{"id":"https://openalex.org/W1584772422","doi":"https://doi.org/10.1016/s0021-9258(18)33610-x","title":"Effects of neighboring DNA homopolymers on the biochemical and physical properties of the Escherichia coli lactose promoter. III. High resolution thermal denaturation and circular dichroism studies.","display_name":"Effects of neighboring DNA homopolymers on the biochemical and physical properties of the Escherichia coli lactose promoter. III. High resolution thermal denaturation and circular dichroism studies.","publication_year":1982,"publication_date":"1982-11-01","ids":{"openalex":"https://openalex.org/W1584772422","doi":"https://doi.org/10.1016/s0021-9258(18)33610-x","mag":"1584772422","pmid":"https://pubmed.ncbi.nlm.nih.gov/6752145"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)33610-x","doi":"https://doi.org/10.1016/s0021-9258(18)33610-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33610-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)33610-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003385068","display_name":"Thomas C. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"T C Goodman","raw_affiliation_strings":["Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","Department of Biochemistry, University of Alabama, Birmingham,","From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","University Station, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biochemistry, University of Alabama, Birmingham,","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"University Station, Birmingham, AL 35294","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103515519","display_name":"Ronald D. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"R D Klein","raw_affiliation_strings":["Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","Department of Biochemistry, University of Alabama, Birmingham,","From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","University Station, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biochemistry, University of Alabama, Birmingham,","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"University Station, Birmingham, AL 35294","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040500435","display_name":"Robert D. Wells","orcid":"https://orcid.org/0000-0002-7240-8473","observed_orcids":["https://orcid.org/0000-0002-7240-8473"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"R D Wells","raw_affiliation_strings":["Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","Department of Biochemistry, University of Alabama, Birmingham,","From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","University Station, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address, Department of Chemistry, Bldg. 18, Room 510, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biochemistry, University of Alabama, Birmingham,","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"From the University of Wisconsin-Madison, Department of Biochemistry, College ofAgricultura1 and Life Sciences, Madison, Wisconsin 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Institut fur Physikalische Biologie, Universitat Dusseldorf, Universitatsstra. 1, D-4000 Dusseldorf, West Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"University Station, Birmingham, AL 35294","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6801,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62616365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"257","issue":"21","first_page":"12970","last_page":"12978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9049999713897705},{"id":"https://openalex.org/keywords/poly-da-poly-dt","display_name":"poly(dA).poly(dT)","score":0.8870000243186951},{"id":"https://openalex.org/keywords/poly-dg-poly-dc","display_name":"poly(dG)-poly(dC)","score":0.984000027179718},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dna-conformation","display_name":"DNA conformation","score":0.847000002861023},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.8510000109672546},{"id":"https://openalex.org/keywords/in-vitro-transcription","display_name":"in vitro transcription","score":0.6629999876022339},{"id":"https://openalex.org/keywords/nucleotide-composition","display_name":"nucleotide composition","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.8075100183486938},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7996764183044434},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6748572587966919},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.5765345096588135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.531365156173706},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.4699844419956207},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4612208306789398},{"id":"https://openalex.org/C2909133011","wikidata":"https://www.wikidata.org/wiki/Q273186","display_name":"Nucleic Acid Denaturation","level":4,"score":0.4475204348564148},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39753133058547974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.385293573141098},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35386136174201965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1927771270275116},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.1537652313709259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11694559454917908},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)33610-x","doi":"https://doi.org/10.1016/s0021-9258(18)33610-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33610-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6752145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6752145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)33610-x","doi":"https://doi.org/10.1016/s0021-9258(18)33610-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)33610-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W176261813","https://openalex.org/W1489398247","https://openalex.org/W1569080502","https://openalex.org/W1571909805","https://openalex.org/W1584285867","https://openalex.org/W1592475523","https://openalex.org/W1608563615","https://openalex.org/W1965058591","https://openalex.org/W1980879384","https://openalex.org/W1981269762","https://openalex.org/W1990369898","https://openalex.org/W1992595091","https://openalex.org/W2003479120","https://openalex.org/W2020586816","https://openalex.org/W2022943870","https://openalex.org/W2023806120","https://openalex.org/W2048482216","https://openalex.org/W2067660191","https://openalex.org/W2073787422","https://openalex.org/W2075969936","https://openalex.org/W2079514845","https://openalex.org/W2089674899","https://openalex.org/W2097632362","https://openalex.org/W2137627774","https://openalex.org/W2156637813","https://openalex.org/W2210296718"],"related_works":["https://openalex.org/W1489398247","https://openalex.org/W1608563615","https://openalex.org/W2137627774","https://openalex.org/W1571909805","https://openalex.org/W1607120100","https://openalex.org/W2016545995","https://openalex.org/W2054362831","https://openalex.org/W1487777358","https://openalex.org/W248136678","https://openalex.org/W2011450905"],"abstract_inverted_index":{"High":[0],"resolution":[1],"thermal":[2,51],"denaturation":[3],"and":[4,29,35,41,47,132,152],"circular":[5],"dichroism":[6],"studies":[7,162],"were":[8],"performed":[9],"on":[10,84,106,185],"a":[11,182],"series":[12],"of":[13,45,53,102,119,143,179,189],"six":[14],"recombinant":[15],"DNA":[16],"restriction":[17],"fragments.":[18,97,191],"The":[19,98,177],"fragments":[20],"varied":[21],"in":[22,82,87,95,120,125],"size":[23],"from":[24],"132":[25],"to":[26,61],"193":[27],"bp":[28],"contained":[30],"Escherichia":[31],"coli":[32],"wild":[33,55,108,150,172],"type":[34,56,109,151,173],"UV5":[36,63,153,175],"lactose":[37],"promoters":[38],"both":[39,76],"with":[40,115],"without":[42],"homopolymer":[43],"insertions":[44],"poly(dA).poly(dT)":[46],"poly(dG).poly(dC).":[48],"A":[49],"differential":[50],"destabilization":[52],"the":[54,62,72,85,88,96,103,107,116,126,149,171,186,190],"promoter":[57,110,154],"region,":[58],"as":[59],"compared":[60],"promoter,":[64],"was":[65,69],"observed":[66],"when":[67],"dA70.dT70":[68],"inserted":[70],"into":[71],"-60":[73],"region":[74,111],"or":[75,174],"DNAs.":[77],"This":[78],"effect":[79,101,184],"may":[80,112],"depend,":[81],"part,":[83],"differences":[86,167],"base":[89,146],"composition":[90],"between":[91,168],"adjoining":[92],"cooperative":[93],"units":[94],"relatively":[99],"larger":[100],"AT":[104],"sequence":[105],"be":[113],"correlated":[114],"increased":[117],"levels":[118],"vitro":[121],"transcription":[122],"activity":[123],"described":[124],"preceding":[127],"paper":[128],"(Klein,":[129],"R.":[130,134],"D.,":[131],"Wells,":[133],"D.":[135],"(1982)":[136],"J.":[137],"Biol.":[138],"Chem.":[139],"257,":[140],"12962-12969).":[141],"Stretches":[142],"homopolymeric":[144],"GC":[145],"pairs":[147],"stabilized":[148],"regions":[155],"by":[156],"over":[157],"2.5":[158],"degrees":[159],"C.":[160],"CD":[161,187],"could":[163],"not":[164],"detect":[165],"conformational":[166],"DNAs":[169],"containing":[170],"promoter.":[176],"presence":[178],"homopolymers":[180],"had":[181],"marked":[183],"spectra":[188]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}