{"id":"https://openalex.org/W1585570053","doi":"https://doi.org/10.4049/jimmunol.0802368","title":"Transitional B Cells Exhibit a B Cell Receptor-Specific Nuclear Defect in Gene Transcription","display_name":"Transitional B Cells Exhibit a B Cell Receptor-Specific Nuclear Defect in Gene Transcription","publication_year":2009,"publication_date":"2009-02-20","ids":{"openalex":"https://openalex.org/W1585570053","doi":"https://doi.org/10.4049/jimmunol.0802368","mag":"1585570053","pmid":"https://pubmed.ncbi.nlm.nih.gov/19234182","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694130"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.0802368","doi":"https://doi.org/10.4049/jimmunol.0802368","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0802368","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045226464","display_name":"Sarah F. Andrews","orcid":"https://orcid.org/0000-0002-2583-1949","observed_orcids":["https://orcid.org/0000-0002-2583-1949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah F Andrews","raw_affiliation_strings":["Department of Immunology","*Department of Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"*Department of Immunology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027470095","display_name":"David J. Rawlings","orcid":"https://orcid.org/0000-0002-0810-1776","observed_orcids":["https://orcid.org/0000-0002-0810-1776","https://orcid.org/0000-0003-4370-4772"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J Rawlings","raw_affiliation_strings":["Department of Immunology","\u2020Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195","*Department of Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"\u2020Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"*Department of Immunology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027470095"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.669,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.82766599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"182","issue":"5","first_page":"2868","last_page":"2878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transitional-b-cells","display_name":"transitional B cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7889999747276306},{"id":"https://openalex.org/keywords/transcriptional-defects","display_name":"transcriptional defects","score":0.7549999952316284},{"id":"https://openalex.org/keywords/a1-gene","display_name":"A1 gene","score":0.6330000162124634},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.777999997138977},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nfat1","display_name":"NFAT1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5376215577125549},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5136858820915222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4816364347934723},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44896697998046875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4301983118057251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35735923051834106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21020877361297607},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.0802368","doi":"https://doi.org/10.4049/jimmunol.0802368","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0802368","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19234182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19234182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2694130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694130","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2694130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694130","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6335822330","display_name":"Model for Gene Therapy in X-linked Agammaglobulinemia","funder_award_id":"R01CA081140","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6840800033","display_name":"Regulation of B Cell Development and Signaling by Btk","funder_award_id":"R01HD037091","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W202503473","https://openalex.org/W1482234266","https://openalex.org/W1498243670","https://openalex.org/W1535444616","https://openalex.org/W1589683070","https://openalex.org/W1595532902","https://openalex.org/W1602448887","https://openalex.org/W1673038424","https://openalex.org/W1826755587","https://openalex.org/W1929112290","https://openalex.org/W1966949480","https://openalex.org/W1974162725","https://openalex.org/W1985118687","https://openalex.org/W1987108454","https://openalex.org/W1989560823","https://openalex.org/W1992714205","https://openalex.org/W1997555839","https://openalex.org/W2000111555","https://openalex.org/W2001625025","https://openalex.org/W2015083674","https://openalex.org/W2044467049","https://openalex.org/W2045640927","https://openalex.org/W2049481139","https://openalex.org/W2054891276","https://openalex.org/W2067938485","https://openalex.org/W2069265397","https://openalex.org/W2071776905","https://openalex.org/W2076198413","https://openalex.org/W2110528006","https://openalex.org/W2111135552","https://openalex.org/W2112801769","https://openalex.org/W2114546337","https://openalex.org/W2117455815","https://openalex.org/W2117817795","https://openalex.org/W2119490532","https://openalex.org/W2127463671","https://openalex.org/W2138804143","https://openalex.org/W2139374966","https://openalex.org/W2141269592","https://openalex.org/W2144972166","https://openalex.org/W2147760686","https://openalex.org/W2149334947","https://openalex.org/W2150597600","https://openalex.org/W2157740207","https://openalex.org/W2163585878","https://openalex.org/W2205422166"],"related_works":["https://openalex.org/W28460437","https://openalex.org/W2467476999","https://openalex.org/W1826755587","https://openalex.org/W4313387796","https://openalex.org/W1885370713","https://openalex.org/W2144972166","https://openalex.org/W2000589064","https://openalex.org/W2034428873","https://openalex.org/W7131785748","https://openalex.org/W2138843126"],"abstract_inverted_index":{"The":[0],"signaling":[1,28],"programs":[2],"that":[3,129],"enforce":[4],"negative":[5],"selection":[6],"in":[7,13,29,38,52,62,103,112],"early":[8],"transitional":[9],"(T1)":[10],"B":[11,35,43,105,131],"cells":[12,132],"response":[14,53],"to":[15,40,46,54,84],"BCR":[16,27,55],"engagement":[17,56],"remain":[18],"poorly":[19],"defined.":[20],"We":[21],"conducted":[22],"a":[23,59,109],"comprehensive":[24],"comparison":[25],"of":[26,64,72],"T1":[30,104,130],"vs":[31],"follicular":[32,41],"mature":[33,42],"splenic":[34],"cells.":[36,106],"T1,":[37],"contrast":[39],"cells,":[44],"failed":[45],"express":[47],"key":[48],"NF-kappaB":[49,95],"target":[50],"genes":[51,77],"and":[57,75,79,82,91,98,137],"exhibited":[58],"striking":[60],"defect":[61],"assembly":[63],"an":[65],"active":[66],"transcriptional":[67,123],"complex":[68],"at":[69],"the":[70,73],"promoter":[71],"survival":[74],"proliferative":[76],"A1":[78],"c-Myc.":[80],"Surprisingly,":[81],"contrary":[83],"previous":[85],"models,":[86],"classical":[87],"protein":[88],"kinase":[89,93],"C":[90],"IkappaB":[92],"activation,":[94],"nuclear":[96],"translocation":[97],"DNA":[99],"binding":[100],"were":[101],"intact":[102],"Furthermore,":[107],"despite":[108],"marked":[110],"reduction":[111],"NFAT1":[113],"expression,":[114],"differential":[115],"NFAT":[116],"or":[117],"AP-1":[118],"activation":[119],"cannot":[120],"explain":[121],"this":[122],"defect.":[124],"Our":[125],"combined":[126],"findings":[127],"demonstrate":[128],"are":[133],"programmed":[134],"for":[135],"signal-":[136],"stage-specific":[138],"\"nuclear":[139],"nonresponsiveness\"":[140],"upon":[141],"encounter":[142],"with":[143],"self-Ags.":[144]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}