{"id":"https://openalex.org/W1584780424","doi":null,"title":"Interactions between mast cells and smooth muscle in asthma models","display_name":"Interactions between mast cells and smooth muscle in asthma models","publication_year":2014,"publication_date":"2014-04-04","ids":{"openalex":"https://openalex.org/W1584780424","mag":"1584780424"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26909599","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Interactions_between_mast_cells_and_smooth_muscle_in_asthma_models/26909599","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/41946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033232215","display_name":"Lisa Sj\u00f6berg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa Sj\u00f6berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033232215"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/airway-smooth-muscle","display_name":"airway smooth muscle","score":0.9679999947547913},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9900000095367432},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.8579999804496765},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.7450000047683716},{"id":"https://openalex.org/keywords/guinea-pig-asthma-model","display_name":"guinea pig asthma model","score":0.7760000228881836},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cysteinyl-leukotrienes","display_name":"cysteinyl leukotrienes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.8406146168708801},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6797187328338623},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5095279812812805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41766831278800964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39344263076782227},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.359235942363739},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3341144323348999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.312375545501709}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26909599","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Interactions_between_mast_cells_and_smooth_muscle_in_asthma_models/26909599","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41946","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1584780424","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/41946","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/41946","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41946","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":154,"referenced_works":["https://openalex.org/W95323076","https://openalex.org/W192548456","https://openalex.org/W387031605","https://openalex.org/W1491456407","https://openalex.org/W1506574814","https://openalex.org/W1549161029","https://openalex.org/W1575966267","https://openalex.org/W1608228045","https://openalex.org/W1655614253","https://openalex.org/W1747499909","https://openalex.org/W1839982681","https://openalex.org/W1958803494","https://openalex.org/W1964924481","https://openalex.org/W1967722955","https://openalex.org/W1968955229","https://openalex.org/W1969734421","https://openalex.org/W1970703972","https://openalex.org/W1971057004","https://openalex.org/W1971484978","https://openalex.org/W1971523219","https://openalex.org/W1974371579","https://openalex.org/W1975075371","https://openalex.org/W1975453068","https://openalex.org/W1978530217","https://openalex.org/W1979317400","https://openalex.org/W1980761348","https://openalex.org/W1982798885","https://openalex.org/W1983024094","https://openalex.org/W1989048950","https://openalex.org/W1989423035","https://openalex.org/W1989878128","https://openalex.org/W1995357195","https://openalex.org/W2002361100","https://openalex.org/W2004490702","https://openalex.org/W2005546041","https://openalex.org/W2007589345","https://openalex.org/W2007810913","https://openalex.org/W2012103095","https://openalex.org/W2013105339","https://openalex.org/W2013377406","https://openalex.org/W2014273697","https://openalex.org/W2016030444","https://openalex.org/W2018986259","https://openalex.org/W2019100913","https://openalex.org/W2019462229","https://openalex.org/W2021704270","https://openalex.org/W2024158949","https://openalex.org/W2024270259","https://openalex.org/W2024678747","https://openalex.org/W2024713421","https://openalex.org/W2026474727","https://openalex.org/W2026810846","https://openalex.org/W2027278345","https://openalex.org/W2030003617","https://openalex.org/W2030208488","https://openalex.org/W2031230900","https://openalex.org/W2032052491","https://openalex.org/W2034131839","https://openalex.org/W2034203371","https://openalex.org/W2035255427","https://openalex.org/W2036277245","https://openalex.org/W2036611467","https://openalex.org/W2037749979","https://openalex.org/W2038344494","https://openalex.org/W2039252747","https://openalex.org/W2039427688","https://openalex.org/W2041082200","https://openalex.org/W2041151984","https://openalex.org/W2041464595","https://openalex.org/W2043099698","https://openalex.org/W2043990114","https://openalex.org/W2047882259","https://openalex.org/W2049038183","https://openalex.org/W2049374822","https://openalex.org/W2049472311","https://openalex.org/W2050706371","https://openalex.org/W2053664189","https://openalex.org/W2055363992","https://openalex.org/W2066968375","https://openalex.org/W2068044260","https://openalex.org/W2069526125","https://openalex.org/W2069935301","https://openalex.org/W2072731639","https://openalex.org/W2073666097","https://openalex.org/W2074947781","https://openalex.org/W2076145284","https://openalex.org/W2076919380","https://openalex.org/W2076928017","https://openalex.org/W2078489088","https://openalex.org/W2079778462","https://openalex.org/W2080725704","https://openalex.org/W2082370179","https://openalex.org/W2086817396","https://openalex.org/W2086923184","https://openalex.org/W2089627898","https://openalex.org/W2090434004","https://openalex.org/W2092598564","https://openalex.org/W2096349085","https://openalex.org/W2099304880","https://openalex.org/W2101664092","https://openalex.org/W2102139611","https://openalex.org/W2103128166","https://openalex.org/W2103332846","https://openalex.org/W2106301295","https://openalex.org/W2106790228","https://openalex.org/W2107275744","https://openalex.org/W2108030975","https://openalex.org/W2109215307","https://openalex.org/W2109749945","https://openalex.org/W2110109947","https://openalex.org/W2111324396","https://openalex.org/W2112597593","https://openalex.org/W2114507693","https://openalex.org/W2120397322","https://openalex.org/W2121686426","https://openalex.org/W2121872020","https://openalex.org/W2122474832","https://openalex.org/W2123994460","https://openalex.org/W2124678205","https://openalex.org/W2124714277","https://openalex.org/W2127514161","https://openalex.org/W2128293635","https://openalex.org/W2129022159","https://openalex.org/W2130025211","https://openalex.org/W2132110968","https://openalex.org/W2137487999","https://openalex.org/W2139775496","https://openalex.org/W2142528119","https://openalex.org/W2144020033","https://openalex.org/W2145420458","https://openalex.org/W2148198599","https://openalex.org/W2149658541","https://openalex.org/W2150536351","https://openalex.org/W2154196772","https://openalex.org/W2154727149","https://openalex.org/W2155216218","https://openalex.org/W2156822702","https://openalex.org/W2157710399","https://openalex.org/W2162008808","https://openalex.org/W2163111319","https://openalex.org/W2164396254","https://openalex.org/W2165098074","https://openalex.org/W2165277651","https://openalex.org/W2166623795","https://openalex.org/W2169075370","https://openalex.org/W2169282830","https://openalex.org/W2169705646","https://openalex.org/W2169932060","https://openalex.org/W2170040424","https://openalex.org/W2170933008","https://openalex.org/W2171914901","https://openalex.org/W2244716392","https://openalex.org/W2279052585","https://openalex.org/W2417079804"],"related_works":["https://openalex.org/W2044798842","https://openalex.org/W7008988606","https://openalex.org/W2768743333","https://openalex.org/W2132915894","https://openalex.org/W4404101494","https://openalex.org/W2113627909","https://openalex.org/W2049374822","https://openalex.org/W2088602794","https://openalex.org/W2169538072","https://openalex.org/W1982643537"],"abstract_inverted_index":{"Allergic":[0],"asthma":[1,7,58,262,519,552,564,601],"is":[2,9,495,507],"the":[3,38,64,82,124,142,160,170,202,214,228,240,271,291,383,457,461,484,502,505,521,542,592,679],"major":[4],"phenotype":[5],"of":[6,75,93,129,146,150,163,172,196,234,242,279,326,331,378,385,402,414,459,493,504,517,544,567,591,642,673,714],"and":[8,23,27,42,63,87,100,105,121,137,144,148,155,175,178,231,244,312,319,341,362,395,416,431,435,449,478,501,527,554,556,708],"characterized":[10],"by":[11,227,266,509],"specific":[12],"responses":[13,97,190],"to":[14,57,79,213,254,259,336,426,644],"allergens":[15],"as":[16,18,237,239],"well":[17,238],"airway":[19,28,40,189,209,356,596,665,705],"hyperresponsiveness":[20,597],"(AHR),":[21],"inflammation":[22,394,432,448,526,707],"remodelling.":[24,450],"Mast":[25,588,629],"cells":[26,31,86,165,335,550,677],"smooth":[29,292,666],"muscle":[30,293,667],"(ASM)":[32],"play":[33],"an":[34,167,207,323,389,670],"important":[35],"role":[36],"in":[37,89,191,216,221,261,275,287,295,346,358,368,397,433,453,483,532,546,598,636,638,678,710],"allergic":[39,94,197,204,273,280,379,467,498,518,523,634,681],"response":[41,215],"there":[43,251],"are":[44,68,183,252],"several":[45,514],"indications":[46],"that":[47,114,182,201,219,250,284,353,422,473,491],"a":[48,192,276,359,410,420,533,559,599,640,711],"cross-talk":[49],"exists":[50],"between":[51,84,98],"these":[52,61,299],"two":[53,180,398],"cell":[54,108,119,134,153,311,348,476,589,630],"types":[55],"contributing":[56],"pathogenesis.":[59],"However,":[60,159,418],"interactions":[62,83],"mechanisms":[65],"behind":[66],"them":[67],"not":[69],"fully":[70],"understood.":[71],"The":[72,307,328,451,469],"overall":[73],"aim":[74],"this":[76,454],"thesis":[77,455],"was":[78,116,157,309,320],"further":[80,371],"elucidate":[81],"mast":[85,101,107,118,133,164,235,247,310,334,347,360,411,428,475,510,534,549,676],"ASM":[88],"different":[90,232,399],"animal":[91,463],"models":[92,401],"asthma.":[95,130,186,403,468,645,715],"When":[96],"wild-type":[99],"cell-deficient":[102],"mice,":[103,437],"with":[104,185,303,388,440,548,702],"without":[106],"engraftment":[109,590],"were":[110,344,406],"compared,":[111],"we":[112,199,351,381,488,539],"found":[113,200,283],"AHR":[115,147,430],"both":[117],"dependent":[120,318],"independent":[122],"using":[123,255,409,419],"same":[125],"chronic":[126],"mouse":[127,277,400,600,712],"model":[128,195,278,464,641,713],"Although":[131],"pulmonary":[132,474],"number,":[135],"distribution":[136,233,479],"possibly":[138],"prostanoid":[139],"secretion":[140,241,325,672],"influenced":[141,375],"severity":[143,555],"localisation":[145],"levels":[149,171],"specific-IgE,":[151],"inflammatory":[152,499],"infiltration":[154],"remodelling":[156,396],"unaffected.":[158],"mere":[161],"presence":[162],"had":[166],"effect":[168],"on":[169,333,392,446,704],"interleukin":[173],"17":[174],"33":[176,663,698],"(IL-17":[177],"IL-33),":[179],"cytokines":[181],"associated":[184],"By":[187],"studying":[188,267,466],"guinea":[193,256],"pig":[194],"asthma,":[198,380],"early":[203,272,522,633,680],"reaction":[205,274],"caused":[206],"altered":[208],"resistance":[210],"more":[211],"similar":[212],"humans":[217],"than":[218],"seen":[220],"mice.":[222],"This":[223],"could":[224],"be":[225],"explained":[226],"greater":[229],"number":[230,477],"cells,":[236,248],"histamine":[243],"cysteinyl-leukotrienes":[245],"from":[246,298,675],"suggesting":[249],"advantages":[253],"pigs":[257],"compared":[258],"mice":[260,289,300],"research.":[263],"We":[264,282],"continued":[265],"how":[268,373],"IL-33":[269,286,332,354,374,386,438,494,512,545],"affected":[270,508],"sensitisation.":[281],"intranasal":[285],"sensitised":[288,434],"increased":[290,355,496],"contraction":[294,668],"isolated":[296],"airways":[297],"when":[301,408,465],"challenged":[302,436],"allergen":[304,366],"ex":[305],"vivo.":[306,369],"increase":[308,337,506],"IL1RL1":[313],"(the":[314],"receptor":[315],"for":[316,529,551,563],"IL-33)":[317],"mediated":[321],"via":[322,669],"enhanced":[324,671],"serotonin.":[327],"direct":[329],"effects":[330,384,445,701],"their":[338],"production,":[339],"storage":[340],"mediator":[342],"release":[343,492],"confirmed":[345],"cultures.":[349],"Finally,":[350,487],"observed":[352,407],"resistance,":[357],"cell-":[361],"serotonin-dependent":[363],"fashion":[364],"following":[365],"challenge":[367],"To":[370],"investigate":[372],"other":[376],"features":[377,516,531],"studied":[382],"combined":[387,439],"allergenic":[390],"antigen":[391,441,703],"AHR,":[393,447,525],"No":[404],"differences":[405],"cell-independent":[412],"protocol":[413,421],"sensitisation":[415],"challenge.":[417],"has":[423],"been":[424],"shown":[425,490],"induce":[427],"cell-dependent":[429,535],"elicited":[442],"synergistic":[443,700],"deleterious":[444],"studies":[452],"emphasise":[456],"importance":[458,543],"choosing":[460],"appropriate":[462],"findings":[470],"herein":[471],"support":[472],"affects":[480],"lung":[481,594],"function":[482],"disease":[485],"state.":[486],"have":[489,540,557],"during":[497],"conditions,":[500],"level":[503],"cells.":[511],"worsens":[513],"characteristic":[515],"including":[520],"reaction,":[524],"remodelling,":[528],"some":[530],"manner.":[536],"In":[537],"conclusion,":[538],"highlighted":[541],"conjunction":[547],"development":[553],"identified":[558],"potential":[560],"new":[561],"target":[562],"therapy.":[565],"List":[566],"scientific":[568],"papers":[569],"I.":[570],"Fuchs":[571,615],"B,":[572,616],"Sj\u00f6berg":[573,617,652,685],"L,":[574,581,618,622,653,686],"M\u00f6ller":[575],"Westerberg":[576],"C,":[577],"Ekoff":[578],"M,":[579,585,694],"Swedin":[580],"Dahl\u00e9n":[582,623,656],"SE,":[583,624,657],"Adner":[584,627,660,693],"Nilsson":[586,619,658,695],"GP.":[587,696],"peripheral":[593],"enhances":[595],"model.":[602],"Am":[603],"J":[604],"Physiol":[605],"Lung":[606],"Cell":[607],"Mol":[608],"Physiol.":[609],"2012;303(12):L1027-36":[610],"https://doi.org/10.1152/ajplung.00227.2012":[611],"II.":[612],"Riley":[613],"JP,":[614],"GP,":[620,659],"Karlsson":[621],"Rao":[625],"NL,":[626],"M.":[628,661],"mediators":[631],"cause":[632],"bronchoconstriction":[635],"guinea-pigs":[637],"vivo:":[639],"relevance":[643],"Clin":[646],"Sci":[647],"(Lond).":[648],"2013;125(11):533-42":[649],"https://doi.org/10.1042/CS20130092":[650],"III.":[651],"Gregory":[654,689],"JA,":[655,690],"Interleukin":[662,697],"causes":[664],"serotonin":[674],"reaction.":[682],"[Manuscript]":[683,716],"IV.":[684],"Zoltowska":[687],"A,":[688],"Lei":[691],"Y,":[692],"elicits":[699],"hyperresponsiveness,":[706],"remodeling":[709]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
