{"id":"https://openalex.org/W158236549","doi":null,"title":"Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists.","display_name":"Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W158236549","mag":"158236549","pmid":"https://pubmed.ncbi.nlm.nih.gov/9475485"},"language":"en","primary_location":{"id":"pmid:9475485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9475485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046643853","display_name":"Markus Ketteler","orcid":"https://orcid.org/0000-0002-7214-1895","observed_orcids":["https://orcid.org/0000-0002-7214-1895"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Ketteler","raw_affiliation_strings":["Department of Endocrinology and Nephrology, University Hospital Benjamin Franklin, Free University of Berlin, Germany. gmkett@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nephrology, University Hospital Benjamin Franklin, Free University of Berlin, Germany. gmkett@aol.com","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072516722","display_name":"Claudia Cetto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Cetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030898365","display_name":"M Kirdorf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kirdorf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075603813","display_name":"G S Jeschke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Jeschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J H Sch\u00e4fer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Sch\u00e4fer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114068575","display_name":"A. Distler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Distler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3597,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.86986853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"64","issue":null,"first_page":"S27","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":1.0},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.7820000052452087},{"id":"https://openalex.org/keywords/myocardial-depression","display_name":"myocardial depression","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bacterial-endotoxin","display_name":"bacterial endotoxin","score":0.871999979019165},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.6389999985694885},{"id":"https://openalex.org/keywords/sepsis-pathophysiology","display_name":"sepsis pathophysiology","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.9016082286834717},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7625195980072021},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7485271692276001},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7243897914886475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6100308895111084},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5076628923416138},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4953106939792633},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.48208481073379517},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.47190481424331665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4342588782310486},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.42567330598831177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3439920246601105}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018746","descriptor_name":"Systemic Inflammatory Response Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018746","descriptor_name":"Systemic Inflammatory Response Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9475485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9475485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:158236549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9475485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2284496795","https://openalex.org/W2155791167","https://openalex.org/W2464895451","https://openalex.org/W1984808347","https://openalex.org/W2134509077","https://openalex.org/W2085081948","https://openalex.org/W108053675","https://openalex.org/W1823047634","https://openalex.org/W2115929723","https://openalex.org/W2397280698"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1,98],"(NO)":[2],"is":[3,39,101,163],"an":[4,87,113],"effector":[5],"molecule":[6],"with":[7,146,182],"multiple":[8],"effects":[9],"on":[10,176],"various":[11],"organ":[12],"systems.":[13],"The":[14],"most":[15],"prominent":[16],"physiological":[17],"actions":[18],"of":[19,56,90,115,203],"NO":[20,82,93,137],"as":[21,67,109,111,154,156,205],"a":[22,40,52,79,122,206],"biological":[23],"mediator":[24],"include":[25],"cGMP-dependent":[26],"vasodilation":[27,128],"and":[28,62,107,129,171,180,204],"cytotoxicity":[29],"against":[30],"pathogens":[31],"in":[32,73,142,152,157,168,178,200,210],"the":[33,91,197,201],"unspecific":[34],"immune":[35],"defense.":[36],"Sepsis":[37],"syndrome":[38],"complex":[41],"disease":[42],"entity":[43],"mostly":[44],"caused":[45,103],"by":[46,104,112,165,185],"overwhelming":[47],"bacterial":[48,105],"infections.":[49],"It":[50,119],"has":[51],"high":[53],"mortality":[54,177],"rate":[55],"40":[57],"to":[58,71,86,126],"60%.":[59],"Catecholamine-resistant":[60],"hypotension":[61,141,151],"myocardial":[63,130],"depression":[64],"are":[65,188],"regarded":[66],"major":[68],"factors":[69],"contributing":[70],"death":[72],"septic":[74,77,143,158,211],"patients.":[75,159],"In":[76],"shock,":[78],"pathophysiologically":[80],"increased":[81],"production":[83],"occurs":[84],"due":[85],"excessive":[88],"induction":[89],"inducible":[92],"synthase":[94,99],"(iNOS).":[95],"Inducible":[96],"nitric":[97],"up-regulation":[100],"probably":[102],"endo-":[106],"exotoxins":[108],"well":[110,155],"increase":[114],"circulating":[116],"pro-inflammatory":[117],"cytokines.":[118],"may":[120],"be":[121],"key":[123],"factor":[124],"leading":[125],"pronounced":[127],"toxicity.":[131],"Experimental":[132],"studies":[133],"have":[134],"confirmed":[135],"that":[136],"overproduction":[138],"causes":[139],"severe":[140],"animals.":[144],"Treatment":[145],"competitive":[147],"NOS-inhibitors":[148],"abolishes":[149],"this":[150],"animals":[153,179],"However,":[160],"their":[161],"use":[162],"complicated":[164],"concomitant":[166],"decreases":[167],"cardiac":[169],"index":[170],"oxygen":[172],"delivery.":[173],"Conclusive":[174],"data":[175],"patients":[181],"sepsis-syndrome":[183],"treated":[184],"NOS":[186],"antagonists":[187],"not":[189],"available.":[190],"This":[191],"article":[192],"discusses":[193],"current":[194],"concepts":[195],"concerning":[196],"L-arginine/NO":[198],"system":[199],"pathophysiology":[202],"potential":[207],"therapeutic":[208],"target":[209],"shock.":[212]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
