{"id":"https://openalex.org/W1586334233","doi":"https://doi.org/10.1113/expphysiol.2005.030924","title":"Hypoxia\u2010inducible factor as a physiological regulator","display_name":"Hypoxia\u2010inducible factor as a physiological regulator","publication_year":2005,"publication_date":"2005-09-13","ids":{"openalex":"https://openalex.org/W1586334233","doi":"https://doi.org/10.1113/expphysiol.2005.030924","mag":"1586334233","pmid":"https://pubmed.ncbi.nlm.nih.gov/16157658"},"language":"en","primary_location":{"id":"doi:10.1113/expphysiol.2005.030924","doi":"https://doi.org/10.1113/expphysiol.2005.030924","is_oa":false,"landing_page_url":"https://doi.org/10.1113/expphysiol.2005.030924","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036848232","display_name":"Patrick Henry Maxwell","orcid":"https://orcid.org/0000-0002-0338-2679","observed_orcids":["https://orcid.org/0000-0002-0338-2679"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Patrick H. Maxwell","raw_affiliation_strings":["Hammersmith Campus, Imperial College, London W12 0NN, UK. p.maxwell@imperial.ac.uk","Hammersmith Campus, Imperial College  Du Cane Road London W12 0NN UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hammersmith Campus, Imperial College, London W12 0NN, UK. p.maxwell@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Hammersmith Campus, Imperial College  Du Cane Road London W12 0NN UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036848232"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":1.441,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.80715706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"90","issue":"6","first_page":"791","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":1.0},{"id":"https://openalex.org/keywords/oxygen-sensing","display_name":"oxygen sensing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.824999988079071},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hif-activation","display_name":"HIF activation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/physiological-regulation","display_name":"physiological regulation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/evolutionary-conservation","display_name":"evolutionary conservation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9679999947547913},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8560018539428711},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7513211369514465},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.7183325886726379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5910878777503967},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.5399489402770996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5114458799362183},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4764062166213989},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44489118456840515},{"id":"https://openalex.org/C2909350873","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-Inducible Factor 1","level":4,"score":0.4433932900428772},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4331849217414856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4312707185745239},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2954285740852356},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.2251882553100586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.193302720785141},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D064799","descriptor_name":"Hypoxia-Inducible Factor-Proline Dioxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/expphysiol.2005.030924","doi":"https://doi.org/10.1113/expphysiol.2005.030924","is_oa":false,"landing_page_url":"https://doi.org/10.1113/expphysiol.2005.030924","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:16157658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16157658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:118753","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/118753/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EXP PHYSIOL , 90 (6) 791 - 797. (2005)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1581708824","https://openalex.org/W1602815497","https://openalex.org/W1963851116","https://openalex.org/W1975234288","https://openalex.org/W1982861439","https://openalex.org/W1982920345","https://openalex.org/W1986538872","https://openalex.org/W1990607537","https://openalex.org/W1991346678","https://openalex.org/W1997422780","https://openalex.org/W2008430621","https://openalex.org/W2015873509","https://openalex.org/W2016160962","https://openalex.org/W2017575850","https://openalex.org/W2020277250","https://openalex.org/W2021656373","https://openalex.org/W2021932335","https://openalex.org/W2024064023","https://openalex.org/W2057199368","https://openalex.org/W2058021996","https://openalex.org/W2059747280","https://openalex.org/W2069698188","https://openalex.org/W2085609942","https://openalex.org/W2094242056","https://openalex.org/W2099397203","https://openalex.org/W2099702971","https://openalex.org/W2103154710","https://openalex.org/W2104127059","https://openalex.org/W2106590335","https://openalex.org/W2108186386","https://openalex.org/W2120657231","https://openalex.org/W2124053736","https://openalex.org/W2129932871","https://openalex.org/W2130219349","https://openalex.org/W2131676053","https://openalex.org/W2135034560","https://openalex.org/W2135705997","https://openalex.org/W2136875815","https://openalex.org/W2140594539","https://openalex.org/W2148194696","https://openalex.org/W2149472502","https://openalex.org/W2152480767","https://openalex.org/W2152890695","https://openalex.org/W2153771223","https://openalex.org/W2169246212","https://openalex.org/W2171597431"],"related_works":["https://openalex.org/W2254935247","https://openalex.org/W2087377825","https://openalex.org/W4254109451","https://openalex.org/W2071895328","https://openalex.org/W2031456802","https://openalex.org/W2073292880","https://openalex.org/W2185891422","https://openalex.org/W2184873029","https://openalex.org/W1506462561","https://openalex.org/W7098881211"],"abstract_inverted_index":{"Hypoxia-inducible":[0],"factor":[1],"(HIF)":[2],"is":[3,33],"a":[4,16,72],"transcription":[5],"complex":[6],"which":[7],"responds":[8],"to":[9,59],"changes":[10,21],"in":[11,22,27,35,40,71],"oxygen,":[12],"providing":[13],"cells":[14],"with":[15],"master":[17],"regulator":[18],"that":[19,55],"coordinates":[20],"gene":[23],"transcription.":[24],"HIF":[25,60,70],"operates":[26],"all":[28],"mammalian":[29],"cell":[30],"types":[31],"and":[32,43,62],"ancient":[34],"evolutionary":[36],"terms,":[37],"being":[38],"conserved":[39],"C.":[41],"elegans":[42],"D.":[44],"melanogaster.":[45],"This":[46],"review":[47],"summarizes":[48],"recent":[49],"insights":[50,64],"into":[51,65],"the":[52,66],"molecular":[53],"events":[54],"link":[56],"reduced":[57],"oxygenation":[58],"activation":[61],"emerging":[63],"extensive":[67],"role":[68],"of":[69,75],"broad":[73],"range":[74],"physiological":[76],"processes.":[77]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}