{"id":"https://openalex.org/W1581985161","doi":"https://doi.org/10.3233/jad-2012-120319","title":"Enhanced Brain Amyloid-\u03b2 Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease","display_name":"Enhanced Brain Amyloid-\u03b2 Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease","publication_year":2012,"publication_date":"2012-07-05","ids":{"openalex":"https://openalex.org/W1581985161","doi":"https://doi.org/10.3233/jad-2012-120319","mag":"1581985161","pmid":"https://pubmed.ncbi.nlm.nih.gov/22504320"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2012-120319","doi":"https://doi.org/10.3233/jad-2012-120319","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2012-120319","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3902015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018122063","display_name":"Hisham Qosa","orcid":"https://orcid.org/0009-0008-1945-2353","observed_orcids":["https://orcid.org/0009-0008-1945-2353"]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisham Qosa","raw_affiliation_strings":["Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA","Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA","institution_ids":["https://openalex.org/I71730758"]},{"raw_affiliation_string":"Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA","institution_ids":["https://openalex.org/I71730758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066429167","display_name":"Alaa H. Abuznait","orcid":"https://orcid.org/0009-0002-7560-7248","observed_orcids":["https://orcid.org/0009-0002-7560-7248"]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alaa H. Abuznait","raw_affiliation_strings":["Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA","institution_ids":["https://openalex.org/I71730758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034466779","display_name":"Ronald A. Hill","orcid":"https://orcid.org/0000-0003-4622-5996","observed_orcids":["https://orcid.org/0000-0003-4622-5996"]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald A. Hill","raw_affiliation_strings":["Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA","institution_ids":["https://openalex.org/I71730758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088699805","display_name":"Amal Kaddoumi","orcid":"https://orcid.org/0000-0001-9792-7766","observed_orcids":["https://orcid.org/0000-0001-9792-7766"]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amal Kaddoumi","raw_affiliation_strings":["Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Science, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA","institution_ids":["https://openalex.org/I71730758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088699805"],"corresponding_institution_ids":["https://openalex.org/I71730758"],"apc_list":null,"apc_paid":null,"fwci":9.2383,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.98554066,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"1","first_page":"151","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.09570000320672989,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":1.0}],"concepts":[{"id":"https://openalex.org/C139647698","wikidata":"https://www.wikidata.org/wiki/Q21111528","display_name":"LRP1","level":5,"score":0.9283282160758972},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.698942244052887},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.6814256310462952},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6330401301383972},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5902352333068848},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.48291322588920593},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4669329524040222},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44688788056373596},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4239528775215149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3797435760498047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3064388632774353},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.2277488112449646},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.22196653485298157},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.213001549243927},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17527735233306885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15362045168876648},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.08737778663635254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026503","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026503","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026503","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-2012-120319","doi":"https://doi.org/10.3233/jad-2012-120319","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2012-120319","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:22504320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22504320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2886282","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3902015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3902015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3902015","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3902015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3902015","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1561353229","display_name":null,"funder_award_id":"5P20RR016456\u201111","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1582172614","display_name":null,"funder_award_id":"P20RR016456","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000911945","display_name":"Louisiana Biomedical Research Network","funder_award_id":"P20GM103424","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W108661447","https://openalex.org/W232292579","https://openalex.org/W1537251972","https://openalex.org/W1580500775","https://openalex.org/W1585244276","https://openalex.org/W1620810572","https://openalex.org/W1803013685","https://openalex.org/W1841389452","https://openalex.org/W1941252177","https://openalex.org/W1964454256","https://openalex.org/W1974479642","https://openalex.org/W1977128117","https://openalex.org/W1978023263","https://openalex.org/W1985603351","https://openalex.org/W1989342312","https://openalex.org/W1997822484","https://openalex.org/W2001324129","https://openalex.org/W2009631046","https://openalex.org/W2016756053","https://openalex.org/W2017294885","https://openalex.org/W2024353040","https://openalex.org/W2033354781","https://openalex.org/W2037059097","https://openalex.org/W2049167261","https://openalex.org/W2054363169","https://openalex.org/W2073699102","https://openalex.org/W2083570791","https://openalex.org/W2090097368","https://openalex.org/W2090710011","https://openalex.org/W2091121281","https://openalex.org/W2100258988","https://openalex.org/W2108072925","https://openalex.org/W2110606022","https://openalex.org/W2111962751","https://openalex.org/W2124443688","https://openalex.org/W2126214304","https://openalex.org/W2135508686","https://openalex.org/W2137910690","https://openalex.org/W2140975778","https://openalex.org/W2143975632","https://openalex.org/W2151654327","https://openalex.org/W2157152668","https://openalex.org/W2163209521","https://openalex.org/W2164829288","https://openalex.org/W2166625407","https://openalex.org/W2167527439","https://openalex.org/W2167863861","https://openalex.org/W2169152986","https://openalex.org/W2269512218","https://openalex.org/W2394956077"],"related_works":["https://openalex.org/W1992051646","https://openalex.org/W4387644765","https://openalex.org/W2020059354","https://openalex.org/W2532956721","https://openalex.org/W2767007469","https://openalex.org/W2941666354","https://openalex.org/W2395867572","https://openalex.org/W2771453510","https://openalex.org/W3126467265","https://openalex.org/W2104306818"],"abstract_inverted_index":{"Rifampicin":[0],"and":[1,75,81,98,135,157,172,212,217,228,235,241,255],"caffeine":[2,50,91,136,216,236,256],"are":[3],"widely":[4],"used":[5],"drugs":[6,55,94,177],"with":[7,47,88,116],"reported":[8],"protective":[9,251],"effect":[10,20,243,252],"against":[11,257],"Alzheimer's":[12],"disease":[13],"(AD).":[14],"However,":[15],"the":[16,36,39,69,126,162,168,187,196,224,231,250],"mechanism":[17],"underlying":[18],"this":[19,25,242],"is":[21,51,213],"incompletely":[22],"understood.":[23],"In":[24,219],"study,":[26],"we":[27],"have":[28],"hypothesized":[29],"that":[30,173,205],"enhanced":[31,174,237],"amyloid-\u03b2":[32],"(A\u03b2)":[33],"clearance":[34,124,169,175,211],"from":[35],"brain":[37,78,84,106,238],"across":[38],"blood-brain":[40],"barrier":[41],"(BBB)":[42],"of":[43,73,128,147,164,170,198,226,253],"wild-type":[44],"mice":[45,83,114,141,149],"treated":[46,115,140],"rifampicin":[48,89,100,131,234,254],"or":[49,90],"caused":[52,180],"by":[53,181,215,233],"both":[54,93,165],"potential":[56],"to":[57,119,167,201],"upregulate":[58],"low-density":[59],"lipoprotein":[60],"receptor":[61],"related":[62],"protein-1":[63],"(LRP1)":[64],"and/or":[65,183],"P-glycoprotein":[66],"(P-gp)":[67],"at":[68,186,230,246],"BBB.":[70,189],"Expression":[71],"studies":[72,110,160],"LRP1":[74,103,156,182,227],"P-gp":[76,96,158,184,229],"in":[77,122,130,209,248],"endothelial":[79],"cells":[80],"isolated":[82],"microvessels":[85],"following":[86,176],"treatment":[87,178],"demonstrated":[92,125,223],"as":[95,101],"inducers,":[97],"only":[99],"an":[102],"inducer.":[104],"Also,":[105],"efflux":[107],"index":[108],"(BEI%)":[109],"conducted":[111],"on":[112],"C57BL/6":[113],"either":[117],"drug":[118],"study":[120],"alterations":[121],"A\u03b2":[123,129,210,239],"BEI%":[127],"(82.4":[132],"\u00b1":[133,138,151],"4.3%)":[134],"(80.4":[137],"4.8%)":[139],"were":[142],"significantly":[143],"higher":[144],"than":[145],"those":[146],"control":[148],"(62.4":[150],"6.1%,":[152],"p":[153],"<":[154],"0.01).":[155],"inhibition":[159],"confirmed":[161],"importance":[163],"proteins":[166],"A\u03b2,":[171],"was":[179],"upregulation":[185,225],"mouse":[188],"Furthermore,":[190],"our":[191,221],"results":[192,222],"provided":[193],"evidence":[194],"for":[195],"presence":[197],"a":[199],"yet":[200],"be":[202],"identified":[203],"transporter/receptor":[204],"plays":[206],"significant":[207],"role":[208],"upregulated":[214],"rifampicin.":[218],"conclusion,":[220],"BBB":[232],"clearance,":[240],"could":[244],"explain,":[245],"least":[247],"part,":[249],"AD.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
