{"id":"https://openalex.org/W1585390653","doi":null,"title":"Pathogenesis of growth failure in renal diseases.","display_name":"Pathogenesis of growth failure in renal diseases.","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W1585390653","mag":"1585390653","pmid":"https://pubmed.ncbi.nlm.nih.gov/18583772"},"language":"en","primary_location":{"id":"pmid:18583772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18583772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108594109","display_name":"Tahir Masood Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139324","display_name":"Post Graduate Medical Institute","ror":"https://ror.org/03b982x90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210139324"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"T M Ahmed","raw_affiliation_strings":["Nephrology Division, Children\u2032s Medical Center, Richmond, Virginia, USA","Department of Pediatrics, Postgraduate Medical Institute, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Children\u2032s Medical Center, Richmond, Virginia, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Postgraduate Medical Institute, Lahore, Pakistan","institution_ids":["https://openalex.org/I4210139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065320011","display_name":"Zhe-Wen Yi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z W Yi","raw_affiliation_strings":["Department of Pediatrics, Hunan Medical University, Hunan, People's Republic of China, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hunan Medical University, Hunan, People's Republic of China, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105529280","display_name":"James C.M. Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Chan","raw_affiliation_strings":["Nephrology Division, Children's Medical Center, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Children's Medical Center, Richmond, Virginia, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06857541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4","first_page":"466","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13091","display_name":"Human Health and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-failure","display_name":"growth failure","score":0.984000027179718},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8410000205039978},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.6690000295639038},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8610000014305115},{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/turner-syndrome","display_name":"Turner syndrome","score":0.8479999899864197},{"id":"https://openalex.org/keywords/exogenous-growth-hormone","display_name":"exogenous growth hormone","score":0.7730000019073486},{"id":"https://openalex.org/keywords/growth-plate-closure","display_name":"growth plate closure","score":0.9039999842643738},{"id":"https://openalex.org/keywords/adult-height","display_name":"adult height","score":0.7139999866485596},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5590000152587891},{"id":"https://openalex.org/keywords/pediatric-renal-failure","display_name":"pediatric renal failure","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8438457250595093},{"id":"https://openalex.org/C2993356106","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal failure","level":2,"score":0.6858976483345032},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.6360864639282227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5871596336364746},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5719578266143799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5387981534004211},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5369906425476074},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5325806140899658},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4625202417373657},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.460754930973053},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.45645779371261597},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18658798933029175}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:18583772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18583772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia","raw_type":"Journal Article"},{"id":"mag:1585390653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18583772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034892136","https://openalex.org/W2063106801","https://openalex.org/W4328047882","https://openalex.org/W2106844782","https://openalex.org/W2146864318","https://openalex.org/W7097854819","https://openalex.org/W2243359242","https://openalex.org/W2003084947","https://openalex.org/W2075893087","https://openalex.org/W36269935"],"abstract_inverted_index":{"This":[0],"article":[1],"reviews":[2],"our":[3],"current":[4],"understanding":[5,84],"of":[6,9,19,32,57,68,80,85,94,108],"the":[7,55,69,77,95,105],"mechanisms":[8],"growth":[10,20,25,59,63,70,86,101,106],"failure":[11],"in":[12,44,76],"chronic":[13,111],"renal":[14,112],"disease.":[15],"The":[16],"neuro-endocrine":[17],"control":[18],"hormone":[21,47,60,102],"secretion":[22],"and":[23,35,91],"insulin-like":[24],"factor":[26],"gene":[27],"expression":[28],"subject":[29],"to":[30,99,103],"use":[31,56,100],"corticosteroids,":[33],"uremia,":[34],"metabolic":[36],"acidosis":[37],"are":[38],"presented.":[39],"It":[40],"has":[41],"been":[42],"shown":[43],"other":[45],"non-growth":[46],"deficient":[48],"conditions":[49],"such":[50,81],"as":[51],"Turner's":[52],"syndrome":[53],"that":[54],"exogenous":[58],"increases":[61],"linear":[62],"but":[64],"also":[65],"accelerates":[66],"closure":[67],"plate":[71],"with":[72,110],"no":[73],"significant":[74],"difference":[75],"final":[78],"height":[79],"children.":[82],"An":[83],"factors":[87],"is":[88],"especially":[89],"important":[90],"timely":[92],"because":[93],"tendency":[96],"these":[97],"days":[98],"overcome":[104],"impairment":[107],"children":[109],"failure.":[113]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}