{"id":"https://openalex.org/W1584601992","doi":null,"title":"Heart rate variability in heart disease. Evaluation of cardiac sympathetic modulation andmodification by interventions","display_name":"Heart rate variability in heart disease. Evaluation of cardiac sympathetic modulation andmodification by interventions","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1584601992","mag":"1584601992"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/14689","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/14689","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047873638","display_name":"Hans Tygesen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hans Tygesen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047873638"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/cardiac-sympathetic-nerve-activity","display_name":"cardiac sympathetic activity","score":0.800000011920929},{"id":"https://openalex.org/keywords/cardiac-autonomic-tone","display_name":"cardiac autonomic tone","score":0.8240000009536743},{"id":"https://openalex.org/keywords/vagal-tone","display_name":"vagal tone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.9390000104904175},{"id":"https://openalex.org/keywords/qt-dispersion","display_name":"QT dispersion","score":0.8920000195503235},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8109999895095825},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6620000004768372},{"id":"https://openalex.org/keywords/beta-blocker-withdrawal","display_name":"beta-blocker withdrawal","score":0.9110000133514404},{"id":"https://openalex.org/keywords/noradrenaline-spillover","display_name":"noradrenaline spillover","score":0.8529999852180481},{"id":"https://openalex.org/keywords/orthostatic-stress","display_name":"orthostatic stress","score":0.7509999871253967},{"id":"https://openalex.org/keywords/head-up-tilt-test","display_name":"head-up tilt","score":0.8019999861717224},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.972000002861023},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cardiac-rehabilitation","display_name":"cardiac rehabilitation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiac-death-risk","display_name":"cardiac death risk","score":0.7210000157356262},{"id":"https://openalex.org/keywords/life-threatening-arrhythmias","display_name":"malignant arrhythmias","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6257550716400146},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5665684938430786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.55714350938797},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5340710282325745},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5293793678283691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5017092227935791},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4302067458629608},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.420354425907135},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2071528434753418},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.096957266330719}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/14689","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/14689","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:1584601992","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/14689","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2515619016","https://openalex.org/W2327029238","https://openalex.org/W1571070063","https://openalex.org/W1264889757","https://openalex.org/W4231978698","https://openalex.org/W2036349005","https://openalex.org/W2057649886","https://openalex.org/W1972233757","https://openalex.org/W2902854835","https://openalex.org/W2397101628"],"abstract_inverted_index":{"Reduced":[0],"heart":[1,33],"rate":[2],"variability":[3],"(HRV)":[4],"has":[5,38],"been":[6,39],"shown":[7],"to":[8,72,105,173,314],"be":[9,96,289],"an":[10,292],"independent":[11],"risk":[12,83,213,338],"factor":[13],"for":[14,45,101,214,339],"cardiac":[15,49,59,85,107,161,215,247,295,352],"death":[16,86],"after":[17,120,151,179,194,241,317,359],"acute":[18],"myocardial":[19,181],"infarction,":[20],"in":[21,29,52,79,93,124,138,164,225,250,261,267,308,312,326,351,364,381],"patients":[22,30,80,125,143,171,251,315,349],"with":[23,31,81,87,126,135,144,158,252,259,276,300],"chronic":[24],"coronary":[25,184],"artery":[26,185],"disease":[27],"and":[28,103,119,130,150,193,196,205,246,271,369,384],"congestive":[32],"failure":[34],"(CHF).":[35],"Furthermore,":[36],"HRV":[37,63,76,94,115,131,155,188,201,244,278,310,377],"proposed":[40,218],"as":[41,98,291],"a":[42,165,180,256,305,322,336],"non-invasive":[43],"tool":[44],"the":[46,88,226,262,268,327,330,365,388],"assessment":[47,57],"of":[48,58,68,75,84,112,167,294,329,362],"autonomic":[50],"tone,":[51],"particular":[53],"vagal":[54,203,309,324],"tone.":[55],"The":[56,66,217],"sympathetic":[60,108,219,296],"activity":[61],"by":[62,77,110],"is":[64,345],"debatable.":[65],"aims":[67],"this":[69,370,382],"thesis":[70],"were":[71,133],"evaluate":[73,106],"changes":[74,92,132],"interventions":[78],"elevated":[82],"underlying":[89],"assumption":[90],"that":[91,283],"could":[95,288,334],"used":[97,290],"surrogate":[99],"endpoint":[100],"mortality":[102],"furthermore":[104],"tone":[109,204],"means":[111],"HRV.Methods:":[113],"(1)":[114],"was":[116,156,189,230,273,390],"measured":[117,160,190],"before":[118],"endoscopic":[121],"transthoracic":[122],"sympathicotomy":[123],"severe":[127],"angina":[128],"pectoris":[129],"compared":[134,157],"QT":[136,207],"dispersion":[137,208],"these":[139],"patients.":[140,168],"(2)":[141],"In":[142,170,348],"CHF":[145,253,301],"on":[146,148,302],"placebo,":[147],"\u00df-blockers":[149],"\u00df-blockade":[152,303,343],"withdrawal,":[153],"baseline":[154],"invasively":[159],"nor-adrenaline(NA)":[162],"spillover":[163,249],"subgroup":[166],"(3)":[169],"randomised":[172],"routine":[174],"or":[175,183],"intensive":[176,366],"exercise":[177,354],"training":[178,363,367],"infarction":[182],"bypass":[186],"surgery,":[187],"at":[191],"base-line":[192],"training.Results":[195],"conclusions:":[197],"Sympathectomy":[198],"increased":[199,356,378],"total":[200],"including":[202],"reduced":[206,212,232],"over":[209],"time":[210],"indicating":[211],"death.":[216],"marker":[220],"LF/HF":[221,260,284],"did":[222],"not":[223,266],"change":[224],"supine":[227,269],"position":[228,270],"but":[229,265],"significantly":[231,357,379],"during":[233,285],"70\u00b0":[234],"head":[235],"up":[236],"tilt":[237],"test":[238],"one":[239,373,385],"month":[240],"surgery.":[242],"Comparing":[243],"indices":[245,311],"NA":[248],"also":[254],"demonstrated":[255],"strong":[257],"correlation":[258,275],"standing":[263],"(r=0.81)":[264],"there":[272],"no":[274],"other":[277],"indices.":[279],"These":[280],"results":[281],"indicate":[282],"orthostatic":[286],"stress":[287],"index":[293],"nerve":[297],"activity.":[298],"Patients":[299],"had":[304,321],"significant":[306,323],"increase":[307],"contrast":[313],"24-hours":[316],"\u00df-blocker":[318],"withdrawal":[319],"who":[320],"reduction":[325],"level":[328],"placebo":[331],"group.":[332],"This":[333],"imply":[335],"potential":[337],"malignant":[340],"arrhythmias":[341],"when":[342],"medication":[344],"discontinuing":[346],"abruptly.":[347],"participating":[350],"rehabilitation,":[353],"capacity":[355],"more":[358,380],"three":[360],"months":[361],"group":[368],"difference":[371],"remained":[372],"year":[374,386],"later.":[375],"Total":[376],"group,":[383],"later":[387],"differences":[389],"still":[391],"significant.":[392]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2016-06-24T00:00:00"}