{"id":"https://openalex.org/W1585961391","doi":"https://doi.org/10.21236/ada411959","title":"The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma","display_name":"The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W1585961391","doi":"https://doi.org/10.21236/ada411959","mag":"1585961391"},"language":"en","primary_location":{"id":"doi:10.21236/ada411959","doi":"https://doi.org/10.21236/ada411959","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada411959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016218082","display_name":"Leszek Kotula","orcid":"https://orcid.org/0000-0002-7977-7124","observed_orcids":["https://orcid.org/0000-0002-7977-7124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leszek Kotula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064851805","display_name":"Jiliu Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiliu XU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066248850","display_name":"Jill A. Macoska","orcid":"https://orcid.org/0000-0001-8471-2221","observed_orcids":["https://orcid.org/0000-0001-8471-2221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill A. Macoska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Piotr Kozlowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piotr Kozlowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109170141","display_name":"Magdalena Martinka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Martinka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cell-growth-regulation","display_name":"cell growth regulation","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C50244902","wikidata":"https://www.wikidata.org/wiki/Q420870","display_name":"Spectrin","level":4,"score":0.8608500957489014},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.6093064546585083},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4687519073486328},{"id":"https://openalex.org/C2910254342","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostatic adenocarcinoma","level":4,"score":0.44271180033683777},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37190622091293335},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3478362560272217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33293473720550537},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3076080083847046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3015301525592804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2867770791053772},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.235548198223114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23220384120941162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1364838182926178},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13152837753295898},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12643027305603027},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.06910142302513123},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.06862470507621765},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21236/ada411959","doi":"https://doi.org/10.21236/ada411959","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada411959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA411959","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA411959","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"pmh:ADA419543","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA419543","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4239185491","https://openalex.org/W2055427099","https://openalex.org/W236353233","https://openalex.org/W7096355815","https://openalex.org/W1973081041","https://openalex.org/W2037782111","https://openalex.org/W7101138530","https://openalex.org/W3026875144","https://openalex.org/W2320910565","https://openalex.org/W2119036448"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,19,28,53],"is":[2],"one":[3,45],"of":[4,8,26,33,40,46,51,76],"the":[5,12,31,47,72,77],"leading":[6,17],"causes":[7,50],"cancer-related":[9],"deaths":[10],"in":[11,20,80,84,87],"United":[13],"States":[14],"and":[15,86],"a":[16,60],"diagnosed":[18,24],"American":[21],"men.":[22],"Newly":[23],"cases":[25,35],"prostate":[27,52,62],"approach":[29],"rapidly":[30],"number":[32],"200,000":[34],"per":[36],"year.":[37],"Genetic":[38],"alterations":[39],"tumor":[41,63,73],"suppressor":[42,64,74],"genes":[43],"are":[44,70],"most":[48],"common":[49],"tumorigenesis.":[54],"Our":[55],"group":[56],"identified":[57],"Hssh3bp1":[58],"as":[59],"candidate":[61,78],"gene.":[65],"In":[66],"this":[67],"research":[68],"we":[69],"testing":[71],"function":[75],"gene":[79],"prostatic":[81],"adenocarcinoma":[82],"using":[83],"vitro":[85],"vivo":[88],"assays.":[89]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}