{"id":"https://openalex.org/W1583019079","doi":null,"title":"Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment.","display_name":"Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment.","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W1583019079","mag":"1583019079","pmid":"https://pubmed.ncbi.nlm.nih.gov/10586942"},"language":"en","primary_location":{"id":"pmid:10586942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10586942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051396126","display_name":"Paulo F. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210127365","display_name":"Hospital de Santo Ant\u00f3nio","ror":"https://ror.org/02m9pj861","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210127365"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"P F Torres","raw_affiliation_strings":["Department of Ophthalmology, Hospital Geral de Santo Ant\u00f3nio, Porto, Portugal","Department of Ophthalmology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, University of Porto, Portugal; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Hospital Geral de Santo Ant\u00f3nio, Porto, Portugal","institution_ids":["https://openalex.org/I4210127365"]},{"raw_affiliation_string":"Department of Ophthalmology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, University of Porto, Portugal; the","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655949","display_name":"Tanja P.A.M. Slegers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T P Slegers","raw_affiliation_strings":["Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068134792","display_name":"Ronald Peek","orcid":"https://orcid.org/0000-0003-2134-3371","observed_orcids":["https://orcid.org/0000-0003-2134-3371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Peek","raw_affiliation_strings":["Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079003683","display_name":"Nico van Rooijen","orcid":"https://orcid.org/0000-0002-6382-1813","observed_orcids":["https://orcid.org/0000-0002-6382-1813"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N van Rooijen","raw_affiliation_strings":["Department of Cell Biology, Free University, Amsterdam, The Netherlands; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Free University, Amsterdam, The Netherlands; and the","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110226260","display_name":"R. D. van der Gaag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R van der Gaag","raw_affiliation_strings":["Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005016013","display_name":"Aize Kijlstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Kijlstra","raw_affiliation_strings":["Department of Ophthalmology, University of Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Amsterdam","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069416813","display_name":"Alex F. de Vos","orcid":"https://orcid.org/0000-0002-2472-3014","observed_orcids":["https://orcid.org/0000-0002-2472-3014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A F de Vos","raw_affiliation_strings":["Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam, the Netherlands; the","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5013,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.79639248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"13","first_page":"3194","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-graft-rejection","display_name":"corneal graft rejection","score":0.9589999914169312},{"id":"https://openalex.org/keywords/clodronate-liposomes","display_name":"clodronate liposomes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cytokine-mrna-expression","display_name":"cytokine mRNA expression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7749999761581421},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7710000276565552},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/interleukin-12-p40","display_name":"interleukin-12p40","score":0.7770000100135803},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6180739998817444},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6071789860725403},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5449806451797485},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5303172469139099},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5017971992492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43608516454696655},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39327898621559143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3809671998023987},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3731541335582733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21944648027420044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004002","descriptor_name":"Clodronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015846","descriptor_name":"Monokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016039","descriptor_name":"Corneal Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:10586942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10586942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.8250","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.8250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/40/13/3194.full.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/8d1c203d-f59d-4720-b585-0810fdeba2ea","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/changes-in-cytokine-mrna-levels-in-experimental-corneal-allografts-after-local-clodronateliposome-treatment(8d1c203d-f59d-4720-b585-0810fdeba2ea).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology and Visual Science, 40(13), 3194 - 3201. Association for Research in Vision and Ophthalmology Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e0745ef3-b721-4dac-a4eb-e4ac58cc9867","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e0745ef3-b721-4dac-a4eb-e4ac58cc9867","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Torres, P F, Slegers, T P A M, Peek, R, Van Rooijen, N, Van Der Gaag, R, Kijlstra, A & De Vos, A F 1999, 'Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment', Investigative Ophthalmology and Visual Science, vol. 40, no. 13, pp. 3194-3201.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1583019079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10586942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W384638","https://openalex.org/W27558630","https://openalex.org/W35722828","https://openalex.org/W107721504","https://openalex.org/W123902827","https://openalex.org/W169105841","https://openalex.org/W197764648","https://openalex.org/W335697314","https://openalex.org/W1210607603","https://openalex.org/W1566342733","https://openalex.org/W1573972274","https://openalex.org/W1584286177","https://openalex.org/W1586272693","https://openalex.org/W1607590096","https://openalex.org/W1661544713","https://openalex.org/W1858992195","https://openalex.org/W1879781226","https://openalex.org/W1970847065","https://openalex.org/W1974826350","https://openalex.org/W1988523451","https://openalex.org/W1993677761","https://openalex.org/W1998944080","https://openalex.org/W2006653274","https://openalex.org/W2027414566","https://openalex.org/W2031599341","https://openalex.org/W2039896640","https://openalex.org/W2052659304","https://openalex.org/W2062811432","https://openalex.org/W2070708359","https://openalex.org/W2070992531","https://openalex.org/W2085997387","https://openalex.org/W2108473659","https://openalex.org/W2112036147","https://openalex.org/W2131761283","https://openalex.org/W2134812217","https://openalex.org/W2139640346","https://openalex.org/W2140944306","https://openalex.org/W2142514170","https://openalex.org/W2148286266","https://openalex.org/W2155229523","https://openalex.org/W2409658494"],"related_works":["https://openalex.org/W2085997387","https://openalex.org/W2001409328","https://openalex.org/W1493413327","https://openalex.org/W2045980186","https://openalex.org/W1607590096","https://openalex.org/W3031150903","https://openalex.org/W2084563352","https://openalex.org/W2097307654","https://openalex.org/W107721504","https://openalex.org/W7055854785"],"abstract_inverted_index":{"PURPOSE:":[0],"Corneal":[1,134],"allograft":[2,161,278],"rejection":[3,162],"in":[4,34,137,154,181,192,199,207,219,261,268],"rats":[5,41,140],"can":[6],"be":[7],"prevented":[8,160],"by":[9,126,141,217,272],"subconjunctival":[10],"injections":[11],"of":[12,27,45,61,81,150,168,257],"liposomes":[13],"containing":[14],"dichloromethylene":[15],"diphosphonate":[16],"(clodronate-LIP),":[17],"which":[18,273],"selectively":[19],"eliminate":[20],"macrophages.":[21],"In":[22],"this":[23],"study,":[24],"the":[25,59,77,166,254,270],"effect":[26],"clodronate-LIP":[28,57,218,274],"treatment":[29,159,251,275],"on":[30,58,64],"cytokine":[31],"mRNA":[32,122,148,180,191,195,213,241,255],"levels":[33,123,149,167,196,214,256],"corneal":[35,43,236,262,277],"allografts":[36],"was":[37,74,144],"examined.":[38],"METHODS:":[39],"AO":[40],"received":[42],"grafts":[44,155,182,208,220,237],"PVG":[46],"rats.":[47],"Rats":[48],"were":[49,124,197,215],"either":[50],"not":[51],"treated":[52],"or":[53],"injected":[54],"subconjunctivally":[55],"with":[56,146],"day":[60],"transplantation":[62,87,225],"and":[63,71,79,88,116,156,163,178,183,189,221,228,247],"postoperative":[65],"days":[66],"(PODs)":[67],"2,":[68],"4,":[69],"6,":[70],"8.":[72],"RNA":[73],"isolated":[75],"from":[76,89],"graft":[78],"rim":[80],"corneas":[82],"at":[83,209],"different":[84],"times":[85],"after":[86,224],"normal":[90,232],"controls.":[91],"Interleukin":[92],"(IL)-1beta,":[93],"IL-1":[94,184],"receptor":[95],"antagonist":[96],"(IL-1RA),":[97],"IL-2,":[98,171,186],"IL-4,":[99,172,187],"IL-6,":[100,173,188],"IL-10,":[101,174,243],"IL-12p40,":[102,244],"tumor":[103],"necrosis":[104],"factor":[105],"(TNF)-alpha,":[106],"TNF-beta/lymphotoxin":[107],"(LT),":[108],"interferon":[109],"(IFN)-gamma,":[110],"monocyte":[111],"chemotactic":[112],"protein":[113,119],"1":[114],"(MCP-1),":[115],"macrophage":[117],"inflammatory":[118],"2":[120],"(MIP-2)":[121],"analyzed":[125],"semiquantitative":[127],"reverse":[128],"transcription-polymerase":[129],"chain":[130],"reaction":[131],"(RT-PCR).":[132],"RESULTS:":[133],"rejection,":[135],"observed":[136],"all":[138,151,258],"untreated":[139],"POD":[142,210],"12,":[143],"associated":[145],"increased":[147,216],"cytokines":[152,259],"investigated":[153,260],"rims.":[157,193],"Clodronate-LIP":[158],"strongly":[164],"decreased":[165],"IL-1beta,":[169],"IL-1RA,":[170],"IFN-gamma,":[175],"TNF-beta/LT,":[176],"MCP-1,":[177,246],"MIP-2":[179],"beta,":[185],"IFN-gamma":[190],"Interleukin-12p40":[194],"unaltered":[198],"clodronate-treated":[200],"rats,":[201],"except":[202],"for":[203,242],"a":[204,231],"transient":[205],"increase":[206],"3.":[211],"TNF-alpha":[212],"rims":[222],"early":[223],"(PODs":[226],"3":[227],"7).":[229],"Despite":[230],"appearance,":[233],"long-term":[234],"accepted":[235],"(POD":[238],"100)":[239],"contained":[240],"TNF-alpha,":[245],"MIP-2.":[248],"CONCLUSIONS:":[249],"Clodronate-liposome":[250],"markedly":[252],"altered":[253],"allografts.":[263],"These":[264],"results":[265],"may":[266],"explain":[267],"part":[269],"mechanism":[271],"prevents":[276],"rejection.":[279]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}