{"id":"https://openalex.org/W1587348581","doi":"https://doi.org/10.1016/s0021-9258(18)99409-3","title":"Potentiometric Titration and Conformational Change in Pepsinogen","display_name":"Potentiometric Titration and Conformational Change in Pepsinogen","publication_year":1967,"publication_date":"1967-11-01","ids":{"openalex":"https://openalex.org/W1587348581","doi":"https://doi.org/10.1016/s0021-9258(18)99409-3","mag":"1587348581","pmid":"https://pubmed.ncbi.nlm.nih.gov/4863743"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)99409-3","doi":"https://doi.org/10.1016/s0021-9258(18)99409-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)99409-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)99409-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041132077","display_name":"Gertrude E. Perlmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gertrude E. Perlmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034119401","display_name":"Avraham Oplatka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avraham Oplatka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113693949","display_name":"Aharon Katchalsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aharon Katchalsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5873,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7955259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"242","issue":"22","first_page":"5163","last_page":"5168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsinogen","display_name":"pepsinogen","score":1.0},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8199999928474426},{"id":"https://openalex.org/keywords/potentiometric-titration","display_name":"potentiometric titration","score":0.847000002861023},{"id":"https://openalex.org/keywords/buffering-capacity","display_name":"buffering capacity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.8889999985694885},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transition-enthalpy","display_name":"transition enthalpy","score":0.6690000295639038},{"id":"https://openalex.org/keywords/optical-rotatory-dispersion","display_name":"optical rotatory dispersion","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C124614425","wikidata":"https://www.wikidata.org/wiki/Q1813495","display_name":"Potentiometric titration","level":3,"score":0.8634128570556641},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8179203271865845},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.7516162395477295},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.7475610375404358},{"id":"https://openalex.org/C38503535","wikidata":"https://www.wikidata.org/wiki/Q903526","display_name":"Optical rotatory dispersion","level":3,"score":0.6221750974655151},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.5966395139694214},{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.5305562019348145},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.4909382164478302},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.47175294160842896},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.46429261565208435},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.41223597526550293},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3809674382209778},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.3327562212944031},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.27900785207748413},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25927984714508057},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.19832062721252441},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.19733926653862},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.12710118293762207},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10171586275100708},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.07400140166282654},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011199","descriptor_name":"Potentiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)99409-3","doi":"https://doi.org/10.1016/s0021-9258(18)99409-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)99409-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4863743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4863743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)99409-3","doi":"https://doi.org/10.1016/s0021-9258(18)99409-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)99409-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W168754130","https://openalex.org/W205279000","https://openalex.org/W219524102","https://openalex.org/W1491443126","https://openalex.org/W1554300312","https://openalex.org/W1810620222","https://openalex.org/W1836923993","https://openalex.org/W1965595695","https://openalex.org/W1974082779","https://openalex.org/W1986565456","https://openalex.org/W2033071249","https://openalex.org/W2073795768","https://openalex.org/W2091453940","https://openalex.org/W2320600355","https://openalex.org/W2734347008","https://openalex.org/W4213059148"],"related_works":["https://openalex.org/W1457218745","https://openalex.org/W2037513626","https://openalex.org/W2142872230","https://openalex.org/W2091453940","https://openalex.org/W2056107133","https://openalex.org/W4299553242","https://openalex.org/W1971149781","https://openalex.org/W1970325893","https://openalex.org/W2479211718","https://openalex.org/W1971248530"],"abstract_inverted_index":{"Abstract":[0],"Potentiometric":[1],"titrations":[2],"of":[3,7,29,35,43,60,73,83,88,106,108,112],"pepsinogen":[4],"as":[5,64],"functions":[6],"ionic":[8,19],"strength":[9,20],"and":[10],"temperature":[11,78],"were":[12,47],"studied.":[13],"It":[14,96],"was":[15,97],"found":[16,48],"that":[17,99],"the":[18,26,30,36,40,61,74,93,100,104,109],"has":[21],"a":[22,57,80],"minor":[23],"effect":[24],"on":[25],"titration":[27],"behavior":[28],"protein.":[31],"The":[32,71],"maximum":[33],"values":[34,51],"buffering":[37],"capacity":[38],"in":[39,92,103],"pH":[41,50,75],"range":[42,105],"6.0":[44],"to":[45,53],"9.0":[46],"at":[49,55],"corresponding":[52],"those":[54],"which":[56],"conformational":[58,94],"change":[59,72],"protein":[62],"occurs":[63,102],"determined":[65],"by":[66],"optical":[67],"rotatory":[68],"dispersion":[69],"measurements.":[70],"transition":[76,101],"with":[77],"gave":[79],"transitional":[81],"enthalpy":[82],"50":[84],"kcal":[85],"per":[86],"mole":[87],"hydrogen":[89],"ions":[90],"liberated":[91],"change.":[95],"shown":[98],"ionization":[107],"three":[110],"histidines":[111],"pepsinogen.":[113]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
