{"id":"https://openalex.org/W15867713","doi":null,"title":"Dynamics of telomere in ageing","display_name":"Dynamics of telomere in ageing","publication_year":2011,"publication_date":"2011-05-12","ids":{"openalex":"https://openalex.org/W15867713","mag":"15867713"},"language":"en","primary_location":{"id":"mag:15867713","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.nitrkl.ac.in/2222/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036892450","display_name":"Amit Chatterjee","orcid":"https://orcid.org/0000-0001-9778-5040","observed_orcids":["https://orcid.org/0000-0001-9778-5040"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amit Chatterjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9778-5040","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036892450"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8289999961853027},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8759999871253967},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6539999842643738},{"id":"https://openalex.org/keywords/buccal-cells","display_name":"buccal epithelial cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.5270000100135803},{"id":"https://openalex.org/keywords/lifestyle-factors","display_name":"lifestyle factors","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9563676118850708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6303009986877441},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5814175009727478},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5294570326805115},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5114794969558716},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49334707856178284},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.44745346903800964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3902670741081238},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.38613054156303406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38462522625923157},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3326954245567322}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:15867713","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.nitrkl.ac.in/2222/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1516272650","https://openalex.org/W1582948192","https://openalex.org/W1967582067","https://openalex.org/W1969649126","https://openalex.org/W1973577066","https://openalex.org/W1998663807","https://openalex.org/W1999872096","https://openalex.org/W2018089879","https://openalex.org/W2021525933","https://openalex.org/W2028320710","https://openalex.org/W2030976397","https://openalex.org/W2032407757","https://openalex.org/W2032546353","https://openalex.org/W2037728125","https://openalex.org/W2058079574","https://openalex.org/W2075818695","https://openalex.org/W2082291199","https://openalex.org/W2094916776","https://openalex.org/W2098898118","https://openalex.org/W2113168077","https://openalex.org/W2120926079","https://openalex.org/W2133643647","https://openalex.org/W2138530492","https://openalex.org/W2139940280","https://openalex.org/W2143658931"],"related_works":["https://openalex.org/W2229880281","https://openalex.org/W7169596175","https://openalex.org/W1983765743","https://openalex.org/W7096142964","https://openalex.org/W4404743020","https://openalex.org/W1592986175","https://openalex.org/W3009359263","https://openalex.org/W2151024629","https://openalex.org/W4414216928","https://openalex.org/W7096830918"],"abstract_inverted_index":{"Telomere":[0,125],"are":[1,13,54,78,178,188,265,279],"composed":[2],"of":[3,16,22,33,61,74,83,87,95,122,135,152,158,166,200,297,305,313],"G":[4],"rich":[5],"nucleotide":[6],"(TTAGGG)n":[7],"typically":[8],"20":[9],"kb":[10],"in":[11,108,128,227,276,288],"length,":[12],"the":[14,20,23,26,30,34,37,52,105,129,133,156,167,193,198,213,294,298,302,314],"regions":[15,107,312],"repetitive":[17,168],"DNA":[18,185],"at":[19,192],"end":[21],"chromosomes.":[24],"As":[25],"eukaryotic":[27],"cells":[28,53,131,264],"divide,":[29],"protective":[31],"ends":[32],"linear":[35],"chromosomes,":[36],"telomeres,":[38],"gradually":[39],"shorten":[40],"with":[41,269,282],"each":[42,72],"cell":[43,123,136],"division.":[44],"When":[45],"a":[46,114,119,143,173],"critical":[47],"telomere":[48,64,77,109,159,260,299],"length":[49,65],"is":[50,161,218],"reached,":[51],"signaled":[55],"into":[56],"senescence,":[57],"an":[58,224],"irreversible":[59],"state":[60],"quiescence.":[62],"Thus,":[63],"has":[66,139],"emerged":[67],"as":[68,85,94,142,236],"replicative":[69],"clock":[70],"within":[71],"population":[73],"cells.":[75],"Since":[76,163],"also":[79],"non":[80],"coding":[81],"sequence":[82,169],"DNA,":[84],"that":[86,205],"introns,":[88],"there":[89],"might":[90,103],"be":[91,104],"specific":[92],"sites":[93],"5\u2019":[96],"splice":[97],"site":[98],"and":[99,110,148,171,215,232,244,246,271,285,300,307],"3\u2019splice":[100],"site,":[101],"which":[102,254],"conserved":[106,295,311],"can":[111,249],"possibility":[112],"generate":[113],"signal":[115],"for":[116,145],"apoptosis":[117],"after":[118],"certain":[120],"time":[121],"division.\r\nSince":[124],"Length":[126],"(TL)":[127],"somatic":[130],"determines":[132],"number":[134],"divisions,":[137],"TL":[138],"been":[140],"proposed":[141],"marker":[144],"biological":[146],"ageing":[147],"cancer.":[149],"Under":[150],"conditions":[151],"chronic":[153],"oxidative":[154,251],"stress,":[155],"rate":[157],"shortening":[160],"increased.":[162],"telomeres":[164,194,214],"consist":[165],"TTAGGG,":[170],"have":[172,292],"high":[174],"GC":[175],"content,":[176],"they":[177],"very":[179],"vulnerable":[180],"to":[181,197,212,258],"base":[182],"oxidation.":[183],"Additionally,":[184],"strand":[186],"breaks":[187],"less":[189,219],"efficiently":[190],"repaired":[191],"when":[195],"compared":[196],"rest":[199],"our":[201,289],"genome.":[202],"This":[203],"means":[204],"reactive":[206],"oxygen":[207],"species":[208],"cause":[209],"more":[210],"damage":[211,217],"this":[216],"well":[220],"repaired.":[221],"Genetics":[222],"play":[223],"important":[225],"role":[226],"determining":[228],"TL,":[229],"but":[230],"environmental":[231],"lifestyle":[233],"factors":[234],"such":[235],"smoking,":[237],"alcohol":[238],"consumption,":[239],"physical":[240],"activity,":[241],"body":[242],"composition":[243],"coffee":[245],"tea":[247],"consumption":[248],"affect":[250],"stress":[252],"levels,":[253],"may":[255],"contribute":[256],"significantly":[257],"accelerated":[259],"shortening.":[261],"Since,":[262],"buccal":[263],"under":[266],"direct":[267],"contact":[268],"smoke":[270],"various":[272],"toxic":[273],"chemical":[274],"substances":[275],"people":[277],"who":[278],"acutely":[280],"habituated":[281],"taking":[283],"tobacco":[284,306],"cigarettes.":[286],"So":[287],"work":[290],"we":[291],"found":[293],"region":[296],"showed":[301],"prolonged":[303],"effect":[304],"cigarettes":[308],"on":[309],"these":[310],"telomere.":[315]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
