{"id":"https://openalex.org/W1582931002","doi":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","title":"Sildenafil (SIL) reduces serum creatinine (SCr) in patients with pulmonary arterial hypertension (PAH): Relationship to clinical outcomes","display_name":"Sildenafil (SIL) reduces serum creatinine (SCr) in patients with pulmonary arterial hypertension (PAH): Relationship to clinical outcomes","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W1582931002","doi":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","mag":"1582931002"},"language":"en","primary_location":{"id":"doi:10.1183/13993003/erj.38.suppl_55.p2281","doi":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081449769","display_name":"David John Webb","orcid":"https://orcid.org/0000-0003-0755-1756","observed_orcids":["https://orcid.org/0000-0003-0755-1756","https://orcid.org/0000-0002-8109-1877","https://orcid.org/0000-0002-3932-3339"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Webb","raw_affiliation_strings":["1Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041984682","display_name":"Jean\u2010Luc Vachi\u00e9ry","orcid":"https://orcid.org/0000-0002-6358-7852","observed_orcids":["https://orcid.org/0000-0002-6358-7852"]},"institutions":[{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Luc Vachiery","raw_affiliation_strings":["2Departement de Cardiologie, CUB-H\u00f4pital Erasme, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Departement de Cardiologie, CUB-H\u00f4pital Erasme, Brussels, Belgium","institution_ids":["https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110189532","display_name":"Lie\u2010Ju Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lie-Ju Hwang","raw_affiliation_strings":["3Department of Statistics, Specialty Care, Pfizer Inc, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Statistics, Specialty Care, Pfizer Inc, New York, NY, United States","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090924072","display_name":"STEPHEN J. WATT","orcid":"https://orcid.org/0000-0003-1403-5493","observed_orcids":["https://orcid.org/0000-0003-1403-5493"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Watt","raw_affiliation_strings":["4Medical, Pulmonary Vascular Disease, Pfizer Inc, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical, Pulmonary Vascular Disease, Pfizer Inc, New York, NY, United States","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024355966","display_name":"Julie Maurey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Maurey","raw_affiliation_strings":["5Regional Medical & Research, Specialty Care - Pulmonary Vascular Disease, Pfizer Inc, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Regional Medical & Research, Specialty Care - Pulmonary Vascular Disease, Pfizer Inc, New York, NY, United States","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"Suppl 55","first_page":"p2281","last_page":"p2281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7120000123977661},{"id":"https://openalex.org/keywords/6-minute-walk-distance","display_name":"6-minute walk distance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/functional-class","display_name":"functional class","score":0.9810000061988831},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8669999837875366},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-arterial-hypertension","display_name":"idiopathic pulmonary arterial hypertension","score":0.640999972820282},{"id":"https://openalex.org/keywords/mortality-risk","display_name":"mortality risk","score":0.4059999883174896},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.42100000381469727},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.38100001215934753},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8825215697288513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5986758470535278},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.553406298160553},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.502227783203125},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4759794771671295},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.46043840050697327},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.459041565656662},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39219406247138977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08523795008659363},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003/erj.38.suppl_55.p2281","doi":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.38.suppl_55.p2281","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112076805","https://openalex.org/W3003923510","https://openalex.org/W1555845594","https://openalex.org/W1997715017","https://openalex.org/W1998625415","https://openalex.org/W2150889420","https://openalex.org/W3029516515","https://openalex.org/W2137353788","https://openalex.org/W4232911620","https://openalex.org/W2013803682"],"abstract_inverted_index":{"Purpose:":[0],"Elevated":[1],"SCr":[2,17,27,109,119,159,200,226,261,266],"associates":[3],"with":[4,29,166,172,191,204,224,269],"poor":[5],"outcome":[6],"in":[7,18,60,72,87,95,262],"PAH.":[8],"We":[9],"retrospectively":[10],"analyzed":[11],"the":[12,187],"effect":[13],"of":[14,98,230,245,277],"SIL":[15,53,64,173],"on":[16],"PAH":[19,47,147,263],"patients":[20],"(pts)":[21],"from":[22,111],"SUPER-1":[23,61],"and":[24,42,62,77,84,120,124,131,133,152,170,176,182,214,239,272,274],"-2":[25],"studies.":[26],"relationships":[28],"6-min":[30],"walk":[31],"distance":[32],"(6MWD),":[33],"functional":[34],"class":[35],"(FC),":[36],"time":[37],"to":[38,66,113],"clinical":[39,278],"worsening":[40,231],"(TTCW),":[41],"survival":[43,89,134],"were":[44,79,137,142],"examined.":[45],"Methods:":[46],"pts":[48],"received":[49],"placebo":[50],"(PBO)":[51],"or":[52,56,156],"20,":[54,180],"40,":[55,181],"80":[57,67,183,192],"mg":[58,68,184,193],"TID":[59,69,194],"open-label":[63],"titrated":[65],"(as":[70],"tolerated)":[71],"SUPER-2.":[73,96],"SCr,":[74],"6MWD,":[75],"FC,":[76],"TTCW":[78,132],"assessed":[80,108],"at":[81,161],"baseline":[82],"(BL)":[83],"wk":[85,114,162],"12":[86,115,163],"SUPER-1;":[88],"was":[90,148,195,202,267],"tracked":[91],"for":[92,179],"3":[93],"y":[94],"Analysis":[97],"covariance":[99],"(treatment":[100],"as":[101,106],"a":[102,240],"factor;":[103],"BL":[104,112,140,165],"value":[105],"covariate)":[107],"change":[110],"(posthoc).":[116],"Relationships":[117],"between":[118],"\u226510%":[121],"6MWD":[122,206,271],"increase":[123],"\u22651-class":[125],"FC":[126,153,215,273],"improvement":[127],"(using":[128],"logistic":[129],"regression)":[130,136],"(Cox":[135],"assessed.":[138],"Results:":[139],"characteristics":[141],"similar":[143],"among":[144],"groups":[145],"(N=277);":[146],"mostly":[149],"idiopathic":[150],"(63%)":[151],"II":[154],"(39%)":[155],"III":[157],"(58%).":[158],"increased":[160],"vs":[164,189],"PBO":[167,190],"(0.032":[168],"mg/dL)":[169],"decreased":[171,260],"(\u20130.001,":[174],"\u20130.035,":[175],"\u20130.048":[177],"mg/dL":[178],"TID,":[185],"respectively);":[186],"difference":[188],"significant":[196],"(":[197],"P":[198,212,221,237,252],"=0.032).":[199],"reduction":[201],"associated":[203,268],"improved":[205,270],"(OR":[207,216],"4.74;":[208],"95%":[209,218,234,249],"CI,":[210,219,235,250],"1.07\u201321.05;":[211],"=0.04)":[213],"6.64;":[217],"1.37\u201332.16;":[220],"=0.019).":[222],"Pts":[223],"higher":[225,228,243],"had":[227],"risk":[229,244,276],"(HR":[232,247],"44.38;":[233],"6.67\u2013295.32;":[236],"<0.0001)":[238],"trend":[241],"toward":[242],"mortality":[246],"2.62;":[248],"0.22\u201330.55;":[251],"=0.44).":[253],"Conclusion:":[254],"In":[255],"posthoc":[256],"analysis,":[257],"sildenafil":[258],"dose-dependently":[259],"pts;":[264],"reduced":[265,275],"worsening.":[279]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}