{"id":"https://openalex.org/W1587019161","doi":null,"title":"Physiological Studies on Candida albicans","display_name":"Physiological Studies on Candida albicans","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1587019161","mag":"1587019161"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unl.edu:bioscidiss-1013","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/bioscidiss/14","pdf_url":"http://digitalcommons.unl.edu/bioscidiss/14","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Biological Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://digitalcommons.unl.edu/bioscidiss/14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051865476","display_name":"Swetha Tati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Swetha Tati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051865476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/pseudohyphae","display_name":"pseudohyphae","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hyphal-morphogenesis","display_name":"hyphal morphogenesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/aromatic-alcohols","display_name":"aromatic alcohols","score":0.9290000200271606},{"id":"https://openalex.org/keywords/high-phosphate","display_name":"high phosphate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gcn4","display_name":"GCN4","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nitrogen-starvation","display_name":"nitrogen starvation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/eif2b","display_name":"eIF2B","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/efg1","display_name":"EFG1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cph1","display_name":"Cph1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/histone-biotinylation","display_name":"histone biotinylation","score":0.925000011920929},{"id":"https://openalex.org/keywords/germ-tube-formation","display_name":"germ tube formation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.5906069278717041},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.338372141122818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3240208625793457}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unl.edu:bioscidiss-1013","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/bioscidiss/14","pdf_url":"http://digitalcommons.unl.edu/bioscidiss/14","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Biological Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},{"id":"mag:1587019161","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/bioscidiss/14/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unl.edu:bioscidiss-1013","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/bioscidiss/14","pdf_url":"http://digitalcommons.unl.edu/bioscidiss/14","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Biological Sciences: Dissertations, Theses, and Student Research","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1587019161.pdf","grobid_xml":"https://content.openalex.org/works/W1587019161.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1533167954","https://openalex.org/W1582560245","https://openalex.org/W1753910563","https://openalex.org/W1972006502","https://openalex.org/W1972243502","https://openalex.org/W1974842971","https://openalex.org/W1980509035","https://openalex.org/W1994886068","https://openalex.org/W2000798486","https://openalex.org/W2001342487","https://openalex.org/W2001652771","https://openalex.org/W2015012952","https://openalex.org/W2032531421","https://openalex.org/W2039656875","https://openalex.org/W2044593393","https://openalex.org/W2046647728","https://openalex.org/W2060322845","https://openalex.org/W2064841563","https://openalex.org/W2093464710","https://openalex.org/W2097263358","https://openalex.org/W2097561128","https://openalex.org/W2100866112","https://openalex.org/W2103682285","https://openalex.org/W2104435753","https://openalex.org/W2109535551","https://openalex.org/W2109785145","https://openalex.org/W2112243625","https://openalex.org/W2112602352","https://openalex.org/W2112927225","https://openalex.org/W2121016429","https://openalex.org/W2122570189","https://openalex.org/W2131404785","https://openalex.org/W2135741099","https://openalex.org/W2139277896","https://openalex.org/W2139851929","https://openalex.org/W2140935709","https://openalex.org/W2141200742","https://openalex.org/W2142554739","https://openalex.org/W2144677145","https://openalex.org/W2147656343","https://openalex.org/W2158254431","https://openalex.org/W2160163805","https://openalex.org/W2164904971","https://openalex.org/W2165459255","https://openalex.org/W2167880806","https://openalex.org/W2168188093","https://openalex.org/W7100294453"],"related_works":["https://openalex.org/W2011758386","https://openalex.org/W2916562017","https://openalex.org/W161426748","https://openalex.org/W2151254944","https://openalex.org/W2046907854","https://openalex.org/W7099164264","https://openalex.org/W3212522814","https://openalex.org/W2046812895","https://openalex.org/W2125080318","https://openalex.org/W2109403646"],"abstract_inverted_index":{"Candida":[0],"albicans":[1,238],"is":[2,15,132,198],"a":[3,121,189],"common":[4],"opportunistic,":[5],"dimorphic":[6],"human":[7],"fungal":[8],"pathogen.":[9],"One":[10],"of":[11,43,48,111,124,142,272,287,292,302,321,329,334],"its":[12],"virulence":[13],"factors":[14,37,47],"the":[16,70,109,166,268,295],"morphological":[17],"switch":[18],"between":[19],"yeasts":[20],"and":[21,30,40,53,176,202,213,245,323,326],"hyphal":[22],"or":[23,79,96,106],"pseudohyphal":[24],"forms,":[25],"which":[26,149,152,197],"can":[27],"invade":[28],"tissues":[29],"cause":[31],"damage.":[32],"Our":[33],"studies":[34,328],"focus":[35],"on":[36],"regulating":[38],"pseudohyphae":[39,49,75,107,161,180],"epigenetic":[41],"modifications":[42],"C.":[44,195,237,273],"albicans.":[45,274],"Regulating":[46],"are":[50,169,253],"aromatic":[51,60,77,112,143,174],"alcohols":[52,61,78,144,175],"high":[54,66,80,115,177],"phosphate.":[55,67],"At":[56],"low":[57,285],"concentrations,":[58],"exogenous":[59],"induced":[62],"pseudohyphae,":[63],"as":[64,222,257,282],"did":[65],"For":[68],"addressing":[69],"pathways":[71,167],"involved":[72,168],"in":[73,86,108,134,153,194,242,250,318],"inducing":[74],"by":[76,162,181],"phosphate,":[81],"we":[82,187],"used":[83,207],"mutants":[84,100],"defective":[85],"cAMP":[87],"dependent":[88],"PKA":[89],"pathway":[90,94],"(efg1/efg1),":[91],"MAP":[92],"kinase":[93],"(cph1/cph1),":[95],"both":[97],"(cph1/cph1/efg1/efg1).":[98],"These":[99],"failed":[101],"to":[102,136,208,266,294,314],"produce":[103],"either":[104],"hyphae":[105],"presence":[110],"alcohols;":[113],"but":[114],"phosphate":[116,158,178],"still":[117,170],"stimulated":[118],"pseudohyphae.":[119],"Gcn4,":[120],"transcription":[122],"activator":[123],"more":[125],"than":[126],"500":[127],"amino":[128,137],"acid":[129,138],"related":[130,313],"genes,":[131],"turned-on":[133],"response":[135],"starvation.":[139],"The":[140],"accumulation":[141],"sends":[145],"nitrogen":[146],"starvation":[147],"signals,":[148],"inhibit":[150],"eIF2B,":[151],"turn":[154],"derepresses":[155],"Gcn4p.":[156],"High":[157],"also":[159,264],"induces":[160],"derepressing":[163,182],"Gcn4p,":[164],"although":[165],"unknown.":[171],"In":[172,184,236],"sum,":[173],"induce":[179],"Gcn4.":[183],"this":[185],"study":[186],"found":[188,258,265],"novel":[190],"posttranslational":[191],"histone":[192,243,251],"modification":[193],"albicans,":[196],"biotinylation.":[199],"Western":[200],"blot":[201],"Mass":[203],"spectrometry":[204],"techniques":[205],"were":[206,215,304],"find":[209],"that":[210],"Histones":[211],"H2B":[212,252],"H4":[214,244],"biotinylated":[216],"at":[217],"every":[218],"condition":[219],"tested":[220],"such":[221],"yeast":[223],"vs.":[224,228,233],"hyphae,":[225],"aerobic":[226],"growth":[227,327],"anaerobic":[229],"growth,":[230],"rich":[231],"medium":[232],"defined":[234],"medium.":[235],"lysines":[239,246],"K8,":[240],"K11":[241],"K17,":[247],"K18,":[248],"K31":[249],"biotin":[254,293],"attachment":[255],"sites":[256],"using":[259],"mass":[260],"spectrometry.":[261],"Biotin":[262],"was":[263],"enhance":[267],"germ":[269,288,299],"tube":[270,276],"formation":[271,277],"Germ":[275],"assays":[278,317],"with":[279],"biotin-starved":[280,308],"cells":[281],"inoculum":[283],"showed":[284,297],"percent":[286],"tubes":[289],"(1-5%).":[290],"Addition":[291],"media":[296],"100%":[298],"tubes.":[300],"Biotinylation":[301],"histones":[303],"not":[305],"detected":[306],"from":[307],"cells.":[309],"Appendix-A":[310],"details":[311],"work":[312],"Farnesol":[315],"quantification":[316],"several":[319],"strains":[320,333],"C.albicans":[322],"Ceratocystis":[324],"ulmi,":[325],"class":[330],"E":[331],"VPS":[332],"Saccharomyces":[335],"Cerevisiae.":[336],"Advisor:":[337],"Kenneth":[338],"W.":[339],"Nickerson":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
