W2121187468","https://openalex.org/W2122018794","https://openalex.org/W2124006710","https://openalex.org/W2124351063","https://openalex.org/W2124715997","https://openalex.org/W2125418992","https://openalex.org/W2125826054","https://openalex.org/W2126321303","https://openalex.org/W2128769815","https://openalex.org/W2128945836","https://openalex.org/W2129271132","https://openalex.org/W2130208436","https://openalex.org/W2130731460","https://openalex.org/W2131186249","https://openalex.org/W2132926880","https://openalex.org/W2133820956","https://openalex.org/W2135572109","https://openalex.org/W2136879569","https://openalex.org/W2137094219","https://openalex.org/W2138678288","https://openalex.org/W2141989506","https://openalex.org/W2142735254","https://openalex.org/W2143625465","https://openalex.org/W2143842034","https://openalex.org/W2146587607","https://openalex.org/W2147618390","https://openalex.org/W2147637673","https://openalex.org/W2147783737","https://openalex.org/W2148994713","https://openalex.org/W2149351690","https://openalex.org/W2150067149","https://openalex.org/W2150320991","https://openalex.org/W2151234959","https://openalex.org/W2152885278","https://openalex.org/W2153456263","https://openalex.org/W2153732314","https://openalex.org/W2156125289","https://openalex.org/W2156145269","https://openalex.org/W2161163382","https://openalex.org/W2162088497","https://openalex.org/W2162748874","https://openalex.org/W2165872127","https://openalex.org/W2167062509","https://openalex.org/W2168909179","https://openalex.org/W2169330513","https://openalex.org/W2170024099","https://openalex.org/W2170951896","https://openalex.org/W2171309014","https://openalex.org/W2171571559","https://openalex.org/W2171706687","https://openalex.org/W2316128914","https://openalex.org/W2324469999","https://openalex.org/W2338541571","https://openalex.org/W2353267094","https://openalex.org/W2484038213","https://openalex.org/W2907823609","https://openalex.org/W3134084687","https://openalex.org/W4232086814"],"related_works":["https://openalex.org/W2335344492","https://openalex.org/W2057929362","https://openalex.org/W1577826155","https://openalex.org/W2320874112","https://openalex.org/W2954684259","https://openalex.org/W4393941633","https://openalex.org/W1977085329","https://openalex.org/W7025178100","https://openalex.org/W4412064224","https://openalex.org/W2799643834"],"abstract_inverted_index":{"The":[0,208,232,259,294],"advent":[1],"of":[2,20,34,41,70,89,134,138,169,210,224,240,284,299],"next":[3,204],"generation":[4,205],"sequencing":[5,206],"technologies":[6],"(NGS)":[7],"has":[8],"deeply":[9,215],"transformed":[10],"today\u2019s":[11],"biology.":[12],"Thanks":[13],"to":[14,30,62,119,214,263,306,311],"this":[15,78],"new":[16],"approach,":[17],"many":[18],"areas":[19],"study":[21,234,261],"have":[22,27],"been":[23],"developed":[24],"and":[25,45,67,73,92,153,157,178,200,227,248,269,281,318],"scientists":[26],"the":[28,42,80,85,127,167,170,211,217,236,264,297,307,312],"ability":[29],"analyze":[31,216],"nucleic":[32],"acids":[33],"any":[35],"biological":[36],"entity.":[37],"Metagenomics":[38],"is":[39,103,130,213,296],"one":[40],"most":[43],"recent":[44],"promising":[46],"fields":[47],"among":[48],"NGS":[49],"applications.":[50],"It":[51],"allows":[52],"microbial":[53,75,136,300],"community":[54,88],"analysis":[55,196],"within":[56],"a":[57,110,241,250,255,282,290],"specific":[58],"environment":[59],"in":[60,96,113,145,173,197,271,315],"order":[61],"obtain":[63],"knowledge":[64],"on":[65,193],"genomes":[66],"taxonomic":[68],"composition":[69,239],"environmental":[71],"microbes":[72],"entire":[74],"communities.":[76],"In":[77],"context,":[79],"human":[81,128],"microbiota,":[82],"represented":[83],"by":[84,132,244],"total":[86],"ecological":[87],"commensal,":[90],"symbiotic,":[91],"pathogenic":[93],"microorganisms":[94],"coexisting":[95],"our":[97],"bodies":[98],"(Lederberg":[99],"J;":[100],"Scientist.":[101],"2001;15:8),":[102],"drawing":[104],"research\u2019s":[105],"attention":[106],"as":[107],"it":[108],"plays":[109],"central":[111],"role":[112,168],"maintaining":[114],"healthy":[115,257,279],"status":[116],"or":[117,309],"leading":[118],"disease":[120,199,226,229,246,287,313],"conditions":[121],"(Wang,":[122],"Zi-Kai":[123],"WJG.":[124],"2013:1541).":[125],"Particularly,":[126],"gut":[129,148,171,218,265],"colonized":[131],"thousands":[133],"different":[135],"species,":[137],"which":[139],"several":[140],"billions":[141],"are":[142],"bacteria":[143],"involved":[144],"important":[146],"functions:":[147],"permeability,":[149],"immune":[150],"system":[151],"development":[152],"activation,":[154],"metabolic":[155],"function":[156],"colonization":[158],"resistance":[159],"(Prakash":[160],"S.":[161],"Nature.":[162,184],"2012;231-241).":[163],"Many":[164],"evidences":[165],"relate":[166],"microbiome":[172,219,237,266],"common":[174],"bowel":[175],"inflammatory":[176],"diseases":[177],"autoimmune":[179],"disorders":[180],"(Xavier":[181],"R.":[182],"J.":[183],"2007:427-434).":[185],"\nHere,":[186],"I":[187],"present":[188],"two":[189],"distinct":[190],"studies":[191],"based":[192],"amplicon":[194],"metagenomics":[195],"Crohn\u2019s":[198,225,245,317],"Celiac":[201,228,275,286,319],"disease,":[202,276],"using":[203],"techniques.":[207],"aim":[209],"project":[212],"composition,":[220],"from":[221],"duodenal":[222],"biopsies":[223],"affected":[230,243],"patients.":[231],"first":[233],"compares":[235],"bacterial":[238],"child":[242],"before":[247],"after":[249],"nutritional":[251],"therapy":[252],"together":[253],"with":[254,273,278],"matched":[256],"control.":[258],"second":[260],"pertains":[262],"characterization":[267],"(bacteria":[268],"fungi)":[270],"adults":[272],"active":[274],"compared":[277],"controls":[280],"group":[283],"non-active":[285],"patients,":[288],"following":[289],"gluten":[291],"free":[292],"diet.":[293],"goal":[295],"identification":[298],"signatures":[301],"that":[302],"could":[303],"be":[304],"related":[305],"pathogenesis":[308],"contribute":[310],"phenotype":[314],"both":[316],"disease.":[320]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
