{"id":"https://openalex.org/W1583828599","doi":"https://doi.org/10.1016/s0021-9258(19)70469-4","title":"Purification and characterization of acid phosphatase-1 from Drosophila melanogaster.","display_name":"Purification and characterization of acid phosphatase-1 from Drosophila melanogaster.","publication_year":1980,"publication_date":"1980-11-01","ids":{"openalex":"https://openalex.org/W1583828599","doi":"https://doi.org/10.1016/s0021-9258(19)70469-4","mag":"1583828599","pmid":"https://pubmed.ncbi.nlm.nih.gov/6776114"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)70469-4","doi":"https://doi.org/10.1016/s0021-9258(19)70469-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)70469-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)70469-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005782295","display_name":"M.I. Feigen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.I. Feigen","raw_affiliation_strings":["Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","From the Department of Biology, University of Oregon, Eugene, Oregon 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"From the Department of Biology, University of Oregon, Eugene, Oregon 97403","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038133612","display_name":"Mitrick A. Johns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Johns","raw_affiliation_strings":["Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","From the Department of Biology, University of Oregon, Eugene, Oregon 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"From the Department of Biology, University of Oregon, Eugene, Oregon 97403","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084768099","display_name":"John H. Postlethwait","orcid":"https://orcid.org/0000-0002-5476-2137","observed_orcids":["https://orcid.org/0000-0002-5476-2137"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.H. Postlethwait","raw_affiliation_strings":["Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","From the Department of Biology, University of Oregon, Eugene, Oregon 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, North Carolina State University, Raleigh, NC 27607 10338","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"From the Department of Biology, University of Oregon, Eugene, Oregon 97403","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030044722","display_name":"Ronald R. Sederoff","orcid":"https://orcid.org/0000-0001-6819-7047","observed_orcids":["https://orcid.org/0000-0001-6819-7047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.R. Sederoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.4124,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59745763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"255","issue":"21","first_page":"10338","last_page":"10343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.1421000063419342,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.1023000031709671,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9929999709129333},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.9900000095367432},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/michaelis-constant","display_name":"Michaelis constant","score":0.7950000166893005},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7379999756813049},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6159999966621399},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/isoelectric-focusing","display_name":"isoelectric focusing","score":0.6740000247955322},{"id":"https://openalex.org/keywords/phosphate-monoester-hydrolysis","display_name":"phosphate monoester hydrolysis","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.9005284309387207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5697294473648071},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.5306695103645325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5020778179168701},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4602595269680023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3767615258693695},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2061520218849182},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1266358494758606}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)70469-4","doi":"https://doi.org/10.1016/s0021-9258(19)70469-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)70469-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6776114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6776114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)70469-4","doi":"https://doi.org/10.1016/s0021-9258(19)70469-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)70469-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W162155683","https://openalex.org/W1489815045","https://openalex.org/W1544481212","https://openalex.org/W1566406366","https://openalex.org/W1570863898","https://openalex.org/W1606423922","https://openalex.org/W1879520716","https://openalex.org/W1885778179","https://openalex.org/W1903091884","https://openalex.org/W1966426159","https://openalex.org/W1967561710","https://openalex.org/W1969896418","https://openalex.org/W1973719552","https://openalex.org/W1978676513","https://openalex.org/W1992026652","https://openalex.org/W2001545393","https://openalex.org/W2016998450","https://openalex.org/W2048808985","https://openalex.org/W2054979333","https://openalex.org/W2058536750","https://openalex.org/W2063458254","https://openalex.org/W2063602277","https://openalex.org/W2066770129","https://openalex.org/W2074724220","https://openalex.org/W2084704408","https://openalex.org/W2084872489","https://openalex.org/W2085270888","https://openalex.org/W2128635872","https://openalex.org/W2340586430"],"related_works":["https://openalex.org/W2057889185","https://openalex.org/W2003950137","https://openalex.org/W2052646919","https://openalex.org/W2319915735","https://openalex.org/W2066475648","https://openalex.org/W2093341494","https://openalex.org/W1995323344","https://openalex.org/W2142043","https://openalex.org/W2026467516","https://openalex.org/W2021498249"],"abstract_inverted_index":{"Acid":[0,170],"phosphatase-1":[1,67,86,171],"(orthophosphoric":[2],"monoester":[3],"phosphohydrolase,":[4],"acid":[5,66,85],"optimum,":[6],"EC":[7],"3.1.3.2),":[8],"the":[9,132,199,207,210],"major":[10,94],"phosphatase":[11],"in":[12,43,89,193],"adult":[13],"Drosophila":[14],"melanogaster,":[15],"has":[16,54],"been":[17],"purified":[18],"to":[19,130],"apparent":[20],"homogeneity.":[21],"The":[22,99,117,138,161,182],"final":[23],"product":[24],"is":[25,168,172,204],"a":[26,30,55,93,102],"glycoprotein":[27],"homodimer":[28],"with":[29,92],"subunit":[31],"molecular":[32],"weight":[33],"of":[34,58,82,105,201,209],"about":[35,79],"50,000,":[36],"as":[37],"measured":[38],"by":[39,64,174],"its":[40],"electrophoretic":[41],"mobility":[42],"denaturing":[44],"conditions":[45],"on":[46],"polyacrylamide":[47],"gels":[48],"containing":[49],"sodium":[50],"dodecyl":[51],"sulfate.":[52],"It":[53],"turnover":[56],"number":[57],"1720":[59],"1-naphthyl":[60,142,166],"phosphate":[61,106,143,146,167],"molecules":[62],"hydrolyzed/s":[63],"each":[65],"molecule":[68],"at":[69,96,134,154],"37":[70,158],"degrees":[71,159,190,197],"C,":[72,198],"pH":[73,97,155,163],"5.0.":[74],"An":[75],"average":[76],"fly":[77],"contains":[78],"5":[80],"ng":[81],"enzyme.":[83],"Pure":[84],"displays":[87],"heterogeneity":[88],"isoelectric":[90],"focusing,":[91],"band":[95],"5.3.":[98],"enzyme":[100,211],"hydrolyzes":[101],"wide":[103],"variety":[104],"monoesters,":[107],"including":[108],"AMP,":[109],"glucose":[110],"6-phosphate,":[111],"ATP,":[112],"choline":[113],"phosphate,":[114,179],"or":[115],"phosphoproteins.":[116],"maximum":[118],"reaction":[119,133,183],"rates":[120],"are":[121,147],"different":[122],"for":[123,141,165,187],"all":[124],"substrates,":[125],"and":[126,144,150,157,180],"some":[127],"substrates":[128],"appear":[129],"inhibit":[131],"high":[135],"substrate":[136],"concentrations.":[137],"Michaelis":[139],"constants":[140],"p-nitrophenyl":[145],"79":[148],"microM":[149],"68":[151],"microM,":[152],"respectively,":[153],"5.0":[156],"C.":[160],"optimum":[162],"level":[164],"4.5.":[169],"inhibited":[173],"L(+)-tartrate":[175],"(but":[176],"not":[177],"D(-)-tartrate),":[178],"fluoride.":[181],"rate":[184,200,208],"increases":[185],"2.1-fold":[186],"every":[188],"10":[189],"C":[191],"rise":[192],"temperature.":[194],"Above":[195],"48":[196],"thermal":[202],"denaturation":[203],"greater":[205],"than":[206],"reaction.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
