{"id":"https://openalex.org/W1585780071","doi":"https://doi.org/10.1002/ange.201101042","title":"Pan\u2010Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells","display_name":"Pan\u2010Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells","publication_year":2011,"publication_date":"2011-05-05","ids":{"openalex":"https://openalex.org/W1585780071","doi":"https://doi.org/10.1002/ange.201101042","mag":"1585780071"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201101042","doi":"https://doi.org/10.1002/ange.201101042","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201101042","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.mit.edu/bitstream/1721.1/73479/1/Jaenisch_Pan-Src%20Family.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010403946","display_name":"Judith Staerk","orcid":"https://orcid.org/0000-0001-8698-6998","observed_orcids":["https://orcid.org/0000-0001-8698-6998"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Staerk","raw_affiliation_strings":["These authors contributed equally to this study","Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085494535","display_name":"Costas Andreas Lyssiotis","orcid":"https://orcid.org/0000-0001-9309-6141","observed_orcids":["https://orcid.org/0000-0001-9309-6141"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Costas A. Lyssiotis","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","These authors contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"These authors contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042962359","display_name":"Lea A. Medeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lea A. Medeiro","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009038754","display_name":"Michael J. Bollong","orcid":"https://orcid.org/0000-0001-9439-1476","observed_orcids":["https://orcid.org/0000-0001-9439-1476"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bollong","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014219037","display_name":"Ruth K. Foreman","orcid":"https://orcid.org/0000-0001-7404-8419","observed_orcids":["https://orcid.org/0000-0001-7404-8419"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth K. Foreman","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054437147","display_name":"Shoutian Zhu","orcid":"https://orcid.org/0000-0001-6748-225X","observed_orcids":["https://orcid.org/0000-0001-6748-225X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoutian Zhu","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102266084","display_name":"Michael E. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Garcia","raw_affiliation_strings":["The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066738691","display_name":"Qing Gao","orcid":"https://orcid.org/0009-0000-9854-9250","observed_orcids":["https://orcid.org/0009-0000-9854-9250"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Gao","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024237316","display_name":"Laure C. Bouchez","orcid":"https://orcid.org/0000-0003-4583-6760","observed_orcids":["https://orcid.org/0000-0003-4583-6760"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laure C. Bouchez","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049449840","display_name":"Luke L. Lairson","orcid":"https://orcid.org/0000-0001-6701-996X","observed_orcids":["https://orcid.org/0000-0001-6701-996X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke L. Lairson","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047447504","display_name":"Bradley D. Charette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley D. Charette","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053856031","display_name":"\u013dubica Supekov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lubica Supekova","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056076888","display_name":"Jeffrey Janes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Janes","raw_affiliation_strings":["The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051085161","display_name":"Achim Brinker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Achim Brinker","raw_affiliation_strings":["The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062921663","display_name":"Charles Y. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Y. Cho","raw_affiliation_strings":["The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (USA)","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087185533","display_name":"Rudolf Jaenisch","orcid":"https://orcid.org/0000-0002-2540-7099","observed_orcids":["https://orcid.org/0000-0002-2540-7099"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rudolf Jaenisch","raw_affiliation_strings":["Peter G. Schultz, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter G. Schultz, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066008654","display_name":"Peter G. Schultz","orcid":"https://orcid.org/0000-0003-3188-1202","observed_orcids":["https://orcid.org/0000-0003-3188-1202"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter G. Schultz","raw_affiliation_strings":["Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","Peter G. Schultz, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Peter G. Schultz, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (USA)","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066008654","https://openalex.org/A5087185533"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.2176,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48519913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"123","issue":"25","first_page":"5852","last_page":"5854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-family-kinase-inhibitor","display_name":"Src family kinase inhibitor","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.7419999837875366},{"id":"https://openalex.org/keywords/direct-reprogramming","display_name":"direct reprogramming","score":0.8799999952316284},{"id":"https://openalex.org/keywords/somatic-cell-reprogramming","display_name":"somatic cell reprogramming","score":0.847000002861023},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.824999988079071},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.8834387063980103},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.803887128829956},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.7640759944915771},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43649184703826904},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.42761868238449097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42077741026878357},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3388262093067169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2771952748298645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2199113667011261},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11525046825408936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06818300485610962},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.06203898787498474}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ange.201101042","doi":"https://doi.org/10.1002/ange.201101042","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201101042","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/73479","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/73479","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/73479/1/Jaenisch_Pan-Src%20Family.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/73479","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/73479","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/73479/1/Jaenisch_Pan-Src%20Family.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1585780071.pdf","grobid_xml":"https://content.openalex.org/works/W1585780071.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1966758700","https://openalex.org/W1992336935","https://openalex.org/W2010031978","https://openalex.org/W2029387074","https://openalex.org/W2030299771","https://openalex.org/W2031569048","https://openalex.org/W2036988959","https://openalex.org/W2047015004","https://openalex.org/W2067191435","https://openalex.org/W2089966673","https://openalex.org/W2090895449","https://openalex.org/W2106374535","https://openalex.org/W2108241558","https://openalex.org/W2138977668","https://openalex.org/W2145615770","https://openalex.org/W2151220680","https://openalex.org/W2158544588","https://openalex.org/W2167121336"],"related_works":["https://openalex.org/W330755297","https://openalex.org/W2793364050","https://openalex.org/W1987965707","https://openalex.org/W1966675386","https://openalex.org/W2104708641","https://openalex.org/W7099537350","https://openalex.org/W2007945346","https://openalex.org/W2151220680","https://openalex.org/W7097919442","https://openalex.org/W4236874697"],"abstract_inverted_index":{"Kleine":[0],"Molek\u00fcle":[1],"erledigen":[2],"den":[3,33],"Job:":[4],"Somatische":[5],"Zellen":[6],"werden":[7,39],"durch":[8],"ektopische":[9],"Expression":[10],"von":[11,58],"Oct4,":[12],"Sox2,":[13],"Klf4":[14],"und":[15,49],"c-Myc":[16],"in":[17],"iPS-Zellen":[18,59],"umprogrammiert.":[19],"Mithilfe":[20],"eines":[21],"zellbasierten":[22],"Hochdurchsatz-Screenings":[23],"wurden":[24],"Inhibitoren":[25],"der":[26,44],"Src-Kinase":[27],"(SFK)":[28],"als":[29],"\u201echemischer":[30],"Ersatz\u201c":[31],"f\u00fcr":[32],"retroviralen":[34],"Sox2-Transport":[35],"identifiziert.":[36],"Diese":[37],"Verbindungen":[38],"genutzt,":[40],"um":[41],"die":[42,55],"Mechanismen":[43],"direkten":[45],"Umprogrammierung":[46],"zu":[47,63],"untersuchen,":[48],"sie":[50],"k\u00f6nnten":[51],"letztlich":[52],"dazu":[53],"beitragen,":[54],"klinische":[56],"Anwendung":[57],"einen":[60],"Schritt":[61],"n\u00e4her":[62],"bringen.":[64]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2016-06-24T00:00:00"}