{"id":"https://openalex.org/W1582987339","doi":"https://doi.org/10.1104/pp.106.2.529","title":"The Apparent Turnover of 1-Aminocyclopropane-1-Carboxylate Synthase in Tomato Cells Is Regulated by Protein Phosphorylation and Dephosphorylation","display_name":"The Apparent Turnover of 1-Aminocyclopropane-1-Carboxylate Synthase in Tomato Cells Is Regulated by Protein Phosphorylation and Dephosphorylation","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W1582987339","doi":"https://doi.org/10.1104/pp.106.2.529","mag":"1582987339","pmid":"https://pubmed.ncbi.nlm.nih.gov/12232347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/159558"},"language":"en","primary_location":{"id":"doi:10.1104/pp.106.2.529","doi":"https://doi.org/10.1104/pp.106.2.529","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.106.2.529","pdf_url":"https://academic.oup.com/plphys/article-pdf/106/2/529/35912249/plphys_v106_2_529.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/plphys/article-pdf/106/2/529/35912249/plphys_v106_2_529.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076127425","display_name":"Pietro Daniele Spanu","orcid":"https://orcid.org/0000-0001-8928-6049","observed_orcids":["https://orcid.org/0000-0001-8928-6049","https://orcid.org/0000-0002-3974-2402"]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P. Spanu","raw_affiliation_strings":["Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I860889466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016747124","display_name":"Debora G. Grosskopf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. G. Grosskopf","raw_affiliation_strings":["Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I860889466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001200025","display_name":"Georg Felix","orcid":"https://orcid.org/0000-0002-6746-6185","observed_orcids":["https://orcid.org/0000-0002-6746-6185"]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Felix","raw_affiliation_strings":["Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I860889466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077364923","display_name":"Thomas Boller","orcid":"https://orcid.org/0000-0001-6768-7503","observed_orcids":["https://orcid.org/0000-0001-6768-7503"]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T. Boller","raw_affiliation_strings":["Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Miescher-Institute, P.O. Box 2543, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I860889466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I860889466"],"apc_list":{"value":3851,"currency":"USD","value_usd":3851},"apc_paid":null,"fwci":9.1281,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.97902592,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"106","issue":"2","first_page":"529","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10473","display_name":"Postharvest Quality and Shelf Life Management","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10473","display_name":"Postharvest Quality and Shelf Life Management","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.17589999735355377,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-aminocyclopropane-1-carboxylic-acid-synthase","display_name":"1-aminocyclopropane-1-carboxylate synthase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enzyme-turnover","display_name":"enzyme turnover","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fungal-elicitors","display_name":"fungal elicitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/k252a","display_name":"K252a","score":0.8309999704360962},{"id":"https://openalex.org/keywords/calyculin-a","display_name":"calyculin A","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cordycepin","display_name":"cordycepin","score":0.925000011920929},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.7860000133514404},{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ethylene-production","display_name":"ethylene production","score":0.7329999804496765},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.9157629013061523},{"id":"https://openalex.org/C2779012821","wikidata":"https://www.wikidata.org/wiki/Q1329233","display_name":"Elicitor","level":3,"score":0.7151973247528076},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6982695460319519},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.6847459077835083},{"id":"https://openalex.org/C2779033064","wikidata":"https://www.wikidata.org/wiki/Q7251487","display_name":"Protein kinase inhibitor","level":4,"score":0.5957047939300537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5954741835594177},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5801462531089783},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.5762320160865784},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5522859692573547},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5522598028182983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5198929309844971},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.44171276688575745},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.396955668926239},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.359042763710022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3245311379432678}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1104/pp.106.2.529","doi":"https://doi.org/10.1104/pp.106.2.529","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.106.2.529","pdf_url":"https://academic.oup.com/plphys/article-pdf/106/2/529/35912249/plphys_v106_2_529.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},{"id":"pmid:12232347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12232347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:159558","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC159558/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1104/pp.106.2.529","doi":"https://doi.org/10.1104/pp.106.2.529","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.106.2.529","pdf_url":"https://academic.oup.com/plphys/article-pdf/106/2/529/35912249/plphys_v106_2_529.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1582987339.pdf","grobid_xml":"https://content.openalex.org/works/W1582987339.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W140944189","https://openalex.org/W1940046342","https://openalex.org/W1985436352","https://openalex.org/W1994434295","https://openalex.org/W2000527439","https://openalex.org/W2001384808","https://openalex.org/W2036381257","https://openalex.org/W2050338578","https://openalex.org/W2062883953","https://openalex.org/W2063555626","https://openalex.org/W2073750975","https://openalex.org/W2081584410","https://openalex.org/W2087226886","https://openalex.org/W2087825350","https://openalex.org/W2090530927","https://openalex.org/W2094231099","https://openalex.org/W2095027488","https://openalex.org/W2106104578","https://openalex.org/W2107730615","https://openalex.org/W2344113470"],"related_works":["https://openalex.org/W2097386616","https://openalex.org/W1994434295","https://openalex.org/W1985436352","https://openalex.org/W2014440450","https://openalex.org/W2307032392","https://openalex.org/W2095027488","https://openalex.org/W2081584410","https://openalex.org/W2173089336","https://openalex.org/W1999509501","https://openalex.org/W2372708243"],"abstract_inverted_index":{"In":[0,109,156],"suspension-cultured":[1],"cells":[2],"of":[3,10,23,25,34,41,46,63,76,82,89,94,100,103,112,130,153,185,199,201],"tomato":[4],"(Lycopersicon":[5],"esculentum":[6],"Mill.),":[7],"the":[8,32,47,72,92,101,110,121,136,145,149,183,190,197,202],"activity":[9,64,141,159,192],"1-aminocyclopropane-1-carboxylate":[11],"synthase":[12],"(ACC-S)":[13],"rapidly":[14],"increases":[15],"in":[16,56,70,91,106,139,182],"response":[17],"to":[18,67],"fungal":[19],"elicitors.":[20],"The":[21],"effect":[22,122],"inhibitors":[24],"protein":[26,29,42,83,125,172,178],"kinases":[27],"and":[28,51,74,96,148,165],"phosphatases":[30],"on":[31,124],"regulation":[33,184],"ACC-S":[35,90,104,140,158],"was":[36,115,160],"studied.":[37],"K-252a,":[38],"an":[39,80,97,128],"inhibitor":[40,81,129],"kinases,":[43],"prevented":[44],"induction":[45],"enzyme":[48],"by":[49,163,169,188,195],"elicitors":[50,95],"promoted":[52],"its":[53,154],"apparent":[54],"turnover":[55,200],"elicitor-stimulated":[57,107],"cells,":[58],"causing":[59],"a":[60,86],"50%":[61],"loss":[62],"within":[65],"4":[66],"8":[68],"min":[69],"both":[71],"presence":[73,111],"absence":[75,93],"cycloheximide.":[77],"Calyculin":[78],"A,":[79],"phosphatases,":[84],"caused":[85],"rapid":[87],"increase":[88,105,138,152],"immediate":[98],"acceleration":[99],"rate":[102,198],"cells.":[108],"cycloheximide":[113],"there":[114],"no":[116],"such":[117],"increase,":[118],"indicating":[119],"that":[120,177],"depended":[123],"synthesis.":[126],"Cordycepin,":[127],"mRNA":[131],"synthesis,":[132],"did":[133],"not":[134,161,187],"prevent":[135],"elicitor-induced":[137],"but":[142,194],"strongly":[143],"reduced":[144],"K-252a-induced":[146],"decay":[147],"calyculin":[150,166],"A-induced":[151],"activity.":[155],"vitro,":[157],"affected":[162],"K-252a":[164],"A":[167],"or":[168],"treatments":[170],"with":[171],"phosphatases.":[173],"These":[174],"results":[175],"suggest":[176],"phosphorylation/dephosphorylation":[179],"is":[180],"involved":[181],"ACC-S,":[186],"regulating":[189],"catalytic":[191],"itself":[193],"controlling":[196],"enzyme.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}