{"id":"https://openalex.org/W1585941552","doi":"https://doi.org/10.1016/s0021-9258(19)75873-6","title":"Chromaffin cell calcium channel kinetics measured isotopically through fast calcium, strontium, and barium fluxes.","display_name":"Chromaffin cell calcium channel kinetics measured isotopically through fast calcium, strontium, and barium fluxes.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W1585941552","doi":"https://doi.org/10.1016/s0021-9258(19)75873-6","mag":"1585941552","pmid":"https://pubmed.ncbi.nlm.nih.gov/2433271"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)75873-6","doi":"https://doi.org/10.1016/s0021-9258(19)75873-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)75873-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)75873-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061438758","display_name":"Cristina R. Artalejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C R Artalejo","raw_affiliation_strings":["Universidad, de Alicante"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad, de Alicante","institution_ids":["https://openalex.org/I130194489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743225","display_name":"Antonio G. Garc\u0131\u0301a","orcid":"https://orcid.org/0000-0002-6517-3565","observed_orcids":["https://orcid.org/0000-0002-6517-3565"]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A G Garc\u00eda","raw_affiliation_strings":["Universidad, de Alicante"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad, de Alicante","institution_ids":["https://openalex.org/I130194489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035703982","display_name":"Dominique Aunis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Aunis","raw_affiliation_strings":["Universidad, de Alicante"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad, de Alicante","institution_ids":["https://openalex.org/I130194489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130194489"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.0959,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.9646329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"262","issue":"2","first_page":"915","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8899999856948853},{"id":"https://openalex.org/keywords/strontium-uptake","display_name":"strontium uptake","score":0.871999979019165},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.6069999933242798},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.972000002861023},{"id":"https://openalex.org/keywords/potassium-induced-depolarization","display_name":"potassium depolarization","score":0.6230000257492065},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.6349999904632568},{"id":"https://openalex.org/keywords/calcium-channel-activators","display_name":"calcium channel activators","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C518915863","wikidata":"https://www.wikidata.org/wiki/Q938","display_name":"Strontium","level":2,"score":0.8835846185684204},{"id":"https://openalex.org/C542576722","wikidata":"https://www.wikidata.org/wiki/Q1112","display_name":"Barium","level":2,"score":0.8641116619110107},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7417396306991577},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6387492418289185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.55324387550354},{"id":"https://openalex.org/C108119643","wikidata":"https://www.wikidata.org/wiki/Q544529","display_name":"Strontium-90","level":3,"score":0.5228443741798401},{"id":"https://openalex.org/C189701845","wikidata":"https://www.wikidata.org/wiki/Q382952","display_name":"Isotopes of calcium","level":3,"score":0.45658937096595764},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.4188392162322998},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38617438077926636},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.24035906791687012},{"id":"https://openalex.org/C158973077","wikidata":"https://www.wikidata.org/wiki/Q192900","display_name":"Radionuclide","level":2,"score":0.09525325894355774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07644042372703552},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0554405152797699},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001464","descriptor_name":"Barium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002837","descriptor_name":"Chromaffin Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013324","descriptor_name":"Strontium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)75873-6","doi":"https://doi.org/10.1016/s0021-9258(19)75873-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)75873-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2433271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2433271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)75873-6","doi":"https://doi.org/10.1016/s0021-9258(19)75873-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)75873-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1588129438","https://openalex.org/W1590908262","https://openalex.org/W1775749144","https://openalex.org/W1836994250","https://openalex.org/W1963552271","https://openalex.org/W1967812690","https://openalex.org/W1978667112","https://openalex.org/W1986995324","https://openalex.org/W1987468391","https://openalex.org/W1990737389","https://openalex.org/W1991911579","https://openalex.org/W1995837298","https://openalex.org/W1998872124","https://openalex.org/W2002494441","https://openalex.org/W2005077264","https://openalex.org/W2019215398","https://openalex.org/W2022514816","https://openalex.org/W2024251771","https://openalex.org/W2024988208","https://openalex.org/W2033464027","https://openalex.org/W2034827961","https://openalex.org/W2043383990","https://openalex.org/W2045544906","https://openalex.org/W2048838076","https://openalex.org/W2051017115","https://openalex.org/W2067995523","https://openalex.org/W2069448376","https://openalex.org/W2073521953","https://openalex.org/W2073887161","https://openalex.org/W2079713804","https://openalex.org/W2087125254","https://openalex.org/W2088092037","https://openalex.org/W2091432500","https://openalex.org/W2113943014","https://openalex.org/W2126697794","https://openalex.org/W2130977556","https://openalex.org/W2144457042","https://openalex.org/W2158449270","https://openalex.org/W2410467118","https://openalex.org/W2748378437","https://openalex.org/W4233847460","https://openalex.org/W4237593635","https://openalex.org/W4300613627","https://openalex.org/W4302766443"],"related_works":["https://openalex.org/W1991911579","https://openalex.org/W2015771567","https://openalex.org/W2752307829","https://openalex.org/W2033464027","https://openalex.org/W2068135815","https://openalex.org/W1999835471","https://openalex.org/W2008614256","https://openalex.org/W2007514577","https://openalex.org/W2414399868","https://openalex.org/W1981216534"],"abstract_inverted_index":{"Fast":[0],"Ca2+":[1,34,45,57,64,72,84,86,118,130,141,160,194,236,279,295,315,329],"uptake":[2,87,131,154,161,218,231,237,280,287],"into":[3],"K+-depolarized":[4],"cultured":[5],"bovine":[6],"adrenal":[7],"chromaffin":[8,77,192,259],"cells":[9,22,260],"has":[10],"been":[11],"isotopically":[12],"measured":[13],"in":[14,222,226,239],"a":[15,107,174],"time":[16],"scale":[17],"of":[18,100,117,129,247,258,266,268,271,273,278,313,334,336],"1-10":[19],"s.":[20,114],"Depolarized":[21],"retained":[23],"as":[24,26,122,233,235],"much":[25,108,175],"80-fold":[27],"45Ca2+":[28],"taken":[29,37,170],"up":[30,38,111,171],"by":[31,39,49,62,89],"resting":[32],"cells;":[33,193],"was":[35,47,93,155,165,169,179,219,232,281],"not":[36,199],"fibroblasts":[40],"or":[41,250,321],"endothelial-like":[42],"cells.":[43],"Because":[44],"entry":[46,119,272],"inhibited":[48],"inorganic":[50],"(La3+,":[51],"Co2+,":[52],"Mg2+)":[53],"and":[54,60,102,162,178,195,225,285],"organic":[55],"(nifedipine)":[56],"channel":[58,65],"antagonists":[59],"enhanced":[61],"the":[63,76,96,123,182,264,269,299,311,317,322,332],"activator":[66],"Bay-K-8644,":[67],"it":[68],"seems":[69,301],"clear":[70],"that":[71,327],"gains":[73],"access":[74],"to":[75,104,112,142,210,244,262,302,309],"cell":[78],"cytosol":[79],"mainly":[80],"through":[81,298],"specific":[82],"voltage-dependent":[83],"channels.":[85,338],"evoked":[88],"59":[90],"mM":[91,140,149,203,212,228,241],"K+":[92,204],"linear":[94,156,180,207],"during":[95],"first":[97],"5":[98],"s":[99,137,146],"stimulation":[101],"continued":[103],"rise":[105],"at":[106,138,147,173,253],"slower":[109],"rate":[110,116,177],"60":[113,211,240],"The":[115,151],"became":[120],"steeper":[121],"external":[124],"[Ca2+]":[125],"increased;":[126],"initial":[127],"rates":[128,270,333],"varied":[132],"from":[133],"0.06":[134],"fmol/cells":[135],".":[136,145],"0.125":[139],"2.85":[143],"fmol/cell":[144],"7.5":[148],"Ca2+.":[150],"early":[152],"90Sr2+":[153],"but":[157,205],"faster":[158,176,282],"than":[159,283],"later":[163],"on":[164],"also":[166],"saturated;":[167],"133Ba2+":[168,251],"still":[172],"for":[181,208],"entire":[183],"depolarization":[184],"period":[185],"(2-60":[186],"s).":[187],"Increased":[188],"[K+]":[189],"gradually":[190],"depolarized":[191],"Sr2+":[196],"uptakes":[197],"were":[198,206],"apparent":[200],"below":[201],"30":[202,209],"K+.":[213,242],"In":[214],"contrast,":[215],"substantial":[216],"Ba2+":[217,230,286],"seen":[220],"even":[221],"K+-free":[223],"solutions;":[224],"5.9":[227],"K+,":[229],"high":[234],"obtained":[238],"Five":[243],"ten-second":[245],"pulses":[246],"45Ca2+,":[248],"90Sr2+,":[249],"given":[252],"different":[254],"times":[255],"after":[256],"pre-depolarization":[257],"served":[261],"analyze":[263],"kinetics":[265],"inactivation":[267,335],"each":[274],"divalent":[275],"cation.":[276],"Inactivation":[277],"Sr2+,":[284],"inactivated":[288],"very":[289],"little.":[290],"Neither":[291],"voltage":[292],"changes":[293],"nor":[294],"ions":[296],"passing":[297],"channels":[300],"cause":[303],"their":[304],"inactivation;":[305],"however,":[306],"experiments":[307],"aimed":[308],"manipulate":[310],"levels":[312,330],"internal":[314],"using":[316],"cell-permeable":[318],"chelator":[319],"Quin-2":[320],"ionophore":[323],"A23187":[324],"strongly":[325],"suggest":[326],"intracellular":[328],"determine":[331],"these":[337]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}