{"id":"https://openalex.org/W158399889","doi":null,"title":"Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms","display_name":"Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W158399889","mag":"158399889"},"language":"en","primary_location":{"id":"pmh:oai:gala.gre.ac.uk:9812","doi":null,"is_oa":true,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","pdf_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030579439","display_name":"Mohammed Maniruzzaman","orcid":"https://orcid.org/0000-0002-3373-5586","observed_orcids":["https://orcid.org/0000-0002-3373-5586","https://orcid.org/0000-0002-6499-9701"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohammed Maniruzzaman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3373-5586","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030579439"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hot-melt-extrusion","display_name":"melt extrusion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oral-solid-dosage-forms","display_name":"oral solid dosage forms","score":0.906000018119812},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8240000009536743},{"id":"https://openalex.org/keywords/drug-polymer-blends","display_name":"drug-polymer blends","score":0.7580000162124634},{"id":"https://openalex.org/keywords/plasticization","display_name":"plasticization","score":0.6050000190734863},{"id":"https://openalex.org/keywords/drug-dissolution-enhancement","display_name":"drug dissolution enhancement","score":0.45500001311302185},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.8939999938011169},{"id":"https://openalex.org/keywords/eudragit-epo","display_name":"Eudragit EPO","score":0.8690000176429749},{"id":"https://openalex.org/keywords/orally-disintegrating-tablets","display_name":"orally disintegrating tablets","score":0.8119999766349792},{"id":"https://openalex.org/keywords/superdisintegrants","display_name":"superdisintegrants","score":0.8460000157356262},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.8619999885559082},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.6690000295639038},{"id":"https://openalex.org/keywords/famotidine","display_name":"famotidine","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2778958987","wikidata":"https://www.wikidata.org/wiki/Q139143","display_name":"Extrusion","level":2,"score":0.8072779178619385},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7437162399291992},{"id":"https://openalex.org/C58968531","wikidata":"https://www.wikidata.org/wiki/Q910212","display_name":"Plasticizer","level":2,"score":0.6964899897575378},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6563903093338013},{"id":"https://openalex.org/C2780077769","wikidata":"https://www.wikidata.org/wiki/Q413433","display_name":"Polyvinylpyrrolidone","level":2,"score":0.6422510147094727},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5479238033294678},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5005483627319336},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.48932120203971863},{"id":"https://openalex.org/C97103648","wikidata":"https://www.wikidata.org/wiki/Q2738101","display_name":"Plastics extrusion","level":2,"score":0.44849491119384766},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.4220535159111023},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.359652042388916},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.22076281905174255},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gala.gre.ac.uk:9812","doi":null,"is_oa":true,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","pdf_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:158399889","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gala.gre.ac.uk:9812","doi":null,"is_oa":true,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","pdf_url":"http://gala.gre.ac.uk/id/eprint/9812/1/Mohammed_Maniruzzaman_2012.pdf","source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311712","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W158399889.pdf","grobid_xml":"https://content.openalex.org/works/W158399889.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W21290552","https://openalex.org/W88552196","https://openalex.org/W433287742","https://openalex.org/W605959634","https://openalex.org/W906779125","https://openalex.org/W1484153881","https://openalex.org/W1498305210","https://openalex.org/W1505352099","https://openalex.org/W1515459678","https://openalex.org/W1964240352","https://openalex.org/W1968054977","https://openalex.org/W1969314709","https://openalex.org/W1970119272","https://openalex.org/W1973780063","https://openalex.org/W1975458606","https://openalex.org/W1975568110","https://openalex.org/W1977201403","https://openalex.org/W1977669661","https://openalex.org/W1980041206","https://openalex.org/W1980535921","https://openalex.org/W1980605786","https://openalex.org/W1982682999","https://openalex.org/W1983314792","https://openalex.org/W1984491503","https://openalex.org/W1986514009","https://openalex.org/W1986703901","https://openalex.org/W1986875887","https://openalex.org/W1988902356","https://openalex.org/W1990617400","https://openalex.org/W1996737293","https://openalex.org/W1998823894","https://openalex.org/W1999759258","https://openalex.org/W2001013492","https://openalex.org/W2001025673","https://openalex.org/W2001714357","https://openalex.org/W2002435842","https://openalex.org/W2004285380","https://openalex.org/W2006473565","https://openalex.org/W2008285632","https://openalex.org/W2009961775","https://openalex.org/W2012323496","https://openalex.org/W2013926500","https://openalex.org/W2014222956","https://openalex.org/W2014851032","https://openalex.org/W2015297129","https://openalex.org/W2016915317","https://openalex.org/W2017589050","https://openalex.org/W2020064892","https://openalex.org/W2028311524","https://openalex.org/W2031195045","https://openalex.org/W2033193022","https://openalex.org/W2033656688","https://openalex.org/W2034277254","https://openalex.org/W2038071832","https://openalex.org/W2038734380","https://openalex.org/W2039752857","https://openalex.org/W2040182825","https://openalex.org/W2041517295","https://openalex.org/W2042090715","https://openalex.org/W2042665261","https://openalex.org/W2044146593","https://openalex.org/W2044594845","https://openalex.org/W2046273170","https://openalex.org/W2049109884","https://openalex.org/W2049555569","https://openalex.org/W2053596602","https://openalex.org/W2055002792","https://openalex.org/W2055251622","https://openalex.org/W2055858460","https://openalex.org/W2057613869","https://openalex.org/W2057712170","https://openalex.org/W2059290758","https://openalex.org/W2061110091","https://openalex.org/W2063047886","https://openalex.org/W2063475958","https://openalex.org/W2065433813","https://openalex.org/W2066487146","https://openalex.org/W2067899925","https://openalex.org/W2069804811","https://openalex.org/W2071363534","https://openalex.org/W2072595316","https://openalex.org/W2072904835","https://openalex.org/W2075854967","https://openalex.org/W2075906722","https://openalex.org/W2075954364","https://openalex.org/W2077830075","https://openalex.org/W2077890095","https://openalex.org/W2078212543","https://openalex.org/W2078633113","https://openalex.org/W2080575627","https://openalex.org/W2081237311","https://openalex.org/W2085966579","https://openalex.org/W2086130473","https://openalex.org/W2087077699","https://openalex.org/W2087539600","https://openalex.org/W2087897341","https://openalex.org/W2087969058","https://openalex.org/W2089089871","https://openalex.org/W2089275244","https://openalex.org/W2089428985","https://openalex.org/W2089890205","https://openalex.org/W2090296204","https://openalex.org/W2090862847","https://openalex.org/W2092089602","https://openalex.org/W2093043474","https://openalex.org/W2093517267","https://openalex.org/W2095386082","https://openalex.org/W2096422707","https://openalex.org/W2097577562","https://openalex.org/W2099448512","https://openalex.org/W2100872293","https://openalex.org/W2101861157","https://openalex.org/W2105798672","https://openalex.org/W2108057702","https://openalex.org/W2115439624","https://openalex.org/W2118190721","https://openalex.org/W2118436621","https://openalex.org/W2119075492","https://openalex.org/W2119223725","https://openalex.org/W2120000151","https://openalex.org/W2121361543","https://openalex.org/W2124932673","https://openalex.org/W2125080242","https://openalex.org/W2125835249","https://openalex.org/W2127853528","https://openalex.org/W2128077794","https://openalex.org/W2132193279","https://openalex.org/W2132217981","https://openalex.org/W2134392979","https://openalex.org/W2148717516","https://openalex.org/W2150697053","https://openalex.org/W2153470573","https://openalex.org/W2155510850","https://openalex.org/W2159269801","https://openalex.org/W2163334892","https://openalex.org/W2167080343","https://openalex.org/W2167286960","https://openalex.org/W2215435994","https://openalex.org/W2253298758","https://openalex.org/W2253573021","https://openalex.org/W2266900840","https://openalex.org/W2321907259","https://openalex.org/W2342782999","https://openalex.org/W2494665721","https://openalex.org/W2602812987","https://openalex.org/W2604772962","https://openalex.org/W2775636289","https://openalex.org/W2908217092","https://openalex.org/W2986529115"],"related_works":["https://openalex.org/W7073629014","https://openalex.org/W10730982","https://openalex.org/W2294801321","https://openalex.org/W2198324371","https://openalex.org/W2921015507","https://openalex.org/W2109351159","https://openalex.org/W2226851146","https://openalex.org/W7047761132","https://openalex.org/W2897806368","https://openalex.org/W2381452118"],"abstract_inverted_index":{"Hot-melt":[0],"extrusion":[1,199],"(HME)":[2],"is":[3],"one":[4],"of":[5,44,52,98,122,178,219,249,276,283,288,298,302,392,403,450,504,524,556,561,572,579,646,651,655,673],"the":[6,12,30,34,42,49,96,99,120,123,159,217,237,250,277,299,393,444,447,451,461,473,477,481,493,502,521,531,562,570,576,580,584,588,652,671],"most":[7],"widely":[8],"used":[9,26,90,234,344,372],"technologies":[10],"in":[11,27,163,186,292,295,317,376,398,410,439,489,494,550,587,611],"plastic,":[13],"rubber":[14],"and":[15,18,25,29,61,77,85,119,136,142,151,225,257,259,265,294,339,363,426,436,453,480,514,540,583,596,678],"food":[16],"industries":[17],"it":[19],"has":[20],"also":[21,184,594],"been":[22],"extensively":[23],"explored":[24],"academia":[28],"pharmaceutical":[31],"industry":[32],"over":[33,639],"last":[35],"decade.":[36],"This":[37],"project":[38],"aims":[39],"to":[40,47,154,176,193,235,243,286,378,459,554,613],"investigate":[41],"efficiency":[43,301],"hydrophilic":[45,92],"polymers":[46,470,479],"enhance":[48],"dissolution":[50,165,260,275],"rate":[51],"poorly":[53],"water-soluble":[54],"APIs":[55,180,452,483],"processed":[56,109,394,618],"by":[57,110,197,215,327,400,416,471,535,619,661],"HME.":[58,328,620],"Indomethacin":[59],"(INM)":[60],"famotidine":[62],"(FMT)":[63],"were":[64,89,108,125,152,204,213,262,325,343,371,488,624],"selected":[65],"as":[66,91,222,345,373],"model":[67,346],"active":[68,348,581],"substances":[69,349,582],"while":[70,228,350,509],"polyvinyl":[71],"caprolactam":[72],"graft":[73],"copolymer,":[74],"Soluplus\u00ae":[75],"(SOL)":[76],"vinylpyrrolidone-vinyl":[78],"acetate":[79],"copolymer":[80,189,366],"grades":[81],"Kollidon\u00ae":[82,322],"VA64":[83,323],"(VA64)":[84,324],"Plasdone\u00ae":[86],"S630":[87],"(S630)":[88],"polymeric":[93,374],"carriers.":[94],"For":[95],"purpose":[97],"study,":[100],"all":[101,173,469],"drug-polymer":[102,518,549],"binary":[103],"blends":[104],"at":[105,148],"various":[106,240],"ratios":[107],"a":[111,187,229,401,643,682],"Randcastle":[112],"single":[113],"screw":[114],"extruder.":[115],"The":[116,162,201,211,247,291,388,485,559,621],"physico-chemical":[117],"properties":[118,248],"morphology":[121],"extrudates":[124],"evaluated":[126,264,397,534],"via":[127],"x-ray":[128],"powder":[129],"diffraction":[130],"(XRPD),":[131],"differential":[132],"scanning":[133,137],"calorimetry":[134],"(DSC)":[135],"electron":[138],"microscopy":[139],"(SEM).":[140],"INM":[141],"FMT":[143],"exhibited":[144],"strong":[145],"plasticization":[146],"effects":[147],"specific":[149],"concentrations":[150],"found":[153],"be":[155],"molecularly":[156],"dispersed":[157],"within":[158],"polymer":[160],"blends.":[161],"vitro":[164,274,293,411],"studies":[166,516],"showed":[167,280,545,569,636],"increased":[168],"INM/FMT":[169],"release":[170,282,616,638,653,666,672],"rates":[171],"for":[172,468,476],"formulations":[174,308,383],"compared":[175,266,285,553],"that":[177,287,443,460,555,670],"pure":[179,482],"alone.":[181,484],"Ibuprofen":[182],"was":[183,233,309,396,413,593,659],"embedded":[185,595],"methacrylate":[188,358],"(Eudragit\u00ae":[190],"EPO)":[191],"matrix":[192],"produce":[194,379],"solid":[195],"dispersions":[196],"hot-melt":[198],"processing.":[200],"obtained":[202,475],"granules":[203,312],"incorporated":[205],"into":[206],"orally":[207],"disintegrating":[208],"tablets":[209,212,252,617,623,658,680],"(ODTs).":[210],"developed":[214],"varying":[216],"ratio":[218],"superdisintegrants":[220],"such":[221],"sodium":[223],"croscarmellose":[224],"cross-linked":[226],"polyvinylpyrrolidone":[227],"direct":[230],"compression":[231],"process":[232],"compress":[236],"ODTs":[238,279],"under":[239],"compaction":[241],"forces":[242],"optimize":[244],"tablet":[245,455],"robustness.":[246],"compressed":[251,622],"which":[253,635,668],"included":[254],"porosity,":[255],"hardness,":[256],"friability":[258],"profiles":[261],"further":[263],"with":[267,423,492,598,627,642],"commercially":[268],"available":[269],"Nurofen\u00ae":[270,289],"Meltlet":[271],"ODTs.":[272],"In":[273,408,457],"extruded":[278,305,382,597],"rapid":[281],"ibuprofen":[284],"Meltlets.":[290],"vivo":[296,399,495],"evaluation":[297,412,438],"masking":[300,390],"hot":[303],"melt":[304],"paracetamol":[306],"(PMOL)":[307],"examined.":[310],"Extruded":[311],"containing":[313],"high":[314],"PMOL":[315],"loadings":[316],"Eudragit":[318],"EPO\u00ae":[319],"(EPO)":[320],"or":[321,604],"prepared":[326],"Similarly":[329],"propranolol":[330],"HCl":[331,334,337,341],"(PRP),":[332],"diphenhydramine":[333],"(DPD),":[335],"cetirizine":[336],"(CTZ)":[338],"verapamil":[340],"(VRP)":[342],"cationic":[347],"pH":[351],"sensitive":[352],"anionic":[353],"methacrylic":[354],"acid":[355],"based":[356],"methyl":[357],"coplolymers":[359],"Eudragit\u00ae":[360,367,632],"L100":[361,551],"(L100)":[362],"ethyl":[364,599,605],"acrylate":[365],"L100-55":[368,557],"(Acryl-EZE\u00ae)":[369],"(L100-55)":[370],"carriers":[375],"order":[377,612,684],"taste":[380,389,435,449,462,466],"masked":[381,446],"determining":[384],"drug-polymers":[385],"intermolecular":[386,532,563],"interactions.":[387],"effect":[391],"formulation":[395,445],"panel":[402],"six":[404],"healthy":[405],"human":[406,440],"volunteers.":[407],"addition,":[409],"carried":[414],"out":[415],"an":[417,628],"Astree":[418],"e-tongue":[419,486],"(Alpha":[420],"MOS)":[421],"equipped":[422],"seven":[424],"sensors":[425],"Taste":[427],"Sensing":[428],"System":[429],"TS5000Z":[430],"(INSENT),":[431],"respectively.":[432],"\\n":[433,590],"\\nThe":[434],"sensory":[437],"volunteers":[441],"demonstrated":[442,465],"bitter":[448],"improved":[454],"palatability.":[456],"addition":[458],"sensing":[463],"technology":[464],"improvement":[467],"correlating":[472],"data":[474],"placebo":[478],"results":[487],"good":[490],"agreement":[491],"evaluation.":[496],"Molecular":[497],"modelling":[498],"(Gaussian":[499],"09)":[500],"predicted":[501],"existence":[503],"two":[505],"possible":[506],"H-bonding":[507],"types":[508],"Fourier":[510],"Transform":[511],"Infra-Red":[512],"(FT-IR)":[513],"NMR":[515],"confirmed":[517,669],"interactions":[519,533,547,564],"between":[520,548,575],"functional":[522],"groups":[523,586],"both":[525,676],"components":[526],"(cationic":[527],"drugs\u2013anionic":[528],"polymers).":[529],"Furthermore,":[530],"Flory-Huggins":[536],"interaction":[537],"parameters":[538],"theory":[539],"X-ray":[541],"photoelectron":[542],"spectroscopy":[543],"(XPS)":[544],"stronger":[546],"systems":[552],"systems.":[558],"mechanism":[560,654],"derived":[565],"from":[566,657,675],"this":[567],"research":[568],"presence":[571],"H":[573],"bonding":[574],"amine":[577],"group":[578],"carboxylic":[585],"polymer.":[589],"\\nHydrocortisone":[591],"(HCS)":[592],"cellulose":[600,606],"N10":[601],"(EC":[602,609],"N10)":[603],"Premium":[607],"7":[608],"P7)":[610],"develop":[614],"sustained":[615,637],"subsequently":[625],"coated":[626,677],"enteric":[629],"coating":[630],"polymer,":[631],"S100":[633],"(15-20%),":[634],"12":[640],"hrs":[641],"lag":[644],"time":[645],"2":[647],"hrs.":[648],"Further":[649],"analysis":[650],"HCS":[656,674],"performed":[660],"implementing":[662],"five":[663],"different":[664],"kinetic":[665,685],"models":[667],"uncoated":[679],"followed":[681],"first":[683],"model.":[686]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}