{"id":"https://openalex.org/W1585340441","doi":null,"title":"COMPARATIVE ANALYSIS OF TWO HUMAN CANCER CELL LINES FOLLOWING EXPOSURE TO LOW DOSE RADIATION","display_name":"COMPARATIVE ANALYSIS OF TWO HUMAN CANCER CELL LINES FOLLOWING EXPOSURE TO LOW DOSE RADIATION","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1585340441","mag":"1585340441"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3491060","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3491060","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3491060","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085759432","display_name":"Gladys N. Nangami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gladys N. Nangami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085759432"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hyper-radiosensitivity","display_name":"hyper-radiosensitivity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/a375-cells","display_name":"A375 cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":1.0},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.875},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.8794798851013184},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.7857377529144287},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5881096720695496},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.5782104730606079},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5409241318702698},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.538589358329773},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5232283473014832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45871761441230774},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45224085450172424},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4410550594329834},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.43556857109069824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43481868505477905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.326659619808197},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.31777477264404297},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3002775311470032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1935361623764038},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1087493896484375},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06662312150001526},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3491060","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3491060","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3491060","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/3718","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/3718","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Dissertation"},{"id":"mag:1585340441","doi":null,"is_oa":false,"landing_page_url":"https://libres.uncg.edu/ir/listing.aspx?id=13912","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W58564167","https://openalex.org/W74583960","https://openalex.org/W176066471","https://openalex.org/W284891813","https://openalex.org/W1442759872","https://openalex.org/W1480741751","https://openalex.org/W1487384429","https://openalex.org/W1498514627","https://openalex.org/W1538460486","https://openalex.org/W1541317652","https://openalex.org/W1553763991","https://openalex.org/W1560653098","https://openalex.org/W1595724240","https://openalex.org/W1642922668","https://openalex.org/W1661087247","https://openalex.org/W1677015114","https://openalex.org/W1823288226","https://openalex.org/W1867181351","https://openalex.org/W1874688327","https://openalex.org/W1899552864","https://openalex.org/W1909048318","https://openalex.org/W1964043165","https://openalex.org/W1965239527","https://openalex.org/W1969158591","https://openalex.org/W1973614704","https://openalex.org/W1973766879","https://openalex.org/W1974838229","https://openalex.org/W1975664090","https://openalex.org/W1976385326","https://openalex.org/W1980311195","https://openalex.org/W1980467302","https://openalex.org/W1981944548","https://openalex.org/W1981997467","https://openalex.org/W1982513951","https://openalex.org/W1982879218","https://openalex.org/W1984152805","https://openalex.org/W1985542467","https://openalex.org/W1985999867","https://openalex.org/W1986965946","https://openalex.org/W1986978393","https://openalex.org/W1987238939","https://openalex.org/W1987531976","https://openalex.org/W1988756673","https://openalex.org/W1989283929","https://openalex.org/W1990752073","https://openalex.org/W1993151115","https://openalex.org/W1995819749","https://openalex.org/W1995981964","https://openalex.org/W1997382995","https://openalex.org/W2000090965","https://openalex.org/W2001399809","https://openalex.org/W2001617515","https://openalex.org/W2002273417","https://openalex.org/W2002599698","https://openalex.org/W2004433299","https://openalex.org/W2007178736","https://openalex.org/W2007456673","https://openalex.org/W2007653607","https://openalex.org/W2009338295","https://openalex.org/W2009963985","https://openalex.org/W2014134684","https://openalex.org/W2015278083","https://openalex.org/W2016868977","https://openalex.org/W2018896819","https://openalex.org/W2019219567","https://openalex.org/W2021784693","https://openalex.org/W2022811243","https://openalex.org/W2028040595","https://openalex.org/W2029081759","https://openalex.org/W2034860606","https://openalex.org/W2036754489","https://openalex.org/W2038236031","https://openalex.org/W2041444090","https://openalex.org/W2044267903","https://openalex.org/W2044772744","https://openalex.org/W2044958420","https://openalex.org/W2047491571","https://openalex.org/W2049048127","https://openalex.org/W2049598883","https://openalex.org/W2050243029","https://openalex.org/W2053383702","https://openalex.org/W2053622195","https://openalex.org/W2055079159","https://openalex.org/W2059852577","https://openalex.org/W2061181324","https://openalex.org/W2064458964","https://openalex.org/W2072319964","https://openalex.org/W2072720547","https://openalex.org/W2074580412","https://openalex.org/W2074981528","https://openalex.org/W2075104267","https://openalex.org/W2075338210","https://openalex.org/W2076485183","https://openalex.org/W2077463854","https://openalex.org/W2077991187","https://openalex.org/W2080434562","https://openalex.org/W2084147994","https://openalex.org/W2087110475","https://openalex.org/W2089414651","https://openalex.org/W2089741467","https://openalex.org/W2091695331","https://openalex.org/W2092194743","https://openalex.org/W2092535642","https://openalex.org/W2096609221","https://openalex.org/W2096855431","https://openalex.org/W2099888675","https://openalex.org/W2100712519","https://openalex.org/W2101739931","https://openalex.org/W2102752109","https://openalex.org/W2104867280","https://openalex.org/W2109143007","https://openalex.org/W2110998462","https://openalex.org/W2111326679","https://openalex.org/W2111420633","https://openalex.org/W2112699943","https://openalex.org/W2113070607","https://openalex.org/W2115732428","https://openalex.org/W2118364944","https://openalex.org/W2119624494","https://openalex.org/W2119999819","https://openalex.org/W2122314043","https://openalex.org/W2122832395","https://openalex.org/W2124252075","https://openalex.org/W2124501557","https://openalex.org/W2127755436","https://openalex.org/W2128148459","https://openalex.org/W2128252882","https://openalex.org/W2130109206","https://openalex.org/W2132305988","https://openalex.org/W2133817674","https://openalex.org/W2134187229","https://openalex.org/W2135687585","https://openalex.org/W2141057680","https://openalex.org/W2144169031","https://openalex.org/W2145579904","https://openalex.org/W2150483305","https://openalex.org/W2154745425","https://openalex.org/W2159099751","https://openalex.org/W2160176818","https://openalex.org/W2161965319","https://openalex.org/W2162048408","https://openalex.org/W2162873935","https://openalex.org/W2166781237","https://openalex.org/W2171697262","https://openalex.org/W2177380697","https://openalex.org/W2178335293","https://openalex.org/W2220538814","https://openalex.org/W2226516765","https://openalex.org/W2316716290","https://openalex.org/W2318901295","https://openalex.org/W2319143898","https://openalex.org/W2323797330","https://openalex.org/W2331050019","https://openalex.org/W2331130318","https://openalex.org/W2334500330","https://openalex.org/W2335427339","https://openalex.org/W2403478040","https://openalex.org/W3205527923"],"related_works":["https://openalex.org/W2318901295","https://openalex.org/W7100796861","https://openalex.org/W80566716","https://openalex.org/W3031107049","https://openalex.org/W2174227220","https://openalex.org/W1976526493","https://openalex.org/W2124252075","https://openalex.org/W2900037222","https://openalex.org/W139177184","https://openalex.org/W2087187996"],"abstract_inverted_index":{"Over":[0],"the":[1,7,68,93,104,113,127,152,200,215],"past":[2],"two":[3,71,175],"decades,":[4],"studies":[5,52,172],"on":[6],"cellular":[8,21],"response":[9,107],"to":[10,34,53,88,163,185],"very":[11,94,186],"low":[12,55,95,109,138,164,187],"dose":[13,38,51,56,96,110,139,188],"radiation":[14,41,97,111,140],"have":[15,30],"been":[16,32],"revolutionizing":[17],"historically-held":[18],"paradigms":[19],"of":[20,26,40,46,70,131,166,170,206],"radioresponse.":[22],"Indeed,":[23],"a":[24,60],"host":[25],"seemingly":[27],"contradictory":[28,178,216],"events":[29],"recently":[31],"reported":[33],"occur":[35],"within":[36],"this":[37,64],"range":[39],"exposure":[42,141,162,184],"which":[43,86],"make":[44],"extrapolation":[45],"data":[47,201],"derived":[48],"from":[49],"high":[50],"these":[54,143,171],"ranges":[57],"no":[58],"longer":[59],"feasible":[61],"alternative.":[62],"In":[63],"study,":[65],"we":[66,101],"investigate":[67,126],"radioresponse":[69],"human":[72,77,82,115,120],"tumor":[73],"cell":[74,105,123,132,144,208],"lines,":[75],"A375":[76,114,192],"melanoma":[78,116],"cells":[79,117,193],"and":[80,118,129,146,154,177],"PC3":[81,119,197],"prostate":[83,121],"cancer":[84,122],"cells,":[85],"appear":[87],"behave":[89],"quite":[90],"differently":[91],"in":[92,112,142,191,196,214],"range.":[98],"More":[99],"specifically,":[100],"(a)":[102],"characterize":[103],"survival":[106,179,217],"following":[108,137,161,183],"lines;":[124,145],"(b)":[125],"kinetics":[128],"magnitude":[130],"cycle":[133,209],"arrest":[134,210],"that":[135,174,203],"occurs":[136],"(c)":[147],"ascertain":[148],"whether":[149],"signaling":[150],"through":[151],"MAPK":[153],"NF-kB":[155],"proliferative":[156],"pathways":[157],"is":[158],"being":[159],"stimulated":[160],"doses":[165],"radiation.":[167],"The":[168],"results":[169],"demonstrate":[173],"different":[176],"responses":[180,218],"are":[181],"seen":[182],"irradiation":[189],"(hyper-radioresistance":[190],"vs.":[194],"hyper-radiosensitivity":[195],"cells).":[198],"Furthermore,":[199],"indicate":[202],"differential":[204],"regulation":[205],"G2/M":[207],"may":[211],"be":[212],"involved":[213],"observed.":[219]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}