{"id":"https://openalex.org/W1586857700","doi":null,"title":"Computational Analysis of Anopheles Gambiae Metabolism to Facilitate Insecticidal Target and Complex Resistance Mechanism Discovery","display_name":"Computational Analysis of Anopheles Gambiae Metabolism to Facilitate Insecticidal Target and Complex Resistance Mechanism Discovery","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W1586857700","mag":"1586857700"},"language":"en","primary_location":{"id":"pmh:oai:eprints.covenantuniversity.edu.ng:3364","doi":null,"is_oa":false,"landing_page_url":"http://eprints.covenantuniversity.edu.ng/3364/1/Abstract.pdf","pdf_url":"http://eprints.covenantuniversity.edu.ng/3364/1/Abstract.pdf","source":{"id":"https://openalex.org/S4306400995","display_name":"Covenant University Repository (Covenant University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186771145","host_organization_name":"Covenant University","host_organization_lineage":["https://openalex.org/I186771145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089089725","display_name":"Marion O. Adebiyi","orcid":"https://orcid.org/0000-0001-7713-956X","observed_orcids":["https://orcid.org/0000-0001-7713-956X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marion O. Adebiyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089089725"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anopheles-gambiae","display_name":"Anopheles gambiae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pyrethroid-resistance","display_name":"pyrethroid resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/permethrin","display_name":"permethrin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/metabolic-networks","display_name":"metabolic networks","score":0.574999988079071},{"id":"https://openalex.org/keywords/essential-enzymes","display_name":"essential enzymes","score":0.5960000157356262},{"id":"https://openalex.org/keywords/pathway-genome-databases","display_name":"pathway/genome databases","score":0.7870000004768372},{"id":"https://openalex.org/keywords/metabolic-network-topology","display_name":"metabolic network topology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/malaria-vectors","display_name":"malaria vectors","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776802408","wikidata":"https://www.wikidata.org/wiki/Q135237","display_name":"Anopheles gambiae","level":3,"score":0.9537184238433838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.627691388130188},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5499408841133118},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5401548147201538},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.4863353371620178},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4593539237976074},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4206518828868866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37318113446235657},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.35797950625419617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31265050172805786},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.16748031973838806},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08235591650009155},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07765498757362366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.covenantuniversity.edu.ng:3364","doi":null,"is_oa":false,"landing_page_url":"http://eprints.covenantuniversity.edu.ng/3364/1/Abstract.pdf","pdf_url":"http://eprints.covenantuniversity.edu.ng/3364/1/Abstract.pdf","source":{"id":"https://openalex.org/S4306400995","display_name":"Covenant University Repository (Covenant University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186771145","host_organization_name":"Covenant University","host_organization_lineage":["https://openalex.org/I186771145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:1586857700","doi":null,"is_oa":false,"landing_page_url":"http://eprints.covenantuniversity.edu.ng/3364/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W62578250","https://openalex.org/W76957165","https://openalex.org/W139923471","https://openalex.org/W151396634","https://openalex.org/W298212978","https://openalex.org/W311212352","https://openalex.org/W632660983","https://openalex.org/W1489268516","https://openalex.org/W1540892680","https://openalex.org/W1544089433","https://openalex.org/W1551787983","https://openalex.org/W1598572316","https://openalex.org/W1607899705","https://openalex.org/W1782773291","https://openalex.org/W1807173209","https://openalex.org/W1847805828","https://openalex.org/W1871026043","https://openalex.org/W1899800855","https://openalex.org/W1901460829","https://openalex.org/W1960744434","https://openalex.org/W1965770236","https://openalex.org/W1966902043","https://openalex.org/W1967225297","https://openalex.org/W1967564010","https://openalex.org/W1968945722","https://openalex.org/W1970016079","https://openalex.org/W1973596131","https://openalex.org/W1975010325","https://openalex.org/W1977298795","https://openalex.org/W1978666849","https://openalex.org/W1979243197","https://openalex.org/W1983202741","https://openalex.org/W1983290704","https://openalex.org/W1989318293","https://openalex.org/W1992306474","https://openalex.org/W1993070549","https://openalex.org/W1997995643","https://openalex.org/W1999046759","https://openalex.org/W2000048173","https://openalex.org/W2003271727","https://openalex.org/W2003947856","https://openalex.org/W2006500919","https://openalex.org/W2007868900","https://openalex.org/W2011584557","https://openalex.org/W2011759977","https://openalex.org/W2013444425","https://openalex.org/W2014905635","https://openalex.org/W2016806296","https://openalex.org/W2017153326","https://openalex.org/W2017548405","https://openalex.org/W2017640261","https://openalex.org/W2023100224","https://openalex.org/W2025718072","https://openalex.org/W2026089579","https://openalex.org/W2027253532","https://openalex.org/W2029230311","https://openalex.org/W2030904136","https://openalex.org/W2031849942","https://openalex.org/W2035282516","https://openalex.org/W2035686342","https://openalex.org/W2036048432","https://openalex.org/W2036670924","https://openalex.org/W2039929923","https://openalex.org/W2043245977","https://openalex.org/W2044854256","https://openalex.org/W2045760616","https://openalex.org/W2052187787","https://openalex.org/W2054467888","https://openalex.org/W2055043387","https://openalex.org/W2055425726","https://openalex.org/W2058076233","https://openalex.org/W2065889670","https://openalex.org/W2068579476","https://openalex.org/W2072067873","https://openalex.org/W2074906123","https://openalex.org/W2077141607","https://openalex.org/W2077723503","https://openalex.org/W2079461600","https://openalex.org/W2080785379","https://openalex.org/W2082283842","https://openalex.org/W2084297869","https://openalex.org/W2086955153","https://openalex.org/W2088842558","https://openalex.org/W2094491295","https://openalex.org/W2097080919","https://openalex.org/W2098086227","https://openalex.org/W2098104648","https://openalex.org/W2099029075","https://openalex.org/W2101536914","https://openalex.org/W2104416728","https://openalex.org/W2106808164","https://openalex.org/W2107031757","https://openalex.org/W2107991694","https://openalex.org/W2110571778","https://openalex.org/W2110641507","https://openalex.org/W2111421616","https://openalex.org/W2111825982","https://openalex.org/W2112705721","https://openalex.org/W2112797448","https://openalex.org/W2113245427","https://openalex.org/W2114406031","https://openalex.org/W2114484738","https://openalex.org/W2115539205","https://openalex.org/W2117176242","https://openalex.org/W2118020555","https://openalex.org/W2124100477","https://openalex.org/W2126314095","https://openalex.org/W2126808369","https://openalex.org/W2127246176","https://openalex.org/W2128287083","https://openalex.org/W2128444567","https://openalex.org/W2128601422","https://openalex.org/W2131142445","https://openalex.org/W2131345844","https://openalex.org/W2132232959","https://openalex.org/W2132957436","https://openalex.org/W2133315237","https://openalex.org/W2135547884","https://openalex.org/W2136623181","https://openalex.org/W2140239055","https://openalex.org/W2143635137","https://openalex.org/W2144317357","https://openalex.org/W2144885342","https://openalex.org/W2146302435","https://openalex.org/W2147472054","https://openalex.org/W2148528659","https://openalex.org/W2150652611","https://openalex.org/W2152841019","https://openalex.org/W2153561525","https://openalex.org/W2155331065","https://openalex.org/W2158140165","https://openalex.org/W2159147345","https://openalex.org/W2165044366","https://openalex.org/W2167065750","https://openalex.org/W2170427655","https://openalex.org/W2171018484","https://openalex.org/W2171775036","https://openalex.org/W2325070865","https://openalex.org/W2493442865","https://openalex.org/W2752412837","https://openalex.org/W2752885492","https://openalex.org/W2809371091","https://openalex.org/W3017143921","https://openalex.org/W3143046264"],"related_works":["https://openalex.org/W7220180560","https://openalex.org/W1641319862","https://openalex.org/W1996890524","https://openalex.org/W4401607814","https://openalex.org/W2159147345","https://openalex.org/W2222168168","https://openalex.org/W2276681597","https://openalex.org/W2078027540","https://openalex.org/W1992103751","https://openalex.org/W4385385359"],"abstract_inverted_index":{"Insecticide":[0,59],"resistance":[1,39,293,303],"is":[2,15,75],"a":[3,17,88,132,185,209],"genetic":[4],"characteristic":[5],"involving":[6],"changes":[7],"in":[8,91,232,261],"one":[9,249],"or":[10],"more":[11,72,186],"insect":[12],"genes.":[13],"It":[14],"also":[16],"major":[18],"public":[19],"health":[20],"challenge":[21],"combating":[22],"world":[23],"efforts":[24],"on":[25],"malaria":[26],"control":[27],"and":[28,57,104,116,119,147,155,181,183,254,295],"strategies.":[29],"The":[30,194],"Malaria":[31],"vector,":[32],"Anopheles":[33,222],"gambiae":[34,138,192,199,223,270,284],"(A.":[35],"gambiae)":[36],"has":[37,98,111,201],"formed":[38],"to":[40,114,161,226,288],"the":[41,48,69,92,102,128,174,205,215,218,228,233,262,265,280,299],"existing":[42],"classes":[43],"of":[44,64,71,107,217,221,238,256,268,282],"insecticides,":[45],"especially":[46],"pyrethroid,":[47],"only":[49],"class":[50],"approved":[51],"for":[52,68,136,190,197,298],"Indoor":[53],"Residual":[54],"Spray":[55],"(IRS)":[56],"Long-Lasting":[58],"Treated":[60],"Net":[61],"(LLITNs).":[62],"Identification":[63],"novel":[65],"insecticidal":[66,85,125,242,252],"targets":[67,86,244],"development":[70],"effective":[73],"insecticides":[74],"therefore":[76],"urgent.":[77],"However,":[78],"deciding":[79],"which":[80,247],"gene":[81,275],"products":[82],"are":[83],"ideal":[84],"remains":[87],"difficult":[89],"task":[90],"search.":[93],"To":[94],"this":[95,306],"end,":[96],"it":[97],"been":[99,202],"shown":[100],"that":[101,213],"dissection":[103],"comprehensive":[105,187],"studies":[106],"biochemical":[108,266],"metabolic":[109,219],"networks":[110],"great":[112],"potential":[113,124,241],"effectively":[115],"specifically":[117,169],"identify":[118],"extract":[120],"essential":[121,229],"enzymes":[122],"as":[123,164],"targets.":[126],"Using":[127],"PathoLogic":[129],"programme,":[130],"AnoCyc,":[131],"pathway/genome":[133],"database":[134],"(PGDB)":[135],"A.":[137,191,198,269,283],"AgamP3":[139,200],"was":[140,166,224,245,271],"constructed,":[141],"using":[142,168],"its":[143,302],"annotated":[144,149,163,188],"genomic":[145],"sequence":[146],"other":[148],"information":[150],"from":[151,173,279],"ANOBASE,":[152],"VECTORBASE,":[153],"UNIPROT":[154],"KEGG":[156],"databases.":[157,207],"Furthermore,":[158],"additional":[159],"annotations":[160],"proteins":[162],"\u201chypothetical\u201d":[165],"gathered":[167],"two":[170,274],"annotation":[171],"tools":[172],"DKFZ":[175],"HUSAR":[176],"open":[177],"servers,":[178],"namely":[179],"GOPET":[180],"DomainSweep":[182],"present":[184],"PGDB":[189,196],"AgamP3.":[193],"resulting":[195],"deployed":[203],"under":[204],"www.bioCyc.org":[206],"Next,":[208],"graph":[210],"based":[211],"model":[212],"analyzed":[214],"topology":[216],"network":[220,267],"developed":[225],"determine":[227],"enzymatic":[230],"reactions":[231],"networks.":[234],"A":[235],"refined":[236],"list":[237],"61":[239],"new":[240],"candidate":[243],"obtained,":[246],"include":[248],"clinically":[250],"validated":[251],"target":[253],"host":[255],"others":[257],"with":[258,273,285],"biological":[259],"evidence":[260],"literature.":[263],"Finally,":[264],"overlaid":[272],"expression":[276],"data":[277],"obtained":[278],"treatment":[281],"pyrethroid":[286],"(permethrin)":[287],"elucidate":[289],"some":[290],"tightly":[291],"linked":[292],"genes":[294],"deduce":[296],"computationally,":[297],"first":[300],"time,":[301],"mechanism(s)":[304],"toward":[305],"insecticide":[307]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
