{"id":"https://openalex.org/W1586594128","doi":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","title":"High\u2010intensity focused ultrasound (HIFU) for definitive treatment of prostate cancer","display_name":"High\u2010intensity focused ultrasound (HIFU) for definitive treatment of prostate cancer","publication_year":2012,"publication_date":"2012-06-06","ids":{"openalex":"https://openalex.org/W1586594128","doi":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","mag":"1586594128","pmid":"https://pubmed.ncbi.nlm.nih.gov/22672199"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-410x.2012.11262.x","doi":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ernesto R. Cordeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ernesto R. Cordeiro","raw_affiliation_strings":["Departments of Urology, AMC university hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, AMC university hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066220603","display_name":"Xavier Cathelineau","orcid":"https://orcid.org/0000-0003-3928-1543","observed_orcids":["https://orcid.org/0000-0003-3928-1543"]},"institutions":[{"id":"https://openalex.org/I4210091726","display_name":"Institute Mutualiste Montsouris","ror":"https://ror.org/00bea5h57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210091726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Cathelineau","raw_affiliation_strings":["Departments of Urology, Institut Mutualiste Montsouris, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Institut Mutualiste Montsouris, Paris","institution_ids":["https://openalex.org/I4210091726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016184390","display_name":"S. Th\u00fcroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128514","display_name":"M\u00fcnchen Klinik Harlaching","ror":"https://ror.org/03a7e0x93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101","https://openalex.org/I4210128514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Th\u00fcroff","raw_affiliation_strings":["Departments of Urology, Harlaching Hospital, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Harlaching Hospital, Munich, Germany","institution_ids":["https://openalex.org/I4210128514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090946201","display_name":"Michael Marberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Marberger","raw_affiliation_strings":["Departments of Urology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080354002","display_name":"S\u00e9bastien Crouzet","orcid":"https://orcid.org/0000-0001-5812-6771","observed_orcids":["https://orcid.org/0000-0001-5812-6771"]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Crouzet","raw_affiliation_strings":["Departments of Urology, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082495905","display_name":"Jean J.M.C.H. de la Rosette","orcid":"https://orcid.org/0000-0002-6308-1763","observed_orcids":["https://orcid.org/0000-0002-6308-1763"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jean J.M.C.H. de la Rosette","raw_affiliation_strings":["Departments of Urology, AMC university hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, AMC university hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082495905"],"corresponding_institution_ids":["https://openalex.org/I2802928900"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":1.262,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.75949367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"110","issue":"9","first_page":"1228","last_page":"1242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-intensity-focused-ultrasound","display_name":"high-intensity focused ultrasound","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/focal-therapy","display_name":"focal therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/definitive-treatment","display_name":"definitive treatment","score":0.8330000042915344},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7940000295639038},{"id":"https://openalex.org/keywords/psa-nadir","display_name":"PSA nadir","score":0.515999972820282},{"id":"https://openalex.org/keywords/treatment-related-complications","display_name":"treatment complications","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cancer-control","display_name":"cancer control","score":0.31299999356269836},{"id":"https://openalex.org/keywords/therapeutic-indications","display_name":"treatment indications","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2777365067","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"High-intensity focused ultrasound","level":3,"score":0.8956040143966675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7657360434532166},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7180173993110657},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5453999042510986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4698656499385834},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.45320063829421997},{"id":"https://openalex.org/C2987496018","wikidata":"https://www.wikidata.org/wiki/Q1860","display_name":"English language","level":2,"score":0.44435474276542664},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4285154938697815},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.427068829536438},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.307237446308136},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.29185426235198975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10029315948486328},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.06866881251335144},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036761","descriptor_name":"Ultrasound, High-Intensity Focused, Transrectal","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D036761","descriptor_name":"Ultrasound, High-Intensity Focused, Transrectal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D036761","descriptor_name":"Ultrasound, High-Intensity Focused, Transrectal","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1464-410x.2012.11262.x","doi":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2012.11262.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},{"id":"pmid:22672199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22672199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU international","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/f43b4215-0e70-405a-ae40-fac43eda7222","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/highintensity-focused-ultrasound-hifu-for-definitive-treatment-of-prostate-cancer(f43b4215-0e70-405a-ae40-fac43eda7222).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BJU international, 110(9), 1228 - 1242. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/bb3d7856-a03f-4620-b8c3-12f4c1448106","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/bb3d7856-a03f-4620-b8c3-12f4c1448106","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cordeiro, E R, Cathelineau, X, Th\u00fcroff, S, Marberger, M, Crouzet, S & de La Rosette, J J M C H 2012, 'High-intensity focused ultrasound (HIFU) for definitive treatment of prostate cancer', BJU international, vol. 110, no. 9, pp. 1228-1242. https://doi.org/10.1111/j.1464-410X.2012.11262.x","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W4846698","https://openalex.org/W17642981","https://openalex.org/W1505962820","https://openalex.org/W1558392243","https://openalex.org/W1562028792","https://openalex.org/W1563827260","https://openalex.org/W1567472737","https://openalex.org/W1915803833","https://openalex.org/W1965717154","https://openalex.org/W1967197865","https://openalex.org/W1967531287","https://openalex.org/W1967832754","https://openalex.org/W1970014288","https://openalex.org/W1970203359","https://openalex.org/W1970691211","https://openalex.org/W1971886854","https://openalex.org/W1982311990","https://openalex.org/W1982386852","https://openalex.org/W1983145936","https://openalex.org/W1984222175","https://openalex.org/W1985752624","https://openalex.org/W1985962834","https://openalex.org/W1986134680","https://openalex.org/W1994258030","https://openalex.org/W1994515728","https://openalex.org/W1995055592","https://openalex.org/W1995067043","https://openalex.org/W1996741497","https://openalex.org/W1997394967","https://openalex.org/W1999913431","https://openalex.org/W2005184420","https://openalex.org/W2009203131","https://openalex.org/W2011874271","https://openalex.org/W2013183573","https://openalex.org/W2013332883","https://openalex.org/W2014966452","https://openalex.org/W2020762361","https://openalex.org/W2021393151","https://openalex.org/W2023139341","https://openalex.org/W2023798810","https://openalex.org/W2026459096","https://openalex.org/W2028609618","https://openalex.org/W2034725282","https://openalex.org/W2040538815","https://openalex.org/W2043275267","https://openalex.org/W2048304411","https://openalex.org/W2048944905","https://openalex.org/W2051035889","https://openalex.org/W2053179102","https://openalex.org/W2057510074","https://openalex.org/W2058126130","https://openalex.org/W2058730737","https://openalex.org/W2059688994","https://openalex.org/W2060974422","https://openalex.org/W2063456541","https://openalex.org/W2066705460","https://openalex.org/W2069948953","https://openalex.org/W2072058446","https://openalex.org/W2073833346","https://openalex.org/W2074359793","https://openalex.org/W2084713534","https://openalex.org/W2085664899","https://openalex.org/W2085889654","https://openalex.org/W2087142672","https://openalex.org/W2087981209","https://openalex.org/W2094043660","https://openalex.org/W2096413175","https://openalex.org/W2097591339","https://openalex.org/W2100342702","https://openalex.org/W2102911743","https://openalex.org/W2104377141","https://openalex.org/W2104737923","https://openalex.org/W2105454326","https://openalex.org/W2106787323","https://openalex.org/W2110328329","https://openalex.org/W2117792530","https://openalex.org/W2118713781","https://openalex.org/W2122321179","https://openalex.org/W2122438191","https://openalex.org/W2123230901","https://openalex.org/W2127423431","https://openalex.org/W2129806101","https://openalex.org/W2134894853","https://openalex.org/W2135369558","https://openalex.org/W2138099766","https://openalex.org/W2138310647","https://openalex.org/W2139549698","https://openalex.org/W2140402608","https://openalex.org/W2146699704","https://openalex.org/W2147799242","https://openalex.org/W2151435813","https://openalex.org/W2154870334","https://openalex.org/W2156549595","https://openalex.org/W2156677943","https://openalex.org/W2157470025","https://openalex.org/W2158334327","https://openalex.org/W2159015983","https://openalex.org/W2162046145","https://openalex.org/W2166423862","https://openalex.org/W2166438301","https://openalex.org/W2324042165","https://openalex.org/W2394919101","https://openalex.org/W2401082117","https://openalex.org/W2406551823","https://openalex.org/W2412632103","https://openalex.org/W2413811840","https://openalex.org/W2442761601","https://openalex.org/W2470206187","https://openalex.org/W2765888684","https://openalex.org/W2767127627","https://openalex.org/W3191783796","https://openalex.org/W4241174091","https://openalex.org/W4251986295"],"related_works":["https://openalex.org/W7099844311","https://openalex.org/W2060059686","https://openalex.org/W3015383055","https://openalex.org/W4236220870","https://openalex.org/W16534191","https://openalex.org/W1806741058","https://openalex.org/W1963955025","https://openalex.org/W2884141894","https://openalex.org/W2113419342","https://openalex.org/W3030369943"],"abstract_inverted_index":{"UNLABELLED:":[0],"What's":[1],"known":[2],"on":[3,81,136,219,235,498],"the":[4,9,34,78,92,116,133,151,158,163,259,269,281,317,376,380,417,424,452,518],"subject?":[5],"and":[6,31,105,121,173,182,190,206,229,245,276,302,358,396,426,491],"What":[7],"does":[8],"study":[10],"add?":[11],"Novel":[12,430],"therapeutic":[13,431],"methods":[14,432],"have":[15,433],"emerged":[16,434],"in":[17,24,47,94,98,153,166,405,435,442,463,508],"recent":[18,436],"years":[19,437],"as":[20,83,141,273,285,379,438],"'focal'":[21,439],"treatment":[22,86,144,222,275,382,440,502],"alternatives":[23],"which":[25,52,443],"cancer":[26,58,295,444,467,505],"foci":[27,445],"can":[28],"be":[29,414,447],"eradicated":[30,448],"greatly":[32,450],"reducing":[33,451],"associated":[35,374,453],"side-effects":[36,454],"of":[37,64,69,77,87,100,109,119,132,145,168,178,188,223,271,283,300,309,316,407,419,423,455,473,478,503,521],"radical":[38,456],"treatment.":[39,287,457],"High-intensity":[40],"focused":[41,138],"ultrasound":[42,139],"(HIFU)":[43,140],"seems":[44,460],"to":[45,56,162,174,184,213,216,328,337,344,355,367,413,461,465,488,516],"result":[46,462],"a":[48,61,84,95,142,154,470],"well":[49],"fitted":[50],"technology,":[51],"has":[53],"proven":[54],"short-":[55,464],"medium-term":[57,466],"control,":[59,468],"with":[60,67,239,375,469,476],"low":[62,471],"rate":[63,472],"complications":[65,373,474],"comparable":[66,475],"those":[68,477],"established":[70,479],"therapies.":[71,480],"This":[72],"is":[73],"an":[74,107,129,176],"up-to-date":[75,130],"review":[76,131],"available":[79,134,159,495],"literature":[80,135,200,260],"HIFU":[82,120,189,220,272,284,377,459,499],"definitive":[85,143,501],"prostate":[88,146,224,294,304,425,504],"cancer.":[89,147,225],"It":[90],"describes":[91],"technique":[93,152],"comprehensive":[96,155],"approach":[97],"terms":[99,167],"technical":[101,169],"features,":[102,170],"procedure,":[103,171],"indications,":[104,172],"gives":[106],"overview":[108,177],"its":[110,122,179,191],"historical":[111,180],"background;":[112,181],"finally,":[113,183],"we":[114],"present":[115,150],"future":[117,186,509],"applications":[118,187],"development":[123,192],"trend.":[124,193],"OBJECTIVES:":[125],"\u2022":[126,148,197,226,251,288,369,400,409,429,458,481],"To":[127,149],"provide":[128],"high-intensity":[137],"approach,":[156],"comparing":[157],"devices":[160],"according":[161],"existing":[164],"evidence":[165],"give":[175],"discuss":[185],"MATERIALS":[194],"AND":[195],"METHODS:":[196],"A":[198],"systematic":[199],"search":[201],"was":[202,319,403],"conducted":[203],"using":[204],"MEDLINE":[205],"EMBASE":[207],"via":[208],"Ovid":[209],"databases":[210],"(January":[211],"2000":[212],"December":[214],"2011),":[215],"identify":[217],"studies":[218,238,266,278,485],"for":[221,500],"Only":[227],"English-language":[228],"human-based":[230],"full":[231],"manuscripts":[232],"that":[233,267,279],"reported":[234,404],"case":[236],"series":[237],">50":[240],"participants,":[241],"patient":[242],"characteristics,":[243],"efficacy":[244,270,282],"safety":[246],"data":[247],"were":[248,256],"included.":[249],"RESULTS:":[250],"No":[252],"randomised":[253],"controlled":[254],"trials":[255],"identified":[257,263],"by":[258,416,449],"search.":[261],"We":[262],"31":[264],"uncontrolled":[265],"examined":[268,280],"primary":[274,381],"two":[277],"salvage":[286],"Most":[289],"treated":[290],"patients":[291,318],"had":[292],"localised":[293],"(stage":[296],"T1-T2);":[297],"Gleason":[298],"scores":[299],"2-10":[301],"mean":[303,313,323],"specific":[305],"antigen":[306],"(PSA)":[307],"values":[308],"4.6-12.7":[310],"ng/mL.":[311,346],"The":[312,322,347,370],"age":[314],"range":[315],"64.1-72":[320],"years.":[321],"follow-up":[324,484],"ranged":[325,334,341,352,364],"from":[326,335,342,353,365],"6.4":[327],"76.8":[329],"months.":[330],"Negative":[331],"biopsy":[332],"rates":[333,351,363],"35":[336],"95%.":[338],"PSA":[339],"nadirs":[340],"0.04":[343],"1.8":[345],"5-year":[348],"disease-free":[349],"survival":[350,362],"61.2":[354],"95%;":[356],"7-":[357],"8-year":[359],"disease":[360],"free":[361],"69":[366],"84%.":[368],"most":[371],"common":[372],"procedure":[378],"included:":[383],"urinary":[384,387,393],"retention":[385],"(<1-20%);":[386],"tract":[388],"infections":[389],"(1.8-47.9%);":[390],"stress":[391],"or":[392],"incontinence":[394],"(<1-34.3%);":[395],"erectile":[397],"dysfunction":[398],"(20-81.6%).":[399],"Recto-urethral":[401],"fistula":[402],"<2%":[406],"patients.":[408],"Treatment-related":[410],"morbidity":[411],"appeared":[412],"reduced":[415],"combination":[418],"transurethral":[420],"resection":[421],"(TURP)":[422],"HIFU.":[427],"CONCLUSIONS:":[428],"alternatives,":[441],"could":[446,514],"However,":[482],"longer-term":[483],"are":[486,506],"needed":[487],"evaluate":[489],"cancer-specific":[490],"overall":[492],"survival.":[493],"If":[494],"promising":[496],"results":[497],"confirmed":[507],"prospective":[510],"trials,":[511],"focal":[512],"therapy":[513],"start":[515],"challenge":[517],"current":[519],"standard":[520],"care.":[522]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}