{"id":"https://openalex.org/W1582437254","doi":null,"title":"A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types","display_name":"A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1582437254","mag":"1582437254"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rots, M, Gommans, W M, Dmitriev, I, Oosterhuis, D, Seki, T, Curiel, D T & Haisma, H J 2004, 'A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types', Gene Therapy and Molecular Biology, vol. 8, pp. 1 - 8.","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107933555","display_name":"Marianne G. Rots","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne G. Rots","raw_affiliation_strings":["Damage and Repair in Cancer Development and Cancer Treatment (DARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Damage and Repair in Cancer Development and Cancer Treatment (DARE)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109006848","display_name":"Willemijn M. Gommans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Willemijn M. Gommans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036159485","display_name":"Igor P. Dmitriev","orcid":"https://orcid.org/0000-0001-9206-1975","observed_orcids":["https://orcid.org/0000-0001-9206-1975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor P. Dmitriev","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9206-1975","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031914042","display_name":"Dorenda Oosterhuis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorenda Oosterhuis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059254858","display_name":"Toshiro Seki","orcid":"https://orcid.org/0000-0002-1963-5140","observed_orcids":["https://orcid.org/0000-0002-1963-5140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiro Seki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1963-5140","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3802-6014","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021729725","display_name":"Hidde J. Haisma","orcid":"https://orcid.org/0000-0003-3997-9052","observed_orcids":["https://orcid.org/0000-0003-3997-9052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidde J. Haisma","raw_affiliation_strings":["Faculty of Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0003-3997-9052","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3572,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60245488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-type-5","display_name":"adenovirus type 5","score":0.9020000100135803},{"id":"https://openalex.org/keywords/adenovirus-type-3","display_name":"adenovirus type 3","score":0.8740000128746033},{"id":"https://openalex.org/keywords/viral-entry-mechanism","display_name":"viral entry mechanism","score":0.38499999046325684},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.5839999914169312},{"id":"https://openalex.org/keywords/major-late-promoter","display_name":"major late promoter","score":0.6449999809265137},{"id":"https://openalex.org/keywords/capsid-engineering","display_name":"capsid engineering","score":0.6060000061988831},{"id":"https://openalex.org/keywords/infection-efficiency","display_name":"infection efficiency","score":0.5899999737739563},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.8436781167984009},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.6412817239761353},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.6101479530334473},{"id":"https://openalex.org/C2780575108","wikidata":"https://www.wikidata.org/wiki/Q7316652","display_name":"Retargeting","level":2,"score":0.5706255435943604},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.5346965193748474},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5345560312271118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5258638858795166},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5045355558395386},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.45906996726989746},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.45715802907943726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4376085102558136},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42377331852912903},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4225379228591919},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.41343551874160767},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3113144040107727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.193015456199646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18170535564422607},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14569091796875},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rots, M, Gommans, W M, Dmitriev, I, Oosterhuis, D, Seki, T, Curiel, D T & Haisma, H J 2004, 'A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types', Gene Therapy and Molecular Biology, vol. 8, pp. 1 - 8.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/c33579ee-61d5-4df8-ac8a-bd99a128edc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gene Therapy and Molecular Biology, 8, 1 - 8","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1582437254","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/a-platform-for-constucting-infectivity-enhanced-fiber-mosaic-aden","pdf_url":null,"source":{"id":"https://openalex.org/S98169967","display_name":"Gene therapy & molecular biology","issn_l":"1529-9120","issn":["1529-9120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Gene therapy & molecular biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1489938529","https://openalex.org/W1516780335","https://openalex.org/W1523680364","https://openalex.org/W1531166036","https://openalex.org/W1641036275","https://openalex.org/W1868077452","https://openalex.org/W1966205801","https://openalex.org/W1980472619","https://openalex.org/W1981755236","https://openalex.org/W1983055880","https://openalex.org/W1996746326","https://openalex.org/W2041200485","https://openalex.org/W2052948073","https://openalex.org/W2070390118","https://openalex.org/W2078455874","https://openalex.org/W2082600436","https://openalex.org/W2084550104","https://openalex.org/W2091334792","https://openalex.org/W2097869227","https://openalex.org/W2098355578","https://openalex.org/W2102648190","https://openalex.org/W2110232710","https://openalex.org/W2112836649","https://openalex.org/W2116175479","https://openalex.org/W2119498791","https://openalex.org/W2128375279","https://openalex.org/W2133822846","https://openalex.org/W2133916339","https://openalex.org/W2147961945","https://openalex.org/W2155605080","https://openalex.org/W2159913430","https://openalex.org/W2162380590","https://openalex.org/W2165269851","https://openalex.org/W2316543256"],"related_works":["https://openalex.org/W2143064142","https://openalex.org/W2334871534","https://openalex.org/W2167857195","https://openalex.org/W2412575645","https://openalex.org/W1980472619","https://openalex.org/W2041200485","https://openalex.org/W2079018821","https://openalex.org/W2080607028","https://openalex.org/W2147961945","https://openalex.org/W2509532692"],"abstract_inverted_index":{"Summary":[0],"Adenoviruses":[1],"type":[2],"5":[3],"have":[4,15],"been":[5],"successfully":[6],"exploited":[7,160],"as":[8],"gene":[9,24,29,184],"transfer":[10,30],"vectors":[11],"and":[12,20,36,65,84],"numerous":[13],"vectorologicalimprovements":[14],"contributed":[16],"to":[17,43,93,161,167],"increasing":[18,179],"efficiency":[19,165],"specificity":[21,83,181],"of":[22,46,61,68,82,101,110,145,153,176,182,191,207],"adenoviral":[23,183],"therapy.":[25],"Despite":[26],"theseimprovements,":[27],"inefficient":[28],"still":[31],"is":[32],"an":[33,74,91,154],"important":[34],"limitation":[35],"is,":[37],"at":[38],"least":[39],"in":[40,178],"part,":[41],"due":[42,166],"the":[44,47,66,99,104,108,111,148,180,205],"lowexpression":[45],"primary":[48],"receptor":[49],"(CAR)":[50],"on":[51,73],"target":[52],"cells.":[53],"Combining":[54],"two":[55,192],"different":[56,143,193],"fiber":[57,60,67,100,135],"types":[58],"(the":[59],"Ad5":[62,105,140],"forCAR-dependent":[63],"uptake":[64],"Ad3":[69,102],"for":[70,80,147],"CAR-independent":[71],"uptake)":[72],"Ad5-based":[75],"capsid":[76],"would":[77],"increasethe":[78],"options":[79],"improvement":[81],"efficiency.":[85],"In":[86,171],"this":[87,187],"study,":[88],"we":[89],"present":[90],"approach":[92,188],"engineer":[94],"fiber-mosaic":[95,119,149],"adenoviruses":[96],"by":[97],"cloning":[98],"into":[103],"genome":[106],"under":[107],"control":[109],"Major":[112],"Late":[113],"Promoterusing":[114],"native":[115],"splicing":[116],"signals.":[117],"Such":[118,198],"viruses":[120],"were":[121],"efficiently":[122],"rescued":[123],"using":[124],"conventional":[125],"293":[126],"cells":[127],"anddemonstrated":[128],"good":[129],"infection":[130,164],"profiles.":[131],"Pre-incubation":[132],"with":[133],"recombinant":[134],"knob":[136],"(either":[137],"derived":[138],"from":[139],"orAd3)":[141],"indicated":[142],"mechanisms":[144],"entry":[146],"viruses.":[150],"The":[151],"introduction":[152],"additional":[155],"entrypathway":[156],"can":[157],"be":[158,175],"further":[159],"overcome":[162],"low":[163,168],"CAR":[169],"expression.":[170],"addition,":[172],"thetechnology":[173],"will":[174,201],"value":[177],"therapy":[185],"since":[186],"allows":[189],"theincorporation":[190],"retargeting":[194],"ligands":[195],"per":[196],"capsid.":[197],"infectivity":[199],"enhancement":[200],"also":[202],"prove":[203],"powerfulin":[204],"context":[206],"replicative":[208],"agents.":[209]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}