{"id":"https://openalex.org/W1583142003","doi":null,"title":"Update on the Dutch Cooperative Trial: mitomycin versus bacillus Calmette-Gu\u00e9rin-Tice versus bacillus Calmette-Gu\u00e9rin RIVM in the treatment of patients with pTA-pT1 papillary carcinoma and carcinoma in situ of the urinary bladder. Dutch South East Cooperative Urological Group.","display_name":"Update on the Dutch Cooperative Trial: mitomycin versus bacillus Calmette-Gu\u00e9rin-Tice versus bacillus Calmette-Gu\u00e9rin RIVM in the treatment of patients with pTA-pT1 papillary carcinoma and carcinoma in situ of the urinary bladder. Dutch South East Cooperative Urological Group.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W1583142003","mag":"1583142003","pmid":"https://pubmed.ncbi.nlm.nih.gov/8727805"},"language":"en","primary_location":{"id":"pmid:8727805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8727805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in urologic oncology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066381176","display_name":"Wim P.J. Witjes","orcid":"https://orcid.org/0000-0002-3600-7920","observed_orcids":["https://orcid.org/0000-0002-3600-7920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Witjes","raw_affiliation_strings":["Department of Urology, University Hospital Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospital Nijmegen, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049365552","display_name":"J.A. Witjes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Witjes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113645301","display_name":"G.O.N. Oosterhof","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G O Oosterhof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109875269","display_name":"M J Debruyne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Debruyne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0301,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.84706793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"14","issue":"1 Suppl 1","first_page":"10","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bcg-vaccine","display_name":"BCG vaccine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/intravesical-chemotherapy","display_name":"intravesical chemotherapy","score":0.7319999933242798},{"id":"https://openalex.org/keywords/superficial-bladder-cancer","display_name":"superficial bladder cancer","score":0.8199999928474426},{"id":"https://openalex.org/keywords/papillary-carcinoma","display_name":"papillary carcinoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"carcinoma in situ","score":0.925000011920929},{"id":"https://openalex.org/keywords/transurethral-resection","display_name":"transurethral resection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bcg-strains","display_name":"BCG vaccine strains","score":0.4699999988079071},{"id":"https://openalex.org/keywords/prognostic-stratification","display_name":"prognostic stratification","score":0.6520000100135803},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/high-grade-tumors","display_name":"high-grade tumors","score":0.6029999852180481},{"id":"https://openalex.org/keywords/time-to-recurrence","display_name":"time to recurrence","score":0.6259999871253967},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8871256709098816},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.7083093523979187},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.674862265586853},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.6619164347648621},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.555040717124939},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4718869924545288},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4617682993412018},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.46008041501045227},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41054463386535645},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38942134380340576},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3766580820083618}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000283","descriptor_name":"Administration, Intravesical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmid:8727805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8727805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in urologic oncology","raw_type":"Clinical Trial"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/23291","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/23291","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/123941","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/123941","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seminars in Urology, 14, 10 - 6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/23291","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/23291","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seminars in Urology, 14, 6 - 10","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1583142003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8727805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2101084002","doi":null,"is_oa":false,"landing_page_url":"https://repository.ubn.ru.nl/handle/2066/23291","pdf_url":null,"source":{"id":"https://openalex.org/S2764909024","display_name":"Seminars in urology","issn_l":"0730-9147","issn":["0730-9147"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Seminars in urology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7073862304","https://openalex.org/W2147633207","https://openalex.org/W3185088747","https://openalex.org/W2351587689","https://openalex.org/W2910173709","https://openalex.org/W3207286222","https://openalex.org/W7100218851","https://openalex.org/W2398561777","https://openalex.org/W1553707208","https://openalex.org/W406168398"],"abstract_inverted_index":{"Prophylactic":[0],"intravesical":[1,317],"treatment":[2,183],"with":[3,70,95,116,187,202,239,259],"chemotherapeutic":[4],"agents":[5],"or":[6],"one":[7],"of":[8,12,29,64,81,121,154,195,230,246,250,256],"the":[9,13,91,122,151,166,170,181,227,235,251],"different":[10,42,92,96],"strains":[11,153,229],"immunomodulator":[14],"bacillus":[15],"Calmette-Gu\u00e9rin":[16],"(BCG)":[17],"reduces":[18],"tumor":[19],"recurrence":[20,48,233,269],"and":[21,34,49,83,99,119,138,158,206,211,254,274,278,297,309],"may":[22],"prevent":[23],"progression":[24,82],"after":[25,125],"transurethral":[26],"resection":[27],"(TUR)":[28],"superficial":[30],"bladder":[31,124],"cancer.":[32],"Clinical":[33],"pathological":[35],"prognostic":[36,97],"factors":[37],"are":[38,300,311],"used":[39],"to":[40,267,302,314,316],"categorize":[41],"groups":[43,98,168,184,299,308],"at":[44],"risk":[45,63,80],"for":[46,265,270,275],"disease":[47],"progression.":[50],"Solitary":[51],"low-grade":[52],"(G1,":[53],"2A),":[54],"low-stage":[55],"(pTa)":[56],"tumors":[57,69,241,284,310],"have":[58,76],"less":[59],"than":[60,217],"a":[61,77,262],"5%":[62],"progression,":[65],"while":[66],"pT1":[67,141,273],"G3":[68],"concomitant":[71],"carcinoma":[72,118],"in":[73,113,148,165,175,185,193,200,222,237,244],"situ":[74],"(CIS)":[75],"considerably":[78],"higher":[79],"metastases.":[84],"Thus,":[85],"prospective":[86],"clinical":[87],"trials":[88],"should":[89],"consider":[90],"risks":[93],"associated":[94],"stratify":[100],"patients":[101,115,186,201,238,257],"accordingly.":[102],"The":[103],"Dutch":[104],"Cooperative":[105],"Trial":[106],"evaluated":[107],"mitomycin":[108,171,196,212],"versus":[109,111,169,272,280],"BCG-Tice":[110,252],"BCG-RIVM":[112,207],"469":[114],"pTA/pT1":[117],"CIS":[120],"urinary":[123],"TUR.":[126],"Of":[127],"437":[128],"evaluable":[129],"patients,":[130,248],"50":[131],"had":[132,135,140],"CIS,":[133],"254":[134],"pTA":[136],"tumors,":[137],"133":[139],"tumors.":[142,204],"No":[143,173,219],"statistical":[144],"differences":[145,174],"were":[146,162,178,208],"observed":[147,179,225],"toxicity":[149],"between":[150,180,226],"two":[152,228],"BCG,":[155],"but":[156],"local":[157],"systemic":[159],"side":[160],"effects":[161],"more":[163,215,304,312],"frequent":[164],"BCG":[167],"group.":[172],"response":[176],"rate":[177],"3":[182,282],"CIS.":[188],"A":[189],"statistically":[190,287],"significant":[191,220,288],"difference":[192,221],"favor":[194],"was":[197,224,242],"seen,":[198],"however,":[199],"papillary":[203,240,283],"Mitomycin":[205],"equally":[209],"effective,":[210],"proved":[213],"significantly":[214],"effective":[216],"BCG-Tice.":[218],"efficacy":[223],"BCG.":[231],"Disease":[232],"during":[234],"study":[236],"seen":[243],"43%":[245],"mitomycin-treated":[247],"64%":[249],"group,":[253],"46%":[255],"treated":[258],"BCG-Rivm.":[260],"However,":[261],"subgroup":[263],"analysis":[264],"time":[266],"first":[268],"pTa":[271],"grade":[276,281],"1":[277],"2":[279],"showed":[285],"no":[286],"between-group":[289],"difference.":[290],"Further":[291],"studies":[292],"comparing":[293],"identical":[294],"regimens,":[295],"doses,":[296],"patient":[298,307],"needed":[301],"define":[303],"clearly":[305],"which":[306],"likely":[313],"respond":[315],"therapy.":[318]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
