{"id":"https://openalex.org/W1586795809","doi":null,"title":"Identification of differential gene expression profile in circulating lympho-monocytes of apparently healthy young adults in presence of cardiovascular risk factors through whole-genome transcriptomic profile analysis with oligo-RNA microarrays","display_name":"Identification of differential gene expression profile in circulating lympho-monocytes of apparently healthy young adults in presence of cardiovascular risk factors through whole-genome transcriptomic profile analysis with oligo-RNA microarrays","publication_year":2010,"publication_date":"2010-03-11","ids":{"openalex":"https://openalex.org/W1586795809","mag":"1586795809"},"language":"en","primary_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/1483","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/1483","pdf_url":"http://hdl.handle.net/1889/1483","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1889/1483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010530479","display_name":"Diego Ardig\u00f2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ardig\u00f2, Diego","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010530479"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.753000020980835},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8849999904632568},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.996999979019165},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.843999981880188},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/transcriptomic-biomarkers","display_name":"transcriptomic biomarkers","score":0.6990000009536743},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.8309999704360962},{"id":"https://openalex.org/keywords/leukocyte-subpopulations","display_name":"leukocyte subpopulations","score":0.7369999885559082},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.578000009059906},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6887747049331665},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6368391513824463},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6180235743522644},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6059646010398865},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6058181524276733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5101304650306702},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.477138489484787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4327571392059326},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4306025505065918},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4104498028755188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3785710334777832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3084544539451599},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dspace-unipr.cineca.it:1889/1483","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/1483","pdf_url":"http://hdl.handle.net/1889/1483","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/1483","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/1483","pdf_url":"http://hdl.handle.net/1889/1483","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1586795809.pdf","grobid_xml":"https://content.openalex.org/works/W1586795809.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W852050983","https://openalex.org/W1993788157","https://openalex.org/W2012004672","https://openalex.org/W1991206821","https://openalex.org/W165876601","https://openalex.org/W2164307020","https://openalex.org/W7135732347","https://openalex.org/W2604652930","https://openalex.org/W2139367613","https://openalex.org/W2095486248"],"abstract_inverted_index":{"Background":[0],"and":[1,39,63,99,102,140,143,163,194,196,237,260,280,301,307,318,350,377],"Aims:":[2],"Preliminary":[3],"evidence":[4],"indicates":[5],"that":[6,381,397],"the":[7,20,28,48,57,64,67,77,105,242,250,256,271,289,295,298,302,337,356,362,388,393],"gene":[8,78,166,214,311,382],"expression":[9,79,109,159,174,215,312,383],"profile":[10,80,110,216,291,313,384],"of":[11,42,47,56,66,69,90,95,137,165,171,180,199,208,233,235,252,268,270,297,304,321,339,358,403],"circulating":[12],"white":[13],"blood":[14,86],"cells":[15,88],"is":[16,51,398],"significantly":[17],"affected":[18],"by":[19,219,230,265,294,371],"exposure":[21],"to":[22,52,156,285,361],"cardiovascular":[23],"(CV)":[24],"risk":[25,97,130,191,342,367],"factors.":[26],"However":[27],"few":[29],"available":[30],"studies":[31],"have":[32],"several":[33,340],"limitations,":[34],"including":[35],"small":[36],"sample":[37],"size":[38],"narrow":[40],"range":[41],"genes":[43,236,253,269,359],"tested.":[44],"The":[45,310],"aim":[46],"present":[49],"thesis":[50],"provide":[53],"a":[54,70,128,205,220,399],"review":[55],"current":[58],"literature":[59,379],"on":[60],"this":[61],"relationship":[62],"presentation":[65],"results":[68],"clinical":[71,106],"research":[72],"program":[73],"aimed":[74],"at":[75,81],"investigating":[76],"whole-genome":[82],"level":[83],"in":[84,93,120,127,168,178,197,224,241,255,276,332,385,392],"peripheral":[85],"mononuclear":[87],"(PBMC)":[89],"healthy":[91,123,334],"volunteers":[92,126],"presence":[94,179,198,338],"CV":[96,129,139,190,341,404],"factors":[98,343,368],"associated":[100,188,248,314,354],"biomarkers.\\nMaterials":[101],"Methods:":[103],"In":[104,210,330],"study,":[107],"PBMC\u2019s":[108],"was":[111,151,217,228,247,263,292],"evaluated":[112],"using":[113,153],"Agilent":[114],"whole":[115],"genome":[116],"oligonucleotide":[117],"mRNA":[118],"microarrays":[119],"167":[121],"apparently":[122,333],"young-adults,":[124],"all":[125,211],"assessment":[131],"study.":[132],"Enrolled":[133],"subjects":[134,277],"were":[135,176],"free":[136],"diabetes,":[138],"inflammatory":[141,363],"diseases,":[142],"did":[144],"not":[145],"take":[146],"pharmacological":[147],"medications.":[148],"Data":[149],"analysis":[150],"performed":[152],"methods":[154],"developed":[155],"address":[157],"differential":[158],"for":[160],"quantitative":[161],"phenotypes":[162],"enrichment":[164,303],"sets":[167],"ranked":[169],"lists":[170],"genes.\\nResults.":[172],"Differential":[173],"profiles":[175],"identified":[177],"cigarette":[181,226,346],"smoking,":[182,347],"high":[183,261,282,348],"LDL-cholesterol":[184,349],"concentrations,":[185],"increased":[186,200],"biomakers":[187],"with":[189,249,315,355],"(like":[192],"IL-6":[193],"TNF-alpha)":[195],"carotid":[201],"intima-media":[202],"thickness":[203],"(IMT),":[204],"surrogate":[206],"marker":[207],"atherosclerosis.":[209],"these":[212],"conditions,":[213],"characterized":[218,229,264,293,370],"pro-inflammatory":[221],"signature.":[222],"More":[223],"detail,":[225],"smoking":[227,246],"an":[231,266],"over-expression":[232,251,267,357],"groups":[234],"molecular":[238],"pathways":[239],"involved":[240,254,391],"innate":[243,306],"immunity,":[244],"whereas":[245],"cell-mediated":[257,308],"immunitary":[258],"response":[259],"IMT":[262,352],"mitochondrial":[272],"respiratory":[273],"chain.":[274],"Interestingly,":[275],"who":[278],"smoked":[279],"had":[281],"LDL-c":[283,287],"compared":[284],"low":[286],"non-smokers,":[288],"transcriptomic":[290,373],"co-presence":[296],"two":[299],"bio-signatures":[300],"both":[305],"immunity.":[309],"gender,":[316],"age,":[317],"different":[319,366,372],"proportions":[320],"leukocyte":[322],"sub-populations":[323],"are":[324,353,369],"also":[325],"presented":[326],"as":[327,345],"collateral":[328],"results.\\nConclusions:":[329],"conclusion,":[331],"young":[335],"adults,":[336],"such":[344],"thickened":[351],"related":[360],"response.":[364],"However,":[365],"\u201csignatures\u201d.":[374],"Presented":[375],"data":[376],"supportive":[378],"suggest":[380],"PBMCs":[386],"reflects":[387],"biological":[389],"processes":[390],"chronic":[394],"sub-clinical":[395],"inflammation":[396],"key":[400],"patho-physiological":[401],"element":[402],"disease.":[405]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
