{"id":"https://openalex.org/W1585385261","doi":"https://doi.org/10.1016/s1054-3589(10)58008-6","title":"GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?","display_name":"GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1585385261","doi":"https://doi.org/10.1016/s1054-3589(10)58008-6","mag":"1585385261","pmid":"https://pubmed.ncbi.nlm.nih.gov/20655483"},"language":"en","primary_location":{"id":"doi:10.1016/s1054-3589(10)58008-6","doi":"https://doi.org/10.1016/s1054-3589(10)58008-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1054-3589(10)58008-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764403048","display_name":"Advances in pharmacology","issn_l":"1054-3589","issn":["1054-3589","1557-8925"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4213309136","display_name":"GABABReceptor Pharmacology - A Tribute to Norman Bowery"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021113194","display_name":"Guillermo Gonz\u00e1lez\u2010Burgos","orcid":"https://orcid.org/0000-0002-1650-8111","observed_orcids":["https://orcid.org/0000-0002-1650-8111"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guillermo Gonzalez-Burgos","raw_affiliation_strings":["Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021113194"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":3.0697,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90909091,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"58","issue":null,"first_page":"175","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gat1","display_name":"GABA transporter 1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gaba-uptake","display_name":"GABA uptake","score":0.6909999847412109},{"id":"https://openalex.org/keywords/volume-transmission","display_name":"volume transmission","score":0.6650000214576721},{"id":"https://openalex.org/keywords/neurogliaform-cells","display_name":"neurogliaform cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extrasynaptic-gaba-receptors","display_name":"extrasynaptic GABA receptors","score":0.734000027179718},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6069999933242798},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.984000027179718},{"id":"https://openalex.org/keywords/cortical-circuits","display_name":"cortical circuits","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2779046065","wikidata":"https://www.wikidata.org/wiki/Q5512772","display_name":"GABA transporter","level":4,"score":0.8595861196517944},{"id":"https://openalex.org/C101027131","wikidata":"https://www.wikidata.org/wiki/Q305671","display_name":"GABAB receptor","level":4,"score":0.7300241589546204},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.644868791103363},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6074050664901733},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5990270972251892},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.539404034614563},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5135765075683594},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4803291857242584},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.475793719291687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47578418254852295},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.4424826502799988},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4271981120109558},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4206516742706299},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.396023690700531},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3012596666812897},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.18847694993019104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18803885579109192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1054-3589(10)58008-6","doi":"https://doi.org/10.1016/s1054-3589(10)58008-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1054-3589(10)58008-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764403048","display_name":"Advances in pharmacology","issn_l":"1054-3589","issn":["1054-3589","1557-8925"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Pharmacology","raw_type":"book-chapter"},{"id":"pmid:20655483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20655483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in pharmacology (San Diego, Calif.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7283109748","display_name":"Schizophrenia and synaptic pruning: Circuit specificity and functional consequences","funder_award_id":"R01MH051234","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8057162315","display_name":"Cortical Circuitry and Cognition in Schizophrenia","funder_award_id":"P50MH045156","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W40087780","https://openalex.org/W1496712779","https://openalex.org/W1516995431","https://openalex.org/W1539985358","https://openalex.org/W1540301663","https://openalex.org/W1626546769","https://openalex.org/W1816535894","https://openalex.org/W1907932603","https://openalex.org/W1965368090","https://openalex.org/W1965432565","https://openalex.org/W1966235122","https://openalex.org/W1967159960","https://openalex.org/W1967212780","https://openalex.org/W1969220120","https://openalex.org/W1969319931","https://openalex.org/W1972124891","https://openalex.org/W1972475596","https://openalex.org/W1972927593","https://openalex.org/W1973422952","https://openalex.org/W1973967768","https://openalex.org/W1986854793","https://openalex.org/W1987274984","https://openalex.org/W1990429945","https://openalex.org/W1991674752","https://openalex.org/W1993861337","https://openalex.org/W1994376562","https://openalex.org/W1995831678","https://openalex.org/W1997185390","https://openalex.org/W1997597168","https://openalex.org/W1997964026","https://openalex.org/W1998836167","https://openalex.org/W2001809841","https://openalex.org/W2004000308","https://openalex.org/W2004937932","https://openalex.org/W2005492539","https://openalex.org/W2008027377","https://openalex.org/W2009074192","https://openalex.org/W2009849655","https://openalex.org/W2010142838","https://openalex.org/W2010575361","https://openalex.org/W2010687489","https://openalex.org/W2010741244","https://openalex.org/W2012534285","https://openalex.org/W2022200746","https://openalex.org/W2025438498","https://openalex.org/W2025603247","https://openalex.org/W2026307239","https://openalex.org/W2028275444","https://openalex.org/W2028345114","https://openalex.org/W2029396149","https://openalex.org/W2030028265","https://openalex.org/W2030434469","https://openalex.org/W2030857678","https://openalex.org/W2033712795","https://openalex.org/W2036038058","https://openalex.org/W2036236793","https://openalex.org/W2036270719","https://openalex.org/W2037228043","https://openalex.org/W2039075215","https://openalex.org/W2039923977","https://openalex.org/W2045066453","https://openalex.org/W2047494050","https://openalex.org/W2047989218","https://openalex.org/W2048058806","https://openalex.org/W2050658671","https://openalex.org/W2051521732","https://openalex.org/W2051838555","https://openalex.org/W2052987076","https://openalex.org/W2053739364","https://openalex.org/W2058022492","https://openalex.org/W2059058978","https://openalex.org/W2059849120","https://openalex.org/W2061619540","https://openalex.org/W2061830798","https://openalex.org/W2062450961","https://openalex.org/W2064273523","https://openalex.org/W2064547319","https://openalex.org/W2065229434","https://openalex.org/W2065341515","https://openalex.org/W2066015662","https://openalex.org/W2069466082","https://openalex.org/W2071847743","https://openalex.org/W2072050520","https://openalex.org/W2072761349","https://openalex.org/W2076742747","https://openalex.org/W2078393981","https://openalex.org/W2078529082","https://openalex.org/W2079839420","https://openalex.org/W2083954196","https://openalex.org/W2086302525","https://openalex.org/W2087356150","https://openalex.org/W2087605748","https://openalex.org/W2089912569","https://openalex.org/W2093098283","https://openalex.org/W2093428018","https://openalex.org/W2094771978","https://openalex.org/W2095938336","https://openalex.org/W2096940802","https://openalex.org/W2101350611","https://openalex.org/W2101574677","https://openalex.org/W2108216486","https://openalex.org/W2112075758","https://openalex.org/W2112541959","https://openalex.org/W2114745427","https://openalex.org/W2118625847","https://openalex.org/W2119343718","https://openalex.org/W2130937345","https://openalex.org/W2131300789","https://openalex.org/W2132949747","https://openalex.org/W2133743587","https://openalex.org/W2134113708","https://openalex.org/W2137303555","https://openalex.org/W2137499349","https://openalex.org/W2138412572","https://openalex.org/W2140252540","https://openalex.org/W2144571934","https://openalex.org/W2153297917","https://openalex.org/W2155924534","https://openalex.org/W2156780983","https://openalex.org/W2165544326","https://openalex.org/W2166454523","https://openalex.org/W2168960186","https://openalex.org/W2172091985","https://openalex.org/W2338442167","https://openalex.org/W2340859740","https://openalex.org/W4245746501","https://openalex.org/W4406056462"],"related_works":["https://openalex.org/W2133743587","https://openalex.org/W2125867435","https://openalex.org/W1816535894","https://openalex.org/W2059058978","https://openalex.org/W2338983518","https://openalex.org/W2134113708","https://openalex.org/W7098413311","https://openalex.org/W2036895793","https://openalex.org/W2130236716","https://openalex.org/W1964219023"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
