{"id":"https://openalex.org/W1587358484","doi":null,"title":"Elastin gene expression in elastotic human breast cancers and epithelial cell lines.","display_name":"Elastin gene expression in elastotic human breast cancers and epithelial cell lines.","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W1587358484","mag":"1587358484","pmid":"https://pubmed.ncbi.nlm.nih.gov/2156612"},"language":"en","primary_location":{"id":"pmid:2156612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2156612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108365377","display_name":"Rajiv Kumar Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"R Krishnan","raw_affiliation_strings":["Department of Pathology, University of Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Adelaide, South Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":null,"display_name":"E G Cleary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G Cleary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5252,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.58734723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"50","issue":"7","first_page":"2164","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.22010000050067902,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin-gene-expression","display_name":"elastin gene expression","score":0.9589999914169312},{"id":"https://openalex.org/keywords/elastosis","display_name":"elastosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7269999980926514},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/stromal-fibroblasts","display_name":"stromal fibroblasts","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-epithelium","display_name":"tumor epithelium","score":0.5519999861717224},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.8740000128746033},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.9310885667800903},{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.7074711918830872},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6089292764663696},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5755877494812012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5273571610450745},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5058981776237488},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5041712522506714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4876495599746704},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4716457724571228},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.452584832906723},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4385264217853546},{"id":"https://openalex.org/C2780299668","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Tropoelastin","level":3,"score":0.43817469477653503},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4292123019695282},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3763383626937866},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2605658173561096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25545501708984375},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.20101770758628845},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11318269371986389},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014333","descriptor_name":"Tropoelastin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2156612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2156612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1587358484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2156612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1967704809","https://openalex.org/W1990799445","https://openalex.org/W2024705563","https://openalex.org/W2042926011","https://openalex.org/W2051091105","https://openalex.org/W2054788853","https://openalex.org/W2069922159","https://openalex.org/W2088146122","https://openalex.org/W2090576508","https://openalex.org/W2096391151","https://openalex.org/W2101108802","https://openalex.org/W2116810805","https://openalex.org/W2134812217","https://openalex.org/W2145879807","https://openalex.org/W2160371166","https://openalex.org/W2190936962","https://openalex.org/W2421588407","https://openalex.org/W2462979523","https://openalex.org/W2465878310","https://openalex.org/W2997816400"],"related_works":["https://openalex.org/W2141106165","https://openalex.org/W7099236030","https://openalex.org/W2027610513","https://openalex.org/W1990799445","https://openalex.org/W2090576508","https://openalex.org/W2047919962","https://openalex.org/W2428054830","https://openalex.org/W207708415","https://openalex.org/W2015907627","https://openalex.org/W151176344"],"abstract_inverted_index":{"Elastosis":[0],"is":[1,15,22,227,280],"a":[2,144,170,186,228,238,267,285],"prominent":[3],"feature":[4],"of":[5,27,57,110,112,133,143,173,177,188,207,211,230,237,241,266,299,306,310,320],"the":[6,19,28,48,113,137,151,155,174,208,212,224,231,234,248,296,300,304,317],"desmoplastic":[7,235,301],"reaction":[8],"in":[9,52,69,103,149,220,233,251,263,277,307,322],"many":[10],"invasive":[11,190],"breast":[12,29,40,53,59,77,93,192,197,222,253,270,278,323],"cancers.":[13,254,324],"It":[14,199],"widely":[16],"held":[17],"that":[18,36,275],"elastic":[20],"tissue":[21,236],"produced":[23,79,101],"by":[24],"fibroblastic":[25,115,152,205],"cells":[26,153,206],"stroma,":[30],"but":[31],"several":[32],"studies":[33,44],"have":[34,62,259],"suggested":[35],"it":[37],"derives":[38],"from":[39,76,169],"cancer":[41,60,94,156],"epithelium.":[42],"In":[43,159],"directed":[45],"to":[46,65,108,283,295],"examining":[47],"mechanisms":[49],"regulating":[50],"desmoplasia":[51],"cancers,":[54,78,223],"cell":[55,70,95,128,157],"lines":[56],"human":[58,92,178],"derivation":[61],"been":[63,182,201],"shown":[64],"synthesize":[66],"immunoreactive":[67],"tropoelastin":[68],"culture.":[71],"Stromal":[72],"fibroblasts,":[73],"grown":[74,97],"out":[75,184],"as":[80,83],"much":[81],"elastin":[82,102,146,164,179,218,232,249,257,311],"did":[84],"nuchal":[85],"ligament":[86],"fibroblasts":[87],"at":[88,105],"similar":[89,99],"passages.":[90],"The":[91,255,272],"lines,":[96],"under":[98,139],"conditions,":[100,142],"culture":[104],"rates":[106],"equivalent":[107],"1.6-15%":[109],"those":[111],"control":[114],"cells.":[116],"These":[117],"included":[118],"two":[119],"estrogen":[120,125],"receptor":[121,126],"positive":[122],"and":[123,154,194,210],"one":[124],"negative":[127],"types.":[129],"Northern":[130],"blot":[131],"analysis":[132],"total":[134],"RNA":[135,166],"showed":[136],"presence,":[138],"high":[140],"stringency":[141],"3.5-kilobase":[145],"mRNA":[147],"band":[148],"both":[150],"lines.":[158],"situ":[160,308],"hybridization,":[161],"with":[162,288],"an":[163],"complementary":[165],"probe":[167],"(prepared":[168],"short":[171],"segment":[172],"translated":[175],"region":[176,214],"mRNA),":[180],"has":[181,200],"carried":[183],"on":[185,303],"selection":[187],"21":[189],"ductal":[191,269],"cancers":[193,279,293],"9":[195],"normal":[196],"samples.":[198],"found":[202],"that,":[203],"while":[204],"stroma":[209],"periductal":[213],"are":[215],"responsible":[216],"for":[217],"synthesis":[219],"most":[221],"malignant":[225],"epithelium":[226],"source":[229,298],"significant":[239],"proportion":[240],"such":[242],"neoplasms.":[243],"Vascular":[244],"endothelium":[245],"also":[246],"expresses":[247],"gene":[250],"some":[252],"elastotic":[256],"may":[258,313],"different":[260,264],"cellular":[261,297],"origins":[262],"portions":[265],"single":[268],"cancer.":[271],"results":[273],"indicate":[274],"elastosis":[276,321],"very":[281],"likely":[282],"be":[284],"complex":[286],"process":[287],"multifactorial":[289],"regulatory":[290],"mechanisms.":[291],"Subclassifying":[292],"according":[294],"elastin,":[302],"basis":[305],"hybridization":[309],"mRNA,":[312],"provide":[314],"insights":[315],"into":[316],"prognostic":[318],"significance":[319]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}