{"id":"https://openalex.org/W1587264386","doi":null,"title":"Muscarinic M1 and M3 Receptors,IP3 and cGMP Functional Regulation in Streptozotocin Induced Diabetic Rats: Insulin and Somatotropin Induced Rejuvenation as a Function of Age","display_name":"Muscarinic M1 and M3 Receptors,IP3 and cGMP Functional Regulation in Streptozotocin Induced Diabetic Rats: Insulin and Somatotropin Induced Rejuvenation as a Function of Age","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W1587264386","mag":"1587264386"},"language":"en","primary_location":{"id":"pmh:oai:dyuthi.cusat.ac.in:purl/2811","doi":null,"is_oa":true,"landing_page_url":"http://dyuthi.cusat.ac.in/purl/2811","pdf_url":"http://dyuthi.cusat.ac.in/purl/2811","source":{"id":"https://openalex.org/S4306401946","display_name":"Dyuthi Digital Repository (Cochin University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20497027","host_organization_name":"Cochin University of Science and Technology","host_organization_lineage":["https://openalex.org/I20497027"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dyuthi.cusat.ac.in/purl/2811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100518780","display_name":"Savitha Balakrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Savitha Balakrishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113484055","display_name":"C.S. Paulose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.S. Paulose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-m1-receptor","display_name":"M1 muscarinic receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":1.0},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.621999979019165},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4729999899864197},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9340000152587891},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.5040000081062317},{"id":"https://openalex.org/keywords/pancreatic-islet-cells","display_name":"pancreatic islet cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.6200000047683716},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8730000257492065},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.6549999713897705},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cholinergic-function","display_name":"cholinergic activity","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6936928629875183},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6695587635040283},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.6104779243469238},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5282149910926819},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.47602513432502747},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46647390723228455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4343223571777344},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32749080657958984}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dyuthi.cusat.ac.in:purl/2811","doi":null,"is_oa":true,"landing_page_url":"http://dyuthi.cusat.ac.in/purl/2811","pdf_url":"http://dyuthi.cusat.ac.in/purl/2811","source":{"id":"https://openalex.org/S4306401946","display_name":"Dyuthi Digital Repository (Cochin University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20497027","host_organization_name":"Cochin University of Science and Technology","host_organization_lineage":["https://openalex.org/I20497027"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1587264386","doi":null,"is_oa":false,"landing_page_url":"https://dyuthi.cusat.ac.in/xmlui/bitstream/purl/2811/1/Dyuthi-T0832.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306513217","display_name":"INFLIBNET","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"INFLIBNET","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dyuthi.cusat.ac.in:purl/2811","doi":null,"is_oa":true,"landing_page_url":"http://dyuthi.cusat.ac.in/purl/2811","pdf_url":"http://dyuthi.cusat.ac.in/purl/2811","source":{"id":"https://openalex.org/S4306401946","display_name":"Dyuthi Digital Repository (Cochin University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20497027","host_organization_name":"Cochin University of Science and Technology","host_organization_lineage":["https://openalex.org/I20497027"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1587264386.pdf","grobid_xml":"https://content.openalex.org/works/W1587264386.grobid-xml"},"referenced_works_count":528,"referenced_works":["https://openalex.org/W845121","https://openalex.org/W51725127","https://openalex.org/W57120418","https://openalex.org/W59084364","https://openalex.org/W66469790","https://openalex.org/W72301255","https://openalex.org/W88764328","https://openalex.org/W94846272","https://openalex.org/W100338727","https://openalex.org/W131197542","https://openalex.org/W157140528","https://openalex.org/W158572393","https://openalex.org/W178004509","https://openalex.org/W262489564","https://openalex.org/W279887307","https://openalex.org/W306179751","https://openalex.org/W799075961","https://openalex.org/W1240281942","https://openalex.org/W1483524632","https://openalex.org/W1499384204","https://openalex.org/W1500979124","https://openalex.org/W1503198961","https://openalex.org/W1503310668","https://openalex.org/W1505000310","https://openalex.org/W1514465145","https://openalex.org/W1549802470","https://openalex.org/W1556488235","https://openalex.org/W1561066485","https://openalex.org/W1562122315","https://openalex.org/W1564829038","https://openalex.org/W1573648604","https://openalex.org/W1581798949","https://openalex.org/W1594153431","https://openalex.org/W1595907824","https://openalex.org/W1596291999","https://openalex.org/W1599277155","https://openalex.org/W1765396147","https://openalex.org/W1765689631","https://openalex.org/W1828467682","https://openalex.org/W1901275661","https://openalex.org/W1922963517","https://openalex.org/W1924799369","https://openalex.org/W1925492557","https://openalex.org/W1928783644","https://openalex.org/W1944989204","https://openalex.org/W1945560395","https://openalex.org/W1946992976","https://openalex.org/W1958547196","https://openalex.org/W1963797455","https://openalex.org/W1963905932","https://openalex.org/W1964172387","https://openalex.org/W1964459202","https://openalex.org/W1964643609","https://openalex.org/W1965021019","https://openalex.org/W1965482152","https://openalex.org/W1965710275","https://openalex.org/W1965875690","https://openalex.org/W1965942143","https://openalex.org/W1966292269","https://openalex.org/W1966445523","https://openalex.org/W1968498807","https://openalex.org/W1968732594","https://openalex.org/W1970518640","https://openalex.org/W1970578796","https://openalex.org/W1970585870","https://openalex.org/W1970599746","https://openalex.org/W1971386092","https://openalex.org/W1972170838","https://openalex.org/W1972419134","https://openalex.org/W1972653989","https://openalex.org/W1972883579","https://openalex.org/W1972942799","https://openalex.org/W1972974216","https://openalex.org/W1973015253","https://openalex.org/W1973208984","https://openalex.org/W1973311433","https://openalex.org/W1973634422","https://openalex.org/W1974358116","https://openalex.org/W1974558664","https://openalex.org/W1974821373","https://openalex.org/W1976369579","https://openalex.org/W1976380907","https://openalex.org/W1976851510","https://openalex.org/W1977041625","https://openalex.org/W1977088848","https://openalex.org/W1977190645","https://openalex.org/W1977347031","https://openalex.org/W1977752866","https://openalex.org/W1978621039","https://openalex.org/W1978745809","https://openalex.org/W1978900411","https://openalex.org/W1979212590","https://openalex.org/W1979371884","https://openalex.org/W1979952002","https://openalex.org/W1979994346","https://openalex.org/W1980166477","https://openalex.org/W1981101710","https://openalex.org/W1981393064","https://openalex.org/W1981583647","https://openalex.org/W1982047847","https://openalex.org/W1982134009","https://openalex.org/W1982465052","https://openalex.org/W1982763126","https://openalex.org/W1982819078","https://openalex.org/W1983443616","https://openalex.org/W1983718509","https://openalex.org/W1983803675","https://openalex.org/W1984146959","https://openalex.org/W1984191033","https://openalex.org/W1984333103","https://openalex.org/W1984770777","https://openalex.org/W1985621046","https://openalex.org/W1985856159","https://openalex.org/W1985938249","https://openalex.org/W1986254612","https://openalex.org/W1986343589","https://openalex.org/W1987592289","https://openalex.org/W1987855116","https://openalex.org/W1988424328","https://openalex.org/W1989043810","https://openalex.org/W1989092000","https://openalex.org/W1989208084","https://openalex.org/W1989592528","https://openalex.org/W1990508123","https://openalex.org/W1991659267","https://openalex.org/W1991735971","https://openalex.org/W1991936003","https://openalex.org/W1992222048","https://openalex.org/W1992713633","https://openalex.org/W1993025013","https://openalex.org/W1993142192","https://openalex.org/W1994067502","https://openalex.org/W1994981254","https://openalex.org/W1995272764","https://openalex.org/W1995565495","https://openalex.org/W1996131583","https://openalex.org/W1996587824","https://openalex.org/W1997129506","https://openalex.org/W1997425415","https://openalex.org/W1997659779","https://openalex.org/W1997994846","https://openalex.org/W1998088266","https://openalex.org/W1998164097","https://openalex.org/W1998656800","https://openalex.org/W1998982047","https://openalex.org/W2000264541","https://openalex.org/W2000843849","https://openalex.org/W2000977514","https://openalex.org/W2001024910","https://openalex.org/W2001189016","https://openalex.org/W2002028309","https://openalex.org/W2002505415","https://openalex.org/W2002748611","https://openalex.org/W2002965456","https://openalex.org/W2003186987","https://openalex.org/W2003522480","https://openalex.org/W2004200103","https://openalex.org/W2004246695","https://openalex.org/W2004340009","https://openalex.org/W2004529130","https://openalex.org/W2004802891","https://openalex.org/W2005101151","https://openalex.org/W2005587109","https://openalex.org/W2005669237","https://openalex.org/W2005926028","https://openalex.org/W2006072112","https://openalex.org/W2006097588","https://openalex.org/W2006232137","https://openalex.org/W2007065880","https://openalex.org/W2007191143","https://openalex.org/W2007829947","https://openalex.org/W2007870596","https://openalex.org/W2007873828","https://openalex.org/W2007912185","https://openalex.org/W2008094227","https://openalex.org/W2008745673","https://openalex.org/W2009216954","https://openalex.org/W2009572605","https://openalex.org/W2009709088","https://openalex.org/W2009770874","https://openalex.org/W2009847291","https://openalex.org/W2010011292","https://openalex.org/W2010049654","https://openalex.org/W2010079434","https://openalex.org/W2010286460","https://openalex.org/W2010357177","https://openalex.org/W2010585911","https://openalex.org/W2010729374","https://openalex.org/W2010745673","https://openalex.org/W2011151996","https://openalex.org/W2011302360","https://openalex.org/W2011564438","https://openalex.org/W2011753617","https://openalex.org/W2011994159","https://openalex.org/W2012675260","https://openalex.org/W2012952734","https://openalex.org/W2013449567","https://openalex.org/W2013492587","https://openalex.org/W2013624095","https://openalex.org/W2013894686","https://openalex.org/W2014627886","https://openalex.org/W2014886522","https://openalex.org/W2015729550","https://openalex.org/W2016021698","https://openalex.org/W2016293448","https://openalex.org/W2017547033","https://openalex.org/W2018438902","https://openalex.org/W2018454759","https://openalex.org/W2018709107","https://openalex.org/W2019209361","https://openalex.org/W2019856386","https://openalex.org/W2019897394","https://openalex.org/W2019911531","https://openalex.org/W2021459007","https://openalex.org/W2022208523","https://openalex.org/W2023057775","https://openalex.org/W2023196735","https://openalex.org/W2024262458","https://openalex.org/W2024674344","https://openalex.org/W2025170140","https://openalex.org/W2028212562","https://openalex.org/W2028655076","https://openalex.org/W2029306655","https://openalex.org/W2029377431","https://openalex.org/W2029717831","https://openalex.org/W2029952781","https://openalex.org/W2029972317","https://openalex.org/W2030206271","https://openalex.org/W2030268547","https://openalex.org/W2031144440","https://openalex.org/W2031806834","https://openalex.org/W2032901458","https://openalex.org/W2034378356","https://openalex.org/W2034783116","https://openalex.org/W2034888244","https://openalex.org/W2034889615","https://openalex.org/W2035261592","https://openalex.org/W2035669202","https://openalex.org/W2035768602","https://openalex.org/W2036731494","https://openalex.org/W2037434894","https://openalex.org/W2037818076","https://openalex.org/W2037908014","https://openalex.org/W2038844837","https://openalex.org/W2039129821","https://openalex.org/W2039582346","https://openalex.org/W2040948638","https://openalex.org/W2041620296","https://openalex.org/W2041686643","https://openalex.org/W2041964617","https://openalex.org/W2042341097","https://openalex.org/W2042397306","https://openalex.org/W2043077389","https://openalex.org/W2043131921","https://openalex.org/W2043645642","https://openalex.org/W2044418826","https://openalex.org/W2044703125","https://openalex.org/W2045227229","https://openalex.org/W2045498849","https://openalex.org/W2046149669","https://openalex.org/W2046287034","https://openalex.org/W2047522236","https://openalex.org/W2048165969","https://openalex.org/W2048561533","https://openalex.org/W2048797394","https://openalex.org/W2049445737","https://openalex.org/W2049895333","https://openalex.org/W2050456578","https://openalex.org/W2050559793","https://openalex.org/W2051353121","https://openalex.org/W2051569791","https://openalex.org/W2052082800","https://openalex.org/W2052445412","https://openalex.org/W2052557155","https://openalex.org/W2052890821","https://openalex.org/W2052985697","https://openalex.org/W2053294180","https://openalex.org/W2053697597","https://openalex.org/W2053766089","https://openalex.org/W2053980736","https://openalex.org/W2054225000","https://openalex.org/W2054371797","https://openalex.org/W2054684401","https://openalex.org/W2054878296","https://openalex.org/W2055841466","https://openalex.org/W2057463798","https://openalex.org/W2057716243","https://openalex.org/W2058393743","https://openalex.org/W2058393789","https://openalex.org/W2058744002","https://openalex.org/W2060255031","https://openalex.org/W2060676082","https://openalex.org/W2061301876","https://openalex.org/W2061944023","https://openalex.org/W2062128964","https://openalex.org/W2062724355","https://openalex.org/W2063042652","https://openalex.org/W2064033151","https://openalex.org/W2064327904","https://openalex.org/W2064468710","https://openalex.org/W2064806863","https://openalex.org/W2065159884","https://openalex.org/W2065441702","https://openalex.org/W2065596380","https://openalex.org/W2065758124","https://openalex.org/W2066048438","https://openalex.org/W2066129669","https://openalex.org/W2066253340","https://openalex.org/W2066482939","https://openalex.org/W2066655203","https://openalex.org/W2068094755","https://openalex.org/W2068451216","https://openalex.org/W2068489576","https://openalex.org/W2069097697","https://openalex.org/W2069870111","https://openalex.org/W2070189344","https://openalex.org/W2070849347","https://openalex.org/W2071027772","https://openalex.org/W2071342245","https://openalex.org/W2071823770","https://openalex.org/W2071927480","https://openalex.org/W2071976087","https://openalex.org/W2072186941","https://openalex.org/W2072652145","https://openalex.org/W2072830036","https://openalex.org/W2072997315","https://openalex.org/W2073014360","https://openalex.org/W2073029307","https://openalex.org/W2073694854","https://openalex.org/W2073695258","https://openalex.org/W2074009730","https://openalex.org/W2074099984","https://openalex.org/W2074267815","https://openalex.org/W2074556443","https://openalex.org/W2074621357","https://openalex.org/W2074772639","https://openalex.org/W2074887424","https://openalex.org/W2075342009","https://openalex.org/W2075412000","https://openalex.org/W2075504285","https://openalex.org/W2076444472","https://openalex.org/W2076479010","https://openalex.org/W2076495374","https://openalex.org/W2076499219","https://openalex.org/W2076752309","https://openalex.org/W2077005037","https://openalex.org/W2077058506","https://openalex.org/W2077230205","https://openalex.org/W2077568262","https://openalex.org/W2077609744","https://openalex.org/W2077847569","https://openalex.org/W2078166635","https://openalex.org/W2078399624","https://openalex.org/W2078438162","https://openalex.org/W2079218217","https://openalex.org/W2079867054","https://openalex.org/W2080085773","https://openalex.org/W2080169155","https://openalex.org/W2081296585","https://openalex.org/W2081997604","https://openalex.org/W2082343114","https://openalex.org/W2082968554","https://openalex.org/W2083664440","https://openalex.org/W2083668719","https://openalex.org/W2084115469","https://openalex.org/W2084643243","https://openalex.org/W2084662089","https://openalex.org/W2084733812","https://openalex.org/W2086510848","https://openalex.org/W2086655329","https://openalex.org/W2086818286","https://openalex.org/W2087015690","https://openalex.org/W2087228485","https://openalex.org/W2088093088","https://openalex.org/W2088297733","https://openalex.org/W2088976410","https://openalex.org/W2089278729","https://openalex.org/W2089552968","https://openalex.org/W2089728262","https://openalex.org/W2090420766","https://openalex.org/W2090484321","https://openalex.org/W2091087292","https://openalex.org/W2091426367","https://openalex.org/W2091453318","https://openalex.org/W2091843594","https://openalex.org/W2092618241","https://openalex.org/W2092621112","https://openalex.org/W2092910924","https://openalex.org/W2093277140","https://openalex.org/W2093374391","https://openalex.org/W2093560108","https://openalex.org/W2094247127","https://openalex.org/W2094625296","https://openalex.org/W2096547809","https://openalex.org/W2098332746","https://openalex.org/W2099092588","https://openalex.org/W2102166270","https://openalex.org/W2103558447","https://openalex.org/W2104105249","https://openalex.org/W2105732055","https://openalex.org/W2105748867","https://openalex.org/W2109094823","https://openalex.org/W2109858658","https://openalex.org/W2110554814","https://openalex.org/W2111382440","https://openalex.org/W2111612257","https://openalex.org/W2111658523","https://openalex.org/W2112379601","https://openalex.org/W2112918293","https://openalex.org/W2113424951","https://openalex.org/W2113630547","https://openalex.org/W2114426644","https://openalex.org/W2115678400","https://openalex.org/W2117100021","https://openalex.org/W2117385529","https://openalex.org/W2117766577","https://openalex.org/W2117800611","https://openalex.org/W2118681944","https://openalex.org/W2118970553","https://openalex.org/W2119136421","https://openalex.org/W2119410682","https://openalex.org/W2120447295","https://openalex.org/W2121926476","https://openalex.org/W2122548823","https://openalex.org/W2122946181","https://openalex.org/W2123311854","https://openalex.org/W2123678525","https://openalex.org/W2124155129","https://openalex.org/W2125608118","https://openalex.org/W2126562474","https://openalex.org/W2127047559","https://openalex.org/W2127077664","https://openalex.org/W2128186768","https://openalex.org/W2128833727","https://openalex.org/W2129108032","https://openalex.org/W2130959916","https://openalex.org/W2132335976","https://openalex.org/W2132408713","https://openalex.org/W2134187539","https://openalex.org/W2135403831","https://openalex.org/W2135612954","https://openalex.org/W2136092848","https://openalex.org/W2138463340","https://openalex.org/W2139281652","https://openalex.org/W2141508238","https://openalex.org/W2142151422","https://openalex.org/W2142211920","https://openalex.org/W2142469259","https://openalex.org/W2143032781","https://openalex.org/W2144750899","https://openalex.org/W2148834690","https://openalex.org/W2150928993","https://openalex.org/W2150932964","https://openalex.org/W2151716122","https://openalex.org/W2151968717","https://openalex.org/W2152420113","https://openalex.org/W2152426612","https://openalex.org/W2152901500","https://openalex.org/W2153289427","https://openalex.org/W2156424672","https://openalex.org/W2156472921","https://openalex.org/W2157829136","https://openalex.org/W2158366082","https://openalex.org/W2159003130","https://openalex.org/W2159838014","https://openalex.org/W2160953928","https://openalex.org/W2161437187","https://openalex.org/W2161685942","https://openalex.org/W2162149310","https://openalex.org/W2162597032","https://openalex.org/W2162612312","https://openalex.org/W2162783545","https://openalex.org/W2162791771","https://openalex.org/W2163187714","https://openalex.org/W2163629303","https://openalex.org/W2164695495","https://openalex.org/W2164907959","https://openalex.org/W2165848705","https://openalex.org/W2165958151","https://openalex.org/W2167483534","https://openalex.org/W2170002187","https://openalex.org/W2170772645","https://openalex.org/W2171776652","https://openalex.org/W2175948374","https://openalex.org/W2176163300","https://openalex.org/W2205867003","https://openalex.org/W2208861702","https://openalex.org/W2212206978","https://openalex.org/W2215359898","https://openalex.org/W2229610656","https://openalex.org/W2245473307","https://openalex.org/W2262398236","https://openalex.org/W2277188422","https://openalex.org/W2286461141","https://openalex.org/W2292283833","https://openalex.org/W2315987042","https://openalex.org/W2316145923","https://openalex.org/W2317351536","https://openalex.org/W2317521098","https://openalex.org/W2319801483","https://openalex.org/W2328569419","https://openalex.org/W2331609610","https://openalex.org/W2331627162","https://openalex.org/W2335851496","https://openalex.org/W2336842108","https://openalex.org/W2340833299","https://openalex.org/W2394987154","https://openalex.org/W2399843877","https://openalex.org/W2402098708","https://openalex.org/W2402342711","https://openalex.org/W2402497529","https://openalex.org/W2402662808","https://openalex.org/W2402913202","https://openalex.org/W2408603747","https://openalex.org/W2408920053","https://openalex.org/W2409408110","https://openalex.org/W2410940461","https://openalex.org/W2411585981","https://openalex.org/W2411934170","https://openalex.org/W2413681815","https://openalex.org/W2413942348","https://openalex.org/W2414132932","https://openalex.org/W2416177625","https://openalex.org/W2468623849","https://openalex.org/W2778941838","https://openalex.org/W3038259685","https://openalex.org/W4321258690","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W2036988181","https://openalex.org/W1906283954","https://openalex.org/W2135031716","https://openalex.org/W2009313832","https://openalex.org/W2008094227","https://openalex.org/W196195977","https://openalex.org/W2079867054","https://openalex.org/W1990828751","https://openalex.org/W2009269338","https://openalex.org/W2033515525"],"abstract_inverted_index":{"The":[0,77],"present":[1],"study":[2,378],"describes":[3],"that":[4,92,382],"acetylcholine":[5,30],"through":[6,401],"muscarinic":[7,82,93,132,138,202,230,252,269,316],"Ml":[8,253],"and\\nM3":[9],"receptors":[10,83,96,116,133,141,164,181,205,223,329,399],"play":[11],"an":[12],"important":[13],"role":[14],"in":[15,37,55,60,66,80,85,102,106,127,153,168,173,184,193,234,288,343,362,409,434],"the":[16,38,42,81,86,222,235,258,275,332,367,410,428],"brain":[17,39,87,295,309,341,375,429],"function":[18,430,442],"during":[19,243,298],"diabetes":[20],"as":[21,27,440],"a":[22,32,294,441],"function\\nof":[23],"age.":[24,444],"Cholinergic":[25],"activity":[26,232,296],"indicated":[28],"by":[29,356],"esterase,":[31],"marker":[33],"for\\ncholinergic":[34],"function,":[35],"decreased":[36],"regions":[40,88],"-":[41],"cerebral":[43,67,103,169,185],"cortex,":[44,68,170,210],"brainstem\\nand":[45],"corpus":[46,70,107,128,154,194,211],"striatum":[47,71,108,129,155,212],"of":[48,97,117,149,189,221,237,279,315,369,412,427,438,443],"old":[49,64,98,118,160,200,241,282,291],"rats":[50,65,119,151,191,219,242,292],"compared":[51],"to":[52,226,330,366,372,407],"young":[53,62,150,190,239,280,289,344],"rats.":[54,283],"diabetic":[56,218],"condition,":[57],"it":[58,74,90,111,379],"was\\nincreased":[59],"both":[61,238],"and":[63,69,89,109,130,147,172,187,213,240,249,254,281,290,305,323,326,345,352,374,394,396,403,422],"while":[72,105,126,152,192],"in\\nbrainstem":[73],"was":[75],"decreased.":[76],"functional":[78,334,383],"changes":[79,263],"were\\nstudied":[84],"showed":[91,120,293,425],"M":[94,139,162,203,270],"I":[95,140,163,271],"rats\\nwere":[99],"down":[100,143,177,197],"regulated":[101,144,167,183,208],"cortex":[104,125,146,186],"brainstem":[110,131,148,174,188],"was\\nup":[112],"regulated.":[113,135,178,198],"Muscarinic":[114,179],"M3":[115,180,255],"no":[121],"significant":[122],"change":[123],"in\\ncerebral":[124,145,209],"were\\ndown":[134],"During":[136],"diabetes,":[137],"were":[142,157,165,176,196,206,224,311],"they":[156,175],"up\\nregulated.":[158],"In":[159,199,215],"rats,":[161,201],"up":[166,207],"corpus\\nstriatum":[171],"were\\nup":[182],"striatum\\nthey":[195],"l":[204],"brainstem.":[214],"insulin":[216],"treated":[217,307],"the\\nactivity":[220],"reversed":[225],"near":[227],"control.":[228],"Pancreatic":[229],"M3\\nreceptor":[231],"increased":[233],"pancreas":[236],"diabetes.\\nIn":[244],"vitro":[245],"studies":[246,267],"using":[247],"carbachol":[248],"antagonists":[250],"for":[251,336],"receptor\\nsubtypes":[256],"confirmed":[257],"specific":[259],"receptor":[260],"mediated":[261,272,400],"neurotransmitter":[262,349],"during\\ndiabetes.":[264],"Calcium":[265],"imaging":[266],"revealed":[268],"Ca2\\n+":[273],"release\\nfrom":[274],"pancreatic":[276],"islet":[277],"cells":[278],"Electrophysiological":[284],"studies\\nusing":[285],"EEG":[286],"recording":[287],"difference":[297],"diabetes.":[299,413],"Long":[300],"term":[301,419],"low":[302,420],"dose":[303],"STH":[304],"INS":[306,423],"rat":[308],"tissues":[310],"used":[312],"for\\ngene":[313],"expression":[314,354],"Ml,":[317,386],"M3,":[318,387],"glutamate":[319,388],"NMDARl,":[320],"mGlu-5,alpha2A,":[321],"beta2,\\nGABAAa1":[322],"GABAB,":[324],"DAD2":[325],"5-HT":[327,397],"2C":[328,398],"observe":[331],"neurotransmitter\\nreceptor":[333],"interrelationship":[335],"integrating":[337],"memory,":[338],"cognition":[339],"and\\nrejuvenating":[340],"functions":[342],"old.":[346],"Studies":[347],"on":[348],"receptor\\ninteraction":[350],"pathways":[351],"gene":[353],"regulation":[355],"second":[357],"messengers":[358],"like":[359],"IP3\\nand":[360],"cGMP":[361,404],"turn":[363],"will":[364,405],"lead":[365,406],"development":[368],"therapeutic":[370],"agents":[371],"manage\\ndiabetes":[373],"activity.From":[376],"this":[377],"is":[380],"suggested":[381],"improvement":[384],"of\\nmuscarinic":[385],"NMDAR1,":[389],"mGlu-5,":[390],"alpha2A,":[391],"beta2,":[392],"GABAAa1":[393],"GABAB,\\nDAD2":[395],"IP3":[402],"therapeutic\\napplications":[408],"management":[411],"Also,":[414],"our":[415],"results":[416],"from":[417],"long":[418],"dose\\nSTH":[421],"treatment":[424],"rejuvenation":[426],"which":[431],"has":[432],"clinical\\nsignificance":[433],"maintaining":[435],"healthy":[436],"period":[437],"life":[439]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}