{"id":"https://openalex.org/W158578124","doi":null,"title":"Immune responses during and after exercise of constant and alternating intensity above the lactate threshold.","display_name":"Immune responses during and after exercise of constant and alternating intensity above the lactate threshold.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W158578124","mag":"158578124","pmid":"https://pubmed.ncbi.nlm.nih.gov/20842100"},"language":"en","primary_location":{"id":"pmid:20842100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20842100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of sports medicine and physical fitness","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075811498","display_name":"Sofia Spanoudaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S Spanoudaki","raw_affiliation_strings":["Department of Sports Medicine & Biology of Physical Activity, Faculty of Physical Education and Sports Science, University of Athens, Athens, Greece. sspanoud@yahoo.gr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sports Medicine & Biology of Physical Activity, Faculty of Physical Education and Sports Science, University of Athens, Athens, Greece. sspanoud@yahoo.gr","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076417458","display_name":"Maria D. Maridaki","orcid":"https://orcid.org/0000-0003-3458-4633","observed_orcids":["https://orcid.org/0000-0003-3458-4633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Maridaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070595532","display_name":"Maria Tsironi","orcid":"https://orcid.org/0000-0002-0569-6217","observed_orcids":["https://orcid.org/0000-0002-0569-6217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tsironi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081015481","display_name":"George J. Baltopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Baltopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002500959","display_name":"Gregory C. Bogdanis","orcid":"https://orcid.org/0000-0003-3382-0438","observed_orcids":["https://orcid.org/0000-0003-3382-0438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G C Bogdanis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061152919","display_name":"Panagiotis Baltopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Baltopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2102,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57317404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"50","issue":"3","first_page":"363","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-immunology","display_name":"exercise immunology","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lactate-threshold","display_name":"lactate threshold","score":0.8550000190734863},{"id":"https://openalex.org/keywords/prolonged-exercise","display_name":"prolonged exercise","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6496174335479736},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.648871660232544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6159393787384033},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6083663702011108},{"id":"https://openalex.org/C2776811442","wikidata":"https://www.wikidata.org/wiki/Q5420058","display_name":"Exercise intensity","level":4,"score":0.6039799451828003},{"id":"https://openalex.org/C2776294035","wikidata":"https://www.wikidata.org/wiki/Q3480702","display_name":"Lactate threshold","level":5,"score":0.5848726034164429},{"id":"https://openalex.org/C196310339","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"VO2 max","level":4,"score":0.574333906173706},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.5310742259025574},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5198386311531067},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.44868505001068115},{"id":"https://openalex.org/C541528975","wikidata":"https://www.wikidata.org/wiki/Q53121","display_name":"Cycling","level":2,"score":0.4223380386829376},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41735750436782837},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.23946449160575867},{"id":"https://openalex.org/C2992422156","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Blood lactate","level":4,"score":0.23169246315956116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14174437522888184},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09641417860984802},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20842100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20842100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of sports medicine and physical fitness","raw_type":"Journal Article"},{"id":"mag:158578124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20842100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W15064424","https://openalex.org/W1758661319","https://openalex.org/W1971412240","https://openalex.org/W1974660325","https://openalex.org/W1978158181","https://openalex.org/W1988501271","https://openalex.org/W1996746152","https://openalex.org/W2011637488","https://openalex.org/W2022909079","https://openalex.org/W2036976011","https://openalex.org/W2048321333","https://openalex.org/W2060683702","https://openalex.org/W2067445057","https://openalex.org/W2072556012","https://openalex.org/W2072814609","https://openalex.org/W2082417333","https://openalex.org/W2084207055","https://openalex.org/W2087504527","https://openalex.org/W2088355439","https://openalex.org/W2089122356","https://openalex.org/W2092239906","https://openalex.org/W2092804935","https://openalex.org/W2093845352","https://openalex.org/W2098057749","https://openalex.org/W2098176136","https://openalex.org/W2099490660","https://openalex.org/W2111074957","https://openalex.org/W2149171039","https://openalex.org/W2153335704","https://openalex.org/W2157554312","https://openalex.org/W2158419796","https://openalex.org/W2158859101","https://openalex.org/W2162357955","https://openalex.org/W2285204915"],"related_works":["https://openalex.org/W2745314962","https://openalex.org/W4294819862","https://openalex.org/W2072556012","https://openalex.org/W4381609752","https://openalex.org/W2007207753","https://openalex.org/W1991286636","https://openalex.org/W2026229676","https://openalex.org/W2401684428","https://openalex.org/W3124212715","https://openalex.org/W7203568473"],"abstract_inverted_index":{"AIM:":[0],"Intense":[1],"and":[2,30,34,40,47,83,134,139,188,205,223,232],"prolonged":[3,36,221],"exercise":[4,37,59,68,106,138,155,187,195,213,226],"greatly":[5],"affects":[6],"circulating":[7],"cytokine":[8],"levels.":[9],"The":[10],"purpose":[11],"of":[12,38,43,74,85,98,112,117,137,177,186,227,241],"this":[13],"study":[14],"was":[15,70,108,161,168,189,208],"to":[16,96,179,196,235],"investigate":[17],"the":[18,44,92,99,103,113,153,184,211,228],"possible":[19],"changes":[20,238],"in":[21,149,170,203,239,244],"tumour":[22],"necrosis":[23],"factor":[24],"-a":[25],"(TNF-a),":[26],"interleukin":[27],"6":[28],"(IL-6)":[29],"cortisol":[31,128,206],"concentrations":[32,151,207],"during":[33],"after":[35,120],"constant":[39,109,222],"alternating":[41,224],"intensity":[42,69,94,107,225,231],"same":[45,229],"duration":[46,233],"total":[48],"work":[49],"performed.":[50],"METHODS:":[51],"Ten":[52],"male":[53],"subjects":[54],"underwent":[55],"two":[56,154,212],"main":[57],"cycling":[58],"trials":[60],"lasting":[61],"one":[62,66],"hour":[63,141,193],"each.":[64],"On":[65,102],"occasion,":[67,105],"alternated":[71],"between":[72,152,210],"46.5\u00b11.9%":[73],"maximal":[75],"oxygen":[76],"uptake":[77],"(VO2max":[78],")":[79],"for":[80,87],"40":[81],"s":[82],"120%":[84],"VO2max":[86],"20":[88],"s,":[89],"so":[90],"that":[91],"mean":[93,230],"corresponded":[95],"105%":[97,111],"lactate":[100,114],"threshold.":[101,115],"other":[104],"at":[110,131,183],"Levels":[116],"TNF-a,":[118],"IL-6":[119,204],"lipo":[121],"polysaccharide":[122],"(LPS)":[123],"stimulation":[124],"as":[125,127],"well":[126],"were":[129,147],"measured":[130],"rest,":[132],"30":[133],"60":[135],"minutes":[136],"1":[140,192],"after.":[142],"RESULTS:":[143],"No":[144,200],"significant":[145,163,201],"differences":[146],"observed":[148,209],"TNF-a":[150,167],"protocols":[156,214],"(P=":[157],"0.75),":[158],"but":[159],"there":[160],"a":[162,174],"time":[164],"effect":[165],"(P<0.01).":[166,199],"increased":[169],"both":[171],"groups":[172],"from":[173],"resting":[175],"value":[176],"436.1\u00b1102.5":[178],"649.5\u00b1187.7":[180],"pg/mL":[181,198],"(P<0.05)":[182],"end":[185],"subsequently":[190],"decreased":[191],"post":[194],"305.9\u00b178.8":[197],"difference":[202],"(P=0.13,":[215],"P=0.10":[216],"accordingly).":[217],"CONCLUSION:":[218],"In":[219],"conclusion,":[220],"seemed":[234],"provoke":[236],"similar":[237],"aspects":[240],"immune":[242],"response":[243],"healthy":[245],"subjects.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}