{"id":"https://openalex.org/W1586119503","doi":null,"title":"Efeito do antiinflamat\u00f3rio n\u00e3o-esteroidal Rofecoxib (Vioxx\u00ae) no processo de reparo \u00f3sseo em t\u00edbias de ratos estressados: estudo microsc\u00f3pico","display_name":"Efeito do antiinflamat\u00f3rio n\u00e3o-esteroidal Rofecoxib (Vioxx\u00ae) no processo de reparo \u00f3sseo em t\u00edbias de ratos estressados: estudo microsc\u00f3pico","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1586119503","mag":"1586119503"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:7c55dee920e14fe8a082f2d6342fdf62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c55dee920e14fe8a082f2d6342fdf62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RGO: Revista Ga\u00facha de Odontologia, Vol 56, Iss 3, Pp 309-314 (2008)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/7c55dee920e14fe8a082f2d6342fdf62","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023503262","display_name":"Victor Prado Curv\u00eallo","orcid":"https://orcid.org/0000-0001-6840-7577","observed_orcids":["https://orcid.org/0000-0001-6840-7577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Prado Curv\u00eallo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6840-7577","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032447243","display_name":"Tetuo Okamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetuo Okamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084792589","display_name":"Luiz Alberto Milanezi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiz Alberto Milanezi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2233,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59620968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"3","first_page":"309","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.996999979019165},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/histomorphology","display_name":"histomorphology","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7502506971359253},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.619197428226471},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.5538502931594849},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4556137025356293},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.44298073649406433},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38681480288505554},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.32193300127983093},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.30261385440826416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23203864693641663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13909471035003662},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.08276253938674927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:7c55dee920e14fe8a082f2d6342fdf62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c55dee920e14fe8a082f2d6342fdf62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RGO: Revista Ga\u00facha de Odontologia, Vol 56, Iss 3, Pp 309-314 (2008)","raw_type":"article"},{"id":"mag:1586119503","doi":null,"is_oa":false,"landing_page_url":"https://www.revistargo.com.br/viewarticle.php?id=1024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2946251650","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7c55dee920e14fe8a082f2d6342fdf62","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:7c55dee920e14fe8a082f2d6342fdf62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c55dee920e14fe8a082f2d6342fdf62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RGO: Revista Ga\u00facha de Odontologia, Vol 56, Iss 3, Pp 309-314 (2008)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W163658884","https://openalex.org/W1535894955","https://openalex.org/W1995717900","https://openalex.org/W2001874316","https://openalex.org/W2006882866","https://openalex.org/W2014837597","https://openalex.org/W2031897773","https://openalex.org/W2037363614","https://openalex.org/W2052192250","https://openalex.org/W2056702525","https://openalex.org/W2066061562","https://openalex.org/W2075530439","https://openalex.org/W2084016881","https://openalex.org/W2121023034","https://openalex.org/W2427145137"],"related_works":["https://openalex.org/W3215330859","https://openalex.org/W2946251650","https://openalex.org/W2168464789","https://openalex.org/W2018691533","https://openalex.org/W2008578657","https://openalex.org/W2418548386","https://openalex.org/W2981100263","https://openalex.org/W2015881541","https://openalex.org/W2099096407","https://openalex.org/W1892257529"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3,6,13,18,61,68,76,82,92,98,105,108,123,131,136,144,165,208,212,217,232,237,256,261,278,281,289,299,307,313],"effect":[4,300],"of":[5,20,30,47,100,110,138,142,158,185,207,211,231,239,255,263,280,291,301,309,315],"nonsteroidal":[7,111],"anti-inflammatory":[8,112,282],"drug":[9,120,283],"Rofecoxib":[10,284],"(Vioxx\u2122)":[11],"on":[12,303],"bone":[14,69,126,233,257,304],"repair":[15,230,254],"process":[16],"in":[17,65,73,81,102,122,130,173,176,182,216,236,250,260,274,288,306,312],"tibiae":[19,169],"stressed":[21,294],"rats.":[22,316],"Methods:":[23],"In":[24,140],"this":[25],"study,":[26],"use":[27],"was":[28,58,71,94],"made":[29],"48":[31],"young":[32],"male":[33],"(Albinus":[34],"Wistar)":[35],"rats":[36,238,262],"weighing":[37],"between":[38],"150":[39],"and":[40,64,86,128,152,167,180,193],"200":[41],"grams,":[42],"divided":[43],"into":[44],"three":[45,83,87],"groups":[46,141],"16":[48],"animals":[49,77,106,145],"each.":[50],"The":[51,199,222],"following":[52],"procedures":[53],"were":[54,146,170,189,202,242,266],"performed:":[55],"Group":[56,74,103,240,251,264,275],"I":[57],"used":[59],"as":[60,204],"control":[62],"group,":[63],"it,":[66],"only":[67],"defect":[70,93,127,234,258],"performed;":[72],"II":[75,241],"received":[78,107],"stressor":[79,115],"stimulus":[80,116],"pre-operative":[84,124],"days":[85,90],"post-":[88],"operative":[89],"after":[91,119],"performed,":[95],"up":[96,134],"to":[97,135,226,244,268],"time":[99,137,210],"sacrifice;":[101],"III":[104,265],"administration":[109],"medication":[113],"(pre-operatively),":[114],"one":[117,225],"hour":[118],"administration,":[121],"period,":[125,133],"stress":[129,302],"post-operative":[132,154,209],"sacrifice.":[139],"four,":[143],"sacrificed":[147],"at":[148],"7,":[149],"14,":[150],"30":[151],"60":[153],"days,":[155],"by":[156],"means":[157],"cervical":[159],"column":[160],"dislocation.":[161],"After":[162],"being":[163],"sacrificed,":[164],"right":[166],"left":[168],"removed,":[171],"fixed":[172],"formalin,":[174],"decalcified":[175],"ethylenodiaminatetracetic":[177],"acid":[178],"(Na.2H2.2H2O)":[179],"included":[181],"paraffin.":[183],"Cuts":[184],"6":[186],"micrometers":[187],"thickness":[188],"stained":[190],"with":[191,293],"hematoxylin":[192],"eosin":[194],"for":[195],"microscopic":[196],"analysis.":[197],"Results:":[198],"results":[200,223],"obtained":[201],"described":[203],"a":[205],"function":[206],"histomorphologic":[213],"occurrences":[214],"observed":[215],"different":[218],"experimental":[219],"groups.":[220],"Conclusion:":[221],"allowed":[224],"conclude":[227],"that:":[228],"1)":[229],"caused":[235,259,311],"shown":[243,267],"be":[245,269,286],"more":[246],"delayed":[247,271],"than":[248,272],"those":[249,273],"I;":[252],"2)":[253],"less":[270],"II;":[276],"3)":[277],"prescription":[279],"can":[285],"indicated":[287],"case":[290,308],"experiments":[292],"animals,":[295],"because":[296],"it":[297],"diminished":[298],"repair,":[305],"defects":[310],"tibia":[314]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
