{"id":"https://openalex.org/W15859722","doi":null,"title":"EFEITO DAS PROSTAGLANDINAS CICLOPENTEN\u00d4NICAS SOBRE A EXPRESS\u00c3O G\u00caNICA DO FATOR NUCLEAR PPAR-\u03b3, DO RECEPTOR DE SCAVENGER CD36 E PROTE\u00cdNAS DE APOPTOSE EM MACR\u00d3FAGOS: IMPLICA\u00c7\u00d5ES PARA A FISIOPATOLOGIA DA ATEROSCLEROSE","display_name":"EFEITO DAS PROSTAGLANDINAS CICLOPENTEN\u00d4NICAS SOBRE A EXPRESS\u00c3O G\u00caNICA DO FATOR NUCLEAR PPAR-\u03b3, DO RECEPTOR DE SCAVENGER CD36 E PROTE\u00cdNAS DE APOPTOSE EM MACR\u00d3FAGOS: IMPLICA\u00c7\u00d5ES PARA A FISIOPATOLOGIA DA ATEROSCLEROSE","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W15859722","mag":"15859722"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3199332","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/5142","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085082770","display_name":"Lav\u00ednia Almeida Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lav\u00ednia Almeida Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085082770"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.14730000495910645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/15-deoxy-delta12-14-prostaglandin-j2","display_name":"15-deoxy-\u039412,14-prostaglandin J2","score":0.906000018119812},{"id":"https://openalex.org/keywords/prostaglandin-a2","display_name":"prostaglandin A2","score":0.890999972820282},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cd36-scavenger-receptor","display_name":"CD36 scavenger receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9240000247955322},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/foam-cells","display_name":"foam cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7900000214576721},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.5568159222602844},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.46284621953964233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37464791536331177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34234970808029175},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23720216751098633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05759555101394653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.03364035487174988},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3199332","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/5142","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5142","pdf_url":"http://hdl.handle.net/10183/5142","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/5142","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5142","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"mag:15859722","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/handle/10183/5142","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3199332","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W15859722.pdf","grobid_xml":"https://content.openalex.org/works/W15859722.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W90900161","https://openalex.org/W194063018","https://openalex.org/W625127082","https://openalex.org/W986965488","https://openalex.org/W1025025131","https://openalex.org/W1782545213","https://openalex.org/W1853133898","https://openalex.org/W1857052429","https://openalex.org/W1968679020","https://openalex.org/W1969469693","https://openalex.org/W1971123289","https://openalex.org/W1976989874","https://openalex.org/W1980456945","https://openalex.org/W1982638309","https://openalex.org/W1987876724","https://openalex.org/W1989633984","https://openalex.org/W1991865867","https://openalex.org/W1994478357","https://openalex.org/W1996716971","https://openalex.org/W1996775663","https://openalex.org/W1997005770","https://openalex.org/W1997745709","https://openalex.org/W1999575880","https://openalex.org/W2012852638","https://openalex.org/W2013592393","https://openalex.org/W2019346242","https://openalex.org/W2024542927","https://openalex.org/W2036795661","https://openalex.org/W2036900851","https://openalex.org/W2050550042","https://openalex.org/W2052704549","https://openalex.org/W2052910631","https://openalex.org/W2053328405","https://openalex.org/W2054197118","https://openalex.org/W2054949240","https://openalex.org/W2061755142","https://openalex.org/W2063329261","https://openalex.org/W2068829557","https://openalex.org/W2070142808","https://openalex.org/W2072433515","https://openalex.org/W2083722269","https://openalex.org/W2086221205","https://openalex.org/W2086996324","https://openalex.org/W2091814080","https://openalex.org/W2092767159","https://openalex.org/W2096013870","https://openalex.org/W2103566243","https://openalex.org/W2108521208","https://openalex.org/W2108791332","https://openalex.org/W2109083452","https://openalex.org/W2110713453","https://openalex.org/W2115268091","https://openalex.org/W2115435531","https://openalex.org/W2116987401","https://openalex.org/W2118645481","https://openalex.org/W2126779719","https://openalex.org/W2127115156","https://openalex.org/W2130328067","https://openalex.org/W2134391394","https://openalex.org/W2157692110","https://openalex.org/W2160156991","https://openalex.org/W2161188230","https://openalex.org/W2161543197","https://openalex.org/W2162458714","https://openalex.org/W2162973361","https://openalex.org/W2164765228","https://openalex.org/W2164850907","https://openalex.org/W2171363744","https://openalex.org/W2265277925","https://openalex.org/W2285372434","https://openalex.org/W2402563601","https://openalex.org/W3153495156","https://openalex.org/W3202475859"],"related_works":["https://openalex.org/W6995687322","https://openalex.org/W84054304","https://openalex.org/W2021758696","https://openalex.org/W2290771786","https://openalex.org/W1521886140","https://openalex.org/W4382344485","https://openalex.org/W6977548403","https://openalex.org/W2089453915","https://openalex.org/W2325041503","https://openalex.org/W1583731895"],"abstract_inverted_index":{"Considerando":[0],"que":[1,106,117,178,347,420],"as":[2,197,224,277,348,403,421],"doen\u00e7as":[3,36],"cardiovasculares":[4],"representam":[5],"a":[6,16,30,35,41,66,80,108,119,154,157,170,185,211,231,247,298,356,385,407,439,452,483],"maior":[7],"causa":[8],"de":[9,22,43,53,77,82,84,92,99,103,110,115,129,145,163,174,207,250,255,266,287,300,310,323,330,376,387,396,414,434,448,492],"mortalidade":[10],"e":[11,34,61,101,113,143,156,202,290,308,315,327,352,399,454],"morbidade":[12],"em":[13,69,152,166,209,257,268,283,374,412,489],"pa\u00edses":[14],"ocidentais,":[15],"aterosclerose":[17],"se":[18],"destaca":[19],"pelo":[20],"fato":[21],"predispor":[23],"os":[24,242],"pacientes":[25],"ao":[26,381],"infarto":[27],"do":[28,45,187,218,264,359,441,446,485],"mioc\u00e1rdio,":[29],"acidentes":[31],"vasculares":[32,37],"cerebrais":[33],"perif\u00e9ricas.":[38],"Neste":[39],"contexto,":[40],"oxida\u00e7\u00e3o":[42],"lipoprote\u00ednas":[44],"plasma,":[46],"particularmente":[47],"LDL,":[48],"\u00e9":[49,59,214],"um":[50],"dos":[51],"fatores":[52,73,104,114,251],"risco":[54],"para":[55,297,302,426,498],"eventos":[56],"cardiovasculares,":[57],"pois":[58],"reconhecida":[60],"internalizada":[62],"por":[63,472],"macr\u00f3fagos,":[64],"ocasionando":[65],"sua":[67],"diferencia\u00e7\u00e3o":[68,254],"foam":[70,258],"cells.":[71],"Diversos":[72],"participam":[74],"deste":[75,479],"processo":[76,265],"diferencia\u00e7\u00e3o,":[78],"como":[79,138,239,261,335],"express\u00e3o":[81,171,248,357,386,440],"receptores":[83],"scavenger":[85,449],"CD":[86,304],"36,":[87,305],"proporcionando":[88],"aumento":[89,95],"na":[90,96,139],"capta\u00e7\u00e3o":[91],"LDL":[93,288,291,377,415],"oxidada,":[94,378],"s\u00edntese":[97,395],"end\u00f3gena":[98],"colesterol":[100,397],"ativa\u00e7\u00e3o":[102,186],"nucleares":[105],"iniciam":[107],"transcri\u00e7\u00e3o":[109],"prote\u00ednas":[111,173,262,309],"espec\u00edficas":[112],"crescimento":[116],"disparam":[118,169],"aterog\u00eanese.":[120],"Os":[121,343,417],"fen\u00f4menos":[122],"celulares":[123],"relacionados":[124,252],"\u00e0":[125,253,469],"apoptose":[126,311,408,462],"tamb\u00e9m":[127,405],"s\u00e3o":[128,159,179,496],"especial":[130,162],"import\u00e2ncia,":[131],"tanto":[132],"no":[133],"desenvolvimento":[134],"da":[135,141,226,270,339,394,429,455,461],"les\u00e3o":[136],"ateroscler\u00f3tica":[137],"estabilidade":[140],"placa":[142],"forma\u00e7\u00e3o":[144],"trombos.":[146],"As":[147],"prostaglandinas":[148],"(PGs)":[149],"ciclopenten\u00f4nicas":[150],"(CP-PGs),":[151],"particular":[153],"PGA2":[155,350,383],"15-des\u00f3xi-\u220612,14-PGJ2":[158],"uma":[160,205],"classe":[161],"PGs":[164,198,225],"que,":[165,432],"diminutas":[167],"concentra\u00e7\u00f5es,":[168],"das":[172,199,234,244,503],"choque":[175],"t\u00e9rmico":[176],"(hsp),":[177],"citoprotetoras.":[180],"Al\u00e9m":[181],"disso,":[182],"CP-PGs":[183,245,349,404,422,488],"bloqueiam":[184],"fator":[188,219,360,442],"nuclear":[189,220,361,443],"pr\u00f3-inflamat\u00f3rio":[190],"NF-\u03baB":[191],"tornando-as":[192],"potentes":[193],"agentes":[194],"antiinflamat\u00f3rios.":[195],"Embora":[196,475],"fam\u00edlias":[200],"A":[201,228],"J":[203],"guardem":[204],"s\u00e9rie":[206],"caracter\u00edsticas":[208],"comum,":[210],"15-des\u00f3xi-\u220612,14-":[212],"PGJ2":[213,353],"o":[215,293,400,427,500],"ligante":[216],"fisiol\u00f3gico":[217],"pr\u00f3-aterog\u00eanico":[221,444],"PPAR-\u03b3,":[222,303,445],"enquanto":[223],"fam\u00edlia":[227],"ativam":[229],"apenas":[230],"via":[232],"citoprotetora":[233],"hsp.":[235],"Este":[236],"trabalho":[237],"teve":[238],"objetivo":[240],"avaliar":[241],"efeitos":[243],"sobre":[246],"g\u00eanica":[249,358],"macr\u00f3fagos":[256],"cells,":[259],"bem":[260],"reguladoras":[263],"apoptose,":[267],"c\u00e9lulas":[269,278,372,410,464],"linhagem":[271],"pr\u00f3-monoc\u00edtica":[272],"humana":[273],"U937.":[274],"Para":[275],"tal,":[276],"foram":[279],"tratadas":[280,411],"com":[281,332,341,402,487],"CPPGs":[282],"presen\u00e7a":[284,375,413],"e/ou":[285],"aus\u00eancia":[286],"nat":[289],"ox,":[292],"RNA":[294],"foi":[295,321],"extra\u00eddo":[296],"realiza\u00e7\u00e3o":[299],"RT-PCR":[301],"HMG-CoA":[306,388,457],"redutase":[307,389],"Caspase":[312],"3,":[313],"p53":[314],"Bcl-xL.":[316],"O":[317,459],"tratamento":[318,401,428,486],"estat\u00edstico":[319],"utilizado":[320],"an\u00e1lise":[322],"vari\u00e2ncia":[324],"(ANOVA":[325],"one-way)":[326],"teste":[328],"\u201ct\u201d":[329],"student,":[331],"resultados":[333,344],"expressos":[334],"m\u00e9dias":[336],"+":[337],"desvios-padr\u00e3o":[338],"m\u00e9dia,":[340],"P<0,05.":[342],"obtidos":[345],"demontraram":[346],"(20\u00b5M-24h)":[351],"(1,5\u00b5M-24h)":[354],"inibiram":[355],"PPAR-":[362],"\u03b3":[363],"(64":[364],"%":[365,368],"(PGA2),":[366],"88":[367],"(15-":[369],"d-PGJ2))":[370],"nas":[371,409,463],"U937,":[373],"quando":[379],"comparado":[380],"controle.":[382],"inibiu":[384,406],"(33":[390],"%),":[391],"enzima":[392,456],"chave":[393],"intracelular,":[398],"oxidada.":[416],"dados":[418],"sugerem":[419],"apresentam":[423],"grande":[424],"potencial":[425],"aterosclerose,":[430,493],"j\u00e1":[431],"al\u00e9m":[433],"apresentarem":[435],"efeito":[436,501],"antiinflamat\u00f3rio,":[437],"inibem":[438],"receptor":[447],"CD36":[450],"(apenas":[451],"15-des\u00f3xi-\u220612,14-PGJ2)":[453],"redutase.":[458],"bloqueio":[460],"estudadas":[465],"pode":[466],"estar":[467],"relacionado":[468],"citoprote\u00e7\u00e3o":[470],"oferecida":[471],"estas":[473],"PGs.":[474],"investiga\u00e7\u00f5es":[476],"in":[477],"vivo":[478],"laborat\u00f3rio":[480],"tenham":[481],"mostrado":[482],"efic\u00e1cia":[484],"camundongos":[490],"portadores":[491],"estudos":[494],"adicionais":[495],"necess\u00e1rios":[497],"esclarecer-se":[499],"antiaterog\u00eanico":[502],"mesmas.":[504]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
