{"id":"https://openalex.org/W1584590118","doi":null,"title":"OJO SECO EN PACIENTES CON ACN\u00c9 TRATADOS CON ISOTRETINO\u00cdNA EN EL SERVICIO DE DERMATOLOG\u00cdA DEL HOSPITAL EUGENIO ESPEJO EN EL A\u00d1O 2014","display_name":"OJO SECO EN PACIENTES CON ACN\u00c9 TRATADOS CON ISOTRETINO\u00cdNA EN EL SERVICIO DE DERMATOLOG\u00cdA DEL HOSPITAL EUGENIO ESPEJO EN EL A\u00d1O 2014","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1584590118","mag":"1584590118"},"language":"es","primary_location":{"id":"pmh:oai:www.dspace.uce.edu.ec:25000/4742","doi":null,"is_oa":true,"landing_page_url":"http://www.dspace.uce.edu.ec/handle/25000/4742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Repositorio UCE","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.dspace.uce.edu.ec/handle/25000/4742","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053534433","display_name":"Lourdes Mar\u00eda Criollo Vinueza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lourdes Mar\u00eda Criollo Vinueza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077266086","display_name":"Viviana Paola Vacacela Guam\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viviana Paola Vacacela Guam\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8980000019073486},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6190000176429749},{"id":"https://openalex.org/keywords/schirmer-test","display_name":"Schirmer test","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ocular-surface-inflammation","display_name":"ocular surface inflammation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/foreign-body-sensation","display_name":"foreign body sensation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/red-eye","display_name":"red eye","score":0.746999979019165},{"id":"https://openalex.org/keywords/drug-induced-dry-eye","display_name":"drug-induced dry eye","score":0.5189999938011169},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.382999986410141},{"id":"https://openalex.org/keywords/dermatology-outpatients","display_name":"dermatology outpatients","score":0.6110000014305115},{"id":"https://openalex.org/keywords/ecuadorian-patients","display_name":"Ecuadorian patients","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4854210317134857},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4510088860988617},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.4010718762874603}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:www.dspace.uce.edu.ec:25000/4742","doi":null,"is_oa":true,"landing_page_url":"http://www.dspace.uce.edu.ec/handle/25000/4742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Repositorio UCE","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:dspace.uce.edu.ec:25000/4742","doi":null,"is_oa":true,"landing_page_url":"http://www.dspace.uce.edu.ec/handle/25000/4742","pdf_url":null,"source":{"id":"https://openalex.org/S4406922895","display_name":"Repositorio Digital de la Universidad Central del Ecuador","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"masterThesis"},{"id":"mag:1584590118","doi":null,"is_oa":false,"landing_page_url":"http://www.dspace.uce.edu.ec/bitstream/25000/4742/1/T-UCE-0006-113.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.dspace.uce.edu.ec:25000/4742","doi":null,"is_oa":true,"landing_page_url":"http://www.dspace.uce.edu.ec/handle/25000/4742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Repositorio UCE","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W33995418","https://openalex.org/W61591094","https://openalex.org/W62632630","https://openalex.org/W113565865","https://openalex.org/W145780728","https://openalex.org/W202387038","https://openalex.org/W934966520","https://openalex.org/W1493113567","https://openalex.org/W1521708885","https://openalex.org/W1557671866","https://openalex.org/W1633846118","https://openalex.org/W1871029534","https://openalex.org/W1898260615","https://openalex.org/W1954240270","https://openalex.org/W1964931370","https://openalex.org/W1965659086","https://openalex.org/W1976923360","https://openalex.org/W1977733303","https://openalex.org/W1979692676","https://openalex.org/W1980539710","https://openalex.org/W1982025205","https://openalex.org/W1982767852","https://openalex.org/W1983280978","https://openalex.org/W1983745922","https://openalex.org/W1983982734","https://openalex.org/W1985062724","https://openalex.org/W1988614811","https://openalex.org/W1992356950","https://openalex.org/W1993900282","https://openalex.org/W1995948415","https://openalex.org/W1995958778","https://openalex.org/W1998459845","https://openalex.org/W1998767457","https://openalex.org/W1999031380","https://openalex.org/W1999940631","https://openalex.org/W2001775092","https://openalex.org/W2001968948","https://openalex.org/W2003650561","https://openalex.org/W2013244765","https://openalex.org/W2013833420","https://openalex.org/W2014595511","https://openalex.org/W2015722919","https://openalex.org/W2019580446","https://openalex.org/W2020915264","https://openalex.org/W2021982362","https://openalex.org/W2022960316","https://openalex.org/W2023427412","https://openalex.org/W2024921065","https://openalex.org/W2026581256","https://openalex.org/W2028465131","https://openalex.org/W2033903424","https://openalex.org/W2034082487","https://openalex.org/W2034728619","https://openalex.org/W2038338078","https://openalex.org/W2045514812","https://openalex.org/W2049906371","https://openalex.org/W2050056255","https://openalex.org/W2050235928","https://openalex.org/W2052188352","https://openalex.org/W2052607038","https://openalex.org/W2055805284","https://openalex.org/W2058499720","https://openalex.org/W2062768474","https://openalex.org/W2063642231","https://openalex.org/W2065975622","https://openalex.org/W2066422243","https://openalex.org/W2067655144","https://openalex.org/W2070093717","https://openalex.org/W2073647169","https://openalex.org/W2073750769","https://openalex.org/W2074932399","https://openalex.org/W2074985483","https://openalex.org/W2078501398","https://openalex.org/W2082514953","https://openalex.org/W2083194567","https://openalex.org/W2085177068","https://openalex.org/W2086015074","https://openalex.org/W2089930894","https://openalex.org/W2091630088","https://openalex.org/W2097262289","https://openalex.org/W2101057221","https://openalex.org/W2105793420","https://openalex.org/W2109945689","https://openalex.org/W2110404975","https://openalex.org/W2115345791","https://openalex.org/W2120773157","https://openalex.org/W2122667058","https://openalex.org/W2127761180","https://openalex.org/W2129742540","https://openalex.org/W2133888101","https://openalex.org/W2136225730","https://openalex.org/W2141388330","https://openalex.org/W2147729585","https://openalex.org/W2154164188","https://openalex.org/W2164403130","https://openalex.org/W2165528777","https://openalex.org/W2171362587","https://openalex.org/W2171866452","https://openalex.org/W2184413367","https://openalex.org/W2404637971","https://openalex.org/W2468221020","https://openalex.org/W2514154279","https://openalex.org/W2598546209","https://openalex.org/W2735954633","https://openalex.org/W2883308265"],"related_works":["https://openalex.org/W3181951324","https://openalex.org/W19859555","https://openalex.org/W6989157939","https://openalex.org/W47097368","https://openalex.org/W6959957362","https://openalex.org/W4392641286","https://openalex.org/W3170131267","https://openalex.org/W2097475273","https://openalex.org/W2164160424","https://openalex.org/W6998477605"],"abstract_inverted_index":{"Contexto:":[0],"El":[1,174],"s\u00edndrome":[2],"de":[3,10,20,32,48,53,59,69,81,98,111,120,134,137,148,176,198,202,218,267],"ojo":[4,54,115,138,160,171,226,252],"seco":[5,139,161,172,253],"corresponde":[6],"a":[7,17,142,230],"la":[8,11,18,33,38,51,132,189,193,211],"alteraci\u00f3n":[9],"pel\u00edcula":[12],"lagrimal":[13,100],"que":[14,24,40,156,245],"se":[15,93,207,237,250,261],"asocia":[16],"persistencia":[19],"un":[21],"proceso":[22],"inflamatorio,":[23],"empeora":[25],"los":[26,91,151,219,243],"s\u00edntomas":[27,107],"y":[28,50,63,106,114,184],"conduce":[29],"al":[30,165,186,214,239],"da\u00f1o":[31],"superficie":[34],"ocular.":[35],"Objetivo:":[36],"Determinar":[37],"asociaci\u00f3n":[39],"existe":[41],"entre":[42],"isotretino\u00edna":[43,73,247],"utilizada":[44],"en":[45,76,123,150,181,188,210,221],"el":[46,77,84,124,126,157,168,182,196,222,255,265],"tratamiento":[47],"acn\u00e9":[49,70],"aparici\u00f3n":[52],"seco.":[55],"Dise\u00f1o:":[56],"Estudio":[57],"descriptivo":[58],"cohorte":[60],"hist\u00f3rico.":[61],"Lugar":[62],"sujetos:":[64],"257":[65],"pacientes":[66,92,121,199,220,244],"con":[67,72,102],"diagn\u00f3stico":[68],"tratados":[71],"v\u00eda":[74,248],"oral":[75,249],"Hospital":[78],"Eugenio":[79],"Espejo":[80],"Quito,":[82],"durante":[83],"a\u00f1o":[85],"2014.":[86],"Mediciones":[87],"principales:":[88],"A":[89],"todos":[90],"les":[94],"valor\u00f3":[95],"Schirmer,":[96],"tiempo":[97,266],"ruptura":[99],"(BUT)":[101],"sus":[103],"respectivas":[104],"escalas":[105],"principales":[108],"como":[109],"sensaci\u00f3n":[110,201],"cuerpo":[112,203],"extra\u00f1o":[113],"rojo.":[116],"Resultados:":[117],"Del":[118],"total":[119],"incluidos":[122],"estudio":[125],"51.8%":[127],"fueron":[128],"del":[129,232,257,269],"sexo":[130],"femenino,":[131],"edad":[133],"mayor":[135],"frecuencia":[136],"fue":[140,179],"15":[141],"24":[143],"a\u00f1os":[144],"(79,8%).":[145],"La":[146,216],"valoraci\u00f3n":[147,194,213],"BUT":[149],"tres":[152],"primeros":[153],"meses":[154],"mostr\u00f3":[155],"80,9%":[158],"tuvieron":[159],"leve,":[162],"sin":[163,228],"embargo":[164,229],"cuarto":[166,233],"mes":[167,224,234],"73,9%":[169],"tuvo":[170],"moderado.":[173],"test":[175],"Schirmer":[177],"inicialmente":[178],"normal":[180],"85,6%,":[183],"disminuy\u00f3":[185],"16%":[187],"segunda":[190,212],"valoraci\u00f3n.":[191],"En":[192,242],"inicial":[195],"25%":[197],"presentaron":[200,225],"extra\u00f1o,":[204],"lo":[205],"cual":[206],"increment\u00f3":[208,238],"dram\u00e1ticamente":[209],"82,9%.":[215],"mitad":[217],"primer":[223],"rojo,":[227],"partir":[231],"este":[235],"signo":[236],"85,6%.":[240],"Conclusiones:":[241],"utilizan":[246],"desarrolla":[251],"desde":[254],"inicio":[256],"tratamiento,":[258],"esta":[259],"patolog\u00eda":[260],"incrementa":[262],"mientras":[263],"transcurre":[264],"utilizaci\u00f3n":[268],"f\u00e1rmaco.":[270]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
