{"id":"https://openalex.org/W1584528239","doi":null,"title":"[Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)].","display_name":"[Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)].","publication_year":1975,"publication_date":"1975-12-01","ids":{"openalex":"https://openalex.org/W1584528239","mag":"1584528239","pmid":"https://pubmed.ncbi.nlm.nih.gov/1195513"},"language":"ja","primary_location":{"id":"pmid:1195513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1195513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016577442","display_name":"\u5e79\u5f25 \u4f50\u85e4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003354656","display_name":"\u9686\u6cbb \u677e\u5c71","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Matsuyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085869381","display_name":"\u4eae \u5bae\u7530","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Miyata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12340172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"6","first_page":"758","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin-stearate","display_name":"erythromycin stearate","score":0.9269999861717224},{"id":"https://openalex.org/keywords/acute-respiratory-tract-infections","display_name":"acute respiratory infections","score":0.8700000047683716},{"id":"https://openalex.org/keywords/enteric-coated-granules","display_name":"enteric-coated granules","score":0.8100000023841858},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gram-positive-cocci","display_name":"Gram-positive cocci","score":0.7720000147819519},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.8519999980926514},{"id":"https://openalex.org/keywords/streptococcus","display_name":"Streptococcus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/staphylococcus","display_name":"Staphylococcus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.8379999995231628},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4453337788581848}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006190","descriptor_name":"Haemophilus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009343","descriptor_name":"Neisseria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013608","descriptor_name":"Tablets, Enteric-Coated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1195513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1195513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"English Abstract"},{"id":"mag:1584528239","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/130004392877","pdf_url":null,"source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Antibiotics","raw_type":null},{"id":"mag:2419559979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1195513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511038753","https://openalex.org/W2522438624","https://openalex.org/W1546172931","https://openalex.org/W326453724","https://openalex.org/W2979098213","https://openalex.org/W7208231601","https://openalex.org/W806529739","https://openalex.org/W1832387568","https://openalex.org/W212195082","https://openalex.org/W2744351819"],"abstract_inverted_index":{"The":[0,169],"results":[1],"of":[2,28,48,77,100,146,173,179,196,229],"clinical":[3],"studies":[4,125],"on":[5],"OE-7":[6,23,52,126,174],"(erythromycin":[7],"stearate,":[8],"enteric":[9],"coated":[10],"granule)":[11],"were":[12,21,141],"as":[13],"follows.":[14],"(1)":[15],"Thirty-two":[16],"cases":[17,36,50,148,162],"with":[18,95,106],"respiratory":[19,71,108],"infections":[20,72,109],"treated":[22],"by":[24,111,175,192],"the":[25,65,75,92,136,176,193,202,227],"oral":[26,177],"route":[27,178,195],"300":[29,180],"mg":[30,39,181,198],"every":[31,40,182,199],"6":[32,183],"hours":[33,42,184,209],"in":[34,43,69,118,144,152,160,226,236],"5":[35,223],"and":[37,60,74,88,114,149,155,214,233],"400":[38,197],"8":[41,145,200],"27":[44],"cases.":[45,133],"In":[46,123],"28":[47],"32":[49,147],"(87.5%)":[51],"was":[53,204,220],"effective.":[54],"Gram-positive":[55],"cocci,":[56],"namely":[57],"pneumococcus,":[58],"alpha-":[59],"beta-streptococcus,":[61],"staphylococcus":[62],"etc.":[63],"are":[64,79,103],"most":[66,76],"important":[67],"pathogens":[68,113],"acute":[70],"statistically":[73],"them":[78],"susceptible":[80],"to":[81,86,131],"many":[82],"chemotherapeutic":[83],"agents,":[84],"especially":[85],"erythromycin":[87],"penicillin.":[89],"This":[90,218],"is":[91],"case":[93],"also":[94],"our":[96,124],"studies.":[97],"Acute":[98],"exacerbation":[99],"asthmatic":[101,121],"patients":[102],"frequently":[104],"complicated":[105],"secondary":[107],"caused":[110],"those":[112],"sometimes":[115],"this":[116],"condition":[117,228],"turn":[119],"exacerbate":[120],"states.":[122],"displayed":[127],"a":[128],"good":[129],"effect":[130,138],"such":[132],"(2)":[134],"As":[135],"side":[137],"gastrointestinal":[139],"disturbances":[140],"slightly":[142],"observed":[143],"allergic":[150],"reactions":[151],"none.":[153],"Hepatic":[154],"renal":[156],"function":[157],"test":[158],"examined":[159],"17":[161],"revealed":[163,185],"no":[164],"change":[165],"after":[166,207,210],"treatment.":[167],"(3)":[168],"mean":[170],"serum":[171],"concentration":[172],"about":[186],"two":[187],"times":[188],"higher":[189],"levels":[190],"than":[191],"same":[194],"hours,":[201],"peak":[203],"both":[205],"reached":[206],"3":[208],"ingestion":[211,232],"1.96":[212],"mcg/ml":[213,216],"0.97":[215],"respectively.":[217],"experiment":[219],"done":[221],"for":[222],"healthy":[224],"persons":[225],"free":[230],"food":[231],"cross":[234],"over":[235],"one":[237],"week":[238],"interval.":[239]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
